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OPENSEQ.org
OPPC - Oligopeptide transport system permease protein OppC
UniProt: P0AFH6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10676
Length: 302 (279)
Sequences: 6348
Seq/Len: 22.75
OPPC
Paralog alert: 0.77 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: DDPB DDPC DPPB DPPC GSIC GSID NIKB NIKC OPPB OPPC SAPB SAPC YEJB YEJE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
237_E 253_S 3.5 1.00
101_G 254_W 3.286 1.00
122_Y 137_M 3.046 1.00
134_D 184_R 2.961 1.00
129_L 206_T 2.839 1.00
254_W 282_T 2.8 1.00
84_F 97_V 2.602 1.00
194_E 197_E 2.585 1.00
68_D 71_M 2.493 1.00
87_D 91_R 2.443 1.00
53_V 101_G 2.431 1.00
60_S 95_V 2.212 1.00
204_V 208_G 2.202 1.00
114_V 172_G 2.198 1.00
190_L 195_F 2.179 1.00
139_R 142_E 2.149 1.00
42_S 285_C 2.135 1.00
88_S 260_D 2.121 1.00
294_R 298_D 2.119 1.00
63_A 66_D 2.109 1.00
207_S 211_I 2.078 1.00
82_H 92_D 2.077 1.00
124_S 187_T 2.07 1.00
49_I 282_T 2.056 1.00
127_G 187_T 2.002 1.00
84_F 274_F 1.863 1.00
55_L 58_M 1.825 1.00
128_Y 206_T 1.824 1.00
51_L 55_L 1.814 1.00
94_L 98_A 1.81 1.00
93_L 257_L 1.784 1.00
30_R 34_M 1.778 1.00
56_A 99_I 1.775 1.00
39_A 292_G 1.769 1.00
45_V 285_C 1.738 1.00
52_F 98_A 1.723 1.00
46_L 285_C 1.696 1.00
61_Q 95_V 1.642 1.00
190_L 214_I 1.638 1.00
186_Q 189_S 1.631 1.00
110_A 168_F 1.621 1.00
187_T 214_I 1.613 1.00
78_M 83_Y 1.607 1.00
124_S 210_V 1.579 1.00
129_L 133_V 1.577 1.00
179_M 229_L 1.573 1.00
84_F 94_L 1.563 1.00
97_V 278_F 1.553 1.00
190_L 193_K 1.548 1.00
43_L 289_I 1.535 1.00
125_L 129_L 1.529 1.00
61_Q 94_L 1.508 1.00
136_V 140_L 1.475 1.00
99_I 102_R 1.457 1.00
205_S 208_G 1.455 1.00
107_V 237_E 1.455 1.00
138_M 180_A 1.443 1.00
42_S 292_G 1.426 1.00
190_L 218_V 1.424 1.00
195_F 217_N 1.424 1.00
57_P 102_R 1.42 1.00
130_G 191_K 1.412 1.00
254_W 278_F 1.395 0.99
62_F 95_V 1.383 0.99
124_S 215_V 1.372 0.99
227_S 290_G 1.371 0.99
132_K 136_V 1.37 0.99
200_Q 206_T 1.369 0.99
127_G 191_K 1.366 0.99
74_S 77_D 1.356 0.99
43_L 47_V 1.35 0.99
116_V 226_A 1.347 0.99
112_A 226_A 1.345 0.99
42_S 288_F 1.335 0.99
138_M 142_E 1.332 0.99
189_S 193_K 1.325 0.99
135_S 139_R 1.31 0.99
34_M 40_V 1.3 0.99
141_L 180_A 1.295 0.99
208_G 212_R 1.293 0.99
126_S 138_M 1.279 0.99
171_I 236_F 1.278 0.99
45_V 281_V 1.276 0.99
41_A 44_I 1.274 0.99
129_L 210_V 1.27 0.99
138_M 141_L 1.269 0.99
83_Y 94_L 1.258 0.99
93_L 271_L 1.253 0.99
197_E 200_Q 1.251 0.99
270_W 274_F 1.248 0.99
165_L 169_V 1.243 0.98
71_M 74_S 1.242 0.98
44_I 48_L 1.238 0.98
269_P 273_L 1.233 0.98
128_Y 209_I 1.221 0.98
261_G 271_L 1.218 0.98
46_L 289_I 1.218 0.98
176_W 180_A 1.213 0.98
77_D 81_G 1.208 0.98
82_H 86_T 1.206 0.98
68_D 82_H 1.2 0.98
111_A 171_I 1.199 0.98
242_F 262_A 1.194 0.98
231_P 283_L 1.194 0.98
261_G 272_L 1.193 0.98
274_F 277_G 1.19 0.98
76_P 270_W 1.184 0.98
120_T 222_V 1.183 0.98
273_L 277_G 1.182 0.98
130_G 134_D 1.178 0.98
126_S 137_M 1.167 0.97
187_T 218_V 1.156 0.97
137_M 180_A 1.149 0.97
163_N 166_L 1.146 0.97
62_F 82_H 1.125 0.97
199_A 213_H 1.109 0.96
65_D 252_S 1.101 0.96
46_L 286_F 1.097 0.96
144_L 176_W 1.096 0.96
37_R 40_V 1.094 0.96
120_T 183_V 1.094 0.96
49_I 281_V 1.084 0.96
118_V 121_L 1.078 0.95
184_R 188_L 1.073 0.95
118_V 176_W 1.07 0.95
74_S 86_T 1.062 0.95
122_Y 180_A 1.055 0.95
241_S 253_S 1.051 0.94
196_I 209_I 1.04 0.94
111_A 233_M 1.036 0.94
96_R 250_P 1.033 0.94
52_F 101_G 1.032 0.94
141_L 177_L 1.03 0.94
197_E 201_V 1.029 0.94
56_A 59_L 1.024 0.93
106_M 110_A 1.024 0.93
69_W 72_M 1.018 0.93
111_A 172_G 1.014 0.93
117_V 121_L 1.012 0.93
47_V 51_L 1.01 0.93
77_D 82_H 1.006 0.93
218_V 221_V 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.675599.90.695Contact Map0.781
3d31C20.913999.90.703Contact Map0.552
3rlfG10.877599.90.709Contact Map0.553
3rlfF10.976899.90.714Contact Map0.481
2onkC40.884199.90.734Contact Map0.563
4b03D30.17888.30.969Contact Map0.033
2kogA10.18548.20.969Contact Map0.226
3hd7A20.18216.30.97Contact Map0.479
3hd7B20.19875.90.971Contact Map0.237
2m8rA10.19875.90.971Contact Map0.112
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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