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OPENSEQ.org
YTFT - Inner membrane ABC transporter permease protein YtfT
UniProt: P39328 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12520
Length: 341 (294)
Sequences: 9365
Seq/Len: 31.85
YTFT
Paralog alert: 0.90 [within 20: 0.55] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
115_L 235_L 4.054 1.00
119_I 231_V 3.763 1.00
212_I 226_V 3.168 1.00
67_A 185_A 2.909 1.00
119_I 235_L 2.828 1.00
118_G 234_G 2.691 1.00
131_I 223_R 2.602 1.00
221_N 224_I 2.599 1.00
205_I 229_T 2.517 1.00
74_T 285_S 2.464 1.00
96_T 117_T 2.391 1.00
122_G 234_G 2.378 1.00
118_G 238_A 2.347 1.00
195_L 201_L 2.335 1.00
123_L 231_V 2.295 1.00
201_L 228_L 2.249 1.00
208_V 225_I 2.239 1.00
100_M 113_S 2.217 1.00
125_N 143_L 2.15 1.00
35_D 298_G 2.117 1.00
224_I 228_L 2.116 1.00
63_A 293_Q 2.072 1.00
189_L 286_V 2.026 1.00
194_L 198_K 2.02 1.00
191_L 195_L 1.985 1.00
123_L 227_M 1.928 1.00
75_L 192_F 1.921 1.00
115_L 239_I 1.848 1.00
201_L 205_I 1.84 1.00
106_S 109_I 1.838 1.00
69_L 264_A 1.813 1.00
213_R 216_K 1.805 1.00
71_I 192_F 1.788 1.00
81_G 136_P 1.779 1.00
126_G 227_M 1.775 1.00
263_D 296_N 1.769 1.00
68_L 243_I 1.751 1.00
193_W 197_R 1.739 1.00
220_V 225_I 1.732 1.00
67_A 289_A 1.73 1.00
183_I 187_L 1.664 1.00
200_A 204_F 1.659 1.00
130_A 223_R 1.65 1.00
68_L 240_A 1.645 1.00
79_T 229_T 1.642 1.00
81_G 230_Y 1.639 1.00
204_F 225_I 1.623 1.00
143_L 147_G 1.623 1.00
78_A 280_F 1.616 1.00
70_A 285_S 1.6 1.00
78_A 206_E 1.598 1.00
97_T 114_A 1.573 1.00
75_L 229_T 1.568 1.00
207_A 215_A 1.562 1.00
271_G 284_L 1.555 1.00
263_D 313_K 1.55 1.00
116_G 120_L 1.542 1.00
74_T 273_G 1.52 1.00
190_I 194_L 1.517 1.00
227_M 231_V 1.492 1.00
34_V 38_V 1.487 1.00
269_V 275_L 1.479 1.00
69_L 90_M 1.476 1.00
187_L 191_L 1.47 1.00
273_G 285_S 1.469 1.00
121_A 147_G 1.458 1.00
111_L 242_I 1.457 1.00
136_P 230_Y 1.445 1.00
108_P 112_L 1.437 1.00
208_V 222_T 1.436 1.00
112_L 116_G 1.434 1.00
67_A 286_V 1.413 1.00
241_G 245_A 1.407 0.99
153_L 308_M 1.397 0.99
204_F 215_A 1.395 0.99
110_V 114_A 1.392 0.99
105_F 113_S 1.391 0.99
212_I 216_K 1.37 0.99
72_G 236_C 1.365 0.99
204_F 220_V 1.359 0.99
28_L 32_L 1.358 0.99
119_I 238_A 1.352 0.99
266_L 317_V 1.351 0.99
127_I 131_I 1.344 0.99
76_V 233_S 1.327 0.99
71_I 188_T 1.326 0.99
116_G 119_I 1.317 0.99
63_A 290_L 1.312 0.99
75_L 196_T 1.309 0.99
216_K 223_R 1.305 0.99
192_F 232_L 1.301 0.99
77_I 268_V 1.3 0.99
281_N 284_L 1.299 0.99
228_L 232_L 1.299 0.99
148_R 261_E 1.298 0.99
176_L 183_I 1.294 0.99
131_I 227_M 1.288 0.99
126_G 130_A 1.287 0.99
231_V 235_L 1.28 0.99
205_I 225_I 1.279 0.99
234_G 238_A 1.273 0.99
188_T 236_C 1.264 0.99
120_L 124_W 1.256 0.99
228_L 231_V 1.249 0.99
127_I 227_M 1.244 0.98
128_L 139_A 1.234 0.98
100_M 110_V 1.226 0.98
73_M 264_A 1.221 0.98
296_N 313_K 1.213 0.98
100_M 105_F 1.209 0.98
70_A 268_V 1.207 0.98
81_G 226_V 1.199 0.98
88_A 148_R 1.197 0.98
215_A 220_V 1.195 0.98
115_L 242_I 1.173 0.98
105_F 109_I 1.164 0.97
133_K 212_I 1.159 0.97
120_L 123_L 1.159 0.97
91_A 151_A 1.146 0.97
186_V 190_I 1.144 0.97
36_S 43_W 1.143 0.97
201_L 232_L 1.141 0.97
94_G 256_A 1.139 0.97
93_A 241_G 1.138 0.97
86_V 237_A 1.13 0.97
94_G 252_D 1.123 0.97
55_S 297_T 1.109 0.96
99_A 154_I 1.103 0.96
73_M 268_V 1.097 0.96
92_I 147_G 1.094 0.96
238_A 242_I 1.094 0.96
73_M 86_V 1.092 0.96
90_M 244_V 1.09 0.96
88_A 144_M 1.089 0.96
68_L 188_T 1.076 0.95
63_A 289_A 1.073 0.95
101_T 110_V 1.071 0.95
237_A 241_G 1.068 0.95
283_L 287_V 1.063 0.95
37_L 40_P 1.062 0.95
85_S 125_N 1.061 0.95
320_V 324_Q 1.054 0.95
193_W 198_K 1.05 0.94
96_T 100_M 1.048 0.94
92_I 121_A 1.032 0.94
94_G 245_A 1.029 0.94
96_T 113_S 1.029 0.94
142_I 318_L 1.029 0.94
124_W 143_L 1.019 0.93
95_A 151_A 1.014 0.93
235_L 239_I 1.005 0.93
30_L 34_V 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g1uA20.82493.80.921Contact Map0.55
2nq2A20.865191.40.927Contact Map0.506
2qi9A20.865188.80.931Contact Map0.558
1u7gA10.542510.30.964Contact Map0.317
3nuhB10.1762.70.973Contact Map0.385
3arcL20.105620.975Contact Map0.522
2ls2A10.07331.70.976Contact Map0.015
3j45G10.09091.20.978Contact Map0
2l8sA10.12021.10.978Contact Map1
3fymA10.1291.10.978Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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