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OPENSEQ.org
UACT - Uric acid transporter UacT
UniProt: Q46821 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13071
Length: 482 (432)
Sequences: 2110
Seq/Len: 4.88
UACT
Paralog alert: 0.73 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: RUTG UACT URAA XANP XANQ YBBY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
194_F 217_F 4.566 1.00
190_A 221_L 4.465 1.00
126_I 306_G 4.026 1.00
157_S 431_A 3.555 1.00
238_W 349_K 3.432 1.00
195_I 214_G 3.283 1.00
231_S 235_D 3.252 1.00
170_A 188_S 3.173 1.00
72_F 345_G 3.069 1.00
198_I 213_L 2.697 1.00
130_F 303_M 2.683 1.00
53_G 63_I 2.619 1.00
230_L 233_L 2.602 1.00
220_L 224_M 2.565 1.00
245_M 307_T 2.554 1.00
192_L 368_V 2.496 1.00
187_I 222_S 2.476 1.00
190_A 194_F 2.456 1.00
131_I 261_T 2.442 1.00
187_I 227_E 2.394 1.00
123_G 252_F 2.334 1.00
59_S 62_A 2.28 1.00
75_G 342_I 2.258 1.00
120_G 251_I 2.249 1.00
399_S 435_A 2.239 1.00
236_A 349_K 2.203 1.00
127_A 257_I 2.187 1.00
34_G 336_S 2.139 1.00
402_V 434_S 2.127 1.00
136_A 296_R 2.085 1.00
216_V 220_L 2.082 1.00
194_F 198_I 2.074 1.00
233_L 353_L 2.058 1.00
275_F 294_G 2.057 1.00
133_T 303_M 2.055 1.00
38_V 340_I 2.05 1.00
73_C 308_F 2.044 1.00
195_I 365_A 2.007 1.00
186_G 190_A 2.007 1.00
119_L 251_I 1.944 1.00
77_V 301_G 1.937 1.00
190_A 217_F 1.915 1.00
135_L 268_F 1.89 1.00
30_L 336_S 1.889 1.00
133_T 296_R 1.873 1.00
232_G 356_S 1.857 1.00
234_H 237_S 1.78 1.00
192_L 398_I 1.763 1.00
437_V 441_F 1.717 1.00
31_I 340_I 1.71 1.00
183_V 227_E 1.702 0.99
220_L 223_W 1.701 0.99
117_G 120_G 1.689 0.99
339_I 343_L 1.682 0.99
171_A 179_Y 1.665 0.99
219_F 228_V 1.652 0.99
92_R 288_S 1.644 0.99
186_G 225_M 1.64 0.99
231_S 234_H 1.631 0.99
130_F 134_L 1.627 0.99
236_A 352_V 1.612 0.99
107_M 121_I 1.604 0.99
395_I 438_L 1.602 0.99
145_L 440_V 1.6 0.99
79_L 342_I 1.57 0.99
218_G 361_V 1.562 0.99
79_L 338_G 1.552 0.99
223_W 230_L 1.531 0.99
79_L 335_I 1.527 0.99
198_I 202_A 1.519 0.99
160_L 374_L 1.513 0.99
206_M 213_L 1.506 0.98
202_A 206_M 1.503 0.98
402_V 430_L 1.499 0.98
182_P 186_G 1.494 0.98
216_V 353_L 1.494 0.98
129_G 302_T 1.467 0.98
37_H 319_N 1.461 0.98
38_V 337_S 1.456 0.98
56_L 111_G 1.451 0.98
187_I 225_M 1.451 0.98
72_F 308_F 1.439 0.98
197_L 201_Y 1.437 0.98
232_G 235_D 1.426 0.98
129_G 303_M 1.413 0.97
82_C 335_I 1.404 0.97
74_C 96_I 1.401 0.97
194_F 221_L 1.396 0.97
133_T 299_G 1.392 0.97
173_G 180_G 1.38 0.97
328_V 333_V 1.378 0.97
433_L 437_V 1.372 0.97
224_M 227_E 1.369 0.97
120_G 253_D 1.367 0.97
391_Y 443_N 1.366 0.97
147_P 439_N 1.357 0.97
190_A 225_M 1.356 0.96
271_S 294_G 1.326 0.96
108_I 111_G 1.326 0.96
219_F 356_S 1.317 0.96
213_L 217_F 1.309 0.95
22_D 284_R 1.308 0.95
125_T 306_G 1.288 0.95
233_L 236_A 1.271 0.94
84_G 92_R 1.268 0.94
41_M 45_A 1.259 0.94
274_M 317_S 1.253 0.94
399_S 434_S 1.252 0.94
290_D 293_R 1.248 0.94
222_S 226_N 1.244 0.94
253_D 256_S 1.244 0.94
41_M 96_I 1.235 0.93
221_L 224_M 1.233 0.93
244_P 309_N 1.227 0.93
166_G 188_S 1.226 0.93
400_L 404_M 1.203 0.92
24_I 332_W 1.197 0.92
172_G 180_G 1.193 0.92
76_I 80_L 1.192 0.92
169_W 359_Q 1.183 0.91
202_A 207_S 1.183 0.91
97_M 315_S 1.181 0.91
149_L 396_V 1.18 0.91
37_H 41_M 1.178 0.91
156_T 400_L 1.176 0.91
323_V 329_H 1.176 0.91
76_I 342_I 1.175 0.91
27_P 31_I 1.171 0.91
126_I 303_M 1.169 0.90
95_V 322_L 1.168 0.90
24_I 30_L 1.165 0.90
166_G 191_V 1.163 0.90
254_P 257_I 1.162 0.90
220_L 231_S 1.16 0.90
386_Y 396_V 1.16 0.90
52_I 107_M 1.14 0.89
40_V 322_L 1.139 0.89
205_F 209_V 1.136 0.89
252_F 257_I 1.123 0.88
289_H 293_R 1.116 0.88
188_S 300_V 1.115 0.88
37_H 40_V 1.11 0.87
391_Y 395_I 1.107 0.87
240_A 348_P 1.106 0.87
183_V 225_M 1.097 0.86
193_I 197_L 1.097 0.86
44_G 318_Q 1.097 0.86
274_M 320_V 1.094 0.86
379_R 383_R 1.083 0.85
275_F 298_D 1.083 0.85
20_E 23_R 1.082 0.85
287_S 290_D 1.08 0.85
189_F 193_I 1.074 0.85
155_I 274_M 1.066 0.84
183_V 187_I 1.062 0.84
126_I 130_F 1.061 0.84
271_S 275_F 1.06 0.84
126_I 250_P 1.049 0.83
34_G 337_S 1.047 0.83
230_L 356_S 1.044 0.82
278_L 323_V 1.043 0.82
100_T 267_V 1.043 0.82
194_F 214_G 1.041 0.82
411_D 414_S 1.041 0.82
90_G 293_R 1.037 0.82
371_G 393_L 1.034 0.82
140_G 292_I 1.033 0.81
133_T 300_V 1.032 0.81
206_M 265_I 1.031 0.81
193_I 196_L 1.027 0.81
70_D 311_F 1.025 0.81
384_C 392_N 1.02 0.80
82_C 334_C 1.019 0.80
44_G 370_F 1.019 0.80
24_I 27_P 1.017 0.80
350_M 353_L 1.017 0.80
127_A 306_G 1.015 0.80
305_G 313_H 1.009 0.79
41_M 319_N 1.007 0.79
135_L 191_V 1.003 0.79
371_G 375_A 1.003 0.79
53_G 58_L 1.002 0.79
172_G 179_Y 1.001 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.87341000.477Contact Map0.582
1pw4A10.852778.20.966Contact Map0.064
3wdoA10.850669.20.968Contact Map0.21
3o7qA10.406651.40.972Contact Map0.413
2jlnA10.8693480.972Contact Map0.261
4ikvA10.898346.80.972Contact Map0.236
4j05A20.935745.90.973Contact Map0.179
2gfpA20.408726.50.976Contact Map0.122
4ldsA20.44422.70.977Contact Map0.193
2cfqA10.802922.20.977Contact Map0.226
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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