| UniProt: | P0AEP3 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11319 | ||
| Length: | 302 (282) | ||
| Sequences: | 5658 | ||
| Seq/Len: | 20.06 |
| GALU
Paralog alert: 0.78 [within 20: 0.17] - ratio of genomes with paralogs Cluster includes: GALF GALU RMLA1 RMLA2 |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 123_H | 229_A | 4.91 | 1.00 | |
| 113_K | 117_H | 3.41 | 1.00 | |
| 56_E | 103_T | 3.355 | 1.00 | |
| 107_V | 121_C | 3.291 | 1.00 | |
| 171_P | 211_N | 3.268 | 1.00 | |
| 182_D | 197_V | 2.913 | 1.00 | |
| 227_L | 251_K | 2.751 | 1.00 | |
| 11_A | 54_I | 2.73 | 1.00 | |
| 227_L | 247_M | 2.719 | 1.00 | |
| 61_T | 65_K | 2.587 | 1.00 | |
| 158_R | 257_Y | 2.546 | 1.00 | |
| 169_V | 256_A | 2.52 | 1.00 | |
| 227_L | 244_A | 2.466 | 1.00 | |
| 195_P | 255_E | 2.423 | 1.00 | |
| 247_M | 250_E | 2.364 | 1.00 | |
| 174_D | 177_A | 2.315 | 1.00 | |
| 57_I | 102_V | 2.287 | 1.00 | |
| 246_D | 250_E | 2.282 | 1.00 | |
| 223_D | 226_P | 2.279 | 1.00 | |
| 15_V | 59_L | 2.251 | 1.00 | |
| 247_M | 251_K | 2.23 | 1.00 | |
| 182_D | 198_G | 2.23 | 1.00 | |
| 243_D | 246_D | 2.225 | 1.00 | |
| 171_P | 258_H | 2.225 | 1.00 | |
| 184_K | 195_P | 2.172 | 1.00 | |
| 200_V | 209_P | 2.091 | 1.00 | |
| 157_R | 161_E | 2.076 | 1.00 | |
| 223_D | 253_T | 2.04 | 1.00 | |
| 223_D | 251_K | 2.007 | 1.00 | |
| 120_L | 123_H | 1.904 | 1.00 | |
| 65_K | 108_R | 1.853 | 1.00 | |
| 46_V | 57_I | 1.835 | 1.00 | |
| 67_S | 70_N | 1.832 | 1.00 | |
| 277_V | 290_F | 1.829 | 1.00 | |
| 130_P | 221_S | 1.816 | 1.00 | |
| 162_T | 255_E | 1.753 | 1.00 | |
| 220_L | 245_I | 1.662 | 1.00 | |
| 245_I | 254_V | 1.66 | 1.00 | |
| 143_Y | 154_E | 1.647 | 1.00 | |
| 23_L | 27_K | 1.635 | 1.00 | |
| 159_F | 166_Q | 1.632 | 1.00 | |
| 181_V | 196_M | 1.619 | 1.00 | |
| 196_M | 256_A | 1.613 | 1.00 | |
| 198_G | 246_D | 1.597 | 1.00 | |
| 155_M | 219_V | 1.58 | 1.00 | |
| 226_P | 230_K | 1.578 | 1.00 | |
| 153_A | 157_R | 1.575 | 1.00 | |
| 163_G | 253_T | 1.565 | 1.00 | |
| 11_A | 49_C | 1.544 | 1.00 | |
| 10_K | 56_E | 1.533 | 1.00 | |
| 154_E | 157_R | 1.519 | 1.00 | |
| 195_P | 253_T | 1.519 | 1.00 | |
| 127_G | 222_A | 1.507 | 1.00 | |
| 39_K | 47_N | 1.499 | 1.00 | |
| 123_H | 225_W | 1.496 | 1.00 | |
| 230_K | 247_M | 1.496 | 1.00 | |
| 204_K | 207_V | 1.485 | 1.00 | |
| 158_R | 162_T | 1.474 | 1.00 | |
| 61_T | 66_N | 1.465 | 1.00 | |
| 43_Q | 71_H | 1.465 | 1.00 | |
| 117_H | 121_C | 1.455 | 1.00 | |
| 42_I | 59_L | 1.445 | 1.00 | |
| 22_M | 26_T | 1.443 | 1.00 | |
| 43_Q | 47_N | 1.439 | 1.00 | |
| 169_V | 181_V | 1.434 | 1.00 | |
| 130_P | 222_A | 1.411 | 1.00 | |
| 66_N | 70_N | 1.411 | 1.00 | |
| 287_G | 291_K | 1.411 | 1.00 | |
| 54_I | 156_I | 1.389 | 0.99 | |
| 46_V | 104_I | 1.383 | 0.99 | |
| 223_D | 227_L | 1.383 | 0.99 | |
| 199_V | 214_I | 1.374 | 0.99 | |
| 175_V | 205_A | 1.359 | 0.99 | |
| 49_C | 134_I | 1.341 | 0.99 | |
| 59_L | 72_F | 1.336 | 0.99 | |
| 231_T | 243_D | 1.332 | 0.99 | |
| 120_L | 229_A | 1.323 | 0.99 | |
| 29_I | 67_S | 1.32 | 0.99 | |
| 212_L | 258_H | 1.319 | 0.99 | |
| 244_A | 247_M | 1.316 | 0.99 | |
| 184_K | 193_S | 1.308 | 0.99 | |
| 141_D | 282_R | 1.301 | 0.99 | |
| 58_V | 125_V | 1.296 | 0.99 | |
| 270_L | 274_Q | 1.294 | 0.99 | |
| 158_R | 166_Q | 1.289 | 0.99 | |
| 130_P | 160_D | 1.281 | 0.99 | |
| 83_E | 95_Q | 1.274 | 0.99 | |
| 42_I | 68_I | 1.267 | 0.99 | |
| 105_M | 125_V | 1.263 | 0.99 | |
| 164_H | 221_S | 1.257 | 0.99 | |
| 222_A | 225_W | 1.256 | 0.99 | |
| 66_N | 69_E | 1.251 | 0.99 | |
| 273_M | 276_F | 1.246 | 0.98 | |
| 223_D | 252_E | 1.246 | 0.98 | |
| 182_D | 200_V | 1.241 | 0.98 | |
| 58_V | 122_A | 1.238 | 0.98 | |
| 126_V | 225_W | 1.225 | 0.98 | |
| 25_A | 28_A | 1.215 | 0.98 | |
| 231_T | 247_M | 1.183 | 0.98 | |
| 21_R | 31_K | 1.177 | 0.98 | |
| 180_V | 213_A | 1.174 | 0.98 | |
| 172_V | 175_V | 1.174 | 0.98 | |
| 272_Y | 276_F | 1.165 | 0.97 | |
| 54_I | 132_A | 1.163 | 0.97 | |
| 65_K | 69_E | 1.137 | 0.97 | |
| 36_L | 139_I | 1.135 | 0.97 | |
| 164_H | 255_E | 1.133 | 0.97 | |
| 158_R | 255_E | 1.128 | 0.97 | |
| 128_D | 222_A | 1.126 | 0.97 | |
| 33_M | 67_S | 1.12 | 0.96 | |
| 183_C | 212_L | 1.11 | 0.96 | |
| 182_D | 209_P | 1.106 | 0.96 | |
| 115_L | 135_L | 1.101 | 0.96 | |
| 196_M | 254_V | 1.096 | 0.96 | |
| 120_L | 239_I | 1.093 | 0.96 | |
| 165_S | 254_V | 1.092 | 0.96 | |
| 141_D | 279_Y | 1.089 | 0.96 | |
| 126_V | 131_V | 1.085 | 0.96 | |
| 80_A | 84_K | 1.079 | 0.95 | |
| 156_I | 219_V | 1.077 | 0.95 | |
| 290_F | 294_L | 1.071 | 0.95 | |
| 9_K | 55_T | 1.069 | 0.95 | |
| 129_E | 222_A | 1.068 | 0.95 | |
| 131_V | 222_A | 1.046 | 0.94 | |
| 92_D | 96_S | 1.043 | 0.94 | |
| 179_G | 201_E | 1.032 | 0.94 | |
| 41_L | 266_C | 1.03 | 0.94 | |
| 176_T | 204_K | 1.03 | 0.94 | |
| 185_G | 193_S | 1.028 | 0.94 | |
| 119_V | 133_V | 1.028 | 0.94 | |
| 273_M | 278_E | 1.018 | 0.93 | |
| 154_E | 158_R | 1.018 | 0.93 | |
| 19_G | 31_K | 1.017 | 0.93 | |
| 181_V | 256_A | 1.017 | 0.93 | |
| 155_M | 168_M | 1.013 | 0.93 | |
| 143_Y | 153_A | 1.008 | 0.93 | |
| 22_M | 34_L | 1.004 | 0.93 | |
| 289_E | 292_A | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2e3dA | 4 | 0.9967 | 100 | 0.301 | Contact Map | 0.861 |
| 2ux8A | 8 | 0.9503 | 100 | 0.358 | Contact Map | 0.753 |
| 2pa4A | 4 | 0.9735 | 100 | 0.365 | Contact Map | 0.755 |
| 3jukA | 4 | 0.9238 | 100 | 0.392 | Contact Map | 0.822 |
| 1iimA | 2 | 0.8444 | 100 | 0.421 | Contact Map | 0.764 |
| 1fxoA | 8 | 0.8444 | 100 | 0.432 | Contact Map | 0.783 |
| 1mc3A | 2 | 0.8477 | 100 | 0.435 | Contact Map | 0.667 |
| 4ecmA | 1 | 0.8212 | 100 | 0.442 | Contact Map | 0.698 |
| 1lvwA | 4 | 0.8444 | 100 | 0.443 | Contact Map | 0.8 |
| 4ho4A | 2 | 0.8377 | 100 | 0.443 | Contact Map | 0.775 |
Sequence Conservation (Image Generated using WebLogo v3)