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OPENSEQ.org

SUGE - Quaternary ammonium compound-resistance protein SugE
UniProt: P69937 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11616
Length: 105 (104)
Sequences: 2074
Seq/Len: 19.94

SUGE
Paralog alert: 0.68 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: EMRE MDTI MDTJ SUGE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
89_S 99_G 2.572 1.00
12_L 41_V 2.143 1.00
48_W 51_K 2.137 1.00
75_I 82_A 2.119 1.00
10_G 65_I 2.08 1.00
73_T 77_L 1.953 1.00
53_L 58_A 1.875 1.00
30_T 34_I 1.842 1.00
19_G 34_I 1.831 1.00
15_V 38_A 1.76 1.00
71_A 90_L 1.692 1.00
16_W 38_A 1.662 1.00
5_I 48_W 1.66 1.00
23_T 26_F 1.611 1.00
5_I 45_L 1.603 1.00
50_M 55_V 1.598 1.00
18_V 73_T 1.573 1.00
39_M 43_M 1.557 1.00
84_P 88_A 1.53 1.00
14_V 69_G 1.514 1.00
92_L 95_L 1.507 1.00
29_L 32_S 1.498 1.00
91_A 95_L 1.483 1.00
50_M 58_A 1.47 1.00
87_L 91_A 1.466 1.00
80_E 86_R 1.39 0.99
15_V 34_I 1.364 0.99
2_S 52_S 1.363 0.99
84_P 87_L 1.356 0.99
83_N 86_R 1.353 0.99
55_V 70_A 1.324 0.99
92_L 96_G 1.314 0.99
16_W 39_M 1.308 0.99
89_S 96_G 1.291 0.99
36_V 40_I 1.274 0.99
26_F 32_S 1.271 0.99
20_L 35_T 1.216 0.98
93_I 96_G 1.213 0.98
8_I 45_L 1.193 0.98
98_I 102_L 1.186 0.98
18_V 22_Y 1.153 0.97
28_R 31_P 1.133 0.97
30_T 33_V 1.128 0.97
7_V 65_I 1.126 0.97
11_L 69_G 1.118 0.96
12_L 38_A 1.108 0.96
17_A 39_M 1.105 0.96
90_L 100_L 1.104 0.96
89_S 103_S 1.1 0.96
46_L 58_A 1.079 0.95
49_A 58_A 1.063 0.95
74_G 80_E 1.055 0.95
27_S 31_P 1.05 0.94
60_A 63_T 1.039 0.94
61_V 65_I 1.025 0.93
22_Y 78_L 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3b5dA2199.90.248Contact Map0.084
2i68A2199.90.29Contact Map0.027
3rqwA100.51433.20.932Contact Map0.144
2kr6A10.61.90.939Contact Map0.031
3kp9A10.92381.50.942Contact Map0.17
2ls4A10.22861.50.943Contact Map0.079
2xutA311.40.944Contact Map0.216
4ikvA10.99051.40.944Contact Map0.285
4lepA211.30.945Contact Map0.226
1pw4A10.99051.20.946Contact Map0.163

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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