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OPENSEQ.org

GMM - GDP-mannose mannosyl hydrolase
UniProt: P32056 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11789
Length: 159 (138)
Sequences: 3208
Seq/Len: 23.25

GMM
Paralog alert: 0.65 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: GMM MUTT NUDG NUDJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_M 73_R 5.23 1.00
26_N 30_E 4.711 1.00
52_V 61_A 3.524 1.00
35_K 125_D 3.358 1.00
57_T 60_A 2.91 1.00
30_E 130_T 2.845 1.00
22_F 62_F 2.335 1.00
130_T 133_A 2.163 1.00
58_L 107_F 2.114 1.00
33_L 129_L 2.018 1.00
75_P 110_R 2.014 1.00
35_K 124_D 1.915 1.00
24_V 66_T 1.898 1.00
76_I 79_G 1.871 1.00
79_G 110_R 1.865 1.00
22_F 109_F 1.85 1.00
29_G 131_S 1.844 1.00
81_F 84_V 1.839 1.00
37_T 124_D 1.793 1.00
81_F 105_L 1.737 1.00
25_E 108_R 1.555 1.00
133_A 136_A 1.546 1.00
34_G 123_H 1.544 1.00
45_W 127_R 1.541 1.00
56_E 64_R 1.525 1.00
73_R 113_E 1.501 1.00
63_E 67_M 1.492 1.00
20_L 61_A 1.487 1.00
145_R 149_L 1.48 1.00
72_L 111_V 1.467 1.00
22_F 66_T 1.456 1.00
58_L 105_L 1.427 1.00
66_T 74_L 1.402 0.99
20_L 62_F 1.366 0.99
129_L 137_S 1.366 0.99
25_E 131_S 1.338 0.99
25_E 110_R 1.325 0.99
129_L 135_L 1.313 0.99
86_Q 101_H 1.293 0.99
66_T 109_F 1.269 0.99
118_L 123_H 1.257 0.99
74_L 109_F 1.25 0.99
76_I 110_R 1.24 0.98
80_Q 108_R 1.23 0.98
39_R 42_Q 1.226 0.98
63_E 79_G 1.217 0.98
118_L 126_Y 1.216 0.98
63_E 74_L 1.214 0.98
65_L 68_A 1.184 0.98
84_V 105_L 1.136 0.97
52_V 103_V 1.118 0.96
63_E 75_P 1.109 0.96
83_G 150_A 1.105 0.96
65_L 69_E 1.103 0.96
36_R 46_F 1.071 0.95
56_E 61_A 1.065 0.95
63_E 76_I 1.051 0.94
34_G 126_Y 1.043 0.94
73_R 112_S 1.041 0.94
52_V 58_L 1.038 0.94
60_A 63_E 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ryaA211000.263Contact Map0.753
4ktbA40.974899.90.358Contact Map0.689
3gwyA20.842899.90.383Contact Map0.766
2qjoA30.943499.90.387Contact Map0.575
3cngA40.911999.90.39Contact Map0.791
3f6aA20.893199.90.391Contact Map0.692
3fk9A20.849199.90.393Contact Map0.677
2b0vA10.886899.90.393Contact Map0.753
3gz5A20.943499.90.396Contact Map0.733
2qjtB20.95699.90.397Contact Map0.66

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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