| UniProt: | P77445 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG14185 | ||
| Length: | 467 (418) | ||
| Sequences: | 17707 | ||
| Seq/Len: | 42.36 |
| EUTE
Paralog alert: 0.86 [within 20: 0.24] - ratio of genomes with paralogs Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 279_D | 374_A | 5.824 | 1.00 | |
| 279_D | 372_R | 3.443 | 1.00 | |
| 251_A | 288_L | 3.344 | 1.00 | |
| 246_E | 278_V | 3.109 | 1.00 | |
| 353_T | 356_H | 3.042 | 1.00 | |
| 282_A | 372_R | 3.024 | 1.00 | |
| 44_K | 208_G | 2.957 | 1.00 | |
| 246_E | 280_S | 2.861 | 1.00 | |
| 299_A | 303_Q | 2.849 | 1.00 | |
| 286_M | 370_V | 2.811 | 1.00 | |
| 170_R | 173_T | 2.781 | 1.00 | |
| 255_Q | 292_Q | 2.666 | 1.00 | |
| 70_H | 73_D | 2.648 | 1.00 | |
| 398_S | 404_M | 2.585 | 1.00 | |
| 311_K | 357_P | 2.556 | 1.00 | |
| 329_D | 342_P | 2.47 | 1.00 | |
| 44_K | 210_G | 2.468 | 1.00 | |
| 406_Q | 410_A | 2.368 | 1.00 | |
| 376_V | 406_Q | 2.227 | 1.00 | |
| 310_L | 314_D | 2.218 | 1.00 | |
| 376_V | 403_N | 2.212 | 1.00 | |
| 59_A | 184_G | 2.141 | 1.00 | |
| 306_Q | 310_L | 2.131 | 1.00 | |
| 284_E | 288_L | 2.089 | 1.00 | |
| 41_A | 208_G | 2.088 | 1.00 | |
| 242_V | 257_I | 2.07 | 1.00 | |
| 276_I | 379_A | 2.038 | 1.00 | |
| 71_A | 95_V | 2.036 | 1.00 | |
| 72_R | 90_K | 2.033 | 1.00 | |
| 37_D | 202_R | 2.028 | 1.00 | |
| 65_E | 69_K | 2.02 | 1.00 | |
| 275_L | 368_L | 1.987 | 1.00 | |
| 287_R | 291_G | 1.966 | 1.00 | |
| 201_Q | 205_K | 1.964 | 1.00 | |
| 66_A | 69_K | 1.959 | 1.00 | |
| 73_D | 170_R | 1.957 | 1.00 | |
| 309_L | 341_V | 1.943 | 1.00 | |
| 374_A | 378_D | 1.936 | 1.00 | |
| 63_I | 175_L | 1.935 | 1.00 | |
| 357_P | 361_T | 1.934 | 1.00 | |
| 37_D | 41_A | 1.934 | 1.00 | |
| 296_K | 305_L | 1.924 | 1.00 | |
| 247_T | 403_N | 1.917 | 1.00 | |
| 349_F | 358_F | 1.898 | 1.00 | |
| 176_N | 186_E | 1.897 | 1.00 | |
| 163_A | 298_T | 1.865 | 1.00 | |
| 47_Q | 51_K | 1.854 | 1.00 | |
| 378_D | 381_A | 1.842 | 1.00 | |
| 283_D | 372_R | 1.838 | 1.00 | |
| 172_I | 191_T | 1.809 | 1.00 | |
| 276_I | 382_L | 1.797 | 1.00 | |
| 62_A | 65_E | 1.796 | 1.00 | |
| 323_R | 351_E | 1.792 | 1.00 | |
| 354_A | 382_L | 1.79 | 1.00 | |
| 72_R | 76_E | 1.788 | 1.00 | |
| 246_E | 403_N | 1.786 | 1.00 | |
| 282_A | 286_M | 1.777 | 1.00 | |
| 394_A | 413_T | 1.756 | 1.00 | |
| 66_A | 174_L | 1.75 | 1.00 | |
| 359_A | 371_V | 1.737 | 1.00 | |
| 77_L | 170_R | 1.735 | 1.00 | |
| 284_E | 287_R | 1.731 | 1.00 | |
| 377_A | 410_A | 1.73 | 1.00 | |
| 278_V | 373_V | 1.703 | 1.00 | |
| 223_A | 226_K | 1.666 | 1.00 | |
| 256_S | 397_H | 1.658 | 1.00 | |
| 52_S | 410_A | 1.628 | 1.00 | |
| 155_S | 188_L | 1.624 | 1.00 | |
| 257_I | 285_L | 1.62 | 1.00 | |
| 380_I | 407_M | 1.61 | 1.00 | |
| 278_V | 375_N | 1.596 | 1.00 | |
| 313_I | 324_D | 1.587 | 1.00 | |
| 66_A | 181_A | 1.579 | 1.00 | |
| 325_W | 350_V | 1.576 | 1.00 | |
| 277_V | 285_L | 1.575 | 1.00 | |
| 306_Q | 330_A | 1.571 | 1.00 | |
| 311_K | 315_E | 1.565 | 1.00 | |
| 37_D | 206_F | 1.56 | 1.00 | |
| 250_L | 288_L | 1.559 | 1.00 | |
| 307_P | 357_P | 1.548 | 1.00 | |
| 245_D | 403_N | 1.544 | 1.00 | |
| 288_L | 291_G | 1.54 | 1.00 | |
| 375_N | 378_D | 1.518 | 1.00 | |
| 303_Q | 307_P | 1.513 | 1.00 | |
| 254_A | 288_L | 1.493 | 1.00 | |
| 323_R | 350_V | 1.492 | 1.00 | |
| 131_S | 156_V | 1.48 | 1.00 | |
| 47_Q | 155_S | 1.48 | 1.00 | |
| 306_Q | 341_V | 1.476 | 1.00 | |
| 66_A | 182_A | 1.475 | 1.00 | |
| 76_E | 80_S | 1.464 | 1.00 | |
| 180_V | 186_E | 1.463 | 1.00 | |
| 324_D | 349_F | 1.46 | 1.00 | |
| 257_I | 275_L | 1.447 | 1.00 | |
| 302_A | 306_Q | 1.426 | 1.00 | |
| 74_L | 170_R | 1.418 | 1.00 | |
| 41_A | 45_V | 1.405 | 0.99 | |
| 68_E | 98_A | 1.403 | 0.99 | |
| 378_D | 382_L | 1.399 | 0.99 | |
| 35_S | 38_D | 1.393 | 0.99 | |
| 245_D | 373_V | 1.392 | 0.99 | |
| 64_R | 68_E | 1.381 | 0.99 | |
| 233_I | 236_G | 1.381 | 0.99 | |
| 40_V | 206_F | 1.381 | 0.99 | |
| 276_I | 373_V | 1.373 | 0.99 | |
| 79_V | 89_D | 1.371 | 0.99 | |
| 377_A | 406_Q | 1.36 | 0.99 | |
| 308_V | 363_L | 1.358 | 0.99 | |
| 299_A | 302_A | 1.353 | 0.99 | |
| 142_V | 158_F | 1.351 | 0.99 | |
| 36_L | 199_T | 1.347 | 0.99 | |
| 242_V | 272_E | 1.346 | 0.99 | |
| 310_L | 313_I | 1.328 | 0.99 | |
| 70_H | 170_R | 1.322 | 0.99 | |
| 373_V | 382_L | 1.318 | 0.99 | |
| 282_A | 350_V | 1.313 | 0.99 | |
| 245_D | 407_M | 1.309 | 0.99 | |
| 243_V | 379_A | 1.307 | 0.99 | |
| 122_E | 409_N | 1.301 | 0.99 | |
| 126_W | 154_N | 1.293 | 0.99 | |
| 62_A | 66_A | 1.292 | 0.99 | |
| 394_A | 416_F | 1.287 | 0.99 | |
| 320_T | 349_F | 1.283 | 0.99 | |
| 290_E | 325_W | 1.28 | 0.99 | |
| 131_S | 213_V | 1.272 | 0.99 | |
| 380_I | 410_A | 1.268 | 0.99 | |
| 360_V | 385_K | 1.266 | 0.99 | |
| 293_H | 348_L | 1.263 | 0.99 | |
| 299_A | 339_L | 1.262 | 0.99 | |
| 63_I | 184_G | 1.259 | 0.99 | |
| 86_R | 90_K | 1.25 | 0.99 | |
| 172_I | 189_L | 1.25 | 0.99 | |
| 283_D | 287_R | 1.246 | 0.98 | |
| 380_I | 384_V | 1.246 | 0.98 | |
| 53_V | 59_A | 1.243 | 0.98 | |
| 302_A | 341_V | 1.239 | 0.98 | |
| 286_M | 290_E | 1.232 | 0.98 | |
| 377_A | 381_A | 1.229 | 0.98 | |
| 201_Q | 227_H | 1.227 | 0.98 | |
| 376_V | 407_M | 1.221 | 0.98 | |
| 175_L | 189_L | 1.22 | 0.98 | |
| 202_R | 206_F | 1.219 | 0.98 | |
| 223_A | 227_H | 1.214 | 0.98 | |
| 305_L | 365_M | 1.214 | 0.98 | |
| 354_A | 385_K | 1.213 | 0.98 | |
| 355_E | 360_V | 1.213 | 0.98 | |
| 40_V | 208_G | 1.205 | 0.98 | |
| 66_A | 177_Q | 1.202 | 0.98 | |
| 42_A | 187_N | 1.199 | 0.98 | |
| 70_H | 177_Q | 1.199 | 0.98 | |
| 146_A | 189_L | 1.195 | 0.98 | |
| 281_V | 284_E | 1.194 | 0.98 | |
| 289_M | 368_L | 1.193 | 0.98 | |
| 360_V | 387_E | 1.193 | 0.98 | |
| 205_K | 227_H | 1.187 | 0.98 | |
| 285_L | 289_M | 1.183 | 0.98 | |
| 404_M | 418_K | 1.179 | 0.98 | |
| 48_Q | 381_A | 1.179 | 0.98 | |
| 71_A | 90_K | 1.171 | 0.98 | |
| 187_N | 190_V | 1.169 | 0.97 | |
| 137_N | 268_I | 1.167 | 0.97 | |
| 278_V | 281_V | 1.166 | 0.97 | |
| 201_Q | 223_A | 1.163 | 0.97 | |
| 162_P | 195_P | 1.16 | 0.97 | |
| 124_A | 450_R | 1.149 | 0.97 | |
| 42_A | 190_V | 1.149 | 0.97 | |
| 245_D | 278_V | 1.148 | 0.97 | |
| 169_Q | 193_A | 1.146 | 0.97 | |
| 120_L | 405_N | 1.142 | 0.97 | |
| 243_V | 407_M | 1.14 | 0.97 | |
| 63_I | 174_L | 1.138 | 0.97 | |
| 130_A | 209_I | 1.137 | 0.97 | |
| 162_P | 197_I | 1.131 | 0.97 | |
| 249_D | 399_R | 1.128 | 0.97 | |
| 381_A | 385_K | 1.125 | 0.97 | |
| 210_G | 412_D | 1.122 | 0.97 | |
| 74_L | 174_L | 1.122 | 0.97 | |
| 128_V | 209_I | 1.099 | 0.96 | |
| 400_N | 403_N | 1.094 | 0.96 | |
| 211_L | 233_I | 1.092 | 0.96 | |
| 130_A | 203_L | 1.086 | 0.96 | |
| 379_A | 382_L | 1.083 | 0.96 | |
| 247_T | 400_N | 1.075 | 0.95 | |
| 220_V | 223_A | 1.073 | 0.95 | |
| 61_A | 65_E | 1.071 | 0.95 | |
| 45_V | 48_Q | 1.07 | 0.95 | |
| 76_E | 86_R | 1.07 | 0.95 | |
| 250_L | 254_A | 1.068 | 0.95 | |
| 245_D | 376_V | 1.059 | 0.95 | |
| 286_M | 350_V | 1.056 | 0.95 | |
| 33_F | 202_R | 1.056 | 0.95 | |
| 283_D | 286_M | 1.054 | 0.95 | |
| 38_D | 42_A | 1.053 | 0.95 | |
| 308_V | 311_K | 1.053 | 0.95 | |
| 146_A | 156_V | 1.051 | 0.94 | |
| 249_D | 252_R | 1.05 | 0.94 | |
| 48_Q | 52_S | 1.049 | 0.94 | |
| 312_N | 349_F | 1.046 | 0.94 | |
| 217_G | 220_V | 1.046 | 0.94 | |
| 239_N | 273_K | 1.046 | 0.94 | |
| 315_E | 357_P | 1.044 | 0.94 | |
| 252_R | 399_R | 1.039 | 0.94 | |
| 243_V | 383_A | 1.035 | 0.94 | |
| 401_I | 404_M | 1.034 | 0.94 | |
| 73_D | 76_E | 1.033 | 0.94 | |
| 254_A | 258_V | 1.025 | 0.93 | |
| 200_A | 204_F | 1.023 | 0.93 | |
| 261_A | 273_K | 1.02 | 0.93 | |
| 222_E | 226_K | 1.02 | 0.93 | |
| 303_Q | 306_Q | 1.018 | 0.93 | |
| 126_W | 211_L | 1.017 | 0.93 | |
| 242_V | 397_H | 1.016 | 0.93 | |
| 260_G | 272_E | 1.015 | 0.93 | |
| 70_H | 173_T | 1.013 | 0.93 | |
| 173_T | 177_Q | 1.01 | 0.93 | |
| 129_V | 211_L | 1.01 | 0.93 | |
| 46_A | 155_S | 1.005 | 0.93 | |
| 408_A | 418_K | 1.004 | 0.93 | |
| 124_A | 409_N | 1.002 | 0.92 | |
| 70_H | 174_L | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4i8pA | 2 | 0.9572 | 100 | 0.208 | Contact Map | 0.79 |
| 2o2pA | 4 | 0.9315 | 100 | 0.21 | Contact Map | 0.815 |
| 1a4sA | 4 | 0.9486 | 100 | 0.212 | Contact Map | 0.785 |
| 3ek1A | 8 | 0.9293 | 100 | 0.213 | Contact Map | 0.815 |
| 1bxsA | 4 | 0.9422 | 100 | 0.213 | Contact Map | 0.805 |
| 1o04A | 8 | 0.9422 | 100 | 0.213 | Contact Map | 0.806 |
| 4i9bA | 2 | 0.9572 | 100 | 0.215 | Contact Map | 0.739 |
| 4lihA | 8 | 0.9315 | 100 | 0.215 | Contact Map | 0.801 |
| 2j6lA | 8 | 0.9379 | 100 | 0.217 | Contact Map | 0.751 |
| 3k2wA | 8 | 0.955 | 100 | 0.217 | Contact Map | 0.86 |
Sequence Conservation (Image Generated using WebLogo v3)