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OPENSEQ.org
PHOE - Outer membrane pore protein E
UniProt: P02932 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10729
Length: 351 (345)
Sequences: 2458
Seq/Len: 7.12
PHOE
Paralog alert: 0.85 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: NMPC OMPC OMPF OMPN PHOE YEDS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
198_G 201_D 4.145 1.00
76_R 99_F 4.022 1.00
63_G 75_G 3.166 1.00
156_N 168_L 3.066 1.00
35_Y 60_G 3.06 1.00
286_Y 304_N 3.033 1.00
72_T 103_K 3.005 1.00
204_I 235_L 2.845 1.00
64_E 72_T 2.688 1.00
311_T 319_S 2.624 1.00
74_Y 111_D 2.598 1.00
71_L 102_L 2.594 1.00
319_S 348_T 2.571 1.00
280_L 310_A 2.504 1.00
210_N 229_E 2.499 1.00
74_Y 101_G 2.475 1.00
154_Y 157_T 2.473 1.00
242_I 274_Y 2.467 1.00
40_A 83_G 2.345 1.00
206_G 231_W 2.32 1.00
314_F 320_A 2.299 1.00
62_K 76_R 2.173 1.00
170_L 191_T 2.169 1.00
239_A 244_L 2.107 1.00
288_L 304_N 2.096 1.00
34_V 61_F 2.094 1.00
121_D 153_T 2.087 1.00
67_I 73_G 1.967 1.00
151_L 171_Q 1.954 1.00
281_R 313_Y 1.95 1.00
35_Y 78_E 1.929 1.00
39_K 321_F 1.923 1.00
34_V 59_F 1.896 1.00
71_L 104_Y 1.881 1.00
168_L 193_L 1.862 1.00
118_A 169_T 1.857 1.00
92_Q 149_S 1.836 1.00
74_Y 109_S 1.833 1.00
90_T 95_T 1.822 1.00
38_V 83_G 1.82 1.00
320_A 347_M 1.814 1.00
114_R 149_S 1.812 1.00
84_N 176_N 1.809 1.00
110_F 152_A 1.795 1.00
66_Q 70_Q 1.769 1.00
37_K 58_R 1.765 1.00
248_Y 266_Q 1.754 1.00
241_N 274_Y 1.708 1.00
324_Y 341_D 1.706 1.00
158_D 164_D 1.688 1.00
97_L 116_L 1.683 1.00
284_L 306_I 1.678 1.00
202_F 237_Y 1.669 1.00
250_E 266_Q 1.663 1.00
118_A 171_Q 1.658 1.00
58_R 96_R 1.657 1.00
79_A 93_Q 1.629 1.00
78_E 96_R 1.617 1.00
280_L 312_Y 1.614 1.00
58_R 78_E 1.609 1.00
246_T 270_A 1.579 1.00
112_Y 152_A 1.568 1.00
204_I 233_T 1.562 1.00
92_Q 95_T 1.559 1.00
319_S 350_Q 1.548 1.00
152_A 174_G 1.537 0.99
79_A 88_S 1.533 0.99
318_M 349_Y 1.531 0.99
157_T 163_I 1.516 0.99
202_F 235_L 1.499 0.99
286_Y 306_I 1.489 0.99
317_N 349_Y 1.483 0.99
208_Y 229_E 1.468 0.99
197_F 201_D 1.468 0.99
245_A 271_V 1.457 0.99
71_L 106_D 1.436 0.99
167_N 194_T 1.434 0.99
276_F 282_P 1.429 0.99
59_F 79_A 1.424 0.99
325_K 329_L 1.423 0.99
80_E 96_R 1.412 0.99
103_K 109_S 1.411 0.99
156_N 163_I 1.4 0.99
82_A 87_E 1.4 0.99
97_L 115_N 1.393 0.99
24_I 34_V 1.389 0.99
35_Y 76_R 1.384 0.99
111_D 115_N 1.378 0.99
282_P 310_A 1.364 0.98
4_S 8_L 1.364 0.98
206_G 233_T 1.361 0.98
122_V 205_S 1.358 0.98
71_L 107_L 1.331 0.98
23_E 30_N 1.324 0.98
148_A 188_G 1.315 0.98
80_E 95_T 1.309 0.98
148_A 151_L 1.307 0.98
104_Y 107_L 1.306 0.98
208_Y 231_W 1.305 0.98
126_T 203_A 1.304 0.98
65_T 315_N 1.302 0.98
74_Y 103_K 1.3 0.98
210_N 227_R 1.295 0.98
86_A 94_K 1.292 0.98
322_V 343_V 1.291 0.98
16_S 20_Q 1.288 0.98
58_R 147_R 1.285 0.98
107_L 154_Y 1.278 0.97
76_R 97_L 1.261 0.97
82_A 85_K 1.256 0.97
322_V 345_V 1.249 0.97
236_K 245_A 1.249 0.97
326_I 329_L 1.248 0.97
167_N 196_D 1.242 0.97
96_R 147_R 1.238 0.97
74_Y 99_F 1.234 0.97
111_D 155_R 1.233 0.97
111_D 153_T 1.207 0.96
37_K 350_Q 1.202 0.96
285_G 307_D 1.199 0.96
273_Q 281_R 1.195 0.96
3_K 6_L 1.189 0.96
275_Q 281_R 1.184 0.95
65_T 317_N 1.179 0.95
232_A 249_S 1.178 0.95
118_A 192_S 1.175 0.95
151_L 173_Q 1.173 0.95
244_L 272_A 1.166 0.95
4_S 9_V 1.162 0.95
46_D 341_D 1.157 0.95
4_S 10_V 1.149 0.94
7_A 10_V 1.14 0.94
153_T 171_Q 1.14 0.94
17_A 20_Q 1.138 0.94
279_G 313_Y 1.127 0.94
71_L 105_K 1.126 0.94
119_L 207_A 1.126 0.94
315_N 318_M 1.119 0.93
238_D 241_N 1.11 0.93
89_D 95_T 1.108 0.93
242_I 246_T 1.082 0.92
196_D 203_A 1.081 0.92
119_L 230_A 1.08 0.92
321_F 346_G 1.078 0.92
43_Y 344_A 1.075 0.91
203_A 236_K 1.073 0.91
238_D 274_Y 1.07 0.91
35_Y 62_K 1.07 0.91
267_N 289_S 1.07 0.91
4_S 14_V 1.067 0.91
107_L 110_F 1.064 0.91
166_L 197_F 1.062 0.91
290_K 302_L 1.061 0.91
236_K 243_Y 1.057 0.90
115_N 153_T 1.055 0.90
171_Q 190_G 1.054 0.90
201_D 237_Y 1.053 0.90
62_K 109_S 1.048 0.90
129_F 309_G 1.048 0.90
65_T 318_M 1.037 0.89
56_Y 95_T 1.019 0.88
55_S 348_T 1.018 0.88
40_A 55_S 1.016 0.88
11_M 14_V 1.014 0.88
2_K 5_T 1.014 0.88
173_Q 176_N 1.011 0.88
72_T 105_K 1.01 0.88
14_V 18_S 1.004 0.87
41_M 344_A 1.003 0.87
277_D 280_L 1.002 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1phoA10.94021000.183Contact Map0.679
2j1nA30.92881000.188Contact Map0.724
3nsgA30.93161000.193Contact Map0.743
2zfgA10.93161000.203Contact Map0.701
2fgqX10.85751000.232Contact Map0.742
4auiA30.88031000.239Contact Map0.774
3vy8X10.91171000.265Contact Map0.744
3prnA10.77211000.337Contact Map0.533
2porA10.80061000.337Contact Map0.538
2o4vA30.931698.40.858Contact Map0.601
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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