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OPENSEQ.org
YCEM - Putative oxidoreductase YceM
UniProt: P75931 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13879
Length: 307 (304)
Sequences: 9538
Seq/Len: 31.38
YCEM
Paralog alert: 0.83 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: YCEM YCJS YDGJ YGJR YHHX YJHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
58_S 82_T 3.333 1.00
81_S 109_L 3.059 1.00
131_E 134_T 2.964 1.00
39_R 43_L 2.892 1.00
104_E 291_V 2.814 1.00
5_R 30_T 2.803 1.00
84_L 115_L 2.775 1.00
81_S 85_N 2.697 1.00
85_N 109_L 2.647 1.00
77_F 105_R 2.633 1.00
124_R 170_D 2.632 1.00
138_T 229_D 2.421 1.00
71_S 79_V 2.383 1.00
198_A 300_I 2.377 1.00
104_E 295_R 2.371 1.00
111_A 288_E 2.369 1.00
56_S 59_S 2.345 1.00
108_E 112_R 2.334 1.00
81_S 105_R 2.332 1.00
77_F 102_D 2.293 1.00
66_A 273_F 2.28 1.00
7_G 60_L 2.248 1.00
43_L 47_E 2.243 1.00
109_L 113_K 2.236 1.00
77_F 81_S 2.228 1.00
75_S 79_V 2.222 1.00
33_G 54_A 2.22 1.00
80_V 92_V 2.203 1.00
275_E 279_N 2.175 1.00
131_E 135_Q 2.095 1.00
89_H 116_T 2.091 1.00
182_L 201_H 2.035 1.00
64_C 88_V 2.02 1.00
104_E 108_E 1.944 1.00
28_D 278_Q 1.942 1.00
84_L 110_A 1.94 1.00
85_N 113_K 1.927 1.00
16_Q 48_S 1.885 1.00
55_D 59_S 1.842 1.00
38_T 41_K 1.841 1.00
80_V 106_L 1.807 1.00
85_N 112_R 1.799 1.00
71_S 75_S 1.79 1.00
3_K 30_T 1.768 1.00
116_T 280_Q 1.766 1.00
99_N 102_D 1.755 1.00
132_L 233_I 1.755 1.00
78_D 82_T 1.752 1.00
89_H 115_L 1.752 1.00
169_V 296_I 1.724 1.00
7_G 64_C 1.721 1.00
5_R 65_D 1.72 1.00
6_I 66_A 1.686 1.00
100_L 298_D 1.68 1.00
67_V 83_L 1.671 1.00
77_F 106_L 1.664 1.00
97_A 106_L 1.66 1.00
117_L 287_G 1.65 1.00
60_L 64_C 1.647 1.00
299_K 303_D 1.646 1.00
272_H 276_C 1.605 1.00
29_W 274_I 1.605 1.00
181_S 203_S 1.598 1.00
120_G 269_C 1.582 1.00
61_A 83_L 1.579 1.00
98_E 102_D 1.575 1.00
202_F 207_L 1.573 1.00
302_R 306_S 1.564 1.00
23_L 68_F 1.554 1.00
178_G 204_A 1.535 1.00
62_A 86_A 1.527 1.00
181_S 201_H 1.512 1.00
26_A 271_R 1.51 1.00
54_A 60_L 1.463 1.00
44_P 48_S 1.448 1.00
97_A 103_A 1.436 1.00
133_K 174_W 1.429 1.00
107_V 291_V 1.417 1.00
84_L 113_K 1.417 1.00
57_L 82_T 1.413 1.00
5_R 32_Q 1.413 1.00
107_V 287_G 1.407 0.99
108_E 111_A 1.393 0.99
105_R 108_E 1.391 0.99
139_A 226_A 1.378 0.99
109_L 112_R 1.375 0.99
82_T 85_N 1.364 0.99
59_S 62_A 1.364 0.99
140_A 229_D 1.363 0.99
42_A 46_C 1.359 0.99
83_L 90_V 1.354 0.99
69_V 80_V 1.346 0.99
58_S 62_A 1.343 0.99
33_G 60_L 1.337 0.99
292_L 295_R 1.334 0.99
11_L 34_A 1.321 0.99
225_Q 234_D 1.311 0.99
57_L 61_A 1.307 0.99
169_V 297_V 1.298 0.99
84_L 90_V 1.29 0.99
89_H 277_V 1.281 0.99
178_G 203_S 1.274 0.99
105_R 109_L 1.263 0.99
63_S 88_V 1.263 0.99
100_L 295_R 1.258 0.99
103_A 291_V 1.253 0.99
100_L 104_E 1.241 0.98
39_R 55_D 1.239 0.98
103_A 294_Q 1.238 0.98
69_V 79_V 1.235 0.98
275_E 281_T 1.235 0.98
4_L 66_A 1.227 0.98
173_L 289_Q 1.221 0.98
87_G 113_K 1.208 0.98
82_T 86_A 1.206 0.98
42_A 53_Y 1.195 0.98
35_W 57_L 1.188 0.98
84_L 109_L 1.178 0.98
102_D 105_R 1.175 0.98
4_L 277_V 1.172 0.98
81_S 106_L 1.171 0.98
173_L 292_L 1.171 0.98
272_H 284_Q 1.169 0.97
302_R 305_M 1.164 0.97
35_W 60_L 1.16 0.97
106_L 117_L 1.15 0.97
44_P 47_E 1.147 0.97
89_H 280_Q 1.143 0.97
72_S 75_S 1.139 0.97
223_T 234_D 1.136 0.97
173_L 202_F 1.131 0.97
143_R 225_Q 1.114 0.96
286_A 289_Q 1.113 0.96
40_A 43_L 1.108 0.96
271_R 275_E 1.104 0.96
57_L 79_V 1.103 0.96
33_G 64_C 1.094 0.96
274_I 278_Q 1.087 0.96
298_D 302_R 1.087 0.96
80_V 84_L 1.081 0.95
91_C 269_C 1.08 0.95
176_S 206_P 1.076 0.95
299_K 302_R 1.075 0.95
34_A 45_I 1.068 0.95
179_K 203_S 1.068 0.95
6_I 29_W 1.055 0.95
25_A 267_V 1.054 0.95
180_A 183_D 1.044 0.94
125_F 272_H 1.042 0.94
41_K 44_P 1.042 0.94
107_V 288_E 1.041 0.94
61_A 86_A 1.034 0.94
7_G 35_W 1.023 0.93
97_A 102_D 1.01 0.93
7_G 33_G 1.01 0.93
91_C 120_G 1.008 0.93
92_V 117_L 1.008 0.93
42_A 55_D 1.007 0.93
101_R 105_R 1.006 0.93
96_L 103_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1h6dA120.9871000.173Contact Map0.774
3ec7A80.99021000.176Contact Map0.789
3uuwA40.9871000.177Contact Map0.787
1tltA20.99671000.183Contact Map0.756
3mz0A10.9871000.194Contact Map0.728
3dtyA40.99671000.195Contact Map0.794
3ceaA40.9871000.2Contact Map0.761
2nvwA20.99671000.202Contact Map0.778
1zh8A20.95111000.202Contact Map0.79
3v5nA40.99671000.204Contact Map0.733
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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