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LSRC - Autoinducer 2 import system permease protein LsrC
UniProt: P77672 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13807
Length: 342 (300)
Sequences: 10313
Seq/Len: 34.38
LSRC
Paralog alert: 0.90 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_L 216_C 4.208 1.00
100_L 212_S 3.794 1.00
193_L 207_R 3.187 1.00
100_L 216_C 2.99 1.00
99_G 215_G 2.819 1.00
48_I 166_T 2.814 1.00
202_R 205_A 2.711 1.00
186_F 210_A 2.683 1.00
112_W 204_E 2.569 1.00
77_L 98_L 2.556 1.00
55_T 265_A 2.469 1.00
103_G 215_G 2.399 1.00
189_T 206_I 2.333 1.00
99_G 219_A 2.323 1.00
104_F 212_S 2.294 1.00
176_L 182_F 2.245 1.00
205_A 209_V 2.237 1.00
182_F 209_V 2.222 1.00
81_L 94_A 2.22 1.00
172_F 176_L 2.123 1.00
96_L 220_L 2.11 1.00
106_N 124_T 2.089 1.00
104_F 208_I 2.07 1.00
24_P 278_V 2.044 1.00
44_A 273_T 1.993 1.00
56_L 173_M 1.941 1.00
175_W 179_K 1.914 1.00
182_F 186_F 1.89 1.00
87_S 90_V 1.888 1.00
50_L 244_A 1.867 1.00
201_V 206_I 1.864 1.00
170_V 266_V 1.826 1.00
107_G 208_I 1.772 1.00
23_L 27_L 1.762 1.00
194_Q 197_R 1.757 1.00
185_S 206_I 1.756 1.00
49_L 221_A 1.737 1.00
188_A 196_A 1.735 1.00
48_I 269_A 1.708 1.00
251_G 264_G 1.664 1.00
51_A 265_A 1.66 1.00
243_K 276_D 1.653 1.00
62_N 211_F 1.647 1.00
181_A 185_S 1.642 1.00
52_M 173_M 1.641 1.00
174_A 178_A 1.638 1.00
60_T 210_A 1.637 1.00
49_L 224_V 1.631 1.00
56_L 210_A 1.608 1.00
171_A 175_W 1.607 1.00
62_N 117_A 1.602 1.00
111_A 204_E 1.589 1.00
89_P 93_V 1.584 1.00
124_T 128_Y 1.579 1.00
78_L 95_T 1.567 1.00
92_C 223_I 1.545 1.00
36_T 277_S 1.505 1.00
53_G 217_M 1.5 1.00
168_I 172_F 1.497 1.00
208_I 212_S 1.493 1.00
261_A 264_G 1.492 1.00
164_W 168_I 1.492 1.00
112_W 208_I 1.485 1.00
59_L 187_Y 1.477 1.00
102_A 128_Y 1.474 1.00
57_V 214_N 1.467 1.00
97_L 101_L 1.458 1.00
93_V 97_L 1.455 1.00
243_K 293_A 1.454 1.00
50_L 71_T 1.452 1.00
59_L 260_G 1.45 1.00
189_T 203_T 1.449 1.00
185_S 196_A 1.447 1.00
209_V 213_L 1.445 1.00
86_Y 94_A 1.426 1.00
193_L 197_R 1.424 1.00
55_T 253_I 1.421 1.00
212_S 216_C 1.406 0.99
108_V 112_W 1.391 0.99
249_V 255_L 1.385 0.99
185_S 201_V 1.385 0.99
253_I 265_A 1.374 0.99
157_L 164_W 1.367 0.99
117_A 211_F 1.367 0.99
91_A 95_T 1.365 0.99
44_A 270_W 1.349 0.99
186_F 206_I 1.338 0.99
100_L 219_A 1.326 0.99
197_R 204_E 1.302 0.99
96_L 223_I 1.3 0.99
73_M 102_A 1.296 0.99
196_A 201_V 1.288 0.99
222_G 226_A 1.287 0.99
48_I 266_V 1.281 0.99
252_G 258_G 1.264 0.99
107_G 111_A 1.262 0.99
97_L 100_L 1.26 0.99
51_A 248_C 1.257 0.99
134_L 288_W 1.252 0.99
86_Y 90_V 1.251 0.99
106_N 120_A 1.231 0.98
209_V 212_S 1.222 0.98
246_A 297_L 1.22 0.98
114_K 193_L 1.219 0.98
109_L 120_A 1.215 0.98
54_A 67_V 1.208 0.98
129_R 241_E 1.19 0.98
54_A 248_C 1.188 0.98
215_G 219_A 1.188 0.98
54_A 244_A 1.185 0.98
56_L 177_L 1.184 0.98
75_A 232_I 1.183 0.98
251_G 268_G 1.169 0.97
219_A 223_I 1.167 0.97
62_N 207_R 1.163 0.97
58_M 248_C 1.16 0.97
71_T 225_F 1.156 0.97
167_I 171_A 1.155 0.97
101_L 104_F 1.149 0.97
103_G 212_S 1.144 0.97
126_G 129_R 1.14 0.97
182_F 213_L 1.134 0.97
67_V 218_A 1.131 0.97
96_L 219_A 1.124 0.97
52_M 169_L 1.121 0.97
276_D 293_A 1.121 0.97
74_C 222_G 1.119 0.96
81_L 91_A 1.113 0.96
77_L 81_L 1.105 0.96
13_A 17_V 1.091 0.96
77_L 94_A 1.09 0.96
108_V 208_I 1.087 0.96
81_L 86_Y 1.085 0.96
69_S 129_R 1.073 0.95
101_L 105_F 1.068 0.95
17_V 21_F 1.068 0.95
78_L 223_I 1.055 0.95
169_L 217_M 1.048 0.94
218_A 222_G 1.044 0.94
56_L 213_L 1.042 0.94
90_V 93_V 1.035 0.94
182_F 206_I 1.031 0.94
66_S 106_N 1.028 0.94
75_A 236_T 1.026 0.94
50_L 67_V 1.025 0.93
263_I 267_L 1.02 0.93
173_M 213_L 1.02 0.93
51_A 247_A 1.018 0.93
21_F 274_Q 1.017 0.93
69_S 125_L 1.014 0.93
79_G 232_I 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nq2A20.839292.80.92Contact Map0.54
4g1uA20.84590.70.924Contact Map0.516
2qi9A20.833390.60.924Contact Map0.577
3ppmA20.17846.90.965Contact Map
2kluA10.1936.10.966Contact Map0
2cfqA10.62874.30.968Contact Map0.387
1u7gA10.51754.20.969Contact Map0.324
2ksfA10.30124.10.969Contact Map0.262
2rddB10.10823.40.97Contact Map
3wdoA10.91233.20.97Contact Map0.192
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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