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OPENSEQ.org

GSTA - Glutathione S-transferase GstA
UniProt: P0A9D2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12613
Length: 201 (195)
Sequences: 11230
Seq/Len: 57.59

GSTA
Paralog alert: 0.77 [within 20: 0.33] - ratio of genomes with paralogs
Cluster includes: GSTA GSTB SSPA YFCF YFCG YIBF YNCG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
180_A 184_R 3.274 1.00
2_K 28_V 3.243 1.00
20_E 188_R 3.179 1.00
71_Q 95_I 3.176 1.00
75_D 91_R 2.882 1.00
2_K 26_T 2.792 1.00
19_R 193_D 2.574 1.00
137_N 177_H 2.562 1.00
18_L 25_F 2.555 1.00
19_R 25_F 2.489 1.00
44_F 50_G 2.472 1.00
144_H 184_R 2.463 1.00
61_T 89_I 2.375 1.00
5_Y 11_S 2.256 1.00
134_Q 175_L 2.192 1.00
141_K 177_H 2.172 1.00
87_N 90_S 2.103 1.00
56_L 62_L 1.92 1.00
144_H 149_Q 1.831 1.00
31_D 34_K 1.795 1.00
75_D 95_I 1.778 1.00
179_A 183_Q 1.773 1.00
46_V 54_A 1.77 1.00
41_D 45_A 1.734 1.00
2_K 56_L 1.725 1.00
43_Y 54_A 1.696 1.00
4_F 56_L 1.691 1.00
177_H 180_A 1.64 1.00
16_I 191_V 1.634 1.00
20_E 190_E 1.61 1.00
130_E 174_G 1.607 1.00
146_I 158_L 1.598 1.00
93_K 96_E 1.591 1.00
46_V 56_L 1.58 1.00
56_L 60_G 1.575 1.00
17_T 70_M 1.569 1.00
183_Q 187_E 1.565 1.00
134_Q 138_E 1.55 1.00
119_E 123_P 1.543 1.00
151_F 156_A 1.533 1.00
4_F 30_V 1.531 1.00
21_S 74_A 1.527 1.00
123_P 127_A 1.525 1.00
137_N 176_E 1.499 1.00
97_W 139_A 1.468 1.00
159_F 185_M 1.449 1.00
187_E 192_Q 1.421 1.00
42_D 45_A 1.413 1.00
84_A 94_T 1.411 1.00
23_K 77_V 1.382 0.99
147_C 152_T 1.376 0.99
63_L 92_Y 1.363 0.99
139_A 143_E 1.348 0.99
5_Y 27_L 1.339 0.99
17_T 82_L 1.299 0.99
1_M 55_L 1.294 0.99
14_S 70_M 1.291 0.99
145_W 185_M 1.28 0.99
51_Q 65_E 1.277 0.99
43_Y 46_V 1.263 0.99
17_T 21_S 1.261 0.99
71_Q 99_N 1.235 0.98
151_F 188_R 1.226 0.98
36_R 40_G 1.219 0.98
64_T 96_E 1.208 0.98
3_L 18_L 1.204 0.98
126_R 130_E 1.201 0.98
90_S 150_R 1.167 0.97
82_L 156_A 1.165 0.97
20_E 156_A 1.16 0.97
84_A 87_N 1.153 0.97
134_Q 174_G 1.152 0.97
124_T 128_Q 1.146 0.97
118_P 121_Y 1.14 0.97
76_S 88_S 1.14 0.97
137_N 141_K 1.138 0.97
70_M 153_I 1.136 0.97
83_L 94_T 1.133 0.97
88_S 92_Y 1.129 0.97
128_Q 131_K 1.123 0.97
99_N 102_A 1.122 0.97
89_I 93_K 1.121 0.97
101_I 158_L 1.121 0.97
189_P 193_D 1.117 0.96
139_A 142_D 1.103 0.96
171_N 174_G 1.09 0.96
159_F 186_A 1.088 0.96
39_N 50_G 1.087 0.96
192_Q 196_S 1.071 0.95
20_E 151_F 1.068 0.95
13_A 66_G 1.056 0.95
57_L 61_T 1.052 0.95
120_E 123_P 1.047 0.94
15_H 19_R 1.046 0.94
13_A 157_Y 1.045 0.94
83_L 95_I 1.04 0.94
151_F 185_M 1.039 0.94
145_W 184_R 1.029 0.94
14_S 69_I 1.024 0.93
127_A 131_K 1.023 0.93
182_M 186_A 1.014 0.93
173_E 179_A 1.011 0.93
183_Q 186_A 1.01 0.93
138_E 141_K 1.008 0.93
94_T 152_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pmtA111000.12Contact Map0.727
1f2eA411000.123Contact Map0.744
2pvqA10.991000.124Contact Map0.637
2dsaA411000.125Contact Map0.802
4kgiA411000.128Contact Map0.775
4gciA211000.13Contact Map0.743
3uarA111000.141Contact Map0.747
2x64A60.97511000.143Contact Map0.794
4gf0A20.991000.152Contact Map0.751
4l8eA10.97511000.154Contact Map0.777

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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