OPENSEQ.org - YHCN - ECOLI GREMLIN

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YHCN - Uncharacterized protein YhcN

UniProt:	P64614	Sequence MKIKTTVAALSVLSVLSFGAFAADSIDAAQAQNREAIGTVSVSGVASSPMDMREMLNKKAEEKGATAYQITEARSGDTWHATAELYK	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG12820
Length:	87 (87)
Sequences:	377
Seq/Len:	4.33

YHCN
Paralog alert: 0.97 [within 20: 0.46] - ratio of genomes with paralogs
Cluster includes: BHSA MCBA YAHO YBIJ YHCN YJFN YJFY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
48_S	51_D	2.484	1.00
58_K	62_E	1.937	1.00
65_A	85_L	1.92	1.00
75_S	79_W	1.842	1.00
36_A	84_E	1.736	0.99
21_F	25_S	1.682	0.99
42_V	52_M	1.589	0.99
49_P	81_A	1.557	0.98
57_N	61_E	1.514	0.98
54_E	58_K	1.501	0.98
1_M	5_T	1.446	0.97
52_M	73_A	1.426	0.97
1_M	9_A	1.385	0.96
53_R	70_I	1.378	0.96
4_K	7_V	1.344	0.95
18_F	22_A	1.342	0.95
48_S	55_M	1.311	0.94
71_T	82_T	1.298	0.94
57_N	84_E	1.269	0.93
23_A	26_I	1.263	0.93
66_T	87_K	1.253	0.92
35_E	69_Q	1.243	0.92
40_V	61_E	1.233	0.92
24_D	27_D	1.23	0.92
47_S	52_M	1.223	0.91
8_A	15_V	1.211	0.91
58_K	61_E	1.204	0.90
69_Q	84_E	1.201	0.90
52_M	75_S	1.199	0.90
26_I	31_A	1.178	0.89
50_M	85_L	1.148	0.87
16_L	19_G	1.148	0.87
52_M	79_W	1.144	0.87
5_T	12_V	1.126	0.86
17_S	21_F	1.121	0.86
1_M	4_K	1.113	0.85
4_K	8_A	1.113	0.85
7_V	12_V	1.107	0.85
31_A	34_R	1.071	0.82
5_T	9_A	1.05	0.80
39_T	71_T	1.042	0.79
70_I	73_A	1.024	0.78
5_T	11_S	1.017	0.77
56_L	81_A	1.005	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2jnaA	2	0.9885	99.9	0.089	Contact Map	0.382
2nocA	1	0.977	99.9	0.089	Contact Map	0.412
2m2jA	1	1	99.8	0.247	Contact Map	0.499
2ma4A	1	0.7356	99.8	0.294	Contact Map	0.449
4evuA	2	0.8046	99.8	0.301	Contact Map	0.577
2qgmA	1	0.8621	30.7	0.88	Contact Map	0.026
3b55A	1	0.8621	21.6	0.889	Contact Map	0.043
2jynA	1	0.5747	10.2	0.904	Contact Map	0.227
4kzkA	1	0.931	6.8	0.911	Contact Map	0.303
2xm6A	1	0.9885	5.9	0.914	Contact Map	0.25

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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