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OPENSEQ.org

EMRE - Multidrug transporter EmrE
UniProt: P23895 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10629
Length: 110 (105)
Sequences: 2061
Seq/Len: 19.63

EMRE
Paralog alert: 0.69 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: EMRE MDTI MDTJ SUGE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
90_G 100_I 2.663 1.00
13_A 42_A 2.268 1.00
76_W 83_L 2.187 1.00
49_Q 52_A 2.146 1.00
11_I 66_V 2.092 1.00
74_L 78_F 1.947 1.00
54_I 59_A 1.869 1.00
20_L 35_G 1.806 1.00
31_W 35_G 1.806 1.00
17_G 39_C 1.718 1.00
72_S 91_M 1.69 1.00
16_I 39_C 1.671 1.00
19_T 74_L 1.619 1.00
51_L 56_T 1.584 1.00
40_Y 44_F 1.579 1.00
88_I 92_M 1.57 1.00
30_L 33_S 1.565 1.00
6_Y 46_L 1.559 1.00
93_L 96_A 1.551 1.00
6_Y 49_Q 1.542 1.00
24_S 27_F 1.524 1.00
15_V 70_L 1.516 1.00
92_M 96_A 1.508 1.00
51_L 59_A 1.38 0.99
85_L 89_I 1.38 0.99
81_Q 87_A 1.37 0.99
85_L 88_I 1.362 0.99
16_I 35_G 1.338 0.99
93_L 97_G 1.337 0.99
84_D 87_A 1.323 0.99
17_G 40_Y 1.323 0.99
90_G 97_G 1.312 0.99
3_P 53_Y 1.312 0.99
37_I 41_C 1.309 0.99
27_F 33_S 1.28 0.99
56_T 71_I 1.276 0.99
21_M 36_T 1.239 0.98
9_G 46_L 1.229 0.98
99_L 103_L 1.219 0.98
94_I 97_G 1.218 0.98
18_T 40_Y 1.195 0.98
31_W 34_V 1.192 0.98
19_T 23_F 1.169 0.97
12_L 70_L 1.155 0.97
90_G 104_L 1.131 0.97
29_R 32_P 1.113 0.96
47_L 59_A 1.107 0.96
8_G 66_V 1.098 0.96
13_A 39_C 1.098 0.96
91_M 101_I 1.086 0.96
75_S 81_Q 1.074 0.95
50_T 59_A 1.056 0.95
62_I 66_V 1.03 0.94
28_T 32_P 1.029 0.94
45_W 49_Q 1.016 0.93
23_F 79_F 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3b5dA2199.90.247Contact Map0.084
2i68A2199.90.292Contact Map0.025
3rqwA100.52.50.938Contact Map0.155
2ls4A10.21822.10.941Contact Map0.09
4gipA30.25451.80.943Contact Map0.164
3kp9A10.92731.70.944Contact Map0.185
2kr6A10.58181.10.949Contact Map0.024
4hg6A10.82730.90.953Contact Map0.083
2mc7A10.27270.90.954Contact Map0.585
2losA10.87270.80.955Contact Map0.12

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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