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OPENSEQ.org

NUDG - CTP pyrophosphohydrolase
UniProt: P77788 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14009
Length: 135 (127)
Sequences: 4952
Seq/Len: 38.99

NUDG
Paralog alert: 0.73 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: GMM MUTT NUDG NUDJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
54_R 60_E 4.493 1.00
13_R 16_K 3.814 1.00
21_Q 100_A 3.133 1.00
39_V 48_A 3.125 1.00
16_K 105_S 2.719 1.00
44_S 47_Q 2.67 1.00
19_L 104_C 2.308 1.00
105_S 108_E 2.198 1.00
21_Q 99_Q 2.033 1.00
62_T 87_P 2.022 1.00
104_C 112_Y 2.006 1.00
64_G 87_P 2.005 1.00
11_I 53_L 1.93 1.00
45_Q 84_W 1.909 1.00
53_L 61_A 1.879 1.00
66_Y 82_H 1.832 1.00
60_E 90_H 1.814 1.00
9_A 86_V 1.788 1.00
50_V 54_R 1.709 1.00
32_W 102_V 1.632 1.00
12_E 85_H 1.626 1.00
61_A 86_V 1.534 1.00
43_E 51_R 1.525 1.00
9_A 49_L 1.485 1.00
19_L 112_Y 1.474 1.00
50_V 61_A 1.426 1.00
23_P 26_S 1.414 1.00
66_Y 69_S 1.388 0.99
71_Q 78_I 1.385 0.99
69_S 82_H 1.383 0.99
23_P 99_Q 1.38 0.99
39_V 45_Q 1.37 0.99
59_I 88_D 1.358 0.99
20_A 98_H 1.351 0.99
31_L 113_P 1.349 0.99
68_A 124_A 1.34 0.99
18_L 101_L 1.33 0.99
108_E 111_Q 1.314 0.99
19_L 114_L 1.308 0.99
5_E 80_H 1.287 0.99
47_Q 50_V 1.283 0.99
45_Q 82_H 1.272 0.99
104_C 110_L 1.261 0.99
5_E 82_H 1.245 0.98
9_A 53_L 1.24 0.98
15_G 106_P 1.214 0.98
7_V 49_L 1.206 0.98
119_I 123_E 1.195 0.98
21_Q 30_G 1.195 0.98
50_V 63_V 1.18 0.98
25_Q 29_A 1.174 0.98
53_L 86_V 1.16 0.97
95_A 98_H 1.147 0.97
49_L 53_L 1.127 0.97
7_V 48_A 1.121 0.97
46_R 50_V 1.107 0.96
67_V 85_H 1.097 0.96
20_A 101_L 1.096 0.96
43_E 48_A 1.048 0.94
8_A 83_A 1.029 0.94
71_Q 80_H 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rrkA1199.90.223Contact Map0.779
3gwyA2199.90.251Contact Map0.814
1mutA10.948199.90.261Contact Map0.316
3fk9A20.970499.90.283Contact Map0.733
3eesA2199.90.292Contact Map0.782
2pbtA40.955699.90.295Contact Map0.84
1x51A10.992699.90.301Contact Map0.552
3r03A2199.90.301Contact Map0.709
3hhjA20.96399.90.302Contact Map0.771
3fspA10.970499.90.304Contact Map0.521

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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