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OPENSEQ.org
YDEP - Protein YdeP
UniProt: P77561 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13798
Length: 759 (701)
Sequences: 3286
Seq/Len: 4.69
YDEP
Paralog alert: 0.74 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: BISC DMSA FDHF FDNG FDOG NAPA TORA TORZ YDEP YNFE YNFF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
132_D 561_A 5.818 1.00
111_Q 124_P 5.791 1.00
693_N 756_E 4.946 1.00
297_R 353_D 4.432 1.00
690_E 757_P 4.32 1.00
549_K 557_G 4.182 1.00
131_F 561_A 4.068 1.00
642_L 684_C 3.837 1.00
289_G 337_I 3.637 1.00
293_L 297_R 3.623 1.00
686_V 711_L 3.578 1.00
696_A 753_V 3.526 1.00
335_K 345_Q 3.391 1.00
680_Q 721_R 3.365 1.00
137_R 140_S 3.339 1.00
215_I 287_L 3.333 1.00
291_M 325_L 3.32 1.00
553_A 557_G 3.313 1.00
320_V 619_S 3.256 1.00
312_D 316_Q 3.206 1.00
133_E 505_Y 3.138 1.00
125_L 505_Y 3.118 1.00
695_I 754_E 3.018 1.00
676_M 755_L 2.975 1.00
695_I 756_E 2.946 1.00
286_L 341_S 2.926 1.00
291_M 388_M 2.911 1.00
693_N 700_D 2.877 1.00
686_V 692_V 2.834 1.00
297_R 309_L 2.829 1.00
141_Y 146_Q 2.795 1.00
210_D 360_R 2.78 1.00
126_S 129_Q 2.761 1.00
114_K 505_Y 2.746 1.00
619_S 623_N 2.724 1.00
134_I 505_Y 2.719 1.00
338_E 345_Q 2.712 1.00
242_A 272_A 2.654 1.00
134_I 487_V 2.636 1.00
292_R 296_E 2.632 1.00
488_H 503_H 2.605 1.00
557_G 561_A 2.588 1.00
124_P 547_M 2.531 1.00
345_Q 349_A 2.528 1.00
111_Q 547_M 2.495 1.00
286_L 348_I 2.484 1.00
310_L 315_I 2.457 1.00
539_G 542_K 2.455 1.00
460_I 489_V 2.445 1.00
114_K 125_L 2.414 1.00
209_C 212_V 2.388 1.00
679_K 720_D 2.363 1.00
347_Q 350_E 2.342 1.00
138_L 458_A 2.342 1.00
344_S 347_Q 2.326 1.00
274_A 350_E 2.319 1.00
131_F 557_G 2.317 1.00
452_C 475_A 2.311 1.00
125_L 133_E 2.301 1.00
394_K 397_A 2.294 1.00
293_L 334_W 2.283 1.00
239_K 354_A 2.24 1.00
295_I 322_F 2.175 1.00
457_R 484_D 2.171 1.00
114_K 133_E 2.166 1.00
683_I 720_D 2.161 1.00
319_T 624_F 2.159 1.00
676_M 711_L 2.157 1.00
295_I 329_V 2.152 1.00
310_L 322_F 2.151 1.00
282_G 340_I 2.117 1.00
116_D 123_K 2.114 1.00
211_L 354_A 2.096 1.00
208_K 395_P 2.092 1.00
674_V 694_L 2.081 1.00
146_Q 457_R 2.079 1.00
292_R 334_W 2.072 1.00
293_L 353_D 2.067 1.00
684_C 754_E 2.046 1.00
276_Y 351_L 2.044 1.00
276_Y 343_L 2.038 1.00
315_I 624_F 2.027 1.00
369_I 382_L 2.015 1.00
233_L 238_A 2.01 1.00
297_R 349_A 1.989 1.00
483_L 486_A 1.97 1.00
388_M 624_F 1.968 1.00
243_I 286_L 1.966 1.00
676_M 686_V 1.966 1.00
295_I 326_R 1.953 1.00
684_C 755_L 1.946 1.00
133_E 137_R 1.939 1.00
338_E 344_S 1.935 1.00
166_F 562_A 1.921 1.00
274_A 354_A 1.921 1.00
293_L 309_L 1.921 1.00
337_I 348_I 1.908 1.00
355_Y 389_K 1.903 1.00
679_K 682_K 1.901 1.00
113_L 506_I 1.9 1.00
333_E 336_D 1.898 1.00
211_L 351_L 1.893 1.00
485_L 505_Y 1.891 1.00
309_L 356_A 1.888 1.00
313_E 317_T 1.868 1.00
315_I 322_F 1.866 1.00
211_L 241_I 1.862 1.00
350_E 354_A 1.856 1.00
335_K 349_A 1.841 1.00
138_L 487_V 1.82 1.00
274_A 347_Q 1.794 1.00
324_E 327_R 1.789 1.00
213_I 243_I 1.771 1.00
282_G 341_S 1.758 1.00
461_C 486_A 1.755 1.00
723_L 753_V 1.718 0.99
674_V 692_V 1.717 0.99
167_A 172_S 1.715 0.99
687_K 690_E 1.705 0.99
355_Y 361_T 1.687 0.99
647_V 724_V 1.68 0.99
510_L 550_S 1.674 0.99
293_L 349_A 1.671 0.99
278_V 343_L 1.669 0.99
141_Y 458_A 1.665 0.99
189_G 379_V 1.652 0.99
141_Y 484_D 1.642 0.99
674_V 723_L 1.641 0.99
234_V 273_S 1.636 0.99
326_R 330_L 1.635 0.99
296_E 330_L 1.63 0.99
274_A 351_L 1.629 0.99
477_A 481_T 1.628 0.99
695_I 700_D 1.628 0.99
110_T 546_V 1.601 0.99
213_I 351_L 1.601 0.99
320_V 623_N 1.58 0.99
327_R 330_L 1.575 0.99
114_K 123_K 1.574 0.99
129_Q 505_Y 1.573 0.99
557_G 560_Q 1.572 0.99
212_V 230_L 1.561 0.99
429_G 435_T 1.559 0.99
286_L 351_L 1.552 0.99
125_L 129_Q 1.55 0.99
243_I 351_L 1.55 0.99
321_G 324_E 1.546 0.99
358_A 361_T 1.544 0.99
129_Q 133_E 1.54 0.99
285_A 340_I 1.531 0.99
309_L 353_D 1.518 0.98
322_F 326_R 1.502 0.98
290_M 355_Y 1.497 0.98
642_L 723_L 1.488 0.98
426_A 430_E 1.485 0.98
112_P 127_W 1.481 0.98
276_Y 347_Q 1.481 0.98
676_M 723_L 1.476 0.98
133_E 485_L 1.461 0.98
210_D 358_A 1.461 0.98
391_N 397_A 1.46 0.98
148_E 456_A 1.457 0.98
671_R 706_R 1.456 0.98
132_D 136_A 1.448 0.98
149_F 167_A 1.422 0.97
215_I 243_I 1.421 0.97
290_M 294_L 1.421 0.97
338_E 341_S 1.421 0.97
676_M 681_A 1.418 0.97
134_I 507_L 1.415 0.97
693_N 702_K 1.409 0.97
325_L 388_M 1.408 0.97
298_D 310_L 1.405 0.97
143_D 146_Q 1.404 0.97
241_I 351_L 1.396 0.97
642_L 754_E 1.392 0.97
294_L 356_A 1.392 0.97
560_Q 571_E 1.392 0.97
322_F 388_M 1.391 0.97
84_A 111_Q 1.376 0.97
544_A 548_L 1.36 0.96
458_A 485_L 1.356 0.96
338_E 348_I 1.352 0.96
63_F 70_A 1.35 0.96
325_L 624_F 1.348 0.96
549_K 553_A 1.344 0.96
298_D 312_D 1.342 0.96
458_A 505_Y 1.333 0.96
692_V 711_L 1.333 0.96
136_A 140_S 1.331 0.96
148_E 447_S 1.329 0.96
332_S 337_I 1.328 0.96
478_V 481_T 1.328 0.96
287_L 382_L 1.327 0.96
367_M 371_Q 1.322 0.95
313_E 316_Q 1.322 0.95
363_I 386_L 1.321 0.95
360_R 397_A 1.32 0.95
493_L 497_H 1.32 0.95
141_Y 485_L 1.318 0.95
245_P 275_Y 1.316 0.95
293_L 296_E 1.315 0.95
296_E 349_A 1.302 0.95
212_V 233_L 1.302 0.95
113_L 124_P 1.3 0.95
642_L 755_L 1.29 0.95
134_I 485_L 1.279 0.94
312_D 326_R 1.279 0.94
131_F 549_K 1.278 0.94
452_C 478_V 1.272 0.94
639_N 697_L 1.266 0.94
387_L 622_A 1.264 0.94
334_W 345_Q 1.261 0.94
315_I 319_T 1.257 0.94
493_L 506_I 1.257 0.94
642_L 680_Q 1.256 0.94
472_D 737_D 1.241 0.93
284_M 378_N 1.241 0.93
338_E 346_T 1.233 0.93
488_H 497_H 1.23 0.93
449_Q 475_A 1.229 0.93
336_D 339_R 1.221 0.92
210_D 359_E 1.22 0.92
147_V 458_A 1.21 0.92
674_V 755_L 1.209 0.92
443_A 744_G 1.206 0.92
291_M 329_V 1.197 0.91
234_V 271_L 1.194 0.91
212_V 238_A 1.193 0.91
66_C 70_A 1.184 0.91
123_K 129_Q 1.182 0.91
681_A 686_V 1.182 0.91
205_D 208_K 1.181 0.90
489_V 554_V 1.177 0.90
617_T 623_N 1.174 0.90
294_L 310_L 1.172 0.90
553_A 560_Q 1.167 0.90
457_R 483_L 1.166 0.90
290_M 351_L 1.165 0.90
293_L 348_I 1.162 0.90
188_V 742_L 1.16 0.89
618_P 623_N 1.157 0.89
290_M 348_I 1.153 0.89
459_L 483_L 1.15 0.89
214_C 217_H 1.149 0.89
644_M 753_V 1.147 0.89
694_L 725_T 1.146 0.89
337_I 341_S 1.145 0.89
241_I 290_M 1.141 0.88
688_N 712_K 1.137 0.88
206_F 362_I 1.135 0.88
292_R 333_E 1.128 0.88
516_D 539_G 1.117 0.87
211_L 358_A 1.116 0.87
131_F 134_I 1.108 0.86
462_M 555_V 1.107 0.86
234_V 240_M 1.105 0.86
289_G 293_L 1.102 0.86
145_N 439_A 1.1 0.86
131_F 553_A 1.094 0.85
369_I 378_N 1.085 0.85
661_D 664_Y 1.085 0.85
137_R 484_D 1.085 0.85
691_R 702_K 1.082 0.84
332_S 340_I 1.082 0.84
510_L 548_L 1.08 0.84
458_A 487_V 1.079 0.84
360_R 394_K 1.076 0.84
355_Y 363_I 1.071 0.84
310_L 388_M 1.07 0.84
110_T 124_P 1.068 0.83
701_G 725_T 1.068 0.83
449_Q 453_T 1.067 0.83
166_F 559_A 1.065 0.83
550_S 553_A 1.062 0.83
192_A 380_Q 1.056 0.82
131_F 558_I 1.056 0.82
247_Q 277_N 1.055 0.82
429_G 436_P 1.055 0.82
122_Y 506_I 1.052 0.82
293_L 352_A 1.052 0.82
151_T 175_F 1.048 0.82
289_G 348_I 1.045 0.82
572_Y 575_E 1.044 0.81
451_I 483_L 1.04 0.81
296_E 334_W 1.04 0.81
144_P 171_G 1.037 0.81
513_S 540_V 1.034 0.81
507_L 554_V 1.034 0.81
311_D 394_K 1.033 0.81
239_K 273_S 1.03 0.80
443_A 446_A 1.03 0.80
332_S 336_D 1.029 0.80
297_R 356_A 1.028 0.80
133_E 458_A 1.027 0.80
361_T 391_N 1.027 0.80
465_N 655_T 1.025 0.80
489_V 509_V 1.022 0.80
139_Q 142_S 1.021 0.79
213_I 290_M 1.021 0.79
293_L 345_Q 1.018 0.79
63_F 66_C 1.017 0.79
207_E 229_S 1.017 0.79
560_Q 565_Q 1.016 0.79
278_V 282_G 1.016 0.79
334_W 338_E 1.014 0.79
242_A 269_T 1.013 0.79
291_M 385_L 1.011 0.79
447_S 456_A 1.011 0.79
278_V 286_L 1.01 0.78
460_I 558_I 1.005 0.78
298_D 309_L 1.005 0.78
629_G 634_P 1.004 0.78
288_K 328_D 1.004 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2iv2X10.85381000.351Contact Map0.799
1h0hA20.87751000.357Contact Map0.714
1kqfA10.91961000.357Contact Map0.749
2napA10.86171000.361Contact Map0.765
3ml1A10.87481000.362Contact Map0.76
2e7zA10.83931000.38Contact Map0.78
2vpzA20.8921000.395Contact Map0.742
2ivfA10.92621000.399Contact Map0.754
1ti6A60.86691000.407Contact Map0.794
1g8kA40.8341000.41Contact Map0.761
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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