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OPENSEQ.org
NMPC - Putative outer membrane porin protein NmpC
UniProt: P21420 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10659
Length: 365 (356)
Sequences: 2401
Seq/Len: 6.74
NMPC
Paralog alert: 0.85 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: NMPC OMPC OMPF OMPN PHOE YEDS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
78_Q 102_F 4.105 1.00
65_G 77_G 3.179 1.00
159_N 171_F 3.132 1.00
74_T 106_K 3.132 1.00
297_Y 315_K 3.121 1.00
37_Y 62_G 3.047 1.00
73_L 105_L 2.902 1.00
208_I 245_L 2.876 1.00
322_T 330_S 2.804 1.00
157_Y 160_N 2.598 1.00
214_K 239_E 2.588 1.00
66_E 74_T 2.585 1.00
252_I 285_Y 2.583 1.00
76_F 104_G 2.565 1.00
291_L 321_A 2.556 1.00
76_F 114_D 2.492 1.00
42_A 85_G 2.408 1.00
64_K 78_Q 2.386 1.00
210_A 241_W 2.351 1.00
124_D 156_T 2.234 1.00
249_A 254_L 2.215 1.00
325_F 331_T 2.207 1.00
299_Q 315_K 2.207 1.00
36_L 63_F 2.161 1.00
73_L 107_F 2.151 1.00
37_Y 80_E 2.101 1.00
173_A 197_F 2.093 1.00
92_G 98_T 2.089 1.00
41_N 332_F 2.081 1.00
36_L 61_L 2.072 1.00
154_V 174_Q 2.052 1.00
86_N 179_N 1.985 1.00
171_F 199_A 1.981 1.00
121_V 172_A 1.913 1.00
95_K 152_T 1.91 1.00
292_R 324_Y 1.901 1.00
76_F 112_S 1.89 1.00
40_V 85_G 1.881 1.00
69_I 75_G 1.88 1.00
258_Y 277_Q 1.854 1.00
295_V 317_V 1.835 1.00
68_Q 72_Q 1.826 1.00
60_R 80_E 1.817 1.00
113_I 155_A 1.792 1.00
117_R 152_T 1.792 1.00
100_L 119_Y 1.768 1.00
161_D 167_D 1.741 1.00
39_K 60_R 1.716 1.00
80_E 99_R 1.716 1.00
291_L 323_Y 1.705 1.00
81_Y 90_S 1.691 1.00
160_N 166_V 1.689 1.00
93_S 98_T 1.675 1.00
121_V 174_Q 1.665 1.00
81_Y 96_D 1.665 1.00
155_A 177_G 1.663 1.00
260_E 277_Q 1.634 1.00
335_Y 355_D 1.624 1.00
60_R 99_R 1.622 1.00
329_M 363_Y 1.587 1.00
212_Y 239_E 1.567 1.00
251_N 285_Y 1.561 0.99
206_F 245_L 1.546 0.99
82_E 99_R 1.542 0.99
208_I 243_A 1.535 0.99
115_Y 155_A 1.521 0.99
95_K 98_T 1.504 0.99
255_A 282_V 1.497 0.99
287_F 293_P 1.495 0.99
297_Y 317_V 1.492 0.99
107_F 110_Y 1.482 0.99
125_I 209_G 1.466 0.99
84_K 89_E 1.465 0.99
206_F 247_Y 1.462 0.99
328_N 363_Y 1.461 0.99
330_S 362_V 1.455 0.99
114_D 118_N 1.445 0.99
170_N 200_T 1.445 0.99
331_T 361_L 1.43 0.99
100_L 118_N 1.429 0.99
256_T 281_A 1.421 0.99
99_R 150_R 1.413 0.99
60_R 150_R 1.411 0.99
151_A 194_G 1.402 0.99
67_T 326_N 1.396 0.99
210_A 243_A 1.389 0.99
37_Y 78_Q 1.381 0.98
212_Y 241_W 1.381 0.98
129_T 207_G 1.379 0.98
73_L 110_Y 1.367 0.98
61_L 81_Y 1.364 0.98
106_K 112_S 1.362 0.98
214_K 237_N 1.36 0.98
6_V 9_S 1.352 0.98
110_Y 157_Y 1.349 0.98
26_I 36_L 1.339 0.98
151_A 154_V 1.332 0.98
82_E 98_T 1.327 0.98
76_F 106_K 1.323 0.98
25_E 32_N 1.313 0.98
170_N 202_E 1.307 0.98
159_N 166_V 1.306 0.98
293_P 321_A 1.299 0.97
169_L 203_Y 1.297 0.97
18_A 22_Q 1.294 0.97
284_Q 292_R 1.293 0.97
3_K 6_V 1.283 0.97
41_N 54_G 1.27 0.97
4_L 16_L 1.256 0.97
114_D 158_R 1.256 0.97
73_L 109_D 1.238 0.96
84_K 87_R 1.233 0.96
78_Q 100_L 1.215 0.96
67_T 328_N 1.21 0.96
110_Y 113_I 1.209 0.96
296_A 318_D 1.207 0.96
76_F 102_F 1.207 0.96
121_V 198_S 1.206 0.96
88_A 97_K 1.2 0.95
2_K 5_T 1.198 0.95
225_G 229_P 1.189 0.95
114_D 156_T 1.188 0.95
37_Y 64_K 1.181 0.95
4_L 11_V 1.174 0.95
207_G 246_K 1.173 0.95
246_K 255_A 1.171 0.95
254_L 283_A 1.167 0.94
288_D 291_L 1.166 0.94
154_V 176_Q 1.159 0.94
329_M 361_L 1.156 0.94
16_L 20_S 1.152 0.94
314_V 338_N 1.135 0.93
39_K 364_Q 1.126 0.93
326_N 329_M 1.111 0.92
92_G 95_K 1.108 0.92
252_I 256_T 1.103 0.92
330_S 364_Q 1.096 0.92
161_D 170_N 1.095 0.92
245_L 256_T 1.095 0.92
4_L 10_A 1.094 0.92
257_T 280_E 1.092 0.91
242_A 259_S 1.089 0.91
286_Q 292_R 1.087 0.91
360_G 365_F 1.086 0.91
202_E 207_G 1.086 0.91
156_T 174_Q 1.076 0.91
122_A 240_V 1.07 0.90
174_Q 196_G 1.068 0.90
283_A 295_V 1.068 0.90
21_A 24_A 1.061 0.90
248_D 285_Y 1.06 0.90
287_F 321_A 1.06 0.90
246_K 253_Y 1.053 0.89
43_K 55_D 1.049 0.89
58_Y 98_T 1.045 0.89
299_Q 313_L 1.042 0.89
166_V 171_F 1.037 0.88
74_T 108_G 1.036 0.88
301_K 313_L 1.034 0.88
25_E 28_N 1.033 0.88
118_N 156_T 1.033 0.88
159_N 168_G 1.03 0.88
205_G 247_Y 1.022 0.87
67_T 329_M 1.021 0.87
176_Q 179_N 1.02 0.87
248_D 251_N 1.015 0.87
36_L 101_A 1.014 0.87
122_A 211_T 1.01 0.87
203_Y 206_F 1.009 0.87
64_K 112_S 1.006 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2j1nA30.91511000.22Contact Map0.7
3nsgA30.90961000.222Contact Map0.729
2zfgA10.90141000.235Contact Map0.673
1phoA10.89861000.241Contact Map0.671
2fgqX10.83841000.275Contact Map0.732
4auiA30.85211000.28Contact Map0.757
3vy8X10.90141000.3Contact Map0.737
2porA10.77261000.378Contact Map0.524
3prnA10.74251000.381Contact Map0.516
2o4vA30.912398.50.86Contact Map0.588
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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