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OPENSEQ.org

MUTT - 8-oxo-dGTP diphosphatase
UniProt: P08337 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10626
Length: 129 (126)
Sequences: 5206
Seq/Len: 41.32

MUTT
Paralog alert: 0.77 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: GMM MUTT NUDG NUDJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_Q 61_T 4.508 1.00
13_N 17_E 3.754 1.00
40_I 49_A 3.235 1.00
22_R 101_P 3.153 1.00
45_T 48_Q 2.762 1.00
17_E 106_S 2.751 1.00
20_I 105_M 2.381 1.00
106_S 109_G 2.315 1.00
22_R 100_Q 2.124 1.00
63_Q 88_E 2.102 1.00
105_M 113_D 1.994 1.00
46_P 85_W 1.979 1.00
65_F 88_E 1.976 1.00
9_G 50_V 1.94 1.00
54_L 62_P 1.928 1.00
61_T 91_E 1.863 1.00
51_V 55_Q 1.765 1.00
67_L 83_W 1.76 1.00
9_G 87_V 1.696 1.00
11_I 54_L 1.64 1.00
33_L 103_E 1.582 1.00
44_E 52_R 1.537 1.00
12_R 86_L 1.525 1.00
62_P 87_V 1.478 1.00
21_T 99_G 1.475 1.00
67_L 70_K 1.464 1.00
70_K 83_W 1.385 0.99
40_I 46_P 1.382 0.99
72_E 79_H 1.38 0.99
24_A 100_Q 1.378 0.99
46_P 83_W 1.373 0.99
9_G 54_L 1.366 0.99
20_I 113_D 1.354 0.99
60_I 89_R 1.336 0.99
51_V 62_P 1.313 0.99
109_G 112_A 1.304 0.99
24_A 27_A 1.298 0.99
69_E 125_K 1.293 0.99
19_F 102_G 1.293 0.99
5_Q 83_W 1.274 0.99
96_G 99_G 1.272 0.99
32_K 114_D 1.269 0.99
16_N 107_L 1.259 0.99
20_I 115_F 1.258 0.99
51_V 64_H 1.25 0.99
48_Q 51_V 1.228 0.98
7_A 50_V 1.196 0.98
5_Q 81_T 1.196 0.98
50_V 54_L 1.182 0.98
120_E 124_A 1.181 0.98
105_M 111_N 1.179 0.98
7_A 49_A 1.179 0.98
54_L 87_V 1.158 0.97
68_F 86_L 1.14 0.97
26_D 30_A 1.134 0.97
47_E 51_V 1.127 0.97
22_R 31_N 1.123 0.97
21_T 102_G 1.118 0.96
72_E 81_T 1.108 0.96
36_P 58_V 1.073 0.95
44_E 49_A 1.053 0.95
33_L 105_M 1.05 0.94
111_N 127_K 1.041 0.94
103_E 113_D 1.026 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1mutA1199.90.185Contact Map0.319
3gwyA20.992299.90.198Contact Map0.812
2rrkA10.992299.90.211Contact Map0.782
3eesA2199.90.226Contact Map0.74
3fk9A20.961299.90.227Contact Map0.737
3hhjA2199.90.231Contact Map0.773
3q93A20.992299.90.232Contact Map0.575
3r03A2199.90.233Contact Map0.71
3fspA10.96999.90.238Contact Map0.507
2pbtA40.953599.90.24Contact Map0.837

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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