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OPENSEQ.org
GALF - UTP--glucose-1-phosphate uridylyltransferase
UniProt: P0AAB6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13578
Length: 297 (268)
Sequences: 7997
Seq/Len: 29.84
GALF
Paralog alert: 0.83 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: GALF GALU RMLA1 RMLA2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
118_R 226_E 4.387 1.00
178_Q 193_V 3.194 1.00
51_E 98_T 3.034 1.00
108_L 112_H 2.948 1.00
166_R 208_D 2.875 1.00
178_Q 194_E 2.798 1.00
102_V 116_C 2.773 1.00
34_K 42_D 2.69 1.00
180_K 191_R 2.629 1.00
200_D 204_T 2.622 1.00
224_E 248_K 2.505 1.00
224_E 244_E 2.489 1.00
191_R 252_D 2.433 1.00
6_A 49_I 2.388 1.00
243_A 247_K 2.332 1.00
56_T 60_K 2.313 1.00
153_R 254_M 2.299 1.00
164_A 253_A 2.273 1.00
10_V 54_L 2.215 1.00
38_Q 66_H 2.192 1.00
220_D 223_P 2.15 1.00
166_R 255_L 2.126 1.00
244_E 248_K 2.09 1.00
170_D 173_E 2.068 1.00
244_E 247_K 2.065 1.00
180_K 186_E 2.025 1.00
7_V 117_A 2.02 1.00
152_A 156_E 1.973 1.00
115_L 118_R 1.969 1.00
224_E 241_A 1.906 1.00
5_K 51_E 1.891 1.00
41_V 52_I 1.882 1.00
240_D 243_A 1.871 1.00
52_I 97_V 1.848 1.00
177_I 192_I 1.766 1.00
125_P 218_S 1.742 1.00
223_P 227_R 1.732 1.00
196_I 206_D 1.71 1.00
154_F 161_Q 1.686 1.00
200_D 203_Q 1.68 1.00
148_A 152_A 1.67 1.00
60_K 103_R 1.662 1.00
220_D 250_S 1.641 1.00
149_A 152_A 1.628 1.00
121_I 126_F 1.626 1.00
157_T 252_D 1.618 1.00
6_A 44_I 1.611 1.00
220_D 248_K 1.595 1.00
61_N 65_N 1.579 1.00
44_I 129_V 1.572 1.00
180_K 193_V 1.535 1.00
62_A 65_N 1.522 1.00
146_N 149_A 1.504 1.00
192_I 253_A 1.486 1.00
242_I 251_V 1.481 1.00
51_E 100_M 1.465 1.00
18_L 22_K 1.465 1.00
194_E 243_A 1.464 1.00
53_L 120_A 1.433 1.00
118_R 222_W 1.428 1.00
159_R 252_D 1.428 1.00
209_I 255_L 1.427 1.00
192_I 251_V 1.416 1.00
114_I 128_V 1.4 0.99
191_R 250_S 1.387 0.99
164_A 177_I 1.384 0.99
217_L 242_I 1.378 0.99
17_M 21_T 1.372 0.99
153_R 157_T 1.372 0.99
54_L 67_F 1.37 0.99
227_R 244_E 1.354 0.99
37_I 54_L 1.352 0.99
127_V 216_V 1.345 0.99
150_M 216_V 1.342 0.99
195_F 211_A 1.329 0.99
24_I 62_A 1.325 0.99
125_P 219_A 1.32 0.99
56_T 61_N 1.311 0.99
100_M 120_A 1.288 0.99
176_V 210_M 1.285 0.99
180_K 184_D 1.276 0.99
241_A 244_E 1.273 0.99
112_H 116_C 1.273 0.99
122_G 219_A 1.27 0.99
115_L 225_L 1.243 0.98
78_E 90_Q 1.243 0.98
38_Q 42_D 1.241 0.98
159_R 250_S 1.233 0.98
175_S 197_E 1.226 0.98
125_P 155_N 1.226 0.98
136_D 279_R 1.225 0.98
110_L 130_L 1.22 0.98
179_T 209_I 1.209 0.98
61_N 64_E 1.205 0.98
178_Q 196_I 1.194 0.98
121_I 222_W 1.183 0.98
115_L 226_E 1.181 0.98
177_I 253_A 1.179 0.98
159_R 218_S 1.174 0.98
37_I 63_V 1.173 0.98
28_M 62_A 1.17 0.97
172_S 200_D 1.164 0.97
220_D 224_E 1.137 0.97
149_A 153_R 1.137 0.97
125_P 216_V 1.127 0.97
171_L 202_P 1.125 0.97
223_P 226_E 1.111 0.96
158_G 250_S 1.099 0.96
16_H 26_K 1.093 0.96
124_N 219_A 1.092 0.96
49_I 151_I 1.09 0.96
220_D 249_Q 1.086 0.96
33_D 39_Y 1.078 0.95
228_T 244_E 1.071 0.95
6_A 129_V 1.068 0.95
41_V 99_I 1.067 0.95
153_R 161_Q 1.062 0.95
267_M 271_Q 1.062 0.95
20_A 266_K 1.058 0.95
178_Q 207_S 1.058 0.95
75_S 79_Q 1.056 0.95
36_M 263_C 1.054 0.95
235_R 238_L 1.048 0.94
261_Y 271_Q 1.043 0.94
126_F 219_A 1.039 0.94
224_E 227_R 1.023 0.93
68_D 101_N 1.019 0.93
60_K 64_E 1.016 0.93
270_M 273_F 1.008 0.93
14_G 26_K 1.007 0.93
150_M 163_L 1.006 0.93
153_R 252_D 1.005 0.93
228_T 240_D 1.004 0.93
11_A 55_V 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2e3dA40.97981000.265Contact Map0.852
2ux8A80.95961000.278Contact Map0.768
2pa4A40.95961000.292Contact Map0.762
3jukA40.94281000.327Contact Map0.841
1iimA20.85861000.359Contact Map0.761
1fxoA80.85521000.371Contact Map0.793
1mc3A20.85521000.371Contact Map0.659
1lvwA40.85521000.373Contact Map0.804
4ecmA10.82831000.38Contact Map0.689
4ho4A20.85521000.383Contact Map0.771
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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