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OPENSEQ.org

MDTJ - Spermidine export protein MdtJ
UniProt: P69212 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13927
Length: 121 (107)
Sequences: 1949
Seq/Len: 18.21

MDTJ
Paralog alert: 0.66 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: EMRE MDTI MDTJ SUGE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
91_G 101_L 2.608 1.00
14_T 43_L 2.325 1.00
77_V 84_L 2.157 1.00
12_I 67_I 2.134 1.00
50_F 53_K 2.133 1.00
75_F 79_L 1.952 1.00
55_I 60_A 1.904 1.00
32_G 36_L 1.82 1.00
21_S 36_L 1.81 1.00
18_G 40_M 1.745 1.00
17_T 40_M 1.738 1.00
73_T 92_L 1.694 1.00
41_I 45_Y 1.672 1.00
20_L 75_F 1.641 1.00
89_I 93_T 1.619 1.00
52_V 57_L 1.611 1.00
25_A 28_S 1.587 1.00
16_I 71_F 1.586 1.00
31_N 34_F 1.568 1.00
7_L 50_F 1.552 1.00
93_T 97_A 1.537 1.00
7_L 47_F 1.517 1.00
94_T 97_A 1.442 1.00
86_L 90_A 1.44 1.00
18_G 41_I 1.438 1.00
52_V 60_A 1.429 1.00
4_Y 54_K 1.426 1.00
17_T 36_L 1.421 1.00
94_T 98_G 1.398 0.99
91_G 98_G 1.292 0.99
100_V 104_S 1.291 0.99
86_L 89_I 1.286 0.99
22_M 37_M 1.262 0.99
82_E 88_K 1.261 0.99
95_L 98_G 1.256 0.99
10_L 47_F 1.249 0.99
28_S 34_F 1.239 0.98
38_L 42_S 1.237 0.98
32_G 35_I 1.221 0.98
19_T 41_I 1.209 0.98
29_E 33_G 1.206 0.98
91_G 105_G 1.203 0.98
85_S 88_K 1.202 0.98
57_L 72_I 1.19 0.98
30_G 33_G 1.187 0.98
14_T 40_M 1.151 0.97
13_A 71_F 1.141 0.97
20_L 24_W 1.103 0.96
9_G 67_I 1.09 0.96
76_S 82_E 1.082 0.96
92_L 102_I 1.06 0.95
46_I 50_F 1.053 0.95
51_A 60_A 1.048 0.94
9_G 13_A 1.027 0.94
16_I 75_F 1.005 0.93
63_L 67_I 1.004 0.93
11_A 47_F 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3b5dA20.909199.90.334Contact Map0.083
2i68A20.991799.90.352Contact Map0.026
3giaA10.925650.937Contact Map0.228
3rqwA100.46283.60.941Contact Map0.131
2ls4A10.19832.40.946Contact Map0.092
2losA10.83472.30.947Contact Map0.116
1z1nX10.34712.10.948Contact Map
4ikvA10.99172.10.948Contact Map0.38
2e84A10.347120.949Contact Map
4apsA20.96691.80.95Contact Map0.356

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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