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OPENSEQ.org
DMSA - Dimethyl sulfoxide reductase DmsA
UniProt: P18775 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10232
Length: 814 (791)
Sequences: 4038
Seq/Len: 5.10
DMSA
Paralog alert: 0.79 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: BISC DMSA FDHF FDNG FDOG NAPA TORA TORZ YDEP YNFE YNFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
736_I 755_A 7.059 1.00
122_Y 137_R 6.972 1.00
145_D 576_R 6.094 1.00
299_G 356_A 4.718 1.00
307_E 372_R 4.605 1.00
730_D 764_G 4.564 1.00
144_Y 576_R 4.382 1.00
695_L 734_R 4.345 1.00
303_V 307_E 4.168 1.00
564_K 572_E 4.062 1.00
743_R 812_E 4.025 1.00
726_I 755_A 3.981 1.00
511_V 523_A 3.752 1.00
354_E 364_A 3.75 1.00
742_V 755_A 3.694 1.00
146_I 525_I 3.664 1.00
743_R 750_E 3.654 1.00
568_E 572_E 3.571 1.00
555_Q 558_K 3.564 1.00
147_I 525_I 3.527 1.00
150_N 153_R 3.46 1.00
233_K 379_P 3.433 1.00
138_I 525_I 3.356 1.00
125_K 525_I 3.246 1.00
154_L 162_S 3.198 1.00
357_S 364_A 3.18 1.00
296_L 360_T 3.158 1.00
302_Y 306_T 3.158 1.00
125_K 138_I 3.126 1.00
301_A 407_L 3.116 1.00
736_I 742_V 3.106 1.00
740_D 813_K 3.037 1.00
137_R 562_E 3.006 1.00
729_L 763_P 2.904 1.00
312_Q 316_D 2.9 1.00
139_S 142_E 2.898 1.00
731_A 757_V 2.863 1.00
153_R 157_E 2.849 1.00
238_F 297_V 2.849 1.00
122_Y 562_E 2.76 1.00
320_V 647_S 2.735 1.00
269_I 282_E 2.722 1.00
151_M 477_M 2.661 1.00
144_Y 572_E 2.636 1.00
266_R 373_E 2.624 1.00
572_E 576_R 2.546 1.00
147_I 510_V 2.528 1.00
302_Y 353_P 2.527 1.00
232_S 235_V 2.521 1.00
734_R 810_Q 2.519 1.00
303_V 353_P 2.502 1.00
125_K 146_I 2.474 1.00
738_N 757_V 2.46 1.00
492_E 793_Q 2.457 1.00
588_T 591_E 2.454 1.00
366_K 369_K 2.447 1.00
364_A 368_I 2.441 1.00
138_I 146_I 2.408 1.00
284_E 369_K 2.405 1.00
352_T 355_W 2.399 1.00
303_V 372_R 2.398 1.00
363_P 366_K 2.398 1.00
129_A 132_E 2.396 1.00
724_M 766_V 2.382 1.00
357_S 363_P 2.345 1.00
125_K 136_E 2.345 1.00
726_I 811_V 2.336 1.00
303_V 309_L 2.336 1.00
354_E 368_I 2.327 1.00
74_R 89_N 2.324 1.00
369_K 373_E 2.323 1.00
310_V 315_L 2.302 1.00
292_T 359_I 2.3 1.00
301_A 337_Y 2.292 1.00
356_A 367_I 2.25 1.00
753_I 768_L 2.226 1.00
508_L 525_I 2.187 1.00
647_S 651_E 2.185 1.00
121_K 561_F 2.158 1.00
142_E 146_I 2.153 1.00
146_I 150_N 2.146 1.00
745_F 750_E 2.146 1.00
724_M 742_V 2.128 1.00
300_L 374_I 2.111 1.00
560_R 563_C 2.11 1.00
536_M 555_Q 2.11 1.00
313_A 317_K 2.103 1.00
374_I 408_T 2.097 1.00
309_L 375_G 2.096 1.00
746_N 809_V 2.096 1.00
307_E 368_I 2.083 1.00
305_I 322_Y 2.082 1.00
308_N 312_Q 2.075 1.00
733_K 763_P 2.065 1.00
309_L 372_R 2.059 1.00
305_I 341_I 2.057 1.00
286_I 370_L 2.053 1.00
234_L 268_I 2.051 1.00
286_I 362_V 2.051 1.00
516_M 520_A 2.022 1.00
142_E 525_I 1.999 1.00
296_L 367_I 1.994 1.00
124_M 526_L 1.991 1.00
234_L 373_E 1.98 1.00
476_K 507_E 1.967 1.00
745_F 810_Q 1.933 1.00
413_I 416_G 1.921 1.00
498_E 501_Q 1.909 1.00
288_I 362_V 1.904 1.00
357_S 367_I 1.903 1.00
272_P 285_W 1.895 1.00
506_C 509_I 1.888 1.00
724_M 768_L 1.887 1.00
374_I 380_A 1.887 1.00
726_I 736_I 1.876 1.00
741_K 754_E 1.872 1.00
738_N 756_K 1.871 1.00
695_L 766_V 1.866 1.00
284_E 366_K 1.865 1.00
304_M 310_V 1.854 1.00
284_E 373_E 1.853 1.00
741_K 752_H 1.84 1.00
127_V 136_E 1.837 1.00
296_L 370_L 1.834 1.00
146_I 508_L 1.818 1.00
479_W 512_I 1.814 1.00
82_I 114_V 1.809 1.00
234_L 370_L 1.803 1.00
511_V 520_A 1.802 1.00
315_L 322_Y 1.788 1.00
75_M 82_I 1.784 1.00
743_R 752_H 1.782 1.00
306_T 368_I 1.779 1.00
295_A 359_I 1.777 1.00
737_H 740_D 1.777 1.00
154_L 477_M 1.772 1.00
751_V 768_L 1.765 1.00
236_V 270_I 1.765 1.00
147_I 527_L 1.763 1.00
228_D 231_N 1.758 1.00
725_W 758_T 1.746 1.00
724_M 744_I 1.743 1.00
300_L 304_M 1.735 1.00
124_M 137_R 1.71 1.00
123_P 140_W 1.71 1.00
231_N 414_N 1.687 1.00
745_F 812_E 1.68 0.99
151_M 510_V 1.679 0.99
564_K 568_E 1.677 0.99
572_E 575_K 1.67 0.99
138_I 142_E 1.665 0.99
154_L 507_E 1.66 0.99
512_I 569_M 1.654 0.99
303_V 368_I 1.648 0.99
726_I 766_V 1.644 0.99
76_H 86_E 1.626 0.99
235_V 265_A 1.622 0.99
270_I 296_L 1.6 0.99
695_L 730_D 1.594 0.99
339_A 342_L 1.592 0.99
530_C 565_T 1.592 0.99
310_V 322_Y 1.591 0.99
158_Y 476_K 1.579 0.99
690_N 747_D 1.565 0.99
235_V 256_L 1.563 0.99
729_L 732_Q 1.56 0.99
692_Q 747_D 1.55 0.99
260_R 283_D 1.547 0.99
695_L 810_Q 1.543 0.99
299_G 367_I 1.543 0.99
127_V 134_K 1.542 0.99
136_E 142_E 1.537 0.99
766_V 809_V 1.531 0.99
598_A 601_R 1.519 0.99
292_T 360_T 1.519 0.99
85_V 111_R 1.518 0.99
612_E 616_Q 1.516 0.99
734_R 811_V 1.51 0.99
609_T 612_E 1.51 0.99
236_V 370_L 1.506 0.99
357_S 362_V 1.492 0.98
480_N 509_I 1.49 0.98
355_W 358_Q 1.48 0.98
744_I 768_L 1.469 0.98
377_T 380_A 1.465 0.98
152_Q 156_K 1.462 0.98
286_I 366_K 1.462 0.98
302_Y 352_T 1.457 0.98
121_K 137_R 1.452 0.98
683_E 748_R 1.451 0.98
758_T 761_M 1.451 0.98
530_C 563_C 1.445 0.98
497_H 501_Q 1.445 0.98
144_Y 568_E 1.439 0.98
407_L 652_I 1.428 0.98
75_M 85_V 1.423 0.98
351_K 356_A 1.422 0.98
269_I 278_G 1.42 0.98
259_A 265_A 1.416 0.98
305_I 310_V 1.405 0.98
516_M 526_L 1.404 0.98
386_W 390_R 1.394 0.97
748_R 791_T 1.392 0.97
112_R 715_V 1.392 0.97
284_E 370_L 1.39 0.97
145_D 149_T 1.39 0.97
149_T 153_R 1.389 0.97
228_D 415_G 1.381 0.97
120_L 526_L 1.374 0.97
303_V 306_T 1.373 0.97
361_G 762_M 1.373 0.97
728_P 759_P 1.372 0.97
144_Y 564_K 1.371 0.97
727_N 763_P 1.367 0.97
568_E 575_K 1.359 0.97
297_V 401_I 1.351 0.97
144_Y 573_L 1.341 0.97
236_V 300_L 1.341 0.97
725_W 756_K 1.34 0.96
575_K 580_E 1.33 0.96
67_C 71_C 1.312 0.96
154_L 508_L 1.31 0.96
141_E 576_R 1.307 0.96
147_I 508_L 1.306 0.96
268_I 370_L 1.304 0.96
724_M 753_I 1.3 0.96
736_I 757_V 1.297 0.96
374_I 382_I 1.296 0.96
152_Q 155_I 1.292 0.95
299_G 303_V 1.292 0.95
140_W 569_M 1.29 0.95
159_G 162_S 1.286 0.95
351_K 359_I 1.284 0.95
306_T 353_P 1.283 0.95
233_K 377_T 1.282 0.95
140_W 527_L 1.281 0.95
319_C 652_I 1.275 0.95
87_T 101_V 1.267 0.95
351_K 355_W 1.266 0.95
315_L 407_L 1.249 0.94
288_I 292_T 1.245 0.94
410_N 416_G 1.241 0.94
514_C 531_T 1.237 0.94
270_I 370_L 1.232 0.94
695_L 727_N 1.232 0.94
237_L 267_M 1.23 0.94
63_C 67_C 1.229 0.94
527_L 569_M 1.223 0.93
114_V 557_I 1.221 0.93
356_A 360_T 1.22 0.93
380_A 410_N 1.22 0.93
233_K 378_K 1.219 0.93
645_T 651_E 1.213 0.93
324_E 339_A 1.21 0.93
77_V 83_K 1.203 0.93
313_A 316_D 1.203 0.93
81_E 115_Y 1.201 0.93
300_L 404_L 1.198 0.92
303_V 367_I 1.197 0.92
190_L 577_L 1.189 0.92
357_S 360_T 1.186 0.92
300_L 371_A 1.185 0.92
287_P 762_M 1.184 0.92
304_M 407_L 1.182 0.92
565_T 568_E 1.18 0.92
75_M 533_S 1.174 0.91
80_G 83_K 1.172 0.91
397_A 401_I 1.168 0.91
150_N 154_L 1.168 0.91
724_M 811_V 1.167 0.91
305_I 338_K 1.164 0.91
155_I 163_I 1.163 0.91
552_F 614_R 1.155 0.90
353_P 368_I 1.155 0.90
74_R 88_D 1.154 0.90
753_I 787_I 1.153 0.90
536_M 552_F 1.152 0.90
268_I 284_E 1.151 0.90
352_T 356_A 1.15 0.90
229_I 381_F 1.149 0.90
151_M 577_L 1.148 0.90
304_M 375_G 1.148 0.90
492_E 495_R 1.146 0.90
74_R 86_E 1.141 0.90
121_K 560_R 1.141 0.90
530_C 559_P 1.14 0.90
477_M 510_V 1.138 0.90
655_Q 659_D 1.136 0.89
726_I 757_V 1.136 0.89
557_I 560_R 1.131 0.89
322_Y 407_L 1.128 0.89
695_L 811_V 1.125 0.89
303_V 364_A 1.124 0.89
238_F 270_I 1.116 0.88
303_V 371_A 1.114 0.88
304_M 374_I 1.11 0.88
61_S 75_M 1.11 0.88
477_M 508_L 1.109 0.88
266_R 283_D 1.109 0.88
310_V 407_L 1.108 0.88
234_L 374_I 1.107 0.88
299_G 352_T 1.105 0.88
163_I 477_M 1.103 0.88
151_M 479_W 1.101 0.87
77_V 557_I 1.098 0.87
289_R 762_M 1.096 0.87
564_K 569_M 1.096 0.87
357_S 365_D 1.095 0.87
304_M 404_L 1.094 0.87
368_I 372_R 1.093 0.87
388_P 401_I 1.093 0.87
272_P 287_P 1.092 0.87
512_I 529_D 1.088 0.87
233_K 263_S 1.088 0.87
297_V 400_A 1.086 0.86
123_P 139_S 1.084 0.86
479_W 573_L 1.084 0.86
304_M 408_T 1.082 0.86
126_R 135_F 1.079 0.86
478_I 506_C 1.078 0.86
309_L 376_S 1.078 0.86
403_M 652_I 1.078 0.86
302_Y 341_I 1.076 0.86
531_T 560_R 1.074 0.86
237_L 240_N 1.072 0.86
594_R 611_E 1.069 0.85
693_Y 746_N 1.069 0.85
365_D 368_I 1.069 0.85
303_V 375_G 1.066 0.85
353_P 364_A 1.066 0.85
274_Y 759_P 1.064 0.85
224_N 228_D 1.057 0.84
290_P 765_V 1.057 0.84
311_D 314_F 1.056 0.84
135_F 526_L 1.054 0.84
352_T 357_S 1.053 0.84
768_L 787_I 1.052 0.84
372_R 376_S 1.051 0.84
116_N 515_H 1.051 0.84
646_P 651_E 1.049 0.84
190_L 570_T 1.047 0.84
62_A 551_I 1.046 0.84
260_R 281_R 1.045 0.83
337_Y 407_L 1.045 0.83
643_L 650_I 1.044 0.83
700_F 767_A 1.044 0.83
72_P 91_G 1.04 0.83
296_L 300_L 1.039 0.83
164_Y 475_I 1.036 0.83
701_H 705_R 1.034 0.83
299_G 355_W 1.034 0.83
125_K 142_E 1.029 0.82
234_L 266_R 1.026 0.82
234_L 377_T 1.025 0.82
751_V 790_L 1.024 0.82
322_Y 338_K 1.021 0.81
115_Y 560_R 1.02 0.81
140_W 564_K 1.019 0.81
353_P 357_S 1.008 0.80
653_Y 674_P 1.008 0.80
554_D 614_R 1.005 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vpzA20.88331000.224Contact Map0.747
2ivfA10.93491000.228Contact Map0.762
1kqfA10.91891000.239Contact Map0.724
1tmoA10.91031000.258Contact Map0.703
2e7zA10.83171000.265Contact Map0.761
1ti6A60.88941000.277Contact Map0.808
1h0hA20.87711000.279Contact Map0.709
1q16A10.9411000.282Contact Map0.73
1eu1A10.86981000.284Contact Map0.762
3ml1A10.85011000.286Contact Map0.742
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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