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OPENSEQ.org
YBBY - Putative purine permease YbbY
UniProt: P77328 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13620
Length: 433 (412)
Sequences: 2090
Seq/Len: 5.07
YBBY
Paralog alert: 0.73 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: RUTG UACT URAA XANP XANQ YBBY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
178_A 209_L 4.7 1.00
182_L 205_T 4.697 1.00
108_A 292_V 4.174 1.00
141_M 416_G 3.678 1.00
226_W 335_A 3.378 1.00
219_S 223_E 3.02 1.00
183_V 202_G 2.962 1.00
52_L 331_A 2.949 1.00
154_M 176_S 2.817 1.00
208_L 212_F 2.715 1.00
186_M 201_V 2.661 1.00
112_V 289_L 2.644 1.00
33_L 43_L 2.644 1.00
175_L 210_W 2.501 1.00
113_L 246_V 2.464 1.00
175_L 215_P 2.463 1.00
39_P 42_S 2.416 1.00
235_G 238_S 2.39 1.00
218_H 221_S 2.387 1.00
105_V 237_L 2.35 1.00
98_D 235_G 2.326 1.00
178_A 182_L 2.282 1.00
204_I 208_L 2.255 1.00
55_A 328_L 2.241 1.00
115_M 289_L 2.208 1.00
383_P 420_A 2.199 1.00
180_M 354_V 2.191 1.00
224_L 335_A 2.19 1.00
221_S 339_L 2.174 1.00
18_F 326_I 2.169 1.00
229_F 293_P 2.161 1.00
386_V 419_L 2.148 1.00
14_G 322_Y 2.134 1.00
182_L 186_M 2.096 1.00
53_A 294_L 2.081 1.00
174_A 178_A 2.062 1.00
97_N 235_G 2.054 1.00
260_I 280_S 2.049 1.00
183_V 351_V 2.014 1.00
115_M 282_V 2 1.00
178_A 205_T 1.949 1.00
57_A 287_M 1.939 1.00
220_L 342_S 1.934 1.00
270_Q 273_G 1.928 1.00
10_S 322_Y 1.917 1.00
325_V 329_L 1.887 1.00
219_S 222_G 1.787 1.00
264_D 272_A 1.778 1.00
11_L 326_I 1.759 1.00
180_M 382_L 1.737 1.00
117_I 253_I 1.715 1.00
174_A 213_C 1.694 1.00
222_G 225_H 1.679 0.99
375_R 428_P 1.678 0.99
208_L 211_Y 1.672 0.99
67_R 274_N 1.665 0.99
112_V 116_L 1.65 0.99
422_L 426_L 1.65 0.99
171_P 215_P 1.648 0.99
59_F 328_L 1.634 0.99
207_W 216_S 1.617 0.99
59_F 324_S 1.61 0.99
129_L 425_N 1.603 0.99
109_L 242_I 1.582 0.99
182_L 209_L 1.572 0.99
206_G 347_V 1.569 0.99
379_R 423_M 1.547 0.99
386_V 415_V 1.543 0.99
111_G 289_L 1.531 0.99
175_L 213_C 1.53 0.99
59_F 321_I 1.519 0.99
144_A 360_L 1.514 0.99
190_L 194_F 1.513 0.99
82_I 103_L 1.509 0.99
111_G 288_T 1.501 0.99
178_A 213_C 1.476 0.98
18_F 323_G 1.465 0.98
201_V 205_T 1.459 0.98
170_L 174_A 1.459 0.98
194_F 201_V 1.449 0.98
207_W 342_S 1.446 0.98
17_W 305_S 1.435 0.98
93_G 98_D 1.433 0.98
115_M 285_G 1.421 0.98
107_I 292_V 1.413 0.98
123_G 257_Y 1.41 0.98
210_W 214_F 1.394 0.97
54_T 71_M 1.368 0.97
224_L 338_R 1.367 0.97
276_R 279_R 1.363 0.97
186_M 190_L 1.342 0.96
98_D 238_S 1.329 0.96
212_F 215_P 1.318 0.96
108_A 289_L 1.316 0.96
140_L 384_L 1.315 0.96
131_T 424_D 1.307 0.96
256_T 280_S 1.304 0.96
314_D 319_S 1.284 0.95
238_S 241_I 1.275 0.95
56_L 328_L 1.271 0.95
220_L 223_E 1.263 0.95
190_L 195_A 1.259 0.94
211_Y 218_H 1.228 0.93
209_L 212_F 1.226 0.93
171_P 213_C 1.216 0.93
73_G 302_F 1.212 0.93
32_L 82_I 1.21 0.93
372_F 380_L 1.208 0.93
237_L 242_I 1.206 0.93
56_L 60_A 1.203 0.93
133_S 380_L 1.194 0.92
164_P 167_K 1.19 0.92
72_E 301_P 1.189 0.92
259_A 303_V 1.186 0.92
185_A 189_F 1.184 0.92
21_I 25_T 1.167 0.91
115_M 286_F 1.166 0.91
17_W 21_I 1.145 0.90
52_L 294_L 1.145 0.90
273_G 276_R 1.141 0.90
211_Y 216_S 1.135 0.89
365_V 369_Q 1.133 0.89
185_A 426_L 1.132 0.89
62_A 320_F 1.127 0.89
228_W 295_A 1.127 0.89
193_R 197_Y 1.125 0.89
418_L 422_L 1.123 0.89
160_G 168_I 1.121 0.89
56_L 294_L 1.12 0.88
64_C 286_F 1.119 0.88
221_S 224_L 1.118 0.88
20_F 308_L 1.116 0.88
239_P 242_I 1.116 0.88
383_P 419_L 1.114 0.88
62_A 321_I 1.111 0.88
256_T 260_I 1.111 0.88
309_L 315_Y 1.11 0.88
21_I 71_M 1.109 0.88
155_L 397_Y 1.108 0.88
28_V 76_G 1.089 0.87
65_G 279_R 1.082 0.86
259_A 306_I 1.076 0.86
17_W 20_F 1.075 0.86
335_A 338_R 1.074 0.86
118_G 282_V 1.074 0.86
50_A 297_I 1.072 0.85
24_N 356_Y 1.071 0.85
171_P 174_A 1.07 0.85
75_G 252_N 1.065 0.85
336_L 339_L 1.063 0.85
112_V 115_M 1.063 0.85
86_T 89_E 1.062 0.85
204_I 339_L 1.062 0.85
171_P 175_L 1.061 0.85
180_M 184_L 1.059 0.84
405_L 409_L 1.058 0.84
163_D 167_K 1.057 0.84
260_I 284_T 1.057 0.84
156_G 168_I 1.053 0.84
291_T 299_F 1.052 0.84
57_A 283_A 1.05 0.84
265_V 369_Q 1.049 0.84
139_M 142_L 1.046 0.83
13_S 303_V 1.045 0.83
371_T 376_N 1.041 0.83
357_L 377_I 1.037 0.83
70_I 308_L 1.036 0.83
71_M 323_G 1.036 0.83
263_T 309_L 1.034 0.82
205_T 209_L 1.032 0.82
177_V 181_C 1.031 0.82
150_F 176_S 1.021 0.81
139_M 259_A 1.021 0.81
138_F 180_M 1.017 0.81
370_I 376_N 1.013 0.81
117_I 179_V 1.013 0.81
109_L 237_L 1.012 0.81
77_L 355_S 1.009 0.80
375_R 379_R 1.006 0.80
176_S 286_F 1.006 0.80
182_L 201_V 1.003 0.80
24_N 304_S 1.002 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.91691000.423Contact Map0.594
1pw4A10.46659.40.976Contact Map0.203
2gfpA20.408860.978Contact Map0.104
3o7qA10.39954.90.979Contact Map0.455
3giaA10.14782.20.983Contact Map0.164
4b19A10.06241.70.984Contact Map0.533
2ko4B10.02771.40.985Contact Map
3j1rA210.061.40.985Contact Map0.885
3arcZ20.13631.10.985Contact Map0.197
3wdoA10.411110.986Contact Map0.209
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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