| UniProt: | P23908 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11286 | ||
| Length: | 383 (377) | ||
| Sequences: | 12823 | ||
| Seq/Len: | 34.01 |
| ARGE
Paralog alert: 0.89 [within 20: 0.18] - ratio of genomes with paralogs Cluster includes: ABGA ABGB ALLC ARGE DAPE PEPT YGEY |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 188_R | 256_C | 3.345 | 1.00 | |
| 40_A | 44_K | 3.209 | 1.00 | |
| 194_G | 202_G | 3.195 | 1.00 | |
| 67_S | 137_Y | 3.176 | 1.00 | |
| 188_R | 258_E | 2.955 | 1.00 | |
| 279_N | 283_A | 2.806 | 1.00 | |
| 189_I | 212_A | 2.762 | 1.00 | |
| 276_G | 280_D | 2.744 | 1.00 | |
| 275_N | 279_N | 2.698 | 1.00 | |
| 319_K | 379_H | 2.676 | 1.00 | |
| 208_L | 291_G | 2.645 | 1.00 | |
| 190_Q | 292_R | 2.64 | 1.00 | |
| 104_K | 360_Y | 2.632 | 1.00 | |
| 186_A | 258_E | 2.616 | 1.00 | |
| 209_M | 244_I | 2.603 | 1.00 | |
| 42_W | 45_D | 2.542 | 1.00 | |
| 14_A | 38_L | 2.54 | 1.00 | |
| 74_G | 135_P | 2.532 | 1.00 | |
| 92_T | 358_D | 2.502 | 1.00 | |
| 188_R | 294_T | 2.495 | 1.00 | |
| 190_Q | 256_C | 2.475 | 1.00 | |
| 209_M | 257_C | 2.39 | 1.00 | |
| 209_M | 259_L | 2.354 | 1.00 | |
| 40_A | 52_V | 2.351 | 1.00 | |
| 186_A | 296_D | 2.27 | 1.00 | |
| 41_D | 45_D | 2.266 | 1.00 | |
| 375_Q | 378_H | 2.262 | 1.00 | |
| 245_H | 258_E | 2.198 | 1.00 | |
| 186_A | 260_H | 2.198 | 1.00 | |
| 14_A | 27_A | 2.175 | 1.00 | |
| 126_D | 374_T | 2.162 | 1.00 | |
| 37_T | 41_D | 2.148 | 1.00 | |
| 210_H | 213_I | 2.139 | 1.00 | |
| 46_L | 125_R | 2.13 | 1.00 | |
| 39_L | 81_T | 2.078 | 1.00 | |
| 190_Q | 294_T | 2.013 | 1.00 | |
| 246_G | 257_C | 2.008 | 1.00 | |
| 43_F | 66_A | 2.004 | 1.00 | |
| 152_R | 156_E | 2 | 1.00 | |
| 93_R | 101_H | 1.979 | 1.00 | |
| 38_L | 42_W | 1.942 | 1.00 | |
| 277_L | 280_D | 1.878 | 1.00 | |
| 212_A | 282_L | 1.877 | 1.00 | |
| 272_N | 276_G | 1.87 | 1.00 | |
| 192_Q | 203_V | 1.858 | 1.00 | |
| 103_G | 364_R | 1.851 | 1.00 | |
| 94_D | 97_T | 1.829 | 1.00 | |
| 320_L | 375_Q | 1.823 | 1.00 | |
| 318_E | 324_K | 1.822 | 1.00 | |
| 8_F | 370_R | 1.8 | 1.00 | |
| 74_G | 137_Y | 1.778 | 1.00 | |
| 93_R | 97_T | 1.777 | 1.00 | |
| 67_S | 135_P | 1.723 | 1.00 | |
| 119_F | 369_T | 1.716 | 1.00 | |
| 203_V | 208_L | 1.71 | 1.00 | |
| 243_H | 260_H | 1.703 | 1.00 | |
| 37_T | 52_V | 1.689 | 1.00 | |
| 211_D | 214_G | 1.674 | 1.00 | |
| 153_Y | 156_E | 1.668 | 1.00 | |
| 18_T | 38_L | 1.664 | 1.00 | |
| 283_A | 287_E | 1.652 | 1.00 | |
| 205_A | 257_C | 1.638 | 1.00 | |
| 338_Q | 343_T | 1.636 | 1.00 | |
| 14_A | 17_A | 1.634 | 1.00 | |
| 270_T | 273_E | 1.633 | 1.00 | |
| 193_S | 255_A | 1.622 | 1.00 | |
| 44_K | 52_V | 1.622 | 1.00 | |
| 76_L | 162_P | 1.615 | 1.00 | |
| 41_D | 44_K | 1.608 | 1.00 | |
| 8_F | 122_D | 1.604 | 1.00 | |
| 125_R | 129_V | 1.601 | 1.00 | |
| 42_W | 46_L | 1.599 | 1.00 | |
| 48_F | 68_I | 1.596 | 1.00 | |
| 40_A | 64_M | 1.595 | 1.00 | |
| 10_E | 14_A | 1.595 | 1.00 | |
| 206_I | 244_I | 1.589 | 1.00 | |
| 273_E | 277_L | 1.588 | 1.00 | |
| 210_H | 214_G | 1.587 | 1.00 | |
| 76_L | 139_L | 1.587 | 1.00 | |
| 77_L | 120_I | 1.584 | 1.00 | |
| 7_P | 125_R | 1.58 | 1.00 | |
| 189_I | 209_M | 1.576 | 1.00 | |
| 286_S | 293_L | 1.567 | 1.00 | |
| 126_D | 130_T | 1.564 | 1.00 | |
| 211_D | 289_W | 1.506 | 1.00 | |
| 40_A | 50_V | 1.503 | 1.00 | |
| 36_I | 81_T | 1.49 | 1.00 | |
| 223_L | 277_L | 1.488 | 1.00 | |
| 13_R | 17_A | 1.478 | 1.00 | |
| 44_K | 50_V | 1.468 | 1.00 | |
| 38_L | 41_D | 1.449 | 1.00 | |
| 188_R | 296_D | 1.437 | 1.00 | |
| 68_I | 128_D | 1.413 | 1.00 | |
| 8_F | 118_A | 1.408 | 1.00 | |
| 16_I | 107_G | 1.405 | 0.99 | |
| 22_S | 146_T | 1.402 | 0.99 | |
| 20_S | 35_L | 1.399 | 0.99 | |
| 367_K | 371_E | 1.387 | 0.99 | |
| 203_V | 291_G | 1.386 | 0.99 | |
| 11_I | 42_W | 1.382 | 0.99 | |
| 368_P | 371_E | 1.371 | 0.99 | |
| 273_E | 276_G | 1.366 | 0.99 | |
| 189_I | 208_L | 1.361 | 0.99 | |
| 375_Q | 379_H | 1.355 | 0.99 | |
| 11_I | 38_L | 1.346 | 0.99 | |
| 120_I | 138_I | 1.343 | 0.99 | |
| 235_P | 267_P | 1.333 | 0.99 | |
| 187_I | 259_L | 1.332 | 0.99 | |
| 207_E | 217_L | 1.328 | 0.99 | |
| 282_L | 293_L | 1.327 | 0.99 | |
| 319_K | 375_Q | 1.325 | 0.99 | |
| 206_I | 246_G | 1.325 | 0.99 | |
| 237_P | 274_L | 1.323 | 0.99 | |
| 183_I | 271_L | 1.32 | 0.99 | |
| 14_A | 18_T | 1.313 | 0.99 | |
| 100_E | 363_T | 1.312 | 0.99 | |
| 49_N | 67_S | 1.308 | 0.99 | |
| 13_R | 100_E | 1.306 | 0.99 | |
| 26_E | 62_F | 1.299 | 0.99 | |
| 79_G | 113_M | 1.298 | 0.99 | |
| 6_P | 10_E | 1.291 | 0.99 | |
| 17_A | 97_T | 1.29 | 0.99 | |
| 17_A | 100_E | 1.28 | 0.99 | |
| 213_I | 259_L | 1.276 | 0.99 | |
| 164_C | 380_F | 1.268 | 0.99 | |
| 280_D | 284_P | 1.265 | 0.99 | |
| 185_N | 261_M | 1.262 | 0.99 | |
| 13_R | 363_T | 1.259 | 0.99 | |
| 77_L | 377_I | 1.258 | 0.99 | |
| 10_E | 13_R | 1.251 | 0.99 | |
| 364_R | 368_P | 1.251 | 0.99 | |
| 76_L | 165_A | 1.25 | 0.99 | |
| 207_E | 218_Q | 1.237 | 0.98 | |
| 13_R | 98_L | 1.234 | 0.98 | |
| 187_I | 212_A | 1.229 | 0.98 | |
| 16_I | 110_T | 1.228 | 0.98 | |
| 276_G | 279_N | 1.225 | 0.98 | |
| 211_D | 288_R | 1.219 | 0.98 | |
| 15_L | 38_L | 1.201 | 0.98 | |
| 153_Y | 157_T | 1.199 | 0.98 | |
| 123_A | 374_T | 1.193 | 0.98 | |
| 244_I | 257_C | 1.19 | 0.98 | |
| 42_W | 125_R | 1.188 | 0.98 | |
| 39_L | 117_F | 1.167 | 0.97 | |
| 11_I | 122_D | 1.166 | 0.97 | |
| 9_I | 13_R | 1.155 | 0.97 | |
| 27_A | 37_T | 1.151 | 0.97 | |
| 103_G | 362_E | 1.151 | 0.97 | |
| 36_I | 64_M | 1.149 | 0.97 | |
| 37_T | 40_A | 1.148 | 0.97 | |
| 104_K | 362_E | 1.144 | 0.97 | |
| 185_N | 275_N | 1.138 | 0.97 | |
| 215_H | 284_P | 1.135 | 0.97 | |
| 315_E | 318_E | 1.134 | 0.97 | |
| 50_V | 66_A | 1.134 | 0.97 | |
| 189_I | 259_L | 1.123 | 0.97 | |
| 79_G | 117_F | 1.117 | 0.96 | |
| 279_N | 295_V | 1.116 | 0.96 | |
| 362_E | 365_F | 1.115 | 0.96 | |
| 17_A | 98_L | 1.1 | 0.96 | |
| 316_V | 379_H | 1.1 | 0.96 | |
| 207_E | 213_I | 1.09 | 0.96 | |
| 215_H | 218_Q | 1.084 | 0.96 | |
| 198_D | 201_R | 1.08 | 0.95 | |
| 126_D | 371_E | 1.074 | 0.95 | |
| 213_I | 244_I | 1.072 | 0.95 | |
| 68_I | 138_I | 1.069 | 0.95 | |
| 130_T | 378_H | 1.057 | 0.95 | |
| 88_D | 94_D | 1.053 | 0.95 | |
| 190_Q | 255_A | 1.051 | 0.94 | |
| 215_H | 281_A | 1.04 | 0.94 | |
| 371_E | 375_Q | 1.036 | 0.94 | |
| 115_G | 366_I | 1.03 | 0.94 | |
| 152_R | 336_F | 1.026 | 0.94 | |
| 213_I | 241_L | 1.018 | 0.93 | |
| 70_Q | 133_K | 1.013 | 0.93 | |
| 216_I | 278_L | 1.012 | 0.93 | |
| 214_G | 218_Q | 1.009 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3pfoA | 2 | 0.9765 | 100 | 0.198 | Contact Map | 0.736 |
| 1vgyA | 2 | 0.9399 | 100 | 0.226 | Contact Map | 0.719 |
| 3iszA | 2 | 0.9321 | 100 | 0.236 | Contact Map | 0.801 |
| 3tx8A | 1 | 0.9217 | 100 | 0.239 | Contact Map | 0.622 |
| 1cg2A | 4 | 0.9452 | 100 | 0.242 | Contact Map | 0.702 |
| 2f7vA | 1 | 0.9217 | 100 | 0.248 | Contact Map | 0.57 |
| 3ct9A | 2 | 0.906 | 100 | 0.249 | Contact Map | 0.681 |
| 3rzaA | 2 | 0.9269 | 100 | 0.251 | Contact Map | 0.733 |
| 3gb0A | 1 | 0.9217 | 100 | 0.255 | Contact Map | 0.738 |
| 4g1pA | 1 | 0.9922 | 100 | 0.271 | Contact Map | 0.694 |
Sequence Conservation (Image Generated using WebLogo v3)