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OPENSEQ.org
RBSC - Ribose transport system permease protein RbsC
UniProt: P0AGI1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10816
Length: 321 (296)
Sequences: 13118
Seq/Len: 44.32
RBSC
Paralog alert: 0.93 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_L 229_L 4.076 1.00
109_A 225_S 3.821 1.00
206_E 220_K 2.941 1.00
109_A 229_L 2.811 1.00
215_N 218_K 2.769 1.00
86_V 107_L 2.742 1.00
112_G 228_G 2.701 1.00
199_I 223_V 2.509 1.00
113_A 225_S 2.473 1.00
57_A 179_M 2.429 1.00
108_G 228_G 2.422 1.00
108_G 232_S 2.373 1.00
64_T 278_T 2.349 1.00
189_M 195_L 2.256 1.00
218_K 222_I 2.241 1.00
188_Y 192_H 2.219 1.00
121_K 217_N 2.205 1.00
90_I 103_A 2.177 1.00
202_L 219_I 2.17 1.00
105_L 233_L 2.164 1.00
195_L 222_I 2.161 1.00
256_D 289_N 2.09 1.00
96_N 99_V 2.087 1.00
185_A 189_M 2.083 1.00
115_T 133_M 2.062 1.00
59_M 257_A 2.05 1.00
113_A 221_I 1.954 1.00
81_A 141_T 1.887 1.00
53_T 286_G 1.834 1.00
187_W 191_H 1.828 1.00
214_I 219_I 1.828 1.00
195_L 199_I 1.797 1.00
33_V 291_G 1.785 1.00
198_Y 219_I 1.781 1.00
101_V 236_I 1.743 1.00
184_L 188_Y 1.737 1.00
116_G 221_I 1.703 1.00
66_V 227_C 1.698 1.00
65_L 186_A 1.677 1.00
201_A 209_T 1.666 1.00
194_R 198_Y 1.633 1.00
58_I 234_A 1.619 1.00
98_L 102_A 1.614 1.00
60_A 278_T 1.59 1.00
183_F 279_L 1.579 1.00
264_G 277_G 1.577 1.00
71_G 126_A 1.567 1.00
116_G 120_A 1.562 1.00
206_E 210_R 1.558 1.00
69_T 223_V 1.556 1.00
59_M 80_L 1.547 1.00
53_T 283_L 1.543 1.00
57_A 282_A 1.541 1.00
207_A 210_R 1.535 1.00
222_I 226_L 1.513 1.00
198_Y 214_I 1.507 1.00
102_A 106_A 1.506 1.00
221_I 225_S 1.5 1.00
202_L 216_V 1.475 1.00
87_A 236_I 1.45 1.00
82_L 111_I 1.438 1.00
65_L 223_V 1.437 1.00
135_L 138_R 1.434 1.00
274_R 277_G 1.423 1.00
225_S 229_L 1.411 1.00
133_M 137_L 1.407 0.99
106_A 109_A 1.401 0.99
198_Y 209_T 1.399 0.99
87_A 104_A 1.393 0.99
68_L 273_G 1.39 0.99
181_I 185_A 1.389 0.99
106_A 110_A 1.382 0.99
71_G 224_Y 1.38 0.99
68_L 200_Y 1.375 0.99
100_A 104_A 1.367 0.99
80_L 238_E 1.359 0.99
177_W 181_I 1.356 0.99
262_V 268_L 1.348 0.99
120_A 217_N 1.346 0.99
32_I 36_L 1.346 0.99
235_G 239_V 1.336 0.99
105_L 236_I 1.335 0.99
62_G 230_L 1.328 0.99
45_N 290_N 1.327 0.99
78_S 138_R 1.325 0.99
64_T 266_T 1.321 0.99
95_V 103_A 1.314 0.99
266_T 278_T 1.311 0.99
57_A 279_L 1.301 0.99
95_V 99_V 1.294 0.99
256_D 306_K 1.293 0.99
61_V 186_A 1.291 0.99
222_I 225_S 1.285 0.99
121_K 221_I 1.277 0.99
63_M 76_V 1.275 0.99
76_V 231_A 1.274 0.99
58_I 237_I 1.273 0.99
63_M 261_V 1.266 0.99
210_R 217_N 1.257 0.99
199_I 219_I 1.255 0.99
104_A 108_G 1.253 0.99
117_V 121_K 1.235 0.98
264_G 281_G 1.23 0.98
85_A 247_P 1.229 0.98
74_L 258_I 1.219 0.98
228_G 232_S 1.218 0.98
110_A 114_V 1.205 0.98
118_I 129_A 1.203 0.98
209_T 214_I 1.202 0.98
110_A 113_A 1.199 0.98
109_A 232_S 1.184 0.98
180_G 184_L 1.168 0.97
138_R 254_E 1.162 0.97
186_A 226_L 1.16 0.97
60_A 261_V 1.16 0.97
86_V 90_I 1.159 0.97
232_S 236_I 1.149 0.97
126_A 224_Y 1.142 0.97
83_T 235_G 1.139 0.97
290_N 293_N 1.137 0.97
91_V 100_A 1.133 0.97
170_L 177_W 1.132 0.97
182_V 230_L 1.129 0.97
65_L 190_L 1.122 0.97
90_I 95_V 1.12 0.96
195_L 226_L 1.119 0.96
99_V 102_A 1.118 0.96
111_I 137_L 1.116 0.96
260_A 281_G 1.111 0.96
84_G 245_A 1.104 0.96
84_G 249_A 1.101 0.96
123_R 206_E 1.101 0.96
259_A 310_I 1.098 0.96
112_G 225_S 1.098 0.96
71_G 220_K 1.075 0.95
308_V 312_L 1.066 0.95
104_A 236_I 1.066 0.95
26_L 30_I 1.064 0.95
202_L 209_T 1.057 0.95
60_A 260_A 1.057 0.95
53_T 282_A 1.057 0.95
105_L 232_S 1.05 0.94
105_L 109_A 1.048 0.94
229_L 233_L 1.034 0.94
276_V 280_I 1.034 0.94
78_S 134_M 1.033 0.94
179_M 183_F 1.027 0.94
77_G 254_E 1.025 0.93
60_A 282_A 1.018 0.93
108_G 112_G 1.012 0.93
117_V 221_I 1.011 0.93
90_I 100_A 1.01 0.93
63_M 257_A 1.007 0.93
69_T 199_I 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2qi9A20.900394.40.904Contact Map0.576
4g1uA20.925293.70.906Contact Map0.508
2nq2A20.878593.10.909Contact Map0.514
2ksfA10.29913.30.966Contact Map0.359
2rddB10.07172.40.969Contact Map1
2kluA10.11531.70.971Contact Map0
1u7gA10.58881.70.971Contact Map0.363
2jwaA20.11841.70.971Contact Map0.562
2ls2A10.07791.50.972Contact Map0.289
1q90R10.14641.40.972Contact Map0.447
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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