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OPENSEQ.org
XANP - Xanthine permease XanP
UniProt: P0AGM9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11194
Length: 463 (436)
Sequences: 2125
Seq/Len: 4.87
XANP
Paralog alert: 0.73 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: RUTG UACT URAA XANP XANQ YBBY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
204_V 235_L 4.627 1.00
208_L 231_A 4.475 1.00
137_M 324_A 4.27 1.00
168_I 447_G 3.567 1.00
181_I 202_A 3.344 1.00
253_L 367_A 3.324 1.00
245_S 249_M 3.117 1.00
209_I 228_A 3.051 1.00
77_F 363_G 2.854 1.00
212_L 227_I 2.795 1.00
141_C 321_F 2.627 1.00
58_C 68_T 2.627 1.00
234_A 238_F 2.598 1.00
249_M 252_E 2.572 1.00
201_L 241_M 2.506 1.00
134_G 266_I 2.486 1.00
201_L 236_A 2.476 1.00
142_T 275_M 2.466 1.00
244_E 247_E 2.438 1.00
64_P 67_D 2.387 1.00
131_A 265_G 2.383 1.00
204_V 208_L 2.329 1.00
415_S 451_A 2.289 1.00
206_L 386_V 2.224 1.00
80_G 360_I 2.21 1.00
39_A 354_V 2.189 1.00
130_A 265_G 2.181 1.00
250_T 367_A 2.153 1.00
418_V 450_T 2.146 1.00
230_A 234_A 2.109 1.00
78_A 326_F 2.093 1.00
260_L 325_V 2.087 1.00
209_I 383_A 2.079 1.00
43_L 358_M 2.074 1.00
208_L 212_L 2.068 1.00
247_E 371_F 2.066 1.00
246_N 374_H 2.029 1.00
200_L 204_V 2.005 1.00
289_I 312_G 2.003 1.00
82_A 319_N 1.969 1.00
144_M 321_F 1.962 1.00
204_V 231_A 1.96 1.00
453_V 457_I 1.94 1.00
35_T 354_V 1.919 1.00
144_M 314_L 1.914 1.00
248_P 252_E 1.852 1.00
147_S 314_L 1.837 1.00
234_A 237_W 1.801 1.00
146_I 282_S 1.798 1.00
407_R 459_P 1.766 1.00
357_L 361_V 1.764 1.00
233_Y 242_L 1.762 1.00
36_L 358_M 1.733 1.00
138_L 271_L 1.72 1.00
245_S 248_P 1.716 1.00
197_K 241_M 1.679 0.99
182_G 193_F 1.667 0.99
200_L 239_M 1.648 0.99
156_I 456_L 1.619 0.99
84_I 356_A 1.619 0.99
141_C 145_V 1.566 0.99
84_I 353_F 1.561 0.99
206_L 414_L 1.552 0.99
220_L 227_I 1.549 0.99
232_G 379_V 1.525 0.99
418_V 446_A 1.517 0.99
171_L 392_A 1.499 0.98
216_R 220_L 1.496 0.98
208_L 235_L 1.495 0.98
140_S 320_S 1.492 0.98
411_I 454_L 1.465 0.98
140_S 321_F 1.464 0.98
111_L 132_L 1.45 0.98
294_D 401_R 1.444 0.98
24_Y 28_D 1.436 0.98
89_A 96_G 1.426 0.98
250_T 370_G 1.41 0.97
201_L 239_M 1.409 0.97
84_I 360_I 1.403 0.97
227_I 231_A 1.402 0.97
42_H 337_N 1.389 0.97
233_Y 374_H 1.389 0.97
204_V 239_M 1.384 0.97
43_L 355_V 1.382 0.97
144_M 317_G 1.381 0.97
79_S 100_I 1.361 0.97
81_V 85_I 1.356 0.96
25_R 28_D 1.344 0.96
27_E 298_Q 1.342 0.96
308_R 311_G 1.339 0.96
346_V 351_V 1.336 0.96
112_I 115_G 1.329 0.96
184_G 194_G 1.327 0.96
158_T 455_N 1.319 0.96
131_A 267_E 1.314 0.96
136_L 324_A 1.312 0.96
196_P 200_L 1.305 0.95
61_L 115_G 1.301 0.95
268_W 271_L 1.298 0.95
285_T 312_G 1.293 0.95
211_L 215_Q 1.291 0.95
235_L 238_F 1.282 0.95
236_A 240_G 1.28 0.95
237_W 244_E 1.269 0.94
267_E 270_L 1.268 0.94
238_F 241_M 1.251 0.94
57_I 111_L 1.25 0.94
77_F 326_F 1.24 0.93
29_R 350_Y 1.24 0.93
230_A 371_F 1.236 0.93
288_D 335_G 1.235 0.93
180_S 377_E 1.235 0.93
212_L 216_R 1.231 0.93
427_L 430_Q 1.23 0.93
216_R 221_R 1.219 0.93
246_N 249_M 1.21 0.92
399_V 402_E 1.208 0.92
87_I 353_F 1.208 0.92
397_R 401_R 1.195 0.92
449_I 453_V 1.19 0.91
137_M 321_F 1.188 0.91
88_K 353_F 1.184 0.91
101_Q 333_C 1.18 0.91
160_L 412_I 1.18 0.91
29_R 35_T 1.175 0.91
46_M 50_V 1.172 0.91
177_G 202_A 1.169 0.90
49_A 336_Q 1.159 0.90
102_G 334_F 1.143 0.89
167_M 416_L 1.143 0.89
259_P 327_N 1.137 0.89
219_Y 223_A 1.135 0.89
46_M 100_I 1.134 0.89
247_E 250_T 1.129 0.88
237_W 242_L 1.128 0.88
235_L 239_M 1.125 0.88
285_T 289_I 1.125 0.88
25_R 298_Q 1.123 0.88
144_M 318_L 1.119 0.88
24_Y 30_P 1.119 0.88
197_K 239_M 1.114 0.87
141_C 144_M 1.112 0.87
203_G 207_A 1.112 0.87
415_S 450_T 1.109 0.87
24_Y 31_P 1.104 0.87
177_G 205_V 1.098 0.86
231_A 235_L 1.096 0.86
266_I 271_L 1.095 0.86
341_I 347_A 1.091 0.86
126_P 131_A 1.086 0.86
145_V 149_V 1.085 0.85
42_H 46_M 1.085 0.85
288_D 338_N 1.084 0.85
190_D 243_P 1.08 0.85
207_A 211_L 1.078 0.85
81_V 360_I 1.075 0.85
53_P 105_F 1.072 0.85
255_M 366_P 1.072 0.85
166_V 288_D 1.071 0.84
87_I 352_G 1.067 0.84
45_A 340_V 1.066 0.84
49_A 388_F 1.058 0.83
82_A 315_A 1.057 0.83
368_V 371_F 1.056 0.83
292_T 341_I 1.053 0.83
32_L 36_L 1.051 0.83
77_F 360_I 1.049 0.83
293_S 300_V 1.042 0.82
106_N 387_M 1.039 0.82
104_S 281_T 1.039 0.82
233_Y 237_W 1.038 0.82
206_L 210_I 1.032 0.81
197_K 201_L 1.029 0.81
416_L 420_L 1.022 0.80
413_A 417_A 1.021 0.80
99_S 292_T 1.02 0.80
307_K 311_G 1.019 0.80
150_L 313_V 1.019 0.80
178_L 421_G 1.018 0.80
137_M 141_C 1.017 0.80
26_L 30_P 1.015 0.80
410_L 414_L 1.014 0.80
26_L 348_S 1.004 0.79
323_S 331_N 1.003 0.79
197_K 200_L 1.002 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.87041000.472Contact Map0.581
3o7qA10.442880.60.963Contact Map0.399
1pw4A10.881263.20.968Contact Map0.048
4ikvA10.894238.10.972Contact Map0.219
2gfpA20.427621.60.975Contact Map0.392
4jr9A10.868318.30.976Contact Map0.162
4j05A20.952512.50.978Contact Map0.16
3wdoA10.805611.60.978Contact Map0.203
2cfqA10.47088.20.98Contact Map0.208
4apsA20.87475.40.981Contact Map0.207
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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