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LSRD - Autoinducer 2 import system permease protein LsrD
UniProt: P0AFS1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13808
Length: 330 (294)
Sequences: 12757
Seq/Len: 43.39
LSRD
Paralog alert: 0.92 [within 20: 0.64] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
94_L 220_L 4.08 1.00
98_A 216_A 3.813 1.00
197_P 211_L 3.058 1.00
98_A 220_L 2.845 1.00
75_A 96_L 2.76 1.00
206_P 209_R 2.759 1.00
101_G 219_G 2.714 1.00
97_G 219_G 2.588 1.00
190_V 214_L 2.515 1.00
102_L 216_A 2.464 1.00
97_G 223_A 2.423 1.00
46_G 170_F 2.414 1.00
53_T 269_T 2.304 1.00
193_I 210_T 2.234 1.00
209_R 213_A 2.178 1.00
110_Y 208_N 2.174 1.00
94_L 224_V 2.159 1.00
85_P 88_L 2.153 1.00
179_L 183_K 2.146 1.00
104_N 122_T 2.125 1.00
180_W 186_A 2.109 1.00
79_L 92_L 2.107 1.00
186_A 213_A 2.102 1.00
247_P 280_Q 2.094 1.00
176_V 180_W 2.08 1.00
48_V 248_A 2.074 1.00
102_L 212_C 1.866 1.00
205_I 210_T 1.856 1.00
22_F 282_G 1.845 1.00
178_W 182_H 1.809 1.00
42_F 277_G 1.785 1.00
189_N 210_T 1.767 1.00
186_A 190_V 1.763 1.00
70_G 130_A 1.75 1.00
192_L 200_A 1.737 1.00
90_I 227_V 1.727 1.00
185_H 189_N 1.676 1.00
55_V 218_T 1.653 1.00
255_G 268_G 1.653 1.00
105_A 212_C 1.642 1.00
198_R 201_L 1.622 1.00
54_M 177_F 1.618 1.00
174_L 270_A 1.613 1.00
175_L 179_L 1.608 1.00
58_S 214_L 1.598 1.00
47_I 225_A 1.589 1.00
46_G 273_V 1.586 1.00
54_M 214_L 1.557 1.00
91_L 95_L 1.554 1.00
60_G 115_P 1.551 1.00
87_P 91_L 1.545 1.00
189_N 205_I 1.543 1.00
48_V 69_I 1.542 1.00
49_A 269_T 1.524 1.00
197_P 201_L 1.516 1.00
193_I 207_V 1.498 1.00
212_C 216_A 1.484 1.00
42_F 274_L 1.469 1.00
189_N 200_A 1.462 1.00
265_S 268_G 1.46 1.00
105_A 109_I 1.458 1.00
124_Y 127_A 1.451 1.00
122_T 126_F 1.449 1.00
109_I 208_N 1.445 1.00
60_G 215_Y 1.44 1.00
69_I 229_L 1.437 1.00
172_I 176_V 1.429 1.00
76_L 93_T 1.415 1.00
253_V 259_I 1.407 0.99
53_T 257_A 1.402 0.99
95_L 99_L 1.401 0.99
257_A 269_T 1.399 0.99
226_A 230_V 1.398 0.99
57_V 191_F 1.397 0.99
74_I 238_S 1.389 0.99
95_L 98_A 1.386 0.99
247_P 297_S 1.382 0.99
213_A 217_M 1.362 0.99
57_V 264_G 1.356 0.99
168_I 172_I 1.355 0.99
76_L 227_V 1.354 0.99
71_L 100_C 1.353 0.99
50_L 177_F 1.348 0.99
94_L 227_V 1.347 0.99
47_I 228_L 1.347 0.99
51_P 221_A 1.346 0.99
213_A 216_A 1.321 0.99
216_A 220_L 1.316 0.99
89_A 93_T 1.315 0.99
46_G 270_A 1.312 0.99
84_V 92_L 1.281 0.99
21_A 25_I 1.28 0.99
67_S 127_A 1.28 0.99
65_F 222_S 1.27 0.99
52_L 252_V 1.265 0.99
219_G 223_A 1.264 0.99
201_L 208_N 1.252 0.99
34_M 281_Q 1.247 0.99
52_L 65_F 1.247 0.99
99_L 103_I 1.229 0.98
49_A 252_V 1.226 0.98
84_V 88_L 1.226 0.98
93_T 97_G 1.222 0.98
200_A 205_I 1.218 0.98
190_V 210_T 1.206 0.98
177_F 217_M 1.203 0.98
112_K 197_P 1.185 0.98
127_A 245_L 1.184 0.98
54_M 181_L 1.183 0.98
107_L 118_I 1.18 0.98
255_G 272_A 1.175 0.98
98_A 223_A 1.174 0.98
106_G 110_Y 1.17 0.97
63_I 249_I 1.169 0.97
115_P 215_Y 1.165 0.97
223_A 227_V 1.158 0.97
49_A 251_A 1.148 0.97
250_T 301_L 1.147 0.97
73_A 236_A 1.144 0.97
161_L 168_I 1.135 0.97
110_Y 212_C 1.129 0.97
60_G 211_L 1.127 0.97
171_L 175_L 1.116 0.96
251_A 272_A 1.112 0.96
42_F 273_V 1.11 0.96
88_L 91_L 1.106 0.96
281_Q 284_Q 1.105 0.96
72_C 226_A 1.094 0.96
100_C 126_F 1.089 0.96
299_A 303_V 1.087 0.96
220_L 224_V 1.083 0.96
75_A 79_L 1.079 0.95
193_I 200_A 1.077 0.95
186_A 217_M 1.077 0.95
73_A 240_L 1.069 0.95
99_L 102_L 1.067 0.95
267_I 271_I 1.06 0.95
78_V 134_S 1.06 0.95
52_L 248_A 1.059 0.95
111_T 118_I 1.034 0.94
106_G 212_C 1.032 0.94
222_S 226_A 1.029 0.94
93_T 227_V 1.022 0.93
292_V 295_A 1.022 0.93
256_G 262_G 1.021 0.93
101_G 216_A 1.016 0.93
67_S 123_L 1.012 0.93
186_A 210_T 1.011 0.93
280_Q 297_S 1.007 0.93
178_W 183_K 1.001 0.92
75_A 92_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nq2A20.872794.30.911Contact Map0.516
4g1uA20.881892.80.916Contact Map0.526
2qi9A20.854585.90.927Contact Map0.578
2rddB10.10324.40.953Contact Map0.505
2kluA10.154511.90.959Contact Map0.094
2m20A20.13338.30.962Contact Map0.485
2ks1B10.133370.963Contact Map0.125
2l2tA20.13335.10.966Contact Map0.36
2jwaA20.13334.70.966Contact Map0.582
2ff6H10.02734.60.966Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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