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OPENSEQ.org
YNFF - Probable dimethyl sulfoxide reductase chain YnfF
UniProt: P77783 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13844
Length: 807 (776)
Sequences: 3854
Seq/Len: 4.97
YNFF
Paralog alert: 0.78 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: BISC DMSA FDHF FDNG FDOG NAPA TORA TORZ YDEP YNFE YNFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
727_I 746_A 7.111 1.00
117_Y 132_R 6.824 1.00
140_D 565_R 5.857 1.00
288_A 345_A 4.727 1.00
296_E 361_R 4.582 1.00
721_D 755_G 4.582 1.00
686_L 725_R 4.504 1.00
139_L 565_R 4.267 1.00
717_I 746_A 4.185 1.00
292_V 296_E 4.177 1.00
500_G 512_C 4.013 1.00
553_K 561_E 4.004 1.00
141_T 514_I 3.791 1.00
343_E 353_A 3.674 1.00
733_V 746_A 3.629 1.00
557_W 561_E 3.592 1.00
734_R 741_E 3.554 1.00
142_I 514_I 3.52 1.00
145_N 148_R 3.446 1.00
734_R 805_E 3.408 1.00
133_I 514_I 3.407 1.00
120_K 133_I 3.315 1.00
120_K 514_I 3.306 1.00
149_I 157_A 3.264 1.00
222_K 368_P 3.245 1.00
290_A 396_L 3.108 1.00
544_P 547_S 3.089 1.00
346_A 353_A 3.046 1.00
285_L 349_T 3.029 1.00
727_I 733_V 3.02 1.00
309_V 638_S 3.014 1.00
227_F 286_A 2.99 1.00
132_R 551_E 2.987 1.00
720_I 754_P 2.981 1.00
301_Q 305_D 2.942 1.00
722_A 748_V 2.901 1.00
291_W 295_T 2.785 1.00
134_S 137_E 2.769 1.00
148_R 152_D 2.749 1.00
731_D 806_K 2.739 1.00
258_V 271_E 2.721 1.00
146_L 466_F 2.684 1.00
715_V 757_T 2.673 1.00
292_V 342_P 2.657 1.00
579_S 582_E 2.649 1.00
117_Y 551_E 2.645 1.00
139_L 561_E 2.592 1.00
120_K 141_T 2.582 1.00
142_I 499_V 2.576 1.00
290_A 326_Y 2.569 1.00
561_E 565_R 2.559 1.00
255_R 362_E 2.558 1.00
353_A 357_I 2.549 1.00
124_K 127_E 2.534 1.00
221_T 224_V 2.495 1.00
291_W 342_P 2.484 1.00
133_I 141_T 2.484 1.00
345_A 356_I 2.447 1.00
638_S 642_E 2.427 1.00
281_T 348_I 2.415 1.00
725_R 803_Q 2.414 1.00
273_E 358_Q 2.411 1.00
70_R 85_T 2.41 1.00
715_V 733_V 2.403 1.00
292_V 361_R 2.396 1.00
352_P 355_K 2.393 1.00
120_K 131_E 2.381 1.00
343_E 357_I 2.368 1.00
729_H 748_V 2.365 1.00
299_V 304_L 2.334 1.00
358_Q 362_E 2.331 1.00
292_V 298_M 2.303 1.00
481_D 786_H 2.297 1.00
497_M 514_I 2.258 1.00
724_A 754_P 2.242 1.00
355_K 358_Q 2.241 1.00
341_T 344_W 2.232 1.00
363_I 397_T 2.22 1.00
744_I 759_I 2.205 1.00
346_A 352_P 2.181 1.00
137_E 141_T 2.146 1.00
298_M 364_G 2.117 1.00
275_L 351_I 2.117 1.00
302_P 306_K 2.085 1.00
736_F 741_E 2.085 1.00
116_K 550_F 2.083 1.00
296_E 357_I 2.082 1.00
715_V 759_I 2.063 1.00
223_L 257_I 2.052 1.00
294_I 330_I 2.052 1.00
396_L 643_I 2.047 1.00
275_L 359_L 2.009 1.00
119_M 515_L 1.996 1.00
289_I 363_I 1.994 1.00
277_I 351_I 1.991 1.00
525_E 544_P 1.987 1.00
273_E 355_K 1.983 1.00
137_E 514_I 1.969 1.00
298_M 361_R 1.958 1.00
273_E 362_E 1.945 1.00
149_I 466_F 1.925 1.00
297_N 301_Q 1.924 1.00
729_H 747_K 1.915 1.00
465_K 496_E 1.911 1.00
505_M 509_A 1.902 1.00
141_T 145_N 1.901 1.00
223_L 362_E 1.9 1.00
402_I 405_G 1.9 1.00
78_V 109_M 1.891 1.00
346_A 356_I 1.89 1.00
285_L 356_I 1.885 1.00
294_I 311_Y 1.875 1.00
500_G 509_A 1.868 1.00
715_V 735_V 1.851 1.00
717_I 804_I 1.843 1.00
261_P 274_W 1.835 1.00
223_L 359_L 1.834 1.00
686_L 757_T 1.828 1.00
716_W 749_T 1.819 1.00
734_R 743_L 1.811 1.00
549_K 552_R 1.791 1.00
363_I 369_A 1.789 1.00
284_A 348_I 1.789 1.00
468_W 501_I 1.786 1.00
289_I 293_L 1.786 1.00
224_V 254_A 1.772 1.00
224_V 245_V 1.772 1.00
295_T 357_I 1.764 1.00
293_L 299_V 1.762 1.00
717_I 757_T 1.758 1.00
717_I 727_I 1.756 1.00
495_C 498_I 1.746 1.00
141_T 497_M 1.745 1.00
561_E 564_K 1.744 1.00
469_C 498_I 1.733 1.00
304_L 311_Y 1.718 1.00
225_V 259_I 1.716 1.00
732_T 743_L 1.712 1.00
600_D 603_E 1.708 1.00
732_T 745_A 1.703 1.00
742_M 759_I 1.676 0.99
153_Y 465_K 1.674 0.99
220_N 403_N 1.673 0.99
728_R 731_D 1.664 0.99
259_I 285_L 1.654 0.99
142_I 516_L 1.651 0.99
683_T 738_N 1.645 0.99
487_E 490_Q 1.637 0.99
292_V 357_I 1.629 0.99
72_H 82_E 1.625 0.99
299_V 311_Y 1.623 0.99
553_K 557_W 1.618 0.99
81_V 106_R 1.608 0.99
501_I 558_M 1.603 0.99
603_E 607_T 1.595 0.99
149_I 496_E 1.588 0.99
285_L 359_L 1.583 0.99
308_C 643_I 1.578 0.99
249_R 272_D 1.578 0.99
225_V 359_L 1.577 0.99
118_P 135_W 1.572 0.99
686_L 721_D 1.561 0.99
519_L 554_P 1.56 0.99
122_V 131_E 1.558 0.99
133_I 137_E 1.555 0.99
681_R 738_N 1.548 0.99
146_L 499_V 1.54 0.99
340_K 345_A 1.539 0.99
217_D 220_N 1.536 0.99
736_F 803_Q 1.527 0.99
720_I 723_Q 1.526 0.99
275_L 355_K 1.522 0.99
140_D 144_D 1.521 0.99
119_M 132_R 1.516 0.99
686_L 803_Q 1.513 0.99
71_L 78_V 1.512 0.99
281_T 349_T 1.493 0.98
288_A 356_I 1.491 0.98
328_A 331_L 1.49 0.98
122_V 129_K 1.489 0.98
346_A 351_I 1.485 0.98
340_K 348_I 1.482 0.98
718_N 754_P 1.476 0.98
273_E 359_L 1.472 0.98
739_N 784_T 1.457 0.98
749_T 752_I 1.453 0.98
225_V 289_I 1.434 0.98
142_I 497_M 1.434 0.98
63_C 67_C 1.431 0.98
147_R 151_K 1.421 0.98
116_K 132_R 1.418 0.98
139_L 562_V 1.416 0.98
589_A 592_K 1.411 0.98
674_D 739_N 1.411 0.98
291_W 341_T 1.41 0.97
350_S 753_L 1.407 0.97
131_E 137_E 1.406 0.97
257_I 359_L 1.402 0.97
735_V 759_I 1.397 0.97
248_A 254_A 1.393 0.97
366_A 369_A 1.389 0.97
222_K 366_A 1.38 0.97
109_M 546_T 1.378 0.97
139_L 557_W 1.358 0.97
149_I 497_M 1.354 0.97
340_K 344_W 1.347 0.96
727_I 748_V 1.347 0.96
486_H 490_Q 1.346 0.96
346_A 349_T 1.34 0.96
719_P 750_P 1.332 0.96
259_I 359_L 1.318 0.96
217_D 404_G 1.318 0.96
716_W 747_K 1.307 0.96
294_I 299_V 1.304 0.95
505_M 515_L 1.298 0.95
158_V 466_F 1.296 0.95
292_V 295_T 1.292 0.95
686_L 718_N 1.288 0.95
344_W 347_K 1.285 0.95
288_A 292_V 1.283 0.95
107_R 706_V 1.282 0.95
736_F 805_E 1.281 0.95
59_C 63_C 1.281 0.95
313_E 328_A 1.277 0.95
136_D 565_R 1.274 0.95
554_P 557_W 1.268 0.95
222_K 252_S 1.265 0.94
302_P 305_D 1.263 0.94
135_W 516_L 1.261 0.94
144_D 148_R 1.261 0.94
636_T 642_E 1.256 0.94
585_K 602_E 1.251 0.94
277_I 281_T 1.247 0.94
737_N 802_V 1.247 0.94
375_W 379_R 1.246 0.94
503_H 520_M 1.244 0.94
139_L 553_K 1.241 0.94
557_W 564_K 1.24 0.94
304_L 396_L 1.238 0.94
294_I 327_K 1.238 0.94
147_R 150_L 1.237 0.94
519_L 552_R 1.236 0.94
286_A 390_I 1.229 0.93
71_L 81_V 1.227 0.93
145_N 149_I 1.227 0.93
292_V 356_I 1.207 0.92
715_V 804_I 1.201 0.92
399_N 405_G 1.197 0.92
70_R 84_D 1.197 0.92
83_S 96_V 1.196 0.92
311_Y 396_L 1.194 0.92
73_V 79_Y 1.193 0.92
299_V 396_L 1.193 0.92
564_K 571_Y 1.192 0.92
646_E 650_K 1.191 0.92
715_V 744_I 1.187 0.92
154_G 157_A 1.183 0.91
291_W 330_I 1.18 0.91
249_R 256_M 1.178 0.91
644_Y 665_P 1.177 0.91
744_I 780_I 1.173 0.91
363_I 371_I 1.164 0.91
345_A 349_T 1.161 0.90
276_P 753_L 1.159 0.90
71_L 522_T 1.159 0.90
227_F 259_I 1.158 0.90
135_W 558_M 1.145 0.90
578_R 586_Y 1.141 0.89
263_Y 268_A 1.139 0.89
789_S 792_A 1.139 0.89
288_A 344_W 1.139 0.89
222_K 367_K 1.139 0.89
289_I 360_A 1.138 0.89
255_R 272_D 1.137 0.89
77_T 110_N 1.136 0.89
717_I 748_V 1.136 0.89
180_L 559_L 1.135 0.89
519_L 548_A 1.135 0.89
369_A 399_N 1.133 0.89
286_A 389_A 1.13 0.89
150_L 158_V 1.13 0.89
295_T 342_P 1.129 0.89
292_V 353_A 1.128 0.89
67_C 99_C 1.128 0.89
546_T 549_K 1.127 0.89
293_L 396_L 1.122 0.88
714_E 747_K 1.122 0.88
292_V 360_A 1.121 0.88
58_S 540_I 1.119 0.88
159_H 464_I 1.119 0.88
467_L 495_C 1.118 0.88
377_P 390_I 1.117 0.88
341_T 345_A 1.115 0.88
278_R 753_L 1.112 0.88
386_T 390_I 1.109 0.87
342_P 357_I 1.106 0.87
311_Y 327_K 1.105 0.87
354_E 357_I 1.103 0.87
116_K 549_K 1.101 0.87
342_P 353_A 1.1 0.87
57_S 71_L 1.098 0.87
257_I 362_E 1.097 0.87
301_Q 327_K 1.095 0.87
293_L 397_T 1.095 0.87
525_E 541_L 1.093 0.86
226_M 256_M 1.092 0.86
392_M 643_I 1.089 0.86
466_F 497_M 1.089 0.86
115_L 515_L 1.088 0.86
57_S 542_A 1.087 0.86
466_F 499_V 1.086 0.86
516_L 558_M 1.083 0.86
293_L 364_G 1.083 0.86
395_V 641_I 1.081 0.86
120_K 142_I 1.081 0.86
357_I 361_R 1.081 0.86
55_V 73_V 1.079 0.85
146_L 566_L 1.077 0.85
757_T 802_V 1.076 0.85
300_D 303_F 1.074 0.85
637_P 642_E 1.071 0.85
759_I 780_I 1.07 0.85
501_I 518_D 1.067 0.85
111_H 504_F 1.066 0.85
157_A 465_K 1.065 0.84
289_I 393_L 1.065 0.84
261_P 276_P 1.064 0.84
285_L 289_I 1.063 0.84
76_D 79_Y 1.063 0.84
346_A 354_E 1.063 0.84
310_G 313_E 1.062 0.84
520_M 549_K 1.06 0.84
16_R 19_L 1.057 0.84
298_M 365_S 1.054 0.84
368_P 405_G 1.049 0.83
553_K 558_M 1.049 0.83
223_L 366_A 1.045 0.83
288_A 341_T 1.043 0.83
249_R 270_R 1.04 0.82
202_A 391_A 1.037 0.82
481_D 484_H 1.037 0.82
110_N 549_K 1.034 0.82
226_M 229_N 1.033 0.82
309_V 642_E 1.029 0.82
292_V 364_G 1.026 0.81
120_K 137_E 1.024 0.81
180_L 566_L 1.021 0.81
342_P 346_A 1.02 0.81
470_Y 559_L 1.019 0.81
257_I 273_E 1.019 0.81
268_A 751_R 1.018 0.81
361_R 365_S 1.017 0.81
520_M 546_T 1.015 0.80
258_V 267_A 1.014 0.80
691_F 758_A 1.013 0.80
133_I 497_M 1.013 0.80
146_L 150_L 1.012 0.80
195_S 198_Q 1.01 0.80
684_Y 737_N 1.006 0.80
73_V 546_T 1.006 0.80
468_W 562_V 1.005 0.79
506_T 509_A 1.005 0.79
262_R 758_A 1.005 0.79
509_A 515_L 1.004 0.79
277_I 285_L 1.004 0.79
118_P 134_S 1.003 0.79
725_R 804_I 1.002 0.79
123_G 127_E 1.001 0.79
309_V 640_K 1 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vpzA20.8911000.218Contact Map0.733
2ivfA10.93311000.222Contact Map0.751
1kqfA10.92441000.242Contact Map0.72
1tmoA10.91821000.244Contact Map0.691
2e7zA10.84141000.258Contact Map0.755
1ti6A60.8911000.267Contact Map0.799
1eu1A10.87861000.271Contact Map0.747
1q16A10.9481000.279Contact Map0.722
1h0hA20.88721000.283Contact Map0.701
3ml1A10.84391000.283Contact Map0.735
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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