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OPENSEQ.org
RUTG - Putative pyrimidine permease RutG
UniProt: P75892 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13853
Length: 442 (411)
Sequences: 2131
Seq/Len: 5.18
RUTG
Paralog alert: 0.73 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: RUTG UACT URAA XANP XANQ YBBY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
182_C 205_V 4.637 1.00
178_M 209_L 4.597 1.00
117_I 297_G 4.341 1.00
153_A 414_A 3.64 1.00
233_W 340_K 3.396 1.00
166_V 176_A 3.321 1.00
226_T 230_H 3.174 1.00
183_I 202_G 3.036 1.00
63_L 336_G 2.906 1.00
186_V 201_V 2.749 1.00
122_V 253_A 2.676 1.00
225_F 228_V 2.566 1.00
121_L 294_M 2.455 1.00
180_V 359_V 2.426 1.00
114_G 244_F 2.4 1.00
111_I 243_A 2.351 1.00
178_M 182_C 2.348 1.00
175_M 222_A 2.313 1.00
66_G 333_M 2.295 1.00
110_S 243_A 2.25 1.00
391_T 418_A 2.25 1.00
204_I 208_L 2.205 1.00
231_A 340_K 2.19 1.00
40_A 331_I 2.187 1.00
36_G 327_A 2.175 1.00
394_L 417_G 2.167 1.00
64_M 299_V 2.127 1.00
267_L 285_A 2.061 1.00
127_G 287_V 2.029 1.00
124_T 294_M 1.973 1.00
227_L 347_T 1.97 1.00
124_T 287_V 1.969 1.00
228_V 344_L 1.968 1.00
68_G 292_A 1.96 1.00
420_L 424_L 1.959 1.00
182_C 186_V 1.946 1.00
32_T 327_A 1.937 1.00
183_I 356_A 1.919 1.00
207_C 223_V 1.902 1.00
174_W 178_M 1.875 1.00
126_I 260_V 1.873 1.00
178_M 205_V 1.869 1.00
79_R 279_D 1.862 1.00
330_V 334_L 1.845 1.00
33_A 331_I 1.758 1.00
281_Y 284_R 1.741 1.00
175_M 210_Y 1.741 1.00
208_L 218_G 1.73 1.00
121_L 125_V 1.717 1.00
226_T 229_S 1.693 1.00
394_L 413_T 1.63 0.99
190_T 194_I 1.601 0.99
229_S 232_A 1.596 0.99
141_L 423_A 1.595 0.99
208_L 211_G 1.593 0.99
180_V 390_V 1.587 0.99
118_A 249_M 1.587 0.99
156_L 365_A 1.586 0.99
70_L 329_A 1.563 0.99
231_A 343_A 1.561 0.99
120_G 293_T 1.526 0.99
206_A 352_V 1.522 0.99
120_G 294_M 1.52 0.99
94_V 112_A 1.503 0.99
70_L 326_V 1.497 0.99
387_M 421_L 1.492 0.99
40_A 328_A 1.473 0.98
186_V 190_T 1.472 0.98
70_L 333_M 1.469 0.98
383_G 387_M 1.456 0.98
171_F 222_A 1.455 0.98
39_H 310_N 1.453 0.98
124_T 290_G 1.448 0.98
263_N 285_A 1.446 0.98
182_C 209_L 1.436 0.98
108_N 111_I 1.432 0.98
116_I 297_G 1.431 0.98
227_L 230_H 1.424 0.98
207_C 347_T 1.424 0.98
194_I 201_V 1.407 0.98
21_V 25_E 1.407 0.98
319_V 324_V 1.388 0.97
65_S 83_Y 1.386 0.97
22_A 25_E 1.38 0.97
26_R 323_L 1.378 0.97
111_I 245_N 1.377 0.97
383_G 426_S 1.37 0.97
379_L 388_V 1.365 0.97
208_L 212_V 1.357 0.97
143_P 422_N 1.348 0.97
201_V 205_V 1.348 0.97
165_S 350_A 1.314 0.96
43_M 47_T 1.299 0.96
21_V 27_L 1.288 0.95
67_I 333_M 1.283 0.95
152_M 392_L 1.28 0.95
54_M 94_V 1.277 0.95
190_T 195_Q 1.277 0.95
185_L 189_F 1.269 0.95
228_V 231_A 1.268 0.95
214_T 220_G 1.255 0.95
67_I 71_L 1.253 0.94
170_A 174_W 1.238 0.94
117_I 294_M 1.233 0.94
24_D 276_R 1.231 0.94
266_H 308_A 1.229 0.94
245_N 248_A 1.223 0.94
128_L 132_K 1.205 0.93
416_F 420_L 1.199 0.93
246_G 249_M 1.197 0.93
117_I 242_P 1.192 0.92
118_A 244_F 1.184 0.92
73_F 326_V 1.182 0.92
63_L 299_V 1.174 0.92
314_M 320_Y 1.169 0.91
85_G 307_Y 1.165 0.91
23_P 27_L 1.161 0.91
263_N 267_L 1.153 0.91
121_L 124_T 1.151 0.91
46_A 361_F 1.151 0.91
362_G 366_V 1.146 0.90
26_R 32_T 1.143 0.90
29_F 33_A 1.143 0.90
87_S 259_L 1.137 0.90
125_V 129_V 1.135 0.90
180_V 184_G 1.134 0.90
151_V 266_H 1.133 0.90
266_H 311_I 1.127 0.89
145_V 388_V 1.126 0.89
193_M 197_L 1.125 0.89
239_F 242_P 1.12 0.89
162_A 179_T 1.116 0.89
46_A 309_E 1.115 0.89
131_M 283_G 1.11 0.88
84_L 306_T 1.107 0.88
162_A 176_A 1.106 0.88
68_G 288_G 1.106 0.88
341_F 344_L 1.099 0.88
204_I 344_L 1.096 0.87
76_T 291_L 1.094 0.87
391_T 417_G 1.093 0.87
42_A 313_V 1.091 0.87
177_V 181_L 1.088 0.87
95_I 98_T 1.086 0.87
89_A 360_V 1.082 0.87
43_M 83_Y 1.079 0.86
39_H 43_M 1.073 0.86
23_P 321_S 1.071 0.86
175_M 213_M 1.071 0.86
173_S 239_F 1.07 0.86
205_V 209_L 1.069 0.86
340_K 343_A 1.068 0.86
235_G 339_P 1.065 0.85
61_S 302_S 1.06 0.85
362_G 385_L 1.058 0.85
35_M 308_A 1.057 0.85
267_L 289_D 1.047 0.84
263_N 289_D 1.046 0.84
82_S 313_V 1.044 0.84
296_S 304_V 1.043 0.84
50_M 88_A 1.042 0.84
22_A 276_R 1.041 0.84
211_G 225_F 1.041 0.84
171_F 175_M 1.031 0.83
97_A 115_G 1.029 0.83
262_E 305_T 1.024 0.82
145_V 149_A 1.02 0.82
123_Y 259_L 1.018 0.82
210_Y 216_V 1.017 0.82
33_A 229_S 1.014 0.81
110_S 240_S 1.01 0.81
270_V 314_M 1.01 0.81
331_I 335_L 1.008 0.81
120_G 290_G 1.008 0.81
119_C 256_A 1.007 0.81
57_D 238_H 1.007 0.81
43_M 310_N 1.005 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.93441000.404Contact Map0.608
2gfpA20.389120.20.975Contact Map0.103
3o7qA10.463810.80.978Contact Map0.241
1pw4A10.46387.70.979Contact Map0.292
2cfqA10.41187.20.979Contact Map0.307
3wdoA10.411840.982Contact Map0.249
4f4lA40.212730.983Contact Map0.238
2lzlA20.03392.90.983Contact Map
2xutA30.42312.30.984Contact Map0.195
4ltoA40.23762.30.984Contact Map0.477
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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