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OPENSEQ.org
GABD - Succinate-semialdehyde dehydrogenase [NADP(+)] GabD
UniProt: P25526 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11329
Length: 482 (470)
Sequences: 17884
Seq/Len: 38.05
GABD
Paralog alert: 0.85 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: ABDH ALDA ALDB ASTD BETB EUTE FEAB GABD PROA PUUC SAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
299_D 398_K 5.405 1.00
243_E 247_K 3.69 1.00
299_D 396_R 3.193 1.00
271_D 308_K 3.151 1.00
266_D 298_Q 2.858 1.00
377_P 380_A 2.776 1.00
334_E 338_A 2.767 1.00
58_N 225_L 2.748 1.00
302_Y 396_R 2.72 1.00
29_D 41_S 2.713 1.00
84_M 117_E 2.705 1.00
345_A 349_E 2.626 1.00
359_K 369_Q 2.616 1.00
266_D 300_G 2.59 1.00
346_D 381_K 2.563 1.00
275_E 312_A 2.534 1.00
86_H 89_D 2.509 1.00
306_A 394_L 2.496 1.00
191_A 194_E 2.46 1.00
331_L 340_V 2.413 1.00
16_N 59_R 2.412 1.00
344_I 368_F 2.377 1.00
420_A 426_V 2.339 1.00
197_I 203_A 2.339 1.00
58_N 227_R 2.259 1.00
310_Q 314_S 2.156 1.00
428_R 432_A 2.154 1.00
46_G 49_E 2.121 1.00
29_D 38_K 2.098 1.00
400_E 428_R 2.037 1.00
353_R 375_D 2.03 1.00
87_Q 110_S 2.022 1.00
400_E 425_R 1.993 1.00
341_E 345_A 1.983 1.00
79_W 196_A 1.977 1.00
13_A 45_M 1.967 1.00
373_L 382_V 1.958 1.00
296_Y 403_V 1.922 1.00
55_D 225_L 1.918 1.00
307_E 311_Q 1.915 1.00
75_I 201_V 1.909 1.00
82_L 198_R 1.898 1.00
304_R 308_K 1.897 1.00
346_D 350_K 1.887 1.00
348_L 354_V 1.876 1.00
88_D 106_K 1.871 1.00
14_L 197_I 1.861 1.00
295_L 392_A 1.844 1.00
262_F 277_A 1.834 1.00
184_Q 333_D 1.831 1.00
341_E 360_A 1.828 1.00
411_E 457_A 1.808 1.00
145_Q 476_K 1.807 1.00
355_V 374_V 1.805 1.00
81_N 85_E 1.805 1.00
82_L 85_E 1.803 1.00
218_N 222_S 1.79 1.00
144_K 473_L 1.767 1.00
267_D 425_R 1.761 1.00
381_K 385_E 1.757 1.00
353_R 374_V 1.744 1.00
341_E 368_F 1.741 1.00
116_I 168_G 1.739 1.00
82_L 195_L 1.725 1.00
89_D 191_A 1.724 1.00
398_K 402_D 1.724 1.00
51_R 219_E 1.721 1.00
51_R 55_D 1.715 1.00
222_S 244_Q 1.708 1.00
61_L 65_R 1.7 1.00
303_D 396_R 1.7 1.00
239_R 457_A 1.684 1.00
313_V 372_I 1.684 1.00
402_D 405_A 1.669 1.00
81_N 117_E 1.666 1.00
266_D 425_R 1.663 1.00
354_V 373_L 1.647 1.00
434_E 456_K 1.643 1.00
296_Y 406_Q 1.64 1.00
302_Y 306_A 1.625 1.00
401_A 432_A 1.616 1.00
88_D 92_R 1.616 1.00
310_Q 355_V 1.616 1.00
193_A 208_V 1.594 1.00
298_Q 397_F 1.591 1.00
416_A 435_Y 1.59 1.00
176_T 205_V 1.589 1.00
378_A 406_Q 1.584 1.00
240_Q 243_E 1.576 1.00
304_R 307_E 1.563 1.00
82_L 199_A 1.552 1.00
18_E 203_A 1.552 1.00
77_R 117_E 1.538 1.00
68_T 71_E 1.535 1.00
312_A 315_K 1.535 1.00
383_S 395_F 1.522 1.00
276_G 419_Y 1.517 1.00
78_N 81_N 1.514 1.00
298_Q 399_D 1.51 1.00
277_A 305_F 1.505 1.00
270_L 308_K 1.485 1.00
86_H 198_R 1.466 1.00
317_H 325_G 1.464 1.00
93_L 191_A 1.462 1.00
338_A 342_E 1.457 1.00
404_I 429_V 1.454 1.00
71_E 74_T 1.454 1.00
51_R 223_N 1.452 1.00
345_A 348_L 1.441 1.00
352_A 373_L 1.44 1.00
84_M 113_A 1.438 1.00
308_K 311_Q 1.429 1.00
342_E 381_K 1.427 1.00
399_D 402_D 1.426 1.00
265_F 425_R 1.417 1.00
297_V 305_F 1.413 1.00
66_A 432_A 1.403 0.99
12_Q 21_D 1.392 0.99
144_K 470_E 1.388 0.99
61_L 176_T 1.386 0.99
38_K 41_S 1.378 0.99
31_T 38_K 1.374 0.99
311_Q 315_K 1.365 0.99
92_R 96_L 1.361 0.99
92_R 322_L 1.353 0.99
282_F 313_V 1.345 0.99
334_E 366_N 1.343 0.99
54_I 223_N 1.337 0.99
20_L 52_A 1.326 0.99
152_A 177_M 1.325 0.99
90_L 191_A 1.325 0.99
274_V 308_K 1.324 0.99
265_F 397_F 1.321 0.99
337_V 341_E 1.32 0.99
277_A 295_L 1.32 0.99
350_K 381_K 1.314 0.99
302_Y 374_V 1.313 0.99
143_I 431_E 1.307 0.99
194_E 198_R 1.298 0.99
311_Q 314_S 1.291 0.99
32_N 35_N 1.29 0.99
402_D 406_Q 1.289 0.99
347_A 373_L 1.288 0.99
343_H 387_T 1.286 0.99
37_D 364_G 1.281 0.99
314_S 356_C 1.267 0.99
242_M 460_L 1.265 0.99
337_V 368_F 1.264 0.99
95_T 105_A 1.264 0.99
55_D 59_R 1.264 0.99
116_I 164_T 1.263 0.99
316_L 328_I 1.262 0.99
196_A 206_F 1.252 0.99
122_E 125_R 1.248 0.99
80_F 117_E 1.236 0.98
79_W 195_L 1.231 0.98
49_E 52_A 1.225 0.98
78_N 82_L 1.224 0.98
262_F 292_A 1.222 0.98
228_K 253_S 1.218 0.98
67_L 71_E 1.218 0.98
397_F 406_Q 1.205 0.98
265_F 429_V 1.2 0.98
401_A 428_R 1.199 0.98
296_Y 397_F 1.199 0.98
50_T 216_V 1.199 0.98
102_L 106_K 1.198 0.98
129_D 467_Y 1.193 0.98
384_K 409_D 1.188 0.98
163_I 179_L 1.181 0.98
334_E 337_V 1.179 0.98
152_A 230_S 1.17 0.97
193_A 206_F 1.166 0.97
404_I 408_N 1.164 0.97
79_W 116_I 1.163 0.97
86_H 191_A 1.162 0.97
14_L 19_W 1.161 0.97
80_F 84_M 1.161 0.97
40_G 187_F 1.159 0.97
90_L 195_L 1.158 0.97
320_D 323_D 1.157 0.97
404_I 432_A 1.15 0.97
32_N 320_D 1.147 0.97
340_V 389_G 1.146 0.97
263_I 403_V 1.144 0.97
54_I 225_L 1.142 0.97
384_K 411_E 1.141 0.97
27_A 41_S 1.14 0.97
143_I 478_M 1.136 0.97
430_G 478_M 1.132 0.97
86_H 195_L 1.129 0.97
144_K 475_I 1.129 0.97
303_D 307_E 1.118 0.96
77_R 124_K 1.118 0.96
379_N 384_K 1.117 0.96
306_A 310_Q 1.116 0.96
87_Q 106_K 1.116 0.96
167_A 206_F 1.114 0.96
95_T 321_G 1.105 0.96
305_F 309_L 1.101 0.96
416_A 438_V 1.098 0.96
218_N 244_Q 1.094 0.96
237_I 240_Q 1.091 0.96
348_L 373_L 1.091 0.96
36_G 364_G 1.084 0.96
337_V 360_A 1.082 0.96
309_L 392_A 1.081 0.95
467_Y 470_E 1.079 0.95
36_G 366_N 1.079 0.95
403_V 406_Q 1.078 0.95
218_N 240_Q 1.077 0.95
56_A 204_G 1.076 0.95
263_I 429_V 1.076 0.95
265_F 298_Q 1.073 0.95
129_D 466_K 1.073 0.95
301_V 304_R 1.073 0.95
298_Q 301_V 1.071 0.95
466_K 470_E 1.067 0.95
141_I 427_F 1.058 0.95
422_D 425_R 1.057 0.95
306_A 355_V 1.056 0.95
67_L 75_I 1.055 0.95
240_Q 244_Q 1.053 0.95
378_A 409_D 1.052 0.95
269_D 421_R 1.051 0.94
234_S 237_I 1.045 0.94
79_W 201_V 1.043 0.94
400_E 429_V 1.043 0.94
319_G 326_V 1.041 0.94
310_Q 356_C 1.038 0.94
314_S 369_Q 1.038 0.94
62_P 405_A 1.036 0.94
426_V 440_I 1.036 0.94
147_I 175_C 1.035 0.94
261_P 416_A 1.032 0.94
26_E 44_K 1.03 0.94
242_M 252_V 1.03 0.94
401_A 405_A 1.03 0.94
151_A 226_V 1.025 0.93
338_A 341_E 1.022 0.93
219_E 223_N 1.02 0.93
239_R 249_I 1.013 0.93
227_R 434_E 1.012 0.93
149_V 226_V 1.011 0.93
158_F 288_T 1.011 0.93
303_D 306_A 1.01 0.93
272_K 421_R 1.01 0.93
340_V 391_L 1.006 0.93
24_N 46_G 1.005 0.93
77_R 121_E 1.005 0.93
462_R 474_E 1.004 0.93
347_A 387_T 1.002 0.92
264_V 305_F 1.002 0.92
265_F 400_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ek1A80.99591000.002Contact Map0.806
4i8pA211000.003Contact Map0.78
3k2wA811000.005Contact Map0.859
1bxsA40.99791000.006Contact Map0.821
1a4sA40.99591000.008Contact Map0.786
1o04A80.99791000.008Contact Map0.826
4f3xA40.99591000.01Contact Map0.717
3ed6A20.99591000.011Contact Map0.785
3ifgA1611000.011Contact Map0.792
1wndA40.99591000.012Contact Map0.742
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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