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OPENSEQ.org
PUUC - Aldehyde dehydrogenase PuuC
UniProt: P23883 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10036
Length: 495 (469)
Sequences: 17262
Seq/Len: 36.81
PUUC
Paralog alert: 0.82 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
312_E 409_T 5.344 1.00
254_K 259_S 3.604 1.00
312_E 407_R 3.14 1.00
284_Q 321_L 3.096 1.00
278_A 311_E 2.846 1.00
347_C 351_D 2.83 1.00
67_R 236_D 2.782 1.00
388_D 391_A 2.775 1.00
38_E 50_K 2.751 1.00
358_R 362_S 2.705 1.00
315_A 407_R 2.675 1.00
371_R 380_G 2.622 1.00
359_E 392_S 2.589 1.00
288_S 325_Q 2.567 1.00
278_A 313_S 2.567 1.00
319_L 405_V 2.551 1.00
97_H 100_E 2.456 1.00
202_R 205_G 2.434 1.00
344_L 353_V 2.411 1.00
25_N 68_G 2.406 1.00
357_I 379_I 2.4 1.00
431_T 437_A 2.356 1.00
95_E 129_R 2.353 1.00
67_R 238_D 2.281 1.00
208_K 214_D 2.186 1.00
323_K 327_Q 2.174 1.00
38_E 47_P 2.14 1.00
55_K 58_D 2.129 1.00
439_R 443_R 2.098 1.00
90_L 207_A 2.07 1.00
411_E 439_R 2.062 1.00
411_E 436_R 2.023 1.00
354_H 358_R 2.016 1.00
384_F 393_L 2.006 1.00
22_L 54_G 1.956 1.00
309_L 414_A 1.955 1.00
86_V 212_L 1.917 1.00
361_E 366_L 1.916 1.00
367_L 385_V 1.911 1.00
359_E 363_K 1.907 1.00
317_E 321_L 1.894 1.00
64_S 236_D 1.892 1.00
195_K 346_D 1.889 1.00
320_A 324_Q 1.885 1.00
93_L 209_E 1.876 1.00
23_F 208_K 1.869 1.00
354_H 372_N 1.867 1.00
308_L 403_L 1.858 1.00
99_E 117_L 1.852 1.00
274_N 290_T 1.851 1.00
422_Q 468_Q 1.825 1.00
93_L 96_A 1.815 1.00
92_D 96_A 1.809 1.00
156_E 487_K 1.799 1.00
392_S 396_E 1.784 1.00
155_R 484_T 1.766 1.00
229_Q 233_R 1.766 1.00
233_R 255_D 1.765 1.00
279_D 436_R 1.761 1.00
98_A 122_P 1.755 1.00
93_L 206_L 1.753 1.00
354_H 379_I 1.752 1.00
60_D 64_S 1.745 1.00
326_A 383_I 1.725 1.00
60_D 230_A 1.718 1.00
409_T 413_Q 1.715 1.00
100_E 202_R 1.711 1.00
70_F 76_S 1.702 1.00
250_K 468_Q 1.698 1.00
366_L 384_F 1.674 1.00
413_Q 416_Q 1.665 1.00
445_K 467_K 1.656 1.00
323_K 367_L 1.656 1.00
309_L 417_L 1.654 1.00
316_D 407_R 1.648 1.00
278_A 436_R 1.627 1.00
315_A 319_L 1.627 1.00
204_A 219_V 1.616 1.00
412_E 443_R 1.604 1.00
389_P 417_L 1.596 1.00
97_H 209_E 1.593 1.00
427_A 446_A 1.592 1.00
93_L 210_A 1.586 1.00
27_E 214_D 1.582 1.00
311_E 408_F 1.581 1.00
251_Q 254_K 1.58 1.00
99_E 103_L 1.574 1.00
104_L 202_R 1.556 1.00
289_A 430_W 1.547 1.00
187_S 216_V 1.544 1.00
317_E 320_A 1.542 1.00
394_S 406_T 1.532 1.00
155_R 481_E 1.527 1.00
89_K 92_D 1.51 1.00
290_T 318_F 1.509 1.00
325_Q 328_N 1.503 1.00
330_Q 338_A 1.494 1.00
128_I 179_G 1.486 1.00
21_R 30_A 1.479 1.00
415_L 440_M 1.478 1.00
365_Q 384_F 1.477 1.00
311_E 410_S 1.468 1.00
82_K 85_A 1.453 1.00
355_S 392_S 1.449 1.00
79_S 82_K 1.449 1.00
358_R 361_E 1.447 1.00
283_L 321_L 1.443 1.00
60_D 234_H 1.423 1.00
321_L 324_Q 1.417 1.00
410_S 413_Q 1.409 1.00
40_V 47_P 1.398 0.99
351_D 355_S 1.397 0.99
88_N 129_R 1.391 0.99
77_L 443_R 1.39 0.99
92_D 129_R 1.388 0.99
70_F 187_S 1.388 0.99
324_Q 328_N 1.388 0.99
47_P 50_K 1.384 0.99
95_E 125_A 1.379 0.99
347_C 377_A 1.379 0.99
310_L 318_F 1.378 0.99
277_F 436_R 1.362 0.99
315_A 385_V 1.361 0.99
63_M 234_H 1.36 0.99
29_T 61_R 1.348 0.99
205_G 209_E 1.347 0.99
290_T 308_L 1.345 0.99
295_F 326_A 1.343 0.99
103_L 107_L 1.343 0.99
287_A 321_L 1.338 0.99
103_L 335_L 1.335 0.99
154_V 442_R 1.334 0.99
277_F 408_F 1.333 0.99
163_A 188_V 1.329 0.99
363_K 392_S 1.328 0.99
88_N 136_D 1.325 0.99
356_F 398_I 1.313 0.99
324_Q 327_Q 1.313 0.99
101_L 202_R 1.311 0.99
134_A 137_K 1.307 0.99
207_A 217_L 1.3 0.99
327_Q 368_L 1.299 0.99
46_A 375_L 1.294 0.99
360_G 384_F 1.294 0.99
41_D 44_T 1.289 0.99
59_I 227_A 1.287 0.99
106_T 116_S 1.285 0.99
350_A 354_H 1.281 0.99
329_W 341_M 1.277 0.99
253_L 471_N 1.268 0.99
128_I 175_C 1.268 0.99
333_H 336_D 1.264 0.99
64_S 68_G 1.25 0.99
413_Q 417_L 1.242 0.98
350_A 379_I 1.24 0.98
78_S 82_K 1.24 0.98
89_K 93_L 1.236 0.98
274_N 305_G 1.235 0.98
239_A 265_W 1.235 0.98
58_D 61_R 1.228 0.98
90_L 206_L 1.225 0.98
174_T 190_L 1.221 0.98
91_A 95_E 1.219 0.98
309_L 408_F 1.217 0.98
277_F 440_M 1.206 0.98
97_H 202_R 1.203 0.98
347_C 350_A 1.202 0.98
408_F 417_L 1.191 0.98
91_A 129_R 1.181 0.98
113_I 117_L 1.175 0.98
163_A 241_A 1.173 0.98
395_R 420_D 1.171 0.98
415_L 419_N 1.17 0.97
49_A 198_L 1.162 0.97
204_A 217_L 1.161 0.97
23_F 28_Y 1.16 0.97
141_E 477_L 1.156 0.97
154_V 489_I 1.153 0.97
412_E 439_R 1.152 0.97
441_S 489_I 1.152 0.97
101_L 206_L 1.151 0.97
353_V 400_G 1.151 0.97
478_H 481_E 1.151 0.97
36_T 50_K 1.148 0.97
415_L 443_R 1.142 0.97
318_F 322_L 1.142 0.97
251_Q 255_D 1.142 0.97
229_Q 255_D 1.138 0.97
395_R 422_Q 1.135 0.97
41_D 333_H 1.133 0.97
97_H 206_L 1.129 0.97
178_L 217_L 1.118 0.96
390_N 395_R 1.111 0.96
155_R 486_L 1.108 0.96
322_L 403_L 1.106 0.96
427_A 449_V 1.106 0.96
63_M 236_D 1.105 0.96
275_I 414_A 1.104 0.96
45_Q 375_L 1.097 0.96
162_A 237_I 1.097 0.96
160_V 237_I 1.093 0.96
141_E 478_H 1.092 0.96
90_L 212_L 1.092 0.96
361_E 384_F 1.092 0.96
350_A 372_N 1.092 0.96
106_T 334_P 1.091 0.96
90_L 128_I 1.088 0.96
316_D 320_A 1.083 0.96
314_I 317_E 1.081 0.95
152_M 438_H 1.081 0.95
389_P 420_D 1.08 0.95
98_A 117_L 1.079 0.95
229_Q 251_Q 1.072 0.95
319_L 323_K 1.071 0.95
248_T 251_Q 1.069 0.95
45_Q 377_A 1.068 0.95
275_I 440_M 1.067 0.95
411_E 440_M 1.067 0.95
319_L 367_L 1.066 0.95
71_E 416_Q 1.066 0.95
477_L 481_E 1.061 0.95
323_K 368_L 1.058 0.95
311_E 314_I 1.055 0.95
78_S 86_V 1.053 0.95
414_A 417_L 1.05 0.94
319_L 385_V 1.044 0.94
253_L 264_V 1.04 0.94
433_D 436_R 1.04 0.94
327_Q 380_G 1.039 0.94
437_A 451_V 1.037 0.94
35_E 53_R 1.035 0.94
230_A 234_H 1.035 0.94
365_Q 391_A 1.033 0.94
158_V 186_N 1.029 0.94
169_F 301_V 1.028 0.94
238_D 445_K 1.026 0.94
412_E 416_Q 1.025 0.93
152_M 491_I 1.024 0.93
245_S 248_T 1.023 0.93
273_A 427_A 1.023 0.93
103_L 113_I 1.022 0.93
473_R 485_E 1.022 0.93
33_E 55_K 1.02 0.93
330_Q 340_T 1.016 0.93
369_D 382_T 1.016 0.93
277_F 311_E 1.013 0.93
250_K 261_M 1.009 0.93
279_D 433_D 1.009 0.93
282_D 432_R 1.007 0.93
162_A 231_L 1.005 0.93
332_G 339_T 1.005 0.93
32_A 61_R 1.004 0.93
41_D 107_L 1.001 0.92
285_Q 432_R 1 0.92
277_F 411_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i8pA20.98991000.039Contact Map0.784
1bxsA40.9961000.043Contact Map0.828
4lihA80.98591000.043Contact Map0.787
2o2pA40.98991000.048Contact Map0.817
3ed6A20.98991000.05Contact Map0.787
3ek1A80.98791000.051Contact Map0.815
1a4sA40.98591000.051Contact Map0.79
1o04A80.99391000.051Contact Map0.83
3u4jA40.98791000.052Contact Map0.815
3k2wA80.97371000.053Contact Map0.862
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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