| UniProt: | P61887 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11454 | ||
| Length: | 293 (288) | ||
| Sequences: | 9650 | ||
| Seq/Len: | 33.51 |
| RMLA2
Paralog alert: 0.91 [within 20: 0.31] - ratio of genomes with paralogs Cluster includes: GALF GALU RMLA1 RMLA2 |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 94_E | 185_K | 4.306 | 1.00 | |
| 136_Q | 167_N | 3.191 | 1.00 | |
| 31_K | 39_S | 3.087 | 1.00 | |
| 149_D | 153_R | 2.973 | 1.00 | |
| 147_E | 155_I | 2.751 | 1.00 | |
| 84_D | 88_Q | 2.748 | 1.00 | |
| 147_E | 156_S | 2.72 | 1.00 | |
| 48_E | 74_Q | 2.619 | 1.00 | |
| 123_V | 131_T | 2.528 | 1.00 | |
| 78_A | 92_I | 2.431 | 1.00 | |
| 202_Q | 206_E | 2.403 | 1.00 | |
| 183_Y | 207_A | 2.344 | 1.00 | |
| 263_D | 266_V | 2.288 | 1.00 | |
| 3_G | 46_I | 2.242 | 1.00 | |
| 153_R | 211_T | 2.23 | 1.00 | |
| 183_Y | 203_M | 2.229 | 1.00 | |
| 136_Q | 214_L | 2.197 | 1.00 | |
| 121_R | 125_A | 2.103 | 1.00 | |
| 35_Y | 64_L | 2.05 | 1.00 | |
| 241_E | 247_K | 2.016 | 1.00 | |
| 2_K | 48_E | 2.013 | 1.00 | |
| 147_E | 166_S | 1.998 | 1.00 | |
| 3_G | 41_L | 1.983 | 1.00 | |
| 122_H | 213_E | 1.976 | 1.00 | |
| 48_E | 76_E | 1.975 | 1.00 | |
| 53_T | 58_K | 1.902 | 1.00 | |
| 256_W | 263_D | 1.898 | 1.00 | |
| 38_L | 49_I | 1.894 | 1.00 | |
| 203_M | 207_A | 1.88 | 1.00 | |
| 278_Y | 281_Y | 1.858 | 1.00 | |
| 139_D | 142_R | 1.843 | 1.00 | |
| 58_K | 62_Q | 1.842 | 1.00 | |
| 199_S | 202_Q | 1.815 | 1.00 | |
| 203_M | 206_E | 1.795 | 1.00 | |
| 179_K | 209_N | 1.792 | 1.00 | |
| 58_K | 79_E | 1.79 | 1.00 | |
| 160_K | 164_P | 1.788 | 1.00 | |
| 41_L | 105_V | 1.76 | 1.00 | |
| 7_A | 51_I | 1.757 | 1.00 | |
| 60_Y | 63_R | 1.746 | 1.00 | |
| 4_I | 93_G | 1.744 | 1.00 | |
| 146_V | 154_A | 1.729 | 1.00 | |
| 129_G | 177_D | 1.727 | 1.00 | |
| 179_K | 182_E | 1.71 | 1.00 | |
| 134_G | 212_V | 1.708 | 1.00 | |
| 149_D | 155_I | 1.698 | 1.00 | |
| 269_A | 272_S | 1.692 | 1.00 | |
| 158_E | 165_K | 1.692 | 1.00 | |
| 91_I | 94_E | 1.683 | 1.00 | |
| 49_I | 73_I | 1.629 | 1.00 | |
| 59_G | 63_R | 1.618 | 1.00 | |
| 183_Y | 200_I | 1.598 | 1.00 | |
| 128_E | 211_T | 1.595 | 1.00 | |
| 156_S | 202_Q | 1.584 | 1.00 | |
| 50_L | 96_F | 1.573 | 1.00 | |
| 262_D | 265_G | 1.572 | 1.00 | |
| 101_P | 177_D | 1.565 | 1.00 | |
| 182_E | 186_Q | 1.559 | 1.00 | |
| 118_P | 121_R | 1.552 | 1.00 | |
| 35_Y | 39_S | 1.534 | 1.00 | |
| 281_Y | 284_E | 1.533 | 1.00 | |
| 267_K | 283_L | 1.511 | 1.00 | |
| 126_R | 211_T | 1.501 | 1.00 | |
| 21_V | 27_P | 1.496 | 1.00 | |
| 97_L | 102_S | 1.487 | 1.00 | |
| 148_F | 168_W | 1.441 | 1.00 | |
| 119_K | 133_F | 1.432 | 1.00 | |
| 117_S | 121_R | 1.43 | 1.00 | |
| 88_Q | 92_I | 1.426 | 1.00 | |
| 21_V | 60_Y | 1.42 | 1.00 | |
| 186_Q | 203_M | 1.413 | 1.00 | |
| 144_G | 159_E | 1.412 | 1.00 | |
| 90_F | 104_L | 1.399 | 0.99 | |
| 94_E | 181_V | 1.395 | 0.99 | |
| 128_E | 209_N | 1.393 | 0.99 | |
| 115_G | 118_P | 1.381 | 0.99 | |
| 154_A | 212_V | 1.34 | 0.99 | |
| 76_E | 96_F | 1.329 | 0.99 | |
| 250_C | 253_E | 1.329 | 0.99 | |
| 134_G | 146_V | 1.327 | 0.99 | |
| 66_G | 77_Y | 1.325 | 0.99 | |
| 267_K | 286_L | 1.31 | 0.99 | |
| 154_A | 210_L | 1.301 | 0.99 | |
| 271_S | 274_A | 1.299 | 0.99 | |
| 101_P | 124_A | 1.298 | 0.99 | |
| 15_H | 19_R | 1.294 | 0.99 | |
| 179_K | 207_A | 1.293 | 0.99 | |
| 118_P | 122_H | 1.286 | 0.99 | |
| 168_W | 214_L | 1.277 | 0.99 | |
| 50_L | 78_A | 1.272 | 0.99 | |
| 91_I | 185_K | 1.265 | 0.99 | |
| 274_A | 283_L | 1.262 | 0.99 | |
| 32_P | 35_Y | 1.262 | 0.99 | |
| 121_R | 258_N | 1.25 | 0.99 | |
| 122_H | 126_R | 1.231 | 0.98 | |
| 102_S | 178_S | 1.228 | 0.98 | |
| 101_P | 178_S | 1.227 | 0.98 | |
| 263_D | 286_L | 1.216 | 0.98 | |
| 34_I | 61_F | 1.213 | 0.98 | |
| 284_E | 287_R | 1.213 | 0.98 | |
| 264_E | 267_K | 1.211 | 0.98 | |
| 265_G | 268_R | 1.206 | 0.98 | |
| 103_C | 175_F | 1.198 | 0.98 | |
| 157_L | 170_V | 1.186 | 0.98 | |
| 101_P | 175_F | 1.182 | 0.98 | |
| 42_M | 73_I | 1.167 | 0.97 | |
| 25_L | 60_Y | 1.166 | 0.97 | |
| 130_A | 176_Y | 1.155 | 0.97 | |
| 153_R | 209_N | 1.139 | 0.97 | |
| 134_G | 168_W | 1.133 | 0.97 | |
| 104_L | 176_Y | 1.132 | 0.97 | |
| 100_E | 178_S | 1.13 | 0.97 | |
| 222_L | 232_E | 1.128 | 0.97 | |
| 182_E | 185_K | 1.128 | 0.97 | |
| 230_L | 234_S | 1.127 | 0.97 | |
| 59_G | 62_Q | 1.123 | 0.97 | |
| 98_N | 178_S | 1.119 | 0.96 | |
| 186_Q | 207_A | 1.112 | 0.96 | |
| 176_Y | 201_N | 1.11 | 0.96 | |
| 62_Q | 79_E | 1.109 | 0.96 | |
| 34_I | 51_I | 1.102 | 0.96 | |
| 145_V | 169_A | 1.088 | 0.96 | |
| 50_L | 93_G | 1.087 | 0.96 | |
| 53_T | 77_Y | 1.064 | 0.95 | |
| 251_L | 264_E | 1.061 | 0.95 | |
| 241_E | 244_Q | 1.06 | 0.95 | |
| 147_E | 158_E | 1.053 | 0.95 | |
| 31_K | 36_Y | 1.045 | 0.94 | |
| 33_M | 224_T | 1.043 | 0.94 | |
| 91_I | 184_A | 1.037 | 0.94 | |
| 178_S | 181_V | 1.031 | 0.94 | |
| 266_V | 286_L | 1.024 | 0.93 | |
| 86_L | 106_L | 1.019 | 0.93 | |
| 215_L | 218_G | 1.015 | 0.93 | |
| 200_I | 203_M | 1.015 | 0.93 | |
| 13_R | 23_K | 1.009 | 0.93 | |
| 25_L | 64_L | 1.008 | 0.93 | |
| 4_I | 50_L | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2x65A | 2 | 0.9693 | 100 | 0.223 | Contact Map | 0.592 |
| 2cu2A | 1 | 0.9659 | 100 | 0.239 | Contact Map | 0.549 |
| 1mc3A | 2 | 1 | 100 | 0.3 | Contact Map | 0.698 |
| 1iimA | 2 | 0.9863 | 100 | 0.31 | Contact Map | 0.798 |
| 1lvwA | 4 | 0.9966 | 100 | 0.311 | Contact Map | 0.816 |
| 4ho4A | 2 | 1 | 100 | 0.315 | Contact Map | 0.803 |
| 1fxoA | 8 | 0.9932 | 100 | 0.319 | Contact Map | 0.805 |
| 2e3dA | 4 | 0.8703 | 100 | 0.383 | Contact Map | 0.868 |
| 3jukA | 4 | 0.8362 | 100 | 0.383 | Contact Map | 0.843 |
| 4ecmA | 1 | 0.8259 | 100 | 0.385 | Contact Map | 0.718 |
Sequence Conservation (Image Generated using WebLogo v3)