OPENSEQ.org - SGCA - ECOLI GREMLIN

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SGCA - Putative phosphotransferase IIA component SgcA

UniProt:	P39363	Sequence MINDIKWVQAQRKATDWRQAVEIATRPLVAYGAAQPCYVNGIIENTLNWGPYYLIAPGIALPHARPEQGANYNQVSITTLRTPVAFGNEECDPVWLLLCVSATDANAHILTIQRISQFIDSPQRLTAVGNASTDDALFALVSG	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG12554
Length:	143 (141)
Sequences:	3522
Seq/Len:	24.98

SGCA
Paralog alert: 0.74 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: PTFA PTKA PTMA PTSN SGCA ULAC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
95_W	129_G	3.603	1.00
5_I	135_D	2.856	1.00
26_R	30_A	2.384	1.00
16_D	19_Q	2.305	1.00
133_T	136_A	2.296	1.00
35_Q	71_N	2.281	1.00
126_T	130_N	2.236	1.00
22_E	39_V	2.188	1.00
24_A	99_C	2.103	1.00
80_L	97_L	2.064	1.00
13_K	81_R	2.038	1.00
25_T	39_V	1.988	1.00
11_Q	79_T	1.981	1.00
42_I	99_C	1.977	1.00
11_Q	81_R	1.915	1.00
18_R	47_L	1.879	1.00
74_Q	101_S	1.848	1.00
40_N	44_E	1.847	1.00
14_A	20_A	1.835	1.00
33_A	72_Y	1.834	1.00
83_P	95_W	1.811	1.00
14_A	23_I	1.784	1.00
9_Q	27_P	1.774	1.00
29_V	34_A	1.768	1.00
132_S	136_A	1.724	1.00
20_A	97_L	1.708	1.00
24_A	78_T	1.664	1.00
70_A	101_S	1.644	1.00
80_L	83_P	1.621	1.00
15_T	19_Q	1.561	1.00
6_K	31_Y	1.539	1.00
135_D	139_A	1.537	1.00
12_R	78_T	1.533	1.00
7_W	31_Y	1.493	1.00
38_Y	101_S	1.436	1.00
44_E	47_L	1.417	1.00
37_C	69_G	1.404	0.99
73_N	103_T	1.383	0.99
9_Q	23_I	1.382	0.99
46_T	53_Y	1.381	0.99
5_I	138_F	1.341	0.99
80_L	95_W	1.313	0.99
21_V	42_I	1.313	0.99
33_A	74_Q	1.311	0.99
27_P	30_A	1.288	0.99
125_L	129_G	1.274	0.99
10_A	79_T	1.222	0.98
25_T	42_I	1.214	0.98
14_A	80_L	1.213	0.98
18_R	43_I	1.203	0.98
22_E	43_I	1.203	0.98
131_A	136_A	1.201	0.98
57_P	125_L	1.196	0.98
131_A	137_L	1.179	0.98
94_V	97_L	1.178	0.98
25_T	99_C	1.178	0.98
79_T	96_L	1.177	0.98
131_A	140_L	1.158	0.97
44_E	48_N	1.155	0.97
8_V	137_L	1.137	0.97
18_R	22_E	1.128	0.97
58_G	95_W	1.128	0.97
12_R	23_I	1.105	0.96
108_H	112_I	1.104	0.96
41_G	44_E	1.09	0.96
19_Q	22_E	1.088	0.96
85_A	93_P	1.074	0.95
67_E	104_D	1.059	0.95
77_I	96_L	1.056	0.95
113_Q	116_S	1.054	0.95
5_I	134_D	1.044	0.94
78_T	99_C	1.043	0.94
28_L	101_S	1.027	0.94
27_P	31_Y	1.02	0.93
75_V	111_T	1.014	0.93
21_V	39_V	1.007	0.93
73_N	102_A	1.004	0.93
85_A	91_C	1.003	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
3oxpA	2	0.993	100	0.079	Contact Map	0.775
2oq3A	1	0.993	100	0.08	Contact Map	0.682
3bjvA	1	0.986	100	0.086	Contact Map	0.796
1a3aA	4	0.979	100	0.087	Contact Map	0.775
2oqtA	4	0.986	100	0.087	Contact Map	0.808
1a6jA	2	0.979	100	0.09	Contact Map	0.733
3lf6A	2	0.986	100	0.094	Contact Map	0.719
2a0jA	1	0.979	100	0.117	Contact Map	0.662
3urrA	2	0.979	100	0.121	Contact Map	0.743
3t43A	2	0.8951	100	0.14	Contact Map	0.765

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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