| UniProt: | P77425 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13623 | ||
| Length: | 411 (388) | ||
| Sequences: | 12259 | ||
| Seq/Len: | 31.60 |
| ALLC
Paralog alert: 0.89 [within 20: 0.18] - ratio of genomes with paralogs Cluster includes: ABGA ABGB ALLC ARGE DAPE PEPT YGEY |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 219_T | 280_K | 3.345 | 1.00 | |
| 44_K | 48_A | 3.337 | 1.00 | |
| 65_R | 119_E | 3.222 | 1.00 | |
| 221_N | 316_G | 3.132 | 1.00 | |
| 225_N | 235_R | 3.126 | 1.00 | |
| 303_E | 307_R | 3.019 | 1.00 | |
| 219_T | 282_T | 3.003 | 1.00 | |
| 340_E | 408_A | 2.916 | 1.00 | |
| 300_Q | 304_N | 2.912 | 1.00 | |
| 344_R | 408_A | 2.906 | 1.00 | |
| 220_L | 245_I | 2.888 | 1.00 | |
| 241_A | 315_I | 2.813 | 1.00 | |
| 219_T | 318_D | 2.743 | 1.00 | |
| 217_T | 282_T | 2.697 | 1.00 | |
| 299_T | 303_E | 2.651 | 1.00 | |
| 344_R | 404_L | 2.637 | 1.00 | |
| 46_R | 49_A | 2.62 | 1.00 | |
| 44_K | 56_F | 2.514 | 1.00 | |
| 221_N | 280_K | 2.504 | 1.00 | |
| 75_V | 117_T | 2.5 | 1.00 | |
| 217_T | 320_D | 2.468 | 1.00 | |
| 242_F | 281_T | 2.445 | 1.00 | |
| 242_F | 267_V | 2.394 | 1.00 | |
| 45_K | 49_A | 2.389 | 1.00 | |
| 221_N | 318_D | 2.379 | 1.00 | |
| 343_E | 348_N | 2.373 | 1.00 | |
| 242_F | 283_F | 2.361 | 1.00 | |
| 404_L | 407_L | 2.278 | 1.00 | |
| 243_S | 246_C | 2.23 | 1.00 | |
| 67_N | 117_T | 2.222 | 1.00 | |
| 339_T | 343_E | 2.213 | 1.00 | |
| 217_T | 284_T | 2.196 | 1.00 | |
| 41_Q | 45_K | 2.192 | 1.00 | |
| 50_S | 105_D | 2.17 | 1.00 | |
| 106_W | 403_M | 2.136 | 1.00 | |
| 38_E | 41_Q | 2.11 | 1.00 | |
| 37_L | 41_Q | 2.067 | 1.00 | |
| 47_M | 64_G | 2.053 | 1.00 | |
| 268_E | 282_T | 2.024 | 1.00 | |
| 42_Q | 46_R | 1.994 | 1.00 | |
| 269_P | 281_T | 1.976 | 1.00 | |
| 338_L | 405_Y | 1.966 | 1.00 | |
| 106_W | 110_Q | 1.954 | 1.00 | |
| 139_K | 143_G | 1.944 | 1.00 | |
| 41_Q | 56_F | 1.935 | 1.00 | |
| 43_F | 82_I | 1.932 | 1.00 | |
| 245_I | 306_M | 1.926 | 1.00 | |
| 219_T | 320_D | 1.911 | 1.00 | |
| 296_R | 300_Q | 1.875 | 1.00 | |
| 15_W | 18_S | 1.85 | 1.00 | |
| 341_L | 408_A | 1.829 | 1.00 | |
| 223_E | 236_R | 1.8 | 1.00 | |
| 301_Q | 304_N | 1.794 | 1.00 | |
| 65_R | 117_T | 1.791 | 1.00 | |
| 19_F | 42_Q | 1.79 | 1.00 | |
| 53_E | 67_N | 1.759 | 1.00 | |
| 48_A | 56_F | 1.746 | 1.00 | |
| 52_L | 66_L | 1.745 | 1.00 | |
| 45_K | 48_A | 1.723 | 1.00 | |
| 238_T | 281_T | 1.696 | 1.00 | |
| 224_S | 279_G | 1.694 | 1.00 | |
| 99_A | 396_G | 1.694 | 1.00 | |
| 75_V | 119_E | 1.693 | 1.00 | |
| 236_R | 241_A | 1.673 | 1.00 | |
| 266_K | 284_T | 1.662 | 1.00 | |
| 244_R | 247_H | 1.662 | 1.00 | |
| 40_Q | 82_I | 1.661 | 1.00 | |
| 14_P | 18_S | 1.66 | 1.00 | |
| 336_A | 339_T | 1.658 | 1.00 | |
| 307_R | 311_D | 1.652 | 1.00 | |
| 15_W | 42_Q | 1.642 | 1.00 | |
| 105_D | 109_T | 1.63 | 1.00 | |
| 364_A | 369_T | 1.629 | 1.00 | |
| 77_L | 121_V | 1.625 | 1.00 | |
| 294_V | 297_D | 1.615 | 1.00 | |
| 220_L | 242_F | 1.61 | 1.00 | |
| 11_E | 15_W | 1.61 | 1.00 | |
| 44_K | 62_L | 1.605 | 1.00 | |
| 44_K | 54_T | 1.597 | 1.00 | |
| 297_D | 301_Q | 1.59 | 1.00 | |
| 243_S | 247_H | 1.585 | 1.00 | |
| 310_C | 317_I | 1.571 | 1.00 | |
| 78_S | 100_A | 1.541 | 1.00 | |
| 236_R | 315_I | 1.535 | 1.00 | |
| 46_R | 50_S | 1.529 | 1.00 | |
| 140_N | 143_G | 1.528 | 1.00 | |
| 239_V | 267_V | 1.525 | 1.00 | |
| 42_Q | 45_K | 1.518 | 1.00 | |
| 244_R | 313_M | 1.504 | 1.00 | |
| 7_Q | 11_E | 1.499 | 1.00 | |
| 341_L | 404_L | 1.49 | 1.00 | |
| 48_A | 54_T | 1.481 | 1.00 | |
| 70_E | 115_L | 1.459 | 1.00 | |
| 394_A | 398_K | 1.453 | 1.00 | |
| 214_R | 295_L | 1.453 | 1.00 | |
| 395_E | 398_K | 1.429 | 1.00 | |
| 297_D | 300_Q | 1.426 | 1.00 | |
| 260_L | 298_F | 1.421 | 1.00 | |
| 306_M | 317_I | 1.412 | 1.00 | |
| 66_L | 108_K | 1.395 | 0.99 | |
| 220_L | 241_A | 1.379 | 0.99 | |
| 108_K | 111_Y | 1.378 | 0.99 | |
| 244_R | 312_E | 1.378 | 0.99 | |
| 77_L | 186_F | 1.371 | 0.99 | |
| 404_L | 408_A | 1.362 | 0.99 | |
| 218_V | 283_F | 1.362 | 0.99 | |
| 80_S | 93_G | 1.357 | 0.99 | |
| 100_A | 120_V | 1.356 | 0.99 | |
| 258_D | 291_D | 1.352 | 0.99 | |
| 342_C | 399_T | 1.35 | 0.99 | |
| 53_E | 65_R | 1.35 | 0.99 | |
| 11_E | 14_P | 1.346 | 0.99 | |
| 345_E | 404_L | 1.338 | 0.99 | |
| 38_E | 42_Q | 1.335 | 0.99 | |
| 77_L | 183_I | 1.334 | 0.99 | |
| 300_Q | 303_E | 1.333 | 0.99 | |
| 239_V | 269_P | 1.323 | 0.99 | |
| 21_A | 39_T | 1.315 | 0.99 | |
| 339_T | 351_V | 1.307 | 0.99 | |
| 304_N | 308_A | 1.305 | 0.99 | |
| 336_A | 340_E | 1.305 | 0.99 | |
| 216_Y | 285_I | 1.296 | 0.99 | |
| 218_V | 245_I | 1.294 | 0.99 | |
| 12_T | 46_R | 1.29 | 0.99 | |
| 340_E | 344_R | 1.265 | 0.99 | |
| 246_C | 283_F | 1.26 | 0.99 | |
| 248_Q | 308_A | 1.259 | 0.99 | |
| 218_V | 319_I | 1.248 | 0.99 | |
| 78_S | 406_Q | 1.244 | 0.98 | |
| 240_Y | 251_E | 1.235 | 0.98 | |
| 9_I | 397_V | 1.223 | 0.98 | |
| 240_Y | 250_V | 1.215 | 0.98 | |
| 391_T | 395_E | 1.208 | 0.98 | |
| 299_T | 321_L | 1.205 | 0.98 | |
| 187_V | 409_W | 1.2 | 0.98 | |
| 12_T | 102_L | 1.197 | 0.98 | |
| 16_L | 39_T | 1.194 | 0.98 | |
| 46_R | 105_D | 1.178 | 0.98 | |
| 220_L | 283_F | 1.178 | 0.98 | |
| 299_T | 323_M | 1.174 | 0.98 | |
| 37_L | 60_G | 1.172 | 0.98 | |
| 389_N | 392_D | 1.171 | 0.98 | |
| 54_T | 64_G | 1.171 | 0.98 | |
| 326_E | 365_P | 1.164 | 0.97 | |
| 337_T | 341_L | 1.157 | 0.97 | |
| 304_N | 307_R | 1.154 | 0.97 | |
| 337_T | 408_A | 1.152 | 0.97 | |
| 217_T | 322_W | 1.152 | 0.97 | |
| 41_Q | 44_K | 1.144 | 0.97 | |
| 267_V | 281_T | 1.141 | 0.97 | |
| 68_G | 117_T | 1.14 | 0.97 | |
| 248_Q | 251_E | 1.138 | 0.97 | |
| 10_E | 14_P | 1.131 | 0.97 | |
| 103_A | 403_M | 1.13 | 0.97 | |
| 12_T | 105_D | 1.125 | 0.97 | |
| 110_Q | 407_L | 1.12 | 0.96 | |
| 248_Q | 305_D | 1.11 | 0.96 | |
| 340_E | 343_E | 1.106 | 0.96 | |
| 246_C | 267_V | 1.099 | 0.96 | |
| 8_A | 105_D | 1.096 | 0.96 | |
| 216_Y | 299_T | 1.09 | 0.96 | |
| 188_E | 371_M | 1.088 | 0.96 | |
| 185_A | 409_W | 1.076 | 0.95 | |
| 212_G | 327_P | 1.067 | 0.95 | |
| 104_I | 120_V | 1.067 | 0.95 | |
| 40_Q | 62_L | 1.065 | 0.95 | |
| 303_E | 319_I | 1.065 | 0.95 | |
| 221_N | 279_G | 1.065 | 0.95 | |
| 76_V | 406_Q | 1.062 | 0.95 | |
| 66_L | 120_V | 1.059 | 0.95 | |
| 341_L | 405_Y | 1.057 | 0.95 | |
| 388_T | 393_L | 1.054 | 0.95 | |
| 247_H | 251_E | 1.053 | 0.95 | |
| 248_Q | 309_I | 1.053 | 0.95 | |
| 70_E | 73_Q | 1.047 | 0.94 | |
| 106_W | 398_K | 1.047 | 0.94 | |
| 80_S | 97_A | 1.042 | 0.94 | |
| 225_N | 277_V | 1.035 | 0.94 | |
| 230_T | 233_G | 1.033 | 0.94 | |
| 55_R | 65_R | 1.029 | 0.94 | |
| 34_P | 125_E | 1.028 | 0.94 | |
| 52_L | 64_G | 1.028 | 0.94 | |
| 249_S | 302_L | 1.026 | 0.94 | |
| 17_S | 90_N | 1.017 | 0.93 | |
| 48_A | 53_E | 1.017 | 0.93 | |
| 398_K | 404_L | 1.014 | 0.93 | |
| 99_A | 189_L | 1.013 | 0.93 | |
| 296_R | 323_M | 1.012 | 0.93 | |
| 240_Y | 246_C | 1.012 | 0.93 | |
| 140_N | 144_L | 1.012 | 0.93 | |
| 403_M | 407_L | 1.008 | 0.93 | |
| 244_R | 251_E | 1.007 | 0.93 | |
| 249_S | 262_L | 1.006 | 0.93 | |
| 74_E | 116_R | 1.004 | 0.93 | |
| 332_K | 336_A | 1.004 | 0.93 | |
| 333_E | 336_A | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1z2lA | 2 | 0.9951 | 100 | 0.197 | Contact Map | 0.715 |
| 3n5fA | 2 | 0.9854 | 100 | 0.206 | Contact Map | 0.763 |
| 2v8hA | 4 | 0.983 | 100 | 0.279 | Contact Map | 0.733 |
| 3gb0A | 1 | 0.8321 | 100 | 0.307 | Contact Map | 0.739 |
| 3rzaA | 2 | 0.8345 | 100 | 0.315 | Contact Map | 0.744 |
| 3pfoA | 2 | 0.8345 | 100 | 0.321 | Contact Map | 0.703 |
| 3io1A | 2 | 0.854 | 100 | 0.334 | Contact Map | 0.728 |
| 1cg2A | 4 | 0.8467 | 100 | 0.336 | Contact Map | 0.691 |
| 1vgyA | 2 | 0.8443 | 100 | 0.344 | Contact Map | 0.706 |
| 4ewtA | 4 | 0.8589 | 100 | 0.345 | Contact Map | 0.76 |
Sequence Conservation (Image Generated using WebLogo v3)