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OPENSEQ.org
GSID - Glutathione transport system permease protein GsiD
UniProt: P75799 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13475
Length: 303 (276)
Sequences: 6316
Seq/Len: 22.88
GSID
Paralog alert: 0.77 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: DDPB DDPC DPPB DPPC GSIC GSID NIKB NIKC OPPB OPPC SAPB SAPC YEJB YEJE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
237_A 253_E 3.26 1.00
101_A 254_W 3.195 1.00
122_L 137_I 3.074 1.00
134_D 184_R 2.94 1.00
129_Y 206_D 2.876 1.00
254_W 282_T 2.646 1.00
194_T 197_E 2.588 1.00
84_F 97_V 2.549 1.00
70_D 73_N 2.49 1.00
54_A 101_A 2.449 1.00
87_D 91_R 2.414 1.00
80_L 83_W 2.275 1.00
204_A 208_T 2.185 1.00
190_L 195_F 2.182 1.00
114_I 172_A 2.168 1.00
88_S 260_E 2.13 1.00
43_A 285_A 2.116 1.00
61_A 95_S 2.114 1.00
139_R 142_D 2.095 1.00
124_L 187_T 2.075 1.00
50_L 282_T 2.023 1.00
294_R 298_D 2.011 1.00
82_H 92_D 1.998 1.00
127_G 187_T 1.993 1.00
207_M 211_L 1.987 1.00
31_W 35_R 1.948 1.00
84_F 274_F 1.873 1.00
94_F 98_L 1.845 1.00
52_V 56_F 1.814 1.00
128_Y 206_D 1.814 1.00
56_F 59_W 1.812 1.00
64_D 68_Y 1.804 1.00
57_A 99_V 1.784 1.00
53_V 98_L 1.741 1.00
93_I 257_M 1.741 1.00
62_P 95_S 1.731 1.00
46_F 285_A 1.722 1.00
40_A 292_G 1.717 1.00
47_V 285_A 1.683 1.00
190_L 214_I 1.647 1.00
110_F 168_I 1.637 1.00
186_N 189_V 1.634 1.00
187_T 214_I 1.621 1.00
97_V 278_A 1.617 1.00
179_F 229_R 1.588 1.00
84_F 94_F 1.574 1.00
129_Y 133_W 1.571 1.00
190_L 193_Q 1.571 1.00
124_L 210_L 1.568 1.00
136_L 140_I 1.498 1.00
125_L 129_Y 1.497 1.00
205_S 208_T 1.494 1.00
138_M 180_A 1.467 1.00
44_A 289_L 1.447 1.00
58_R 102_Q 1.441 1.00
132_W 136_L 1.439 1.00
43_A 292_G 1.429 1.00
62_P 94_F 1.426 1.00
99_V 102_Q 1.421 1.00
107_A 237_A 1.408 1.00
130_E 191_K 1.404 0.99
195_F 217_G 1.401 0.99
63_Y 95_S 1.393 0.99
190_L 218_T 1.39 0.99
189_V 193_Q 1.378 0.99
116_A 226_F 1.377 0.99
43_A 288_L 1.375 0.99
200_R 206_D 1.374 0.99
79_S 82_H 1.368 0.99
227_T 290_G 1.358 0.99
44_A 48_I 1.351 0.99
127_G 191_K 1.342 0.99
35_R 41_M 1.342 0.99
138_M 142_D 1.34 0.99
76_N 79_S 1.34 0.99
124_L 215_L 1.336 0.99
165_A 169_I 1.323 0.99
78_P 270_H 1.316 0.99
254_W 278_A 1.316 0.99
135_R 139_R 1.31 0.99
112_V 226_F 1.304 0.99
138_M 141_C 1.292 0.99
141_C 180_A 1.289 0.99
171_V 236_S 1.274 0.99
129_Y 210_L 1.273 0.99
46_F 281_L 1.257 0.99
274_F 277_L 1.257 0.99
208_T 212_R 1.254 0.99
261_A 272_A 1.253 0.99
261_A 271_V 1.244 0.98
197_E 200_R 1.239 0.98
45_L 49_L 1.233 0.98
270_H 274_F 1.225 0.98
269_P 273_V 1.221 0.98
126_A 138_M 1.221 0.98
47_V 289_L 1.214 0.98
231_G 283_V 1.213 0.98
128_Y 209_V 1.211 0.98
73_N 76_N 1.207 0.98
111_A 171_V 1.207 0.98
42_T 45_L 1.207 0.98
93_I 271_V 1.207 0.98
130_E 134_D 1.197 0.98
83_W 94_F 1.19 0.98
120_T 222_I 1.179 0.98
176_I 180_A 1.17 0.97
242_F 262_R 1.168 0.97
163_G 166_N 1.161 0.97
187_T 218_T 1.136 0.97
126_A 137_I 1.127 0.97
76_N 86_V 1.127 0.97
137_I 180_A 1.127 0.97
199_A 213_H 1.117 0.96
57_A 60_I 1.116 0.96
120_T 183_V 1.114 0.96
66_E 252_P 1.111 0.96
273_V 277_L 1.092 0.96
196_I 209_V 1.083 0.96
50_L 281_L 1.079 0.95
63_Y 82_H 1.076 0.95
118_I 176_I 1.074 0.95
184_R 188_L 1.071 0.95
70_D 82_H 1.068 0.95
118_I 121_L 1.062 0.95
106_A 110_F 1.056 0.95
38_H 41_M 1.053 0.95
122_L 180_A 1.043 0.94
56_F 60_I 1.042 0.94
144_L 176_I 1.04 0.94
48_I 52_V 1.039 0.94
63_Y 81_Q 1.037 0.94
141_C 177_P 1.034 0.94
111_A 233_S 1.031 0.94
241_S 253_E 1.03 0.94
43_A 46_F 1.029 0.94
82_H 86_V 1.026 0.94
47_V 286_F 1.023 0.93
79_S 83_W 1.023 0.93
117_A 121_L 1.009 0.93
77_G 270_H 1.005 0.93
218_T 221_S 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.673399.90.713Contact Map0.793
3rlfG10.877999.90.721Contact Map0.501
3d31C20.910999.90.731Contact Map0.557
3rlfF10.96799.90.735Contact Map0.478
2onkC40.871399.80.755Contact Map0.564
2bn5B10.06273.20.975Contact Map
2kogA10.20132.80.976Contact Map0.309
2kncA10.14852.60.976Contact Map0.449
4l0nA100.05942.40.976Contact Map
2jo8A20.05942.40.977Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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