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OPENSEQ.org

YFCF - Glutathione S-transferase YfcF
UniProt: P77544 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14109
Length: 214 (202)
Sequences: 11286
Seq/Len: 55.87

YFCF
Paralog alert: 0.77 [within 20: 0.33] - ratio of genomes with paralogs
Cluster includes: GSTA GSTB SSPA YFCF YFCG YIBF YNCG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
28_E 199_R 3.501 1.00
7_T 36_K 3.446 1.00
191_D 195_F 3.392 1.00
77_E 103_R 3.383 1.00
81_D 99_R 2.997 1.00
7_T 34_H 2.985 1.00
27_Q 204_R 2.692 1.00
26_L 33_F 2.659 1.00
27_Q 33_F 2.635 1.00
10_S 19_V 2.605 1.00
51_Q 57_R 2.583 1.00
158_P 195_F 2.523 1.00
150_E 188_R 2.453 1.00
67_F 97_E 2.411 1.00
95_D 98_N 2.227 1.00
154_V 188_R 2.168 1.00
63_Q 68_E 1.973 1.00
7_T 63_Q 1.902 1.00
81_D 103_R 1.848 1.00
53_Y 61_L 1.831 1.00
190_V 194_T 1.779 1.00
28_E 201_S 1.765 1.00
48_P 52_G 1.743 1.00
39_D 42_S 1.733 1.00
136_A 140_A 1.731 1.00
24_V 202_V 1.709 1.00
188_R 191_D 1.706 1.00
50_W 61_L 1.681 1.00
10_S 35_I 1.67 1.00
25_A 76_A 1.651 1.00
63_Q 66_D 1.643 1.00
9_W 63_Q 1.631 1.00
194_T 198_Q 1.616 1.00
29_K 80_E 1.613 1.00
132_A 136_A 1.593 1.00
160_L 171_L 1.587 1.00
9_W 38_I 1.585 1.00
101_R 104_Q 1.581 1.00
93_P 102_A 1.534 1.00
64_I 78_Y 1.533 1.00
164_W 169_T 1.526 1.00
31_L 83_F 1.517 1.00
147_A 151_H 1.511 1.00
172_A 196_Q 1.501 1.00
53_Y 63_Q 1.496 1.00
6_I 62_L 1.493 1.00
161_F 165_C 1.467 1.00
147_A 186_P 1.441 1.00
198_Q 203_Q 1.429 1.00
69_L 100_A 1.375 0.99
49_T 52_G 1.367 0.99
22_A 76_A 1.353 0.99
50_W 53_Y 1.348 0.99
25_A 91_I 1.317 0.99
25_A 29_K 1.314 0.99
164_W 199_R 1.304 0.99
6_I 31_L 1.299 0.99
107_A 110_R 1.299 0.99
159_N 196_Q 1.292 0.99
152_L 157_Q 1.291 0.99
64_I 82_R 1.282 0.99
86_P 90_R 1.259 0.99
203_Q 207_A 1.252 0.99
58_R 71_E 1.247 0.99
150_E 154_V 1.241 0.98
44_E 47_Q 1.214 0.98
96_L 100_A 1.194 0.98
91_I 169_T 1.194 0.98
139_K 143_E 1.193 0.98
28_E 164_W 1.191 0.98
200_A 204_R 1.185 0.98
8_L 26_L 1.185 0.98
70_S 104_Q 1.184 0.98
46_L 57_R 1.183 0.98
92_Y 102_A 1.182 0.98
76_A 166_I 1.179 0.98
97_E 101_R 1.172 0.98
28_E 169_T 1.168 0.97
150_E 187_E 1.161 0.97
82_R 96_L 1.15 0.97
21_S 72_S 1.136 0.97
194_T 197_W 1.101 0.96
23_W 27_Q 1.097 0.96
193_A 197_W 1.09 0.96
64_I 83_F 1.084 0.96
159_N 195_F 1.084 0.96
172_A 197_W 1.082 0.96
64_I 67_F 1.077 0.95
192_Y 196_Q 1.071 0.95
22_A 75_I 1.062 0.95
151_H 154_V 1.061 0.95
137_E 141_S 1.06 0.95
6_I 83_F 1.055 0.95
77_E 107_A 1.054 0.95
21_S 170_D 1.052 0.95
107_A 111_S 1.048 0.94
98_N 163_E 1.045 0.94
140_A 143_E 1.022 0.93
105_I 152_L 1.022 0.93
102_A 165_C 1.016 0.93
200_A 203_Q 1.01 0.93
195_F 198_Q 1.009 0.93
16_S 19_V 1.007 0.93
164_W 196_Q 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4isdA50.9861000.16Contact Map0.856
4mp4A30.9861000.161Contact Map0.763
4jbbA10.97661000.172Contact Map0.64
1e6bA10.97661000.191Contact Map0.658
3n5oA20.96731000.192Contact Map0.827
4kdxA20.95331000.192Contact Map0.763
4e8hA40.95791000.194Contact Map0.811
4ielA20.95331000.197Contact Map0.747
4ivfA80.96731000.201Contact Map0.778
3ibhA10.96261000.202Contact Map0.725

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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