May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
OMPN - Outer membrane protein N
UniProt: P77747 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13375
Length: 377 (357)
Sequences: 2235
Seq/Len: 6.26
OMPN
Paralog alert: 0.84 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: NMPC OMPC OMPF OMPN PHOE YEDS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_Q 99_F 3.867 1.00
156_N 168_F 3.226 1.00
35_Y 60_G 3.186 1.00
63_G 75_G 3.147 1.00
72_T 103_K 3.023 1.00
214_A 245_L 2.942 1.00
299_F 326_K 2.907 1.00
71_L 102_L 2.83 1.00
333_T 341_S 2.708 1.00
154_Y 157_T 2.646 1.00
220_S 239_D 2.548 1.00
74_Y 101_G 2.496 1.00
252_I 287_Y 2.488 1.00
64_E 72_T 2.454 1.00
74_Y 111_D 2.423 1.00
40_G 83_A 2.397 1.00
62_K 76_Q 2.377 1.00
216_A 241_W 2.363 1.00
301_M 326_K 2.353 1.00
293_L 332_A 2.322 1.00
121_D 153_T 2.288 1.00
249_A 254_L 2.243 1.00
170_V 202_L 2.193 1.00
336_F 342_T 2.153 1.00
34_L 61_F 2.146 1.00
35_Y 78_E 2.11 1.00
71_L 104_F 2.11 1.00
39_D 343_Y 2.106 1.00
151_V 171_Q 2.095 1.00
34_L 59_L 2.052 1.00
84_N 176_N 2.031 1.00
258_Y 279_Q 1.996 1.00
158_D 164_N 1.954 1.00
118_V 169_A 1.941 1.00
114_R 149_N 1.936 1.00
66_Q 70_Q 1.891 1.00
294_R 335_Y 1.887 1.00
74_Y 109_S 1.877 1.00
297_V 328_A 1.859 1.00
67_I 73_G 1.827 1.00
90_K 95_T 1.817 1.00
37_K 58_R 1.803 1.00
92_Q 149_N 1.785 1.00
168_F 204_T 1.775 1.00
79_Y 93_S 1.752 1.00
78_E 96_R 1.744 1.00
260_E 279_Q 1.724 1.00
97_L 116_Y 1.7 1.00
79_Y 88_S 1.673 1.00
38_V 83_A 1.668 1.00
110_F 152_A 1.664 1.00
112_Y 152_A 1.646 1.00
118_V 171_Q 1.642 1.00
208_L 211_G 1.642 1.00
251_N 287_Y 1.633 1.00
339_N 375_Y 1.631 1.00
92_Q 95_T 1.612 1.00
152_A 174_G 1.605 1.00
214_A 243_A 1.599 1.00
346_Y 367_D 1.59 0.99
255_A 284_T 1.584 0.99
80_N 96_R 1.582 0.99
58_R 78_E 1.569 0.99
212_F 245_L 1.559 0.99
167_N 205_T 1.548 0.99
341_S 374_V 1.548 0.99
58_R 96_R 1.509 0.99
293_L 334_Y 1.492 0.99
35_Y 76_Q 1.491 0.99
97_L 115_N 1.487 0.99
111_D 115_N 1.477 0.99
82_Q 87_E 1.477 0.99
58_R 147_R 1.477 0.99
289_F 295_P 1.471 0.99
216_A 243_A 1.463 0.99
220_S 237_K 1.456 0.99
256_T 283_V 1.454 0.99
340_M 375_Y 1.439 0.99
59_L 79_Y 1.415 0.99
104_F 107_Y 1.413 0.99
342_T 373_L 1.396 0.98
82_Q 85_N 1.393 0.98
4_K 8_L 1.389 0.98
212_F 247_Y 1.385 0.98
16_A 20_H 1.38 0.98
218_Y 239_D 1.375 0.98
96_R 147_R 1.37 0.98
166_L 208_L 1.369 0.98
122_I 215_G 1.36 0.98
148_A 199_G 1.35 0.98
298_S 329_D 1.336 0.98
39_D 52_G 1.332 0.98
103_K 109_S 1.325 0.97
167_N 207_D 1.322 0.97
295_P 332_A 1.32 0.97
252_I 256_T 1.306 0.97
80_N 95_T 1.303 0.97
126_T 213_S 1.299 0.97
56_Y 95_T 1.298 0.97
65_T 337_N 1.293 0.97
24_V 34_L 1.292 0.97
148_A 151_V 1.258 0.96
23_E 30_N 1.252 0.96
4_K 14_L 1.249 0.96
299_F 328_A 1.247 0.96
288_Q 294_R 1.244 0.96
107_Y 154_Y 1.243 0.96
35_Y 62_K 1.237 0.96
86_T 94_W 1.222 0.95
218_Y 241_W 1.217 0.95
76_Q 97_L 1.215 0.95
242_T 259_S 1.207 0.95
71_L 107_Y 1.206 0.95
129_L 331_G 1.196 0.95
71_L 106_D 1.196 0.95
65_T 340_M 1.192 0.95
65_T 339_N 1.181 0.94
4_K 10_I 1.179 0.94
119_M 240_A 1.179 0.94
74_Y 103_K 1.179 0.94
213_S 246_K 1.173 0.94
118_V 203_S 1.172 0.94
74_Y 99_F 1.16 0.93
3_S 6_L 1.158 0.93
208_L 212_F 1.148 0.93
2_K 5_V 1.145 0.93
337_N 340_M 1.132 0.92
111_D 155_R 1.125 0.92
111_D 153_T 1.117 0.92
171_Q 201_G 1.117 0.92
173_Q 176_N 1.114 0.91
89_S 95_T 1.113 0.91
248_D 288_Q 1.11 0.91
248_D 251_N 1.103 0.91
23_E 26_N 1.099 0.91
3_S 7_A 1.096 0.91
246_K 255_A 1.092 0.90
4_K 9_L 1.086 0.90
107_Y 110_F 1.085 0.90
72_T 105_A 1.078 0.90
290_D 293_L 1.077 0.90
158_D 167_N 1.075 0.89
257_M 282_E 1.073 0.89
5_V 9_L 1.072 0.89
19_A 22_A 1.069 0.89
151_V 173_Q 1.066 0.89
286_Q 294_R 1.066 0.89
1_M 4_K 1.064 0.89
119_M 217_A 1.062 0.89
248_D 287_Y 1.062 0.89
280_N 302_S 1.057 0.88
173_Q 199_G 1.056 0.88
341_S 376_Q 1.055 0.88
207_D 213_S 1.055 0.88
122_I 169_A 1.051 0.88
245_L 256_T 1.04 0.87
211_G 247_Y 1.04 0.87
331_G 345_D 1.037 0.87
325_V 349_N 1.037 0.87
3_S 20_H 1.034 0.87
71_L 105_A 1.033 0.87
254_L 285_A 1.032 0.87
351_L 363_I 1.031 0.87
7_A 10_I 1.022 0.86
156_N 163_V 1.02 0.86
246_K 253_Y 1.02 0.86
40_G 84_N 1.018 0.86
62_K 109_S 1.017 0.86
34_L 98_A 1.009 0.85
114_R 147_R 1.004 0.85
170_V 204_T 1.004 0.85
14_L 18_A 1.003 0.85
115_N 153_T 1.002 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2j1nA30.90721000.224Contact Map0.695
3nsgA30.88591000.228Contact Map0.721
1phoA10.87271000.237Contact Map0.659
2zfgA10.87531000.245Contact Map0.673
2fgqX10.81171000.275Contact Map0.73
4auiA30.82491000.283Contact Map0.762
3vy8X10.86741000.304Contact Map0.735
2porA10.75331000.377Contact Map0.524
3prnA10.71881000.379Contact Map0.508
2o4vA30.888698.10.875Contact Map0.567
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 2.2381 seconds.