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OPENSEQ.org
FADK - Short-chain-fatty-acid--CoA ligase
UniProt: P38135 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12357
Length: 548 (514)
Sequences: 30251
Seq/Len: 58.85
FADK
Paralog alert: 0.82 [within 20: 0.45] - ratio of genomes with paralogs
Cluster includes: ACSA CAIC ENTE FADK LCFA MENE PRPE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
190_L 207_M 3.936 1.00
385_E 419_C 3.678 1.00
120_K 195_F 3.296 1.00
72_I 100_A 3.241 1.00
366_E 388_R 3.24 1.00
61_S 97_K 2.977 1.00
399_E 402_L 2.926 1.00
420_R 428_K 2.825 1.00
76_D 124_K 2.803 1.00
79_A 123_A 2.793 1.00
209_T 394_M 2.76 1.00
371_D 375_K 2.725 1.00
438_V 443_N 2.658 1.00
456_H 498_F 2.653 1.00
57_D 97_K 2.578 1.00
122_Q 398_D 2.576 1.00
461_D 520_R 2.541 1.00
77_R 103_V 2.496 1.00
368_K 376_T 2.462 1.00
384_E 414_Y 2.413 1.00
271_A 275_Q 2.392 1.00
41_I 50_S 2.353 1.00
370_V 386_A 2.345 1.00
382_E 418_L 2.247 1.00
454_L 462_A 2.24 1.00
453_L 478_A 2.233 1.00
91_I 127_F 2.231 1.00
37_M 40_K 2.181 1.00
31_Q 57_D 2.165 1.00
231_V 257_R 2.159 1.00
120_K 399_E 2.156 1.00
230_D 306_R 2.136 1.00
400_P 404_A 2.136 1.00
59_A 90_V 2.119 1.00
66_W 70_K 2.115 1.00
44_V 257_R 2.104 1.00
386_A 414_Y 2.093 1.00
95_C 100_A 2.092 1.00
57_D 61_S 2.083 1.00
402_L 405_R 2.081 1.00
63_L 90_V 2.067 1.00
357_T 428_K 2.037 1.00
74_S 189_E 2.033 1.00
477_C 513_V 2.028 1.00
527_Q 530_L 1.971 1.00
230_D 279_T 1.971 1.00
369_V 419_C 1.962 1.00
33_T 37_M 1.954 1.00
116_W 202_L 1.954 1.00
54_S 58_H 1.922 1.00
401_E 405_R 1.917 1.00
439_R 444_I 1.898 1.00
317_K 321_R 1.893 1.00
39_D 54_S 1.889 1.00
368_K 386_A 1.886 1.00
421_M 427_I 1.874 1.00
422_D 428_K 1.87 1.00
455_Q 502_R 1.862 1.00
68_L 98_I 1.854 1.00
73_E 76_D 1.832 1.00
448_E 507_K 1.816 1.00
115_V 119_N 1.8 1.00
52_T 55_A 1.756 1.00
51_Y 90_V 1.754 1.00
490_S 493_E 1.747 1.00
259_V 278_C 1.745 1.00
186_H 189_E 1.723 1.00
78_I 95_C 1.722 1.00
458_K 493_E 1.721 1.00
422_D 426_Y 1.718 1.00
96_L 191_A 1.707 1.00
530_L 533_K 1.692 1.00
464_V 478_A 1.692 1.00
60_A 97_K 1.69 1.00
435_D 528_K 1.687 1.00
277_R 304_A 1.686 1.00
479_Y 531_L 1.685 1.00
79_A 105_L 1.683 1.00
209_T 212_N 1.674 1.00
419_C 429_I 1.656 1.00
61_S 65_N 1.653 1.00
72_I 78_I 1.646 1.00
63_L 94_A 1.638 1.00
382_E 430_T 1.636 1.00
32_Q 36_A 1.635 1.00
94_A 98_I 1.627 1.00
420_R 430_T 1.619 1.00
75_G 189_E 1.615 1.00
78_I 100_A 1.608 1.00
354_F 424_A 1.601 1.00
153_Q 157_V 1.601 1.00
283_G 288_V 1.569 1.00
190_L 394_M 1.564 1.00
42_A 56_L 1.556 1.00
193_V 397_F 1.555 1.00
379_P 421_M 1.554 1.00
367_I 387_S 1.548 1.00
454_L 461_D 1.544 1.00
492_E 496_A 1.541 1.00
321_R 324_Q 1.536 1.00
227_T 230_D 1.536 1.00
207_M 395_G 1.532 1.00
41_I 52_T 1.524 1.00
79_A 118_L 1.52 1.00
273_L 304_A 1.517 1.00
121_C 195_F 1.517 1.00
450_E 464_V 1.509 1.00
481_V 518_L 1.502 1.00
77_R 397_F 1.501 1.00
212_N 392_V 1.498 1.00
465_V 479_Y 1.495 1.00
44_V 276_Q 1.491 1.00
371_D 377_L 1.486 1.00
89_T 248_V 1.48 1.00
336_S 413_Y 1.479 1.00
66_W 172_I 1.473 1.00
378_P 381_C 1.472 1.00
58_H 62_C 1.462 1.00
212_N 340_S 1.453 1.00
195_F 205_G 1.453 1.00
40_K 229_Q 1.447 1.00
233_M 278_C 1.439 1.00
498_F 502_R 1.436 1.00
120_K 398_D 1.433 1.00
124_K 152_Q 1.431 1.00
268_A 271_A 1.425 1.00
406_A 413_Y 1.423 1.00
55_A 58_H 1.419 1.00
385_E 429_I 1.413 1.00
437_I 446_S 1.41 1.00
105_L 114_L 1.409 1.00
230_D 280_C 1.407 0.99
521_T 527_Q 1.406 0.99
310_C 315_I 1.404 0.99
44_V 50_S 1.403 0.99
83_P 129_P 1.401 0.99
500_R 508_Y 1.396 0.99
45_D 86_C 1.396 0.99
188_D 211_N 1.395 0.99
274_E 300_A 1.394 0.99
60_A 94_A 1.394 0.99
72_I 125_M 1.391 0.99
75_G 394_M 1.369 0.99
33_T 36_A 1.365 0.99
393_F 407_L 1.364 0.99
51_Y 86_C 1.362 0.99
387_S 415_S 1.36 0.99
38_P 54_S 1.36 0.99
251_P 256_A 1.359 0.99
50_S 276_Q 1.358 0.99
288_V 308_F 1.358 0.99
101_V 190_L 1.353 0.99
56_L 93_L 1.344 0.99
41_I 257_R 1.34 0.99
467_M 477_C 1.339 0.99
41_I 44_V 1.33 0.99
460_H 483_K 1.329 0.99
382_E 420_R 1.326 0.99
196_T 206_V 1.325 0.99
495_V 512_I 1.322 0.99
241_A 244_F 1.313 0.99
482_L 514_V 1.312 0.99
231_V 278_C 1.31 0.99
418_L 433_K 1.307 0.99
261_L 272_L 1.304 0.99
59_A 62_C 1.295 0.99
265_T 268_A 1.295 0.99
221_C 254_I 1.291 0.99
63_L 127_F 1.283 0.99
208_L 212_N 1.275 0.99
286_P 313_T 1.269 0.99
408_D 414_Y 1.255 0.99
119_N 202_L 1.255 0.99
372_D 433_K 1.253 0.99
80_F 91_I 1.246 0.98
207_M 397_F 1.246 0.98
496_A 501_K 1.244 0.98
34_A 57_D 1.244 0.98
447_R 451_D 1.24 0.98
480_V 512_I 1.237 0.98
316_P 319_V 1.236 0.98
72_I 76_D 1.235 0.98
118_L 123_A 1.232 0.98
384_E 433_K 1.227 0.98
354_F 426_Y 1.218 0.98
272_L 276_Q 1.217 0.98
452_I 502_R 1.215 0.98
281_M 305_L 1.215 0.98
369_V 377_L 1.212 0.98
361_A 367_I 1.21 0.98
193_V 205_G 1.201 0.98
389_G 392_V 1.199 0.98
477_C 511_H 1.199 0.98
231_V 259_V 1.196 0.98
293_N 322_E 1.188 0.98
469_D 475_R 1.186 0.98
385_E 427_I 1.183 0.98
116_W 120_K 1.182 0.98
452_I 499_S 1.181 0.98
377_L 381_C 1.181 0.98
77_R 101_V 1.179 0.98
388_R 412_W 1.179 0.98
437_I 476_S 1.179 0.98
360_Y 426_Y 1.176 0.98
467_M 511_H 1.176 0.98
365_V 391_N 1.175 0.98
30_W 34_A 1.17 0.97
498_F 501_K 1.17 0.97
31_Q 97_K 1.169 0.97
479_Y 515_I 1.168 0.97
480_V 514_V 1.165 0.97
168_S 171_Q 1.16 0.97
504_A 507_K 1.158 0.97
479_Y 532_R 1.157 0.97
315_I 320_A 1.157 0.97
103_V 121_C 1.153 0.97
494_V 512_I 1.149 0.97
435_D 447_R 1.147 0.97
120_K 202_L 1.146 0.97
93_L 252_F 1.14 0.97
436_I 445_S 1.134 0.97
56_L 90_V 1.132 0.97
500_R 505_K 1.129 0.97
367_I 385_E 1.126 0.97
367_I 427_I 1.118 0.96
77_R 193_V 1.113 0.96
51_Y 59_A 1.111 0.96
56_L 60_A 1.108 0.96
187_G 211_N 1.107 0.96
453_L 462_A 1.106 0.96
491_L 514_V 1.102 0.96
51_Y 56_L 1.1 0.96
237_P 240_H 1.099 0.96
440_G 472_L 1.098 0.96
113_E 507_K 1.096 0.96
478_A 512_I 1.094 0.96
116_W 195_F 1.089 0.96
482_L 489_L 1.088 0.96
468_S 474_E 1.087 0.96
222_A 363_A 1.087 0.96
418_L 431_G 1.084 0.96
63_L 91_I 1.084 0.96
57_D 60_A 1.082 0.96
42_A 53_Y 1.08 0.95
518_L 526_I 1.079 0.95
59_A 87_E 1.079 0.95
66_W 69_A 1.076 0.95
499_S 508_Y 1.074 0.95
64_A 97_K 1.073 0.95
358_D 429_I 1.072 0.95
515_I 518_L 1.067 0.95
491_L 512_I 1.067 0.95
194_L 337_T 1.066 0.95
371_D 381_C 1.064 0.95
401_E 404_A 1.058 0.95
197_S 523_S 1.056 0.95
456_H 494_V 1.055 0.95
206_V 393_F 1.053 0.95
339_S 413_Y 1.052 0.95
86_C 90_V 1.051 0.94
259_V 272_L 1.05 0.94
207_M 394_M 1.047 0.94
110_R 113_E 1.046 0.94
211_N 390_P 1.045 0.94
369_V 427_I 1.044 0.94
442_E 506_Y 1.04 0.94
82_L 85_W 1.035 0.94
284_A 287_F 1.035 0.94
76_D 100_A 1.035 0.94
115_V 147_Q 1.033 0.94
81_Q 114_L 1.031 0.94
40_K 257_R 1.026 0.94
231_V 279_T 1.025 0.93
67_M 127_F 1.023 0.93
455_Q 498_F 1.022 0.93
191_A 210_H 1.017 0.93
49_A 59_A 1.016 0.93
280_C 307_F 1.016 0.93
264_F 287_F 1.015 0.93
190_L 209_T 1.01 0.93
31_Q 61_S 1.01 0.93
67_M 95_C 1.009 0.93
493_E 496_A 1.005 0.93
259_V 276_Q 1.005 0.93
456_H 493_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1mdbA10.97451000.165Contact Map0.775
3o83A20.97261000.172Contact Map0.756
3tsyA10.98361000.179Contact Map0.786
3ni2A10.95071000.183Contact Map0.812
3r44A10.9381000.187Contact Map0.816
2d1sA10.96351000.189Contact Map0.736
1v25A20.95261000.192Contact Map0.752
3etcA20.96531000.193Contact Map0.851
4iz6A20.97811000.193Contact Map0.753
3g7sA20.95621000.194Contact Map0.813
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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