| UniProt: | P37744 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11978 | ||
| Length: | 293 (259) | ||
| Sequences: | 7978 | ||
| Seq/Len: | 30.80 |
| RMLA1
Paralog alert: 0.90 [within 20: 0.20] - ratio of genomes with paralogs Cluster includes: GALF GALU RMLA1 RMLA2 |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 97_E | 188_K | 4.633 | 1.00 | |
| 139_H | 170_N | 3.174 | 1.00 | |
| 152_D | 156_T | 3.003 | 1.00 | |
| 87_D | 91_Q | 2.985 | 1.00 | |
| 51_D | 77_N | 2.835 | 1.00 | |
| 205_R | 209_E | 2.698 | 1.00 | |
| 81_K | 95_I | 2.638 | 1.00 | |
| 186_M | 210_Q | 2.593 | 1.00 | |
| 126_A | 134_T | 2.592 | 1.00 | |
| 244_E | 250_K | 2.545 | 1.00 | |
| 150_E | 159_S | 2.539 | 1.00 | |
| 6_G | 49_I | 2.521 | 1.00 | |
| 186_M | 206_I | 2.443 | 1.00 | |
| 124_E | 128_N | 2.353 | 1.00 | |
| 150_E | 158_I | 2.331 | 1.00 | |
| 34_K | 42_S | 2.318 | 1.00 | |
| 156_T | 214_S | 2.255 | 1.00 | |
| 161_E | 168_K | 2.095 | 1.00 | |
| 142_D | 145_R | 2.053 | 1.00 | |
| 206_I | 209_E | 2.013 | 1.00 | |
| 5_K | 51_D | 2.001 | 1.00 | |
| 182_D | 212_R | 1.997 | 1.00 | |
| 125_A | 216_A | 1.989 | 1.00 | |
| 202_D | 205_R | 1.982 | 1.00 | |
| 6_G | 44_L | 1.977 | 1.00 | |
| 56_S | 61_T | 1.968 | 1.00 | |
| 139_H | 217_M | 1.963 | 1.00 | |
| 206_I | 210_Q | 1.953 | 1.00 | |
| 41_L | 52_I | 1.916 | 1.00 | |
| 51_D | 79_Q | 1.889 | 1.00 | |
| 163_K | 167_P | 1.877 | 1.00 | |
| 186_M | 203_I | 1.875 | 1.00 | |
| 132_G | 180_D | 1.861 | 1.00 | |
| 52_I | 76_L | 1.857 | 1.00 | |
| 61_T | 82_V | 1.84 | 1.00 | |
| 94_I | 97_E | 1.827 | 1.00 | |
| 10_A | 54_I | 1.778 | 1.00 | |
| 38_Y | 42_S | 1.775 | 1.00 | |
| 159_S | 205_R | 1.759 | 1.00 | |
| 63_R | 66_Q | 1.738 | 1.00 | |
| 129_K | 214_S | 1.73 | 1.00 | |
| 137_A | 215_V | 1.706 | 1.00 | |
| 150_E | 169_S | 1.701 | 1.00 | |
| 152_D | 158_I | 1.698 | 1.00 | |
| 44_L | 108_V | 1.692 | 1.00 | |
| 149_V | 157_A | 1.668 | 1.00 | |
| 182_D | 185_Q | 1.668 | 1.00 | |
| 104_D | 180_D | 1.657 | 1.00 | |
| 24_V | 30_P | 1.642 | 1.00 | |
| 122_L | 136_F | 1.596 | 1.00 | |
| 61_T | 65_Q | 1.585 | 1.00 | |
| 91_Q | 95_I | 1.581 | 1.00 | |
| 53_L | 99_F | 1.551 | 1.00 | |
| 157_A | 215_V | 1.493 | 1.00 | |
| 137_A | 149_V | 1.467 | 1.00 | |
| 182_D | 210_Q | 1.463 | 1.00 | |
| 185_Q | 189_N | 1.456 | 1.00 | |
| 118_D | 121_K | 1.445 | 1.00 | |
| 189_N | 206_I | 1.438 | 1.00 | |
| 62_P | 66_Q | 1.426 | 1.00 | |
| 18_Y | 22_M | 1.409 | 1.00 | |
| 94_I | 188_K | 1.398 | 0.99 | |
| 233_L | 237_S | 1.397 | 0.99 | |
| 53_L | 96_G | 1.396 | 0.99 | |
| 151_F | 171_Y | 1.388 | 0.99 | |
| 131_S | 214_S | 1.376 | 0.99 | |
| 171_Y | 217_M | 1.361 | 0.99 | |
| 24_V | 63_R | 1.36 | 0.99 | |
| 120_P | 124_E | 1.347 | 0.99 | |
| 125_A | 129_K | 1.334 | 0.99 | |
| 121_K | 124_E | 1.324 | 0.99 | |
| 38_Y | 67_L | 1.323 | 0.99 | |
| 69_G | 80_Y | 1.302 | 0.99 | |
| 189_N | 210_Q | 1.301 | 0.99 | |
| 79_Q | 99_F | 1.292 | 0.99 | |
| 104_D | 127_V | 1.28 | 0.99 | |
| 137_A | 171_Y | 1.271 | 0.99 | |
| 41_L | 78_L | 1.26 | 0.99 | |
| 147_G | 162_E | 1.259 | 0.99 | |
| 101_G | 181_N | 1.246 | 0.98 | |
| 182_D | 186_M | 1.238 | 0.98 | |
| 65_Q | 82_V | 1.235 | 0.98 | |
| 132_G | 212_R | 1.231 | 0.98 | |
| 28_L | 63_R | 1.229 | 0.98 | |
| 231_Q | 245_E | 1.218 | 0.98 | |
| 97_E | 184_V | 1.213 | 0.98 | |
| 121_K | 125_A | 1.21 | 0.98 | |
| 131_S | 212_R | 1.191 | 0.98 | |
| 7_I | 96_G | 1.182 | 0.98 | |
| 35_P | 38_Y | 1.181 | 0.98 | |
| 17_L | 21_T | 1.178 | 0.98 | |
| 56_S | 80_Y | 1.177 | 0.98 | |
| 103_D | 181_N | 1.163 | 0.97 | |
| 179_Y | 204_N | 1.163 | 0.97 | |
| 37_I | 64_F | 1.162 | 0.97 | |
| 190_L | 206_I | 1.149 | 0.97 | |
| 150_E | 168_K | 1.139 | 0.97 | |
| 238_N | 241_A | 1.137 | 0.97 | |
| 45_M | 76_L | 1.131 | 0.97 | |
| 234_I | 238_N | 1.13 | 0.97 | |
| 104_D | 181_N | 1.126 | 0.97 | |
| 160_L | 173_V | 1.123 | 0.97 | |
| 150_E | 161_E | 1.123 | 0.97 | |
| 53_L | 81_K | 1.122 | 0.97 | |
| 229_T | 246_R | 1.122 | 0.97 | |
| 133_A | 179_Y | 1.12 | 0.96 | |
| 148_V | 172_A | 1.095 | 0.96 | |
| 64_F | 68_L | 1.094 | 0.96 | |
| 105_C | 181_N | 1.085 | 0.96 | |
| 49_I | 123_M | 1.081 | 0.95 | |
| 16_R | 26_K | 1.048 | 0.94 | |
| 41_L | 76_L | 1.046 | 0.94 | |
| 28_L | 67_L | 1.036 | 0.94 | |
| 36_M | 227_T | 1.034 | 0.94 | |
| 49_I | 106_A | 1.034 | 0.94 | |
| 122_L | 178_F | 1.033 | 0.94 | |
| 85_S | 91_Q | 1.03 | 0.94 | |
| 100_I | 105_C | 1.026 | 0.94 | |
| 159_S | 166_E | 1.022 | 0.93 | |
| 37_I | 54_I | 1.02 | 0.93 | |
| 12_G | 16_R | 1.016 | 0.93 | |
| 93_F | 107_L | 1.014 | 0.93 | |
| 234_I | 237_S | 1.008 | 0.93 | |
| 157_A | 213_L | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1iimA | 2 | 0.9966 | 100 | 0.191 | Contact Map | 0.773 |
| 1fxoA | 8 | 0.9966 | 100 | 0.193 | Contact Map | 0.793 |
| 1lvwA | 4 | 0.9966 | 100 | 0.198 | Contact Map | 0.793 |
| 1mc3A | 2 | 0.9966 | 100 | 0.2 | Contact Map | 0.652 |
| 4ho4A | 2 | 0.9898 | 100 | 0.207 | Contact Map | 0.763 |
| 2e3dA | 4 | 0.884 | 100 | 0.433 | Contact Map | 0.845 |
| 3jukA | 4 | 0.8464 | 100 | 0.44 | Contact Map | 0.817 |
| 4ecmA | 1 | 0.8464 | 100 | 0.441 | Contact Map | 0.7 |
| 2pa4A | 4 | 0.9249 | 100 | 0.455 | Contact Map | 0.743 |
| 2ux8A | 8 | 0.8669 | 100 | 0.456 | Contact Map | 0.762 |
Sequence Conservation (Image Generated using WebLogo v3)