| UniProt: | P80668 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13179 | ||
| Length: | 499 (471) | ||
| Sequences: | 17311 | ||
| Seq/Len: | 36.75 |
| FEAB
Paralog alert: 0.81 [within 20: 0.21] - ratio of genomes with paralogs Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 316_A | 415_A | 5.338 | 1.00 | |
| 260_R | 264_D | 3.673 | 1.00 | |
| 316_A | 413_R | 3.113 | 1.00 | |
| 288_Q | 325_G | 3.081 | 1.00 | |
| 283_K | 315_E | 2.853 | 1.00 | |
| 351_R | 355_D | 2.841 | 1.00 | |
| 67_W | 242_H | 2.779 | 1.00 | |
| 38_A | 50_S | 2.763 | 1.00 | |
| 394_D | 397_L | 2.745 | 1.00 | |
| 362_D | 366_A | 2.722 | 1.00 | |
| 376_N | 386_A | 2.712 | 1.00 | |
| 319_F | 413_R | 2.634 | 1.00 | |
| 363_D | 398_R | 2.604 | 1.00 | |
| 283_K | 317_P | 2.598 | 1.00 | |
| 95_E | 129_R | 2.598 | 1.00 | |
| 292_E | 329_A | 2.57 | 1.00 | |
| 323_V | 411_L | 2.533 | 1.00 | |
| 97_H | 100_E | 2.482 | 1.00 | |
| 208_R | 211_E | 2.404 | 1.00 | |
| 25_D | 68_R | 2.391 | 1.00 | |
| 361_L | 385_V | 2.378 | 1.00 | |
| 437_T | 443_A | 2.345 | 1.00 | |
| 348_L | 357_V | 2.343 | 1.00 | |
| 67_W | 244_A | 2.22 | 1.00 | |
| 214_S | 220_D | 2.21 | 1.00 | |
| 327_E | 331_K | 2.173 | 1.00 | |
| 38_A | 47_E | 2.145 | 1.00 | |
| 55_N | 58_D | 2.123 | 1.00 | |
| 445_E | 449_R | 2.085 | 1.00 | |
| 370_E | 392_N | 2.068 | 1.00 | |
| 358_C | 362_D | 2.04 | 1.00 | |
| 417_G | 445_E | 2.022 | 1.00 | |
| 90_F | 213_A | 2.005 | 1.00 | |
| 417_G | 442_Q | 2 | 1.00 | |
| 390_V | 399_L | 1.979 | 1.00 | |
| 93_L | 215_E | 1.969 | 1.00 | |
| 98_S | 122_G | 1.964 | 1.00 | |
| 22_L | 54_A | 1.957 | 1.00 | |
| 365_Q | 371_L | 1.946 | 1.00 | |
| 99_E | 117_R | 1.924 | 1.00 | |
| 324_S | 328_Q | 1.914 | 1.00 | |
| 321_T | 325_G | 1.911 | 1.00 | |
| 86_I | 218_I | 1.908 | 1.00 | |
| 363_D | 367_Q | 1.903 | 1.00 | |
| 23_Y | 214_S | 1.89 | 1.00 | |
| 313_Y | 420_A | 1.887 | 1.00 | |
| 201_T | 350_S | 1.885 | 1.00 | |
| 64_M | 242_H | 1.878 | 1.00 | |
| 358_C | 377_G | 1.864 | 1.00 | |
| 370_E | 391_V | 1.864 | 1.00 | |
| 92_D | 96_Q | 1.843 | 1.00 | |
| 279_A | 294_L | 1.841 | 1.00 | |
| 312_I | 409_V | 1.837 | 1.00 | |
| 372_I | 391_V | 1.829 | 1.00 | |
| 93_L | 96_Q | 1.827 | 1.00 | |
| 428_E | 474_Q | 1.808 | 1.00 | |
| 161_K | 490_C | 1.779 | 1.00 | |
| 358_C | 385_V | 1.775 | 1.00 | |
| 162_E | 493_K | 1.773 | 1.00 | |
| 235_A | 239_S | 1.771 | 1.00 | |
| 398_R | 402_E | 1.764 | 1.00 | |
| 284_D | 442_Q | 1.761 | 1.00 | |
| 239_S | 261_T | 1.759 | 1.00 | |
| 60_D | 236_A | 1.729 | 1.00 | |
| 60_D | 64_M | 1.718 | 1.00 | |
| 128_M | 185_M | 1.717 | 1.00 | |
| 100_E | 208_R | 1.715 | 1.00 | |
| 330_V | 389_L | 1.714 | 1.00 | |
| 256_K | 474_Q | 1.711 | 1.00 | |
| 415_A | 419_E | 1.705 | 1.00 | |
| 93_L | 212_L | 1.692 | 1.00 | |
| 70_F | 76_A | 1.688 | 1.00 | |
| 418_E | 449_R | 1.682 | 1.00 | |
| 419_E | 422_Q | 1.676 | 1.00 | |
| 451_Q | 473_K | 1.658 | 1.00 | |
| 313_Y | 423_L | 1.653 | 1.00 | |
| 371_L | 390_V | 1.652 | 1.00 | |
| 327_E | 372_I | 1.639 | 1.00 | |
| 320_D | 413_R | 1.638 | 1.00 | |
| 319_F | 323_V | 1.614 | 1.00 | |
| 283_K | 442_Q | 1.605 | 1.00 | |
| 210_A | 225_V | 1.602 | 1.00 | |
| 99_E | 103_Q | 1.598 | 1.00 | |
| 193_S | 222_V | 1.598 | 1.00 | |
| 395_A | 423_L | 1.596 | 1.00 | |
| 433_A | 452_A | 1.587 | 1.00 | |
| 93_L | 216_A | 1.582 | 1.00 | |
| 27_R | 220_D | 1.581 | 1.00 | |
| 257_G | 260_R | 1.569 | 1.00 | |
| 161_K | 487_D | 1.564 | 1.00 | |
| 88_L | 129_R | 1.559 | 1.00 | |
| 321_T | 324_S | 1.549 | 1.00 | |
| 92_D | 129_R | 1.547 | 1.00 | |
| 89_R | 92_D | 1.535 | 1.00 | |
| 400_T | 412_V | 1.529 | 1.00 | |
| 293_G | 436_W | 1.526 | 1.00 | |
| 329_A | 332_S | 1.521 | 1.00 | |
| 104_L | 208_R | 1.505 | 1.00 | |
| 21_G | 30_P | 1.504 | 1.00 | |
| 315_E | 414_V | 1.504 | 1.00 | |
| 421_L | 446_Y | 1.502 | 1.00 | |
| 294_L | 322_L | 1.5 | 1.00 | |
| 97_H | 215_E | 1.493 | 1.00 | |
| 315_E | 416_D | 1.487 | 1.00 | |
| 334_Q | 342_V | 1.483 | 1.00 | |
| 79_L | 82_E | 1.483 | 1.00 | |
| 95_E | 125_L | 1.474 | 1.00 | |
| 82_E | 85_R | 1.468 | 1.00 | |
| 369_A | 390_V | 1.46 | 1.00 | |
| 359_S | 398_R | 1.459 | 1.00 | |
| 362_D | 365_Q | 1.443 | 1.00 | |
| 287_P | 325_G | 1.43 | 1.00 | |
| 60_D | 240_H | 1.427 | 1.00 | |
| 325_G | 328_Q | 1.424 | 1.00 | |
| 416_D | 419_E | 1.42 | 1.00 | |
| 328_Q | 332_S | 1.408 | 1.00 | |
| 355_D | 359_S | 1.404 | 0.99 | |
| 77_G | 449_R | 1.403 | 0.99 | |
| 351_R | 383_Y | 1.392 | 0.99 | |
| 47_E | 50_S | 1.386 | 0.99 | |
| 40_F | 47_E | 1.379 | 0.99 | |
| 314_I | 322_L | 1.373 | 0.99 | |
| 282_L | 442_Q | 1.364 | 0.99 | |
| 319_F | 391_V | 1.362 | 0.99 | |
| 103_Q | 339_M | 1.351 | 0.99 | |
| 294_L | 312_I | 1.348 | 0.99 | |
| 29_G | 61_N | 1.345 | 0.99 | |
| 70_F | 193_S | 1.342 | 0.99 | |
| 299_F | 330_V | 1.336 | 0.99 | |
| 103_Q | 107_L | 1.33 | 0.99 | |
| 291_I | 325_G | 1.327 | 0.99 | |
| 328_Q | 331_K | 1.326 | 0.99 | |
| 63_V | 240_H | 1.326 | 0.99 | |
| 134_L | 137_K | 1.325 | 0.99 | |
| 367_Q | 398_R | 1.321 | 0.99 | |
| 160_R | 448_D | 1.308 | 0.99 | |
| 101_L | 208_R | 1.307 | 0.99 | |
| 331_K | 373_R | 1.303 | 0.99 | |
| 41_D | 44_T | 1.302 | 0.99 | |
| 282_L | 414_V | 1.292 | 0.99 | |
| 360_F | 404_V | 1.291 | 0.99 | |
| 337_P | 340_S | 1.285 | 0.99 | |
| 354_C | 385_V | 1.281 | 0.99 | |
| 169_G | 194_I | 1.279 | 0.99 | |
| 128_M | 181_M | 1.277 | 0.99 | |
| 211_E | 215_E | 1.274 | 0.99 | |
| 46_Q | 381_E | 1.273 | 0.99 | |
| 64_M | 68_R | 1.272 | 0.99 | |
| 354_C | 358_C | 1.27 | 0.99 | |
| 91_A | 129_R | 1.269 | 0.99 | |
| 106_T | 116_S | 1.262 | 0.99 | |
| 333_L | 345_I | 1.259 | 0.99 | |
| 259_A | 477_T | 1.254 | 0.99 | |
| 213_A | 223_F | 1.253 | 0.99 | |
| 419_E | 423_L | 1.244 | 0.98 | |
| 58_D | 61_N | 1.242 | 0.98 | |
| 364_A | 390_V | 1.239 | 0.98 | |
| 279_A | 309_S | 1.236 | 0.98 | |
| 78_R | 82_E | 1.233 | 0.98 | |
| 113_I | 117_R | 1.229 | 0.98 | |
| 245_K | 270_T | 1.227 | 0.98 | |
| 91_A | 95_E | 1.224 | 0.98 | |
| 180_G | 196_I | 1.219 | 0.98 | |
| 313_Y | 414_V | 1.218 | 0.98 | |
| 282_L | 446_Y | 1.212 | 0.98 | |
| 89_R | 93_L | 1.209 | 0.98 | |
| 90_F | 212_L | 1.207 | 0.98 | |
| 421_L | 425_N | 1.196 | 0.98 | |
| 418_E | 445_E | 1.194 | 0.98 | |
| 97_H | 208_R | 1.19 | 0.98 | |
| 88_L | 136_T | 1.186 | 0.98 | |
| 414_V | 423_L | 1.184 | 0.98 | |
| 351_R | 354_C | 1.184 | 0.98 | |
| 401_R | 426_D | 1.183 | 0.98 | |
| 90_F | 128_M | 1.18 | 0.98 | |
| 59_V | 233_C | 1.177 | 0.98 | |
| 101_L | 212_L | 1.174 | 0.98 | |
| 421_L | 449_R | 1.169 | 0.97 | |
| 447_S | 495_V | 1.165 | 0.97 | |
| 49_A | 204_L | 1.163 | 0.97 | |
| 484_D | 487_D | 1.163 | 0.97 | |
| 35_K | 50_S | 1.161 | 0.97 | |
| 23_Y | 28_P | 1.16 | 0.97 | |
| 98_S | 117_R | 1.153 | 0.97 | |
| 257_G | 261_T | 1.151 | 0.97 | |
| 169_G | 247_S | 1.149 | 0.97 | |
| 357_V | 406_G | 1.145 | 0.97 | |
| 235_A | 261_T | 1.139 | 0.97 | |
| 141_K | 484_D | 1.138 | 0.97 | |
| 160_R | 495_V | 1.137 | 0.97 | |
| 401_R | 428_E | 1.133 | 0.97 | |
| 210_A | 223_F | 1.133 | 0.97 | |
| 322_L | 326_F | 1.132 | 0.97 | |
| 184_V | 223_F | 1.131 | 0.97 | |
| 41_D | 337_P | 1.122 | 0.97 | |
| 97_H | 212_L | 1.12 | 0.96 | |
| 280_I | 420_A | 1.119 | 0.96 | |
| 365_Q | 390_V | 1.116 | 0.96 | |
| 396_K | 401_R | 1.104 | 0.96 | |
| 320_D | 324_S | 1.101 | 0.96 | |
| 63_V | 242_H | 1.098 | 0.96 | |
| 106_T | 338_G | 1.096 | 0.96 | |
| 433_A | 455_V | 1.096 | 0.96 | |
| 141_K | 483_P | 1.094 | 0.96 | |
| 326_F | 409_V | 1.092 | 0.96 | |
| 236_A | 240_H | 1.09 | 0.96 | |
| 45_G | 383_Y | 1.087 | 0.96 | |
| 73_R | 422_Q | 1.087 | 0.96 | |
| 280_I | 446_Y | 1.086 | 0.96 | |
| 161_K | 492_T | 1.085 | 0.96 | |
| 235_A | 257_G | 1.082 | 0.96 | |
| 323_V | 327_E | 1.081 | 0.95 | |
| 254_T | 257_G | 1.079 | 0.95 | |
| 354_C | 377_G | 1.079 | 0.95 | |
| 158_W | 444_L | 1.073 | 0.95 | |
| 327_E | 373_R | 1.073 | 0.95 | |
| 395_A | 426_D | 1.072 | 0.95 | |
| 45_G | 381_E | 1.071 | 0.95 | |
| 90_F | 218_I | 1.071 | 0.95 | |
| 318_L | 321_T | 1.06 | 0.95 | |
| 417_G | 446_Y | 1.059 | 0.95 | |
| 331_K | 386_A | 1.059 | 0.95 | |
| 78_R | 86_I | 1.058 | 0.95 | |
| 323_V | 372_I | 1.056 | 0.95 | |
| 168_A | 243_V | 1.054 | 0.95 | |
| 443_A | 457_V | 1.054 | 0.95 | |
| 439_N | 442_Q | 1.048 | 0.94 | |
| 483_P | 487_D | 1.045 | 0.94 | |
| 32_Q | 55_N | 1.043 | 0.94 | |
| 420_A | 423_L | 1.039 | 0.94 | |
| 34_E | 53_D | 1.037 | 0.94 | |
| 103_Q | 113_I | 1.032 | 0.94 | |
| 334_Q | 344_Q | 1.031 | 0.94 | |
| 239_S | 264_D | 1.027 | 0.94 | |
| 323_V | 391_V | 1.024 | 0.93 | |
| 259_A | 269_V | 1.023 | 0.93 | |
| 336_G | 343_A | 1.021 | 0.93 | |
| 284_D | 439_N | 1.021 | 0.93 | |
| 175_F | 305_V | 1.019 | 0.93 | |
| 359_S | 363_D | 1.019 | 0.93 | |
| 31_A | 61_N | 1.018 | 0.93 | |
| 315_E | 318_L | 1.015 | 0.93 | |
| 256_K | 266_L | 1.013 | 0.93 | |
| 418_E | 422_Q | 1.007 | 0.93 | |
| 166_V | 243_V | 1.003 | 0.93 | |
| 479_R | 491_E | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4i8pA | 2 | 0.986 | 100 | 0.075 | Contact Map | 0.782 |
| 3k2wA | 8 | 0.9679 | 100 | 0.077 | Contact Map | 0.864 |
| 3ek1A | 8 | 0.976 | 100 | 0.077 | Contact Map | 0.803 |
| 4lihA | 8 | 0.9739 | 100 | 0.081 | Contact Map | 0.787 |
| 1a4sA | 4 | 0.9659 | 100 | 0.081 | Contact Map | 0.787 |
| 1bxsA | 4 | 0.976 | 100 | 0.082 | Contact Map | 0.826 |
| 3ed6A | 2 | 0.986 | 100 | 0.082 | Contact Map | 0.789 |
| 2o2pA | 4 | 0.992 | 100 | 0.083 | Contact Map | 0.821 |
| 4f3xA | 4 | 0.976 | 100 | 0.084 | Contact Map | 0.722 |
| 3u4jA | 4 | 0.986 | 100 | 0.084 | Contact Map | 0.81 |
Sequence Conservation (Image Generated using WebLogo v3)