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OPENSEQ.org
YCJS - Uncharacterized oxidoreductase YcjS
UniProt: P77503 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13916
Length: 351 (345)
Sequences: 8647
Seq/Len: 25.06
YCJS
Paralog alert: 0.80 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: YCEM YCJS YDGJ YGJR YHHX YJHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
65_Q 91_M 3.376 1.00
11_R 36_E 3.039 1.00
113_R 330_Y 3.035 1.00
90_L 118_T 3.033 1.00
140_Q 143_E 2.906 1.00
133_R 192_D 2.875 1.00
93_L 124_K 2.868 1.00
45_L 49_Q 2.677 1.00
90_L 94_E 2.665 1.00
94_E 118_T 2.655 1.00
120_R 327_E 2.646 1.00
142_R 146_T 2.635 1.00
86_Y 114_E 2.578 1.00
205_S 242_E 2.574 1.00
152_E 272_D 2.558 1.00
143_E 147_N 2.549 1.00
113_R 334_Q 2.524 1.00
239_G 339_L 2.506 1.00
63_D 66_A 2.494 1.00
117_D 121_K 2.425 1.00
90_L 114_E 2.417 1.00
13_A 67_M 2.41 1.00
49_Q 53_E 2.377 1.00
84_F 88_H 2.349 1.00
341_Q 345_T 2.301 1.00
39_A 61_W 2.286 1.00
86_Y 111_Q 2.266 1.00
204_K 244_H 2.257 1.00
118_T 122_L 2.254 1.00
75_V 312_F 2.237 1.00
80_S 88_H 2.229 1.00
86_Y 90_L 2.187 1.00
89_T 101_C 2.163 1.00
98_H 125_V 2.138 1.00
140_Q 144_Q 2.088 1.00
93_L 119_A 2.067 1.00
314_N 318_G 2.067 1.00
113_R 117_D 2.05 1.00
73_P 97_C 2.017 1.00
9_P 36_E 1.973 1.00
80_S 84_F 1.931 1.00
94_E 121_K 1.904 1.00
34_D 317_Q 1.888 1.00
62_D 66_A 1.886 1.00
94_E 122_L 1.879 1.00
108_T 111_Q 1.872 1.00
126_L 326_A 1.811 1.00
87_E 91_M 1.801 1.00
12_V 75_V 1.797 1.00
98_H 124_K 1.788 1.00
59_S 70_A 1.782 1.00
35_L 313_I 1.778 1.00
191_L 335_L 1.777 1.00
44_R 47_Q 1.762 1.00
11_R 74_D 1.76 1.00
125_V 319_K 1.749 1.00
76_V 92_A 1.737 1.00
109_P 337_A 1.723 1.00
13_A 73_P 1.713 1.00
86_Y 115_M 1.67 1.00
29_Y 77_S 1.665 1.00
89_T 115_M 1.662 1.00
205_S 350_E 1.643 1.00
144_Q 149_V 1.637 1.00
243_F 249_L 1.622 1.00
107_M 111_Q 1.605 1.00
67_M 73_P 1.597 1.00
69_L 95_A 1.58 1.00
150_L 271_G 1.574 1.00
204_K 242_E 1.561 1.00
61_W 70_A 1.554 1.00
200_F 245_N 1.526 1.00
311_A 315_H 1.525 1.00
153_I 269_F 1.521 1.00
116_C 330_Y 1.513 1.00
338_A 349_V 1.496 1.00
39_A 67_M 1.491 1.00
11_R 38_V 1.483 1.00
50_A 54_K 1.478 1.00
66_A 69_L 1.466 1.00
61_W 67_M 1.464 1.00
32_R 310_E 1.463 1.00
106_A 115_M 1.461 1.00
64_P 91_M 1.459 1.00
93_L 122_L 1.452 1.00
117_D 120_R 1.449 1.00
118_T 121_K 1.44 1.00
114_E 117_D 1.44 1.00
141_L 276_A 1.429 1.00
78_V 89_T 1.428 1.00
154_Y 272_D 1.42 1.00
93_L 99_V 1.419 1.00
116_C 326_A 1.418 1.00
207_N 348_R 1.415 1.00
64_P 68_L 1.398 0.99
195_M 328_Q 1.397 0.99
92_A 99_V 1.393 0.99
112_A 330_Y 1.387 0.99
129_D 308_S 1.38 0.99
48_A 60_V 1.362 0.99
331_I 334_Q 1.354 0.99
111_Q 114_E 1.348 0.99
202_A 244_H 1.338 0.99
205_S 348_R 1.33 0.99
91_M 94_E 1.328 0.99
142_R 196_Y 1.322 0.99
341_Q 344_E 1.317 0.99
114_E 118_T 1.317 0.99
48_A 52_A 1.316 0.99
17_A 40_V 1.3 0.99
71_V 97_C 1.285 0.99
106_A 112_A 1.28 0.99
150_L 153_I 1.269 0.99
98_H 319_K 1.256 0.99
203_V 243_F 1.255 0.99
109_P 113_R 1.251 0.99
144_Q 147_N 1.25 0.99
72_K 97_C 1.246 0.98
325_D 328_Q 1.231 0.98
98_H 316_V 1.226 0.98
78_V 88_H 1.225 0.98
65_Q 69_L 1.224 0.98
41_C 67_M 1.219 0.98
91_M 95_A 1.218 0.98
10_L 316_V 1.214 0.98
143_E 146_T 1.21 0.98
195_M 331_I 1.205 0.98
66_A 70_A 1.202 0.98
46_S 49_Q 1.198 0.98
68_L 92_A 1.197 0.98
41_C 64_P 1.19 0.98
81_P 84_F 1.189 0.98
64_P 88_H 1.188 0.98
337_A 341_Q 1.184 0.98
109_P 334_Q 1.178 0.98
10_L 75_V 1.177 0.98
157_T 268_S 1.176 0.98
90_L 115_M 1.174 0.98
150_L 274_A 1.167 0.97
198_L 247_G 1.166 0.97
112_A 333_Q 1.161 0.97
45_L 62_D 1.161 0.97
12_V 35_L 1.158 0.97
116_C 327_E 1.14 0.97
191_L 336_V 1.138 0.97
314_N 320_P 1.133 0.97
93_L 118_T 1.133 0.97
338_A 342_S 1.119 0.96
70_A 73_P 1.114 0.96
39_A 73_P 1.109 0.96
68_L 95_A 1.109 0.96
195_M 243_F 1.106 0.96
311_A 323_I 1.101 0.96
106_A 111_Q 1.1 0.96
194_A 249_L 1.1 0.96
96_G 122_L 1.099 0.96
210_S 343_A 1.089 0.96
134_F 311_A 1.088 0.96
105_P 326_A 1.077 0.95
101_C 115_M 1.075 0.95
70_A 97_C 1.073 0.95
50_A 53_E 1.067 0.95
310_E 314_N 1.061 0.95
268_S 277_T 1.055 0.95
127_A 312_F 1.048 0.94
203_V 241_I 1.045 0.94
345_T 349_V 1.043 0.94
82_N 185_D 1.042 0.94
338_A 341_Q 1.035 0.94
40_V 51_L 1.032 0.94
271_G 274_A 1.031 0.94
157_T 252_E 1.029 0.94
89_T 99_V 1.018 0.93
105_P 112_A 1.015 0.93
313_I 317_Q 1.012 0.93
13_A 76_V 1.012 0.93
22_D 54_K 1.011 0.93
209_H 242_E 1.008 0.93
101_C 126_L 1.007 0.93
200_F 244_H 1.003 0.93
48_A 62_D 1.002 0.92
25_H 77_S 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dtyA40.95441000.206Contact Map0.765
1h6dA120.95441000.207Contact Map0.782
2nvwA20.99151000.213Contact Map0.797
3v5nA40.95161000.214Contact Map0.749
1zh8A20.91451000.218Contact Map0.769
4gqaA40.98581000.233Contact Map0.782
4fb5A20.97441000.235Contact Map0.784
3ceaA40.94871000.237Contact Map0.776
3btvA20.98861000.238Contact Map0.779
4hadA40.92591000.24Contact Map0.751
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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