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OPENSEQ.org
YHHX - Uncharacterized oxidoreductase YhhX
UniProt: P46853 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12944
Length: 345 (337)
Sequences: 8852
Seq/Len: 26.27
YHHX
Paralog alert: 0.81 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: YCEM YCJS YDGJ YGJR YHHX YJHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
58_D 84_R 3.328 1.00
83_K 111_L 3.059 1.00
133_T 136_K 2.998 1.00
106_K 323_L 2.94 1.00
145_E 241_K 2.935 1.00
4_N 30_H 2.89 1.00
86_L 117_L 2.882 1.00
192_H 215_F 2.768 1.00
126_R 181_D 2.693 1.00
87_E 111_L 2.66 1.00
83_K 87_E 2.624 1.00
79_F 107_E 2.577 1.00
135_K 139_E 2.552 1.00
106_K 327_E 2.504 1.00
56_D 59_E 2.495 1.00
113_K 320_S 2.471 1.00
136_K 140_S 2.447 1.00
212_A 332_G 2.439 1.00
39_A 42_E 2.403 1.00
191_D 217_G 2.344 1.00
83_K 107_E 2.332 1.00
110_A 114_S 2.315 1.00
77_S 81_Y 2.293 1.00
79_F 104_Q 2.281 1.00
68_L 305_L 2.277 1.00
111_L 115_K 2.243 1.00
73_T 81_Y 2.235 1.00
42_E 46_P 2.219 1.00
79_F 83_K 2.217 1.00
307_Q 311_H 2.199 1.00
33_H 54_T 2.196 1.00
6_A 60_V 2.172 1.00
82_A 94_V 2.155 1.00
91_N 118_T 2.148 1.00
133_T 137_A 2.081 1.00
334_E 338_P 2.068 1.00
106_K 110_A 2.048 1.00
86_L 112_A 2.037 1.00
55_S 59_E 2.012 1.00
87_E 115_K 1.919 1.00
143_L 240_G 1.915 1.00
118_T 312_G 1.889 1.00
66_V 90_K 1.883 1.00
28_S 310_T 1.877 1.00
73_T 77_S 1.873 1.00
101_T 104_Q 1.838 1.00
82_A 108_L 1.816 1.00
87_E 114_S 1.816 1.00
134_A 245_F 1.812 1.00
2_V 30_H 1.802 1.00
180_M 328_I 1.79 1.00
146_I 238_V 1.788 1.00
15_T 47_I 1.776 1.00
91_N 117_L 1.747 1.00
52_H 63_D 1.737 1.00
80_E 84_R 1.724 1.00
119_V 319_E 1.714 1.00
137_A 142_K 1.713 1.00
102_L 330_E 1.69 1.00
29_W 306_Y 1.688 1.00
99_T 108_L 1.687 1.00
216_Y 221_A 1.68 1.00
69_V 85_A 1.665 1.00
22_V 70_V 1.658 1.00
79_F 108_L 1.648 1.00
5_C 68_L 1.635 1.00
25_R 28_S 1.63 1.00
147_V 241_K 1.606 1.00
43_E 47_I 1.603 1.00
54_T 63_D 1.598 1.00
100_P 104_Q 1.586 1.00
4_N 67_K 1.569 1.00
60_V 66_V 1.552 1.00
304_A 308_T 1.545 1.00
6_A 66_V 1.542 1.00
331_R 335_Q 1.542 1.00
61_L 85_A 1.532 1.00
122_Y 301_V 1.529 1.00
25_R 303_D 1.516 1.00
191_D 215_F 1.511 1.00
150_E 237_I 1.489 1.00
62_N 88_A 1.488 1.00
109_F 323_L 1.472 1.00
111_L 114_S 1.446 1.00
109_F 319_E 1.439 1.00
91_N 309_I 1.434 1.00
143_L 243_G 1.42 1.00
86_L 115_K 1.42 1.00
190_P 216_Y 1.42 1.00
54_T 60_V 1.407 0.99
110_A 113_K 1.386 0.99
324_T 327_E 1.384 0.99
4_N 32_A 1.383 0.99
57_L 84_R 1.38 0.99
107_E 110_A 1.369 0.99
33_H 60_V 1.365 0.99
105_A 323_L 1.358 0.99
135_K 185_S 1.356 0.99
86_L 92_V 1.351 0.99
58_D 62_N 1.342 0.99
189_R 324_T 1.339 0.99
197_I 336_A 1.335 0.99
180_M 329_L 1.335 0.99
59_E 62_N 1.335 0.99
10_F 34_I 1.331 0.99
307_Q 313_A 1.329 0.99
85_A 92_V 1.313 0.99
143_L 146_I 1.31 0.99
184_I 189_R 1.31 0.99
84_R 87_E 1.308 0.99
187_F 219_L 1.305 0.99
71_V 82_A 1.299 0.99
237_I 246_I 1.289 0.99
189_R 217_G 1.284 0.99
184_I 321_E 1.277 0.99
57_L 61_L 1.272 0.99
35_F 57_L 1.266 0.99
105_A 326_L 1.262 0.99
137_A 140_S 1.26 0.99
99_T 105_A 1.241 0.98
83_K 108_L 1.234 0.98
334_E 337_S 1.234 0.98
64_P 90_K 1.228 0.98
39_A 55_S 1.222 0.98
89_G 115_K 1.22 0.98
65_D 90_K 1.219 0.98
107_E 111_L 1.218 0.98
184_I 324_T 1.215 0.98
102_L 327_E 1.212 0.98
318_K 321_E 1.21 0.98
331_R 334_E 1.204 0.98
102_L 106_K 1.2 0.98
304_A 316_Y 1.2 0.98
41_P 45_A 1.198 0.98
86_L 111_L 1.194 0.98
184_I 216_Y 1.187 0.98
3_I 309_I 1.185 0.98
104_Q 107_E 1.178 0.98
71_V 81_Y 1.177 0.98
136_K 139_E 1.165 0.97
108_L 119_V 1.16 0.97
3_I 68_L 1.147 0.97
63_D 66_V 1.141 0.97
91_N 312_G 1.137 0.97
43_E 46_P 1.132 0.97
84_R 88_A 1.131 0.97
303_D 307_Q 1.129 0.97
330_E 334_E 1.125 0.97
235_K 246_I 1.124 0.97
194_A 213_Q 1.117 0.96
74_H 77_S 1.116 0.96
5_C 29_W 1.115 0.96
57_L 81_Y 1.115 0.96
63_D 90_K 1.115 0.96
59_E 63_D 1.111 0.96
196_D 215_F 1.109 0.96
143_L 245_F 1.108 0.96
127_F 304_A 1.1 0.96
33_H 66_V 1.095 0.96
109_F 320_S 1.095 0.96
126_R 321_E 1.091 0.96
306_Y 310_T 1.08 0.95
35_F 60_V 1.062 0.95
28_S 303_D 1.061 0.95
183_I 221_A 1.056 0.95
98_F 105_A 1.054 0.95
61_L 88_A 1.051 0.94
118_T 309_I 1.048 0.94
82_A 92_V 1.043 0.94
190_P 214_L 1.022 0.93
71_V 85_A 1.017 0.93
19_L 31_V 1.015 0.93
194_A 335_Q 1.011 0.93
82_A 86_L 1.009 0.93
150_E 224_K 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3f4lA60.99711000.166Contact Map0.729
3i23A20.99131000.185Contact Map0.752
1h6dA120.9421000.208Contact Map0.786
3fhlA40.98841000.209Contact Map0.783
3kuxA10.98551000.21Contact Map0.745
3gdoA20.98551000.21Contact Map0.797
3e82A40.97971000.211Contact Map0.785
1zh8A20.90141000.214Contact Map0.786
3moiA10.97971000.222Contact Map0.703
4hktA40.92751000.229Contact Map0.757
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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