| UniProt: | P27550 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11448 | ||
| Length: | 652 (605) | ||
| Sequences: | 16154 | ||
| Seq/Len: | 26.70 |
| ACSA
Paralog alert: 0.80 [within 20: 0.25] - ratio of genomes with paralogs Cluster includes: ACSA CAIC ENTE FADK LCFA MENE PRPE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 129_I | 157_A | 4.282 | 1.00 | |
| 258_P | 275_L | 4.149 | 1.00 | |
| 464_L | 502_A | 4.091 | 1.00 | |
| 177_D | 263_Y | 3.6 | 1.00 | |
| 445_Q | 467_T | 3.536 | 1.00 | |
| 450_D | 454_N | 3.394 | 1.00 | |
| 133_D | 181_R | 3.201 | 1.00 | |
| 181_R | 215_E | 3.111 | 1.00 | |
| 136_A | 180_S | 3.104 | 1.00 | |
| 93_T | 107_H | 3.017 | 1.00 | |
| 179_N | 479_G | 3.014 | 1.00 | |
| 118_C | 154_R | 2.998 | 1.00 | |
| 447_A | 455_P | 2.924 | 1.00 | |
| 521_N | 526_R | 2.899 | 1.00 | |
| 148_A | 184_I | 2.894 | 1.00 | |
| 277_T | 475_R | 2.778 | 1.00 | |
| 480_D | 483_R | 2.756 | 1.00 | |
| 299_D | 381_R | 2.659 | 1.00 | |
| 544_E | 604_K | 2.617 | 1.00 | |
| 503_R | 511_W | 2.603 | 1.00 | |
| 344_Q | 348_K | 2.558 | 1.00 | |
| 481_H | 485_E | 2.531 | 1.00 | |
| 536_L | 561_A | 2.479 | 1.00 | |
| 482_E | 486_Q | 2.391 | 1.00 | |
| 120_F | 151_A | 2.367 | 1.00 | |
| 134_V | 160_S | 2.353 | 1.00 | |
| 91_D | 111_K | 2.352 | 1.00 | |
| 83_D | 114_H | 2.339 | 1.00 | |
| 436_S | 511_W | 2.331 | 1.00 | |
| 120_F | 147_V | 2.33 | 1.00 | |
| 177_D | 480_D | 2.316 | 1.00 | |
| 461_E | 501_G | 2.314 | 1.00 | |
| 483_R | 486_Q | 2.313 | 1.00 | |
| 541_K | 578_E | 2.284 | 1.00 | |
| 123_T | 240_L | 2.276 | 1.00 | |
| 93_T | 109_S | 2.275 | 1.00 | |
| 131_K | 257_D | 2.255 | 1.00 | |
| 89_N | 92_R | 2.253 | 1.00 | |
| 96_I | 326_T | 2.247 | 1.00 | |
| 116_D | 147_V | 2.245 | 1.00 | |
| 111_K | 115_R | 2.235 | 1.00 | |
| 522_V | 527_L | 2.224 | 1.00 | |
| 129_I | 182_L | 2.222 | 1.00 | |
| 114_H | 154_R | 2.208 | 1.00 | |
| 449_V | 465_V | 2.153 | 1.00 | |
| 504_R | 510_Y | 2.141 | 1.00 | |
| 125_L | 155_I | 2.125 | 1.00 | |
| 350_Q | 379_S | 2.124 | 1.00 | |
| 135_V | 152_C | 2.12 | 1.00 | |
| 447_A | 465_V | 2.116 | 1.00 | |
| 152_C | 157_A | 2.11 | 1.00 | |
| 484_F | 488_Y | 2.104 | 1.00 | |
| 539_H | 582_W | 2.085 | 1.00 | |
| 114_H | 118_C | 2.08 | 1.00 | |
| 135_V | 157_A | 2.074 | 1.00 | |
| 396_E | 400_K | 2.074 | 1.00 | |
| 94_A | 113_L | 2.058 | 1.00 | |
| 537_V | 545_A | 2.056 | 1.00 | |
| 433_K | 507_D | 2.041 | 1.00 | |
| 547_V | 561_A | 2.034 | 1.00 | |
| 448_L | 502_A | 2.032 | 1.00 | |
| 300_I | 326_T | 2.024 | 1.00 | |
| 254_N | 257_D | 2.018 | 1.00 | |
| 560_Y | 597_H | 2.017 | 1.00 | |
| 611_M | 614_I | 2.007 | 1.00 | |
| 120_F | 184_I | 2.003 | 1.00 | |
| 463_S | 497_F | 2.003 | 1.00 | |
| 92_R | 298_G | 1.985 | 1.00 | |
| 346_V | 379_S | 1.984 | 1.00 | |
| 117_V | 151_A | 1.96 | 1.00 | |
| 153_A | 259_L | 1.956 | 1.00 | |
| 134_V | 478_F | 1.942 | 1.00 | |
| 465_V | 497_F | 1.94 | 1.00 | |
| 108_I | 147_V | 1.913 | 1.00 | |
| 275_L | 476_T | 1.904 | 1.00 | |
| 129_I | 135_V | 1.9 | 1.00 | |
| 415_Q | 496_Y | 1.872 | 1.00 | |
| 123_T | 127_L | 1.87 | 1.00 | |
| 151_A | 155_I | 1.863 | 1.00 | |
| 90_G | 111_K | 1.855 | 1.00 | |
| 96_I | 107_H | 1.841 | 1.00 | |
| 112_E | 115_R | 1.839 | 1.00 | |
| 328_L | 351_V | 1.831 | 1.00 | |
| 577_A | 581_N | 1.821 | 1.00 | |
| 392_P | 396_E | 1.809 | 1.00 | |
| 541_K | 569_E | 1.803 | 1.00 | |
| 280_G | 473_Q | 1.785 | 1.00 | |
| 172_A | 176_I | 1.779 | 1.00 | |
| 34_V | 37_T | 1.776 | 1.00 | |
| 450_D | 456_L | 1.773 | 1.00 | |
| 538_A | 586_E | 1.767 | 1.00 | |
| 107_H | 349_H | 1.764 | 1.00 | |
| 299_D | 352_N | 1.749 | 1.00 | |
| 115_R | 119_R | 1.743 | 1.00 | |
| 85_H | 89_N | 1.738 | 1.00 | |
| 136_A | 175_I | 1.73 | 1.00 | |
| 96_I | 349_H | 1.726 | 1.00 | |
| 236_W | 239_D | 1.714 | 1.00 | |
| 29_Q | 33_N | 1.713 | 1.00 | |
| 84_R | 88_E | 1.702 | 1.00 | |
| 86_L | 114_H | 1.696 | 1.00 | |
| 614_I | 617_K | 1.695 | 1.00 | |
| 173_G | 270_K | 1.684 | 1.00 | |
| 536_L | 545_A | 1.682 | 1.00 | |
| 502_A | 512_I | 1.681 | 1.00 | |
| 562_Y | 615_L | 1.662 | 1.00 | |
| 178_S | 263_Y | 1.656 | 1.00 | |
| 140_P | 186_S | 1.651 | 1.00 | |
| 300_I | 351_V | 1.65 | 1.00 | |
| 130_K | 133_D | 1.646 | 1.00 | |
| 584_R | 592_T | 1.619 | 1.00 | |
| 127_L | 216_H | 1.616 | 1.00 | |
| 97_W | 143_P | 1.612 | 1.00 | |
| 487_T | 496_Y | 1.601 | 1.00 | |
| 116_D | 119_R | 1.598 | 1.00 | |
| 93_T | 96_I | 1.594 | 1.00 | |
| 109_S | 112_E | 1.591 | 1.00 | |
| 347_D | 375_T | 1.59 | 1.00 | |
| 418_T | 496_Y | 1.589 | 1.00 | |
| 117_V | 154_R | 1.575 | 1.00 | |
| 446_P | 510_Y | 1.572 | 1.00 | |
| 356_T | 361_I | 1.569 | 1.00 | |
| 306_D | 309_W | 1.567 | 1.00 | |
| 118_C | 122_N | 1.564 | 1.00 | |
| 446_P | 466_I | 1.555 | 1.00 | |
| 158_V | 258_P | 1.553 | 1.00 | |
| 466_I | 498_S | 1.551 | 1.00 | |
| 183_V | 202_V | 1.55 | 1.00 | |
| 457_E | 460_T | 1.547 | 1.00 | |
| 258_P | 475_R | 1.545 | 1.00 | |
| 505_D | 511_W | 1.541 | 1.00 | |
| 531_E | 591_A | 1.538 | 1.00 | |
| 564_T | 602_L | 1.536 | 1.00 | |
| 177_D | 479_G | 1.523 | 1.00 | |
| 162_I | 171_V | 1.512 | 1.00 | |
| 136_A | 162_I | 1.502 | 1.00 | |
| 113_L | 150_L | 1.5 | 1.00 | |
| 385_S | 390_I | 1.491 | 1.00 | |
| 108_I | 143_P | 1.485 | 1.00 | |
| 505_D | 509_Y | 1.475 | 1.00 | |
| 580_R | 596_L | 1.474 | 1.00 | |
| 484_F | 487_T | 1.469 | 1.00 | |
| 264_T | 274_V | 1.466 | 1.00 | |
| 448_L | 456_L | 1.464 | 1.00 | |
| 120_F | 148_A | 1.458 | 1.00 | |
| 422_M | 466_I | 1.441 | 1.00 | |
| 124_L | 182_L | 1.434 | 1.00 | |
| 146_A | 317_L | 1.432 | 1.00 | |
| 581_N | 585_K | 1.426 | 1.00 | |
| 444_V | 472_G | 1.416 | 1.00 | |
| 115_R | 246_D | 1.413 | 1.00 | |
| 261_I | 478_F | 1.405 | 0.99 | |
| 182_L | 216_H | 1.403 | 0.99 | |
| 265_S | 607_S | 1.397 | 0.99 | |
| 579_V | 596_L | 1.387 | 0.99 | |
| 263_Y | 273_G | 1.378 | 0.99 | |
| 576_Y | 580_R | 1.378 | 0.99 | |
| 320_P | 325_A | 1.373 | 0.99 | |
| 341_R | 344_Q | 1.37 | 0.99 | |
| 539_H | 579_V | 1.367 | 0.99 | |
| 605_T | 611_M | 1.366 | 0.99 | |
| 296_H | 299_D | 1.366 | 0.99 | |
| 458_G | 504_R | 1.363 | 0.99 | |
| 539_H | 578_E | 1.362 | 0.99 | |
| 485_E | 488_Y | 1.361 | 0.99 | |
| 584_R | 589_P | 1.355 | 0.99 | |
| 132_G | 257_D | 1.346 | 0.99 | |
| 258_P | 277_T | 1.343 | 0.99 | |
| 122_N | 245_S | 1.341 | 0.99 | |
| 106_K | 116_D | 1.335 | 0.99 | |
| 82_L | 86_L | 1.333 | 0.99 | |
| 280_G | 419_G | 1.327 | 0.99 | |
| 550_I | 595_V | 1.327 | 0.99 | |
| 255_A | 279_G | 1.322 | 0.99 | |
| 461_E | 503_R | 1.321 | 0.99 | |
| 256_E | 279_G | 1.321 | 0.99 | |
| 302_W | 351_V | 1.318 | 0.99 | |
| 93_T | 326_T | 1.314 | 0.99 | |
| 361_I | 383_L | 1.31 | 0.99 | |
| 450_D | 460_T | 1.31 | 0.99 | |
| 543_A | 566_N | 1.308 | 0.99 | |
| 433_K | 509_Y | 1.306 | 0.99 | |
| 253_M | 257_D | 1.305 | 0.99 | |
| 550_I | 560_Y | 1.299 | 0.99 | |
| 124_L | 184_I | 1.297 | 0.99 | |
| 277_T | 280_G | 1.297 | 0.99 | |
| 423_I | 510_Y | 1.284 | 0.99 | |
| 582_W | 585_K | 1.284 | 0.99 | |
| 30_Q | 41_E | 1.279 | 0.99 | |
| 390_I | 395_W | 1.278 | 0.99 | |
| 467_T | 495_M | 1.277 | 0.99 | |
| 139_M | 220_L | 1.276 | 0.99 | |
| 120_F | 124_L | 1.271 | 0.99 | |
| 299_D | 353_I | 1.269 | 0.99 | |
| 126_E | 244_A | 1.267 | 0.99 | |
| 276_H | 280_G | 1.264 | 0.99 | |
| 176_I | 270_K | 1.261 | 0.99 | |
| 160_S | 178_S | 1.26 | 0.99 | |
| 582_W | 586_E | 1.258 | 0.99 | |
| 501_G | 514_G | 1.256 | 0.99 | |
| 565_L | 598_W | 1.255 | 0.99 | |
| 113_L | 147_V | 1.25 | 0.99 | |
| 52_Y | 55_V | 1.245 | 0.98 | |
| 127_L | 240_L | 1.244 | 0.98 | |
| 391_N | 394_A | 1.239 | 0.98 | |
| 106_K | 144_E | 1.238 | 0.98 | |
| 320_P | 327_T | 1.236 | 0.98 | |
| 548_V | 562_Y | 1.233 | 0.98 | |
| 530_A | 534_S | 1.223 | 0.98 | |
| 520_L | 559_I | 1.222 | 0.98 | |
| 108_I | 116_D | 1.218 | 0.98 | |
| 170_A | 591_A | 1.218 | 0.98 | |
| 464_L | 512_I | 1.215 | 0.98 | |
| 350_Q | 376_D | 1.213 | 0.98 | |
| 108_I | 113_L | 1.212 | 0.98 | |
| 489_F | 493_K | 1.211 | 0.98 | |
| 538_A | 582_W | 1.21 | 0.98 | |
| 119_R | 246_D | 1.208 | 0.98 | |
| 459_A | 506_E | 1.207 | 0.98 | |
| 86_L | 90_G | 1.202 | 0.98 | |
| 113_L | 117_V | 1.2 | 0.98 | |
| 150_L | 321_L | 1.197 | 0.98 | |
| 518_D | 612_R | 1.195 | 0.98 | |
| 501_G | 516_V | 1.193 | 0.98 | |
| 173_G | 177_D | 1.192 | 0.98 | |
| 114_H | 117_V | 1.191 | 0.98 | |
| 461_E | 513_T | 1.19 | 0.98 | |
| 488_Y | 497_F | 1.189 | 0.98 | |
| 130_K | 181_R | 1.187 | 0.98 | |
| 535_A | 583_V | 1.182 | 0.98 | |
| 123_T | 244_A | 1.181 | 0.98 | |
| 143_P | 147_V | 1.181 | 0.98 | |
| 92_R | 326_T | 1.179 | 0.98 | |
| 482_E | 485_E | 1.174 | 0.98 | |
| 397_W | 401_K | 1.172 | 0.98 | |
| 95_I | 146_A | 1.17 | 0.97 | |
| 129_I | 155_I | 1.169 | 0.97 | |
| 433_K | 505_D | 1.165 | 0.97 | |
| 347_D | 376_D | 1.165 | 0.97 | |
| 83_D | 154_R | 1.16 | 0.97 | |
| 583_V | 592_T | 1.157 | 0.97 | |
| 386_V | 412_T | 1.154 | 0.97 | |
| 299_D | 325_A | 1.152 | 0.97 | |
| 134_V | 179_N | 1.149 | 0.97 | |
| 468_D | 473_Q | 1.149 | 0.97 | |
| 489_F | 497_F | 1.146 | 0.97 | |
| 446_P | 464_L | 1.146 | 0.97 | |
| 576_Y | 598_W | 1.132 | 0.97 | |
| 105_S | 348_K | 1.123 | 0.97 | |
| 147_V | 237_W | 1.123 | 0.97 | |
| 124_L | 152_C | 1.121 | 0.97 | |
| 137_I | 148_A | 1.12 | 0.96 | |
| 440_P | 446_P | 1.12 | 0.96 | |
| 456_L | 460_T | 1.115 | 0.96 | |
| 158_V | 478_F | 1.112 | 0.96 | |
| 572_S | 578_E | 1.112 | 0.96 | |
| 274_V | 474_A | 1.11 | 0.96 | |
| 474_A | 488_Y | 1.11 | 0.96 | |
| 580_R | 584_R | 1.105 | 0.96 | |
| 338_T | 341_R | 1.105 | 0.96 | |
| 261_I | 273_G | 1.103 | 0.96 | |
| 305_A | 311_T | 1.1 | 0.96 | |
| 116_D | 144_E | 1.098 | 0.96 | |
| 110_Y | 325_A | 1.089 | 0.96 | |
| 340_A | 344_Q | 1.087 | 0.96 | |
| 142_V | 220_L | 1.087 | 0.96 | |
| 187_D | 221_K | 1.086 | 0.96 | |
| 147_V | 151_A | 1.082 | 0.96 | |
| 175_I | 180_S | 1.081 | 0.95 | |
| 588_G | 591_A | 1.081 | 0.95 | |
| 578_E | 581_N | 1.08 | 0.95 | |
| 300_I | 328_L | 1.075 | 0.95 | |
| 340_A | 375_T | 1.075 | 0.95 | |
| 172_A | 208_N | 1.073 | 0.95 | |
| 533_E | 547_V | 1.068 | 0.95 | |
| 542_I | 579_V | 1.067 | 0.95 | |
| 259_L | 278_T | 1.064 | 0.95 | |
| 95_I | 143_P | 1.063 | 0.95 | |
| 85_H | 88_E | 1.062 | 0.95 | |
| 447_A | 495_M | 1.061 | 0.95 | |
| 152_C | 159_H | 1.059 | 0.95 | |
| 519_V | 528_G | 1.059 | 0.95 | |
| 449_V | 455_P | 1.058 | 0.95 | |
| 366_A | 397_W | 1.056 | 0.95 | |
| 439_R | 509_Y | 1.055 | 0.95 | |
| 398_Y | 402_I | 1.053 | 0.95 | |
| 95_I | 108_I | 1.052 | 0.95 | |
| 403_G | 406_K | 1.045 | 0.94 | |
| 560_Y | 595_V | 1.044 | 0.94 | |
| 503_R | 513_T | 1.044 | 0.94 | |
| 120_F | 237_W | 1.037 | 0.94 | |
| 345_V | 349_H | 1.035 | 0.94 | |
| 173_G | 263_Y | 1.035 | 0.94 | |
| 74_T | 254_N | 1.035 | 0.94 | |
| 602_L | 610_I | 1.033 | 0.94 | |
| 311_T | 355_Y | 1.031 | 0.94 | |
| 523_S | 555_K | 1.03 | 0.94 | |
| 133_D | 157_A | 1.03 | 0.94 | |
| 121_A | 155_I | 1.028 | 0.94 | |
| 53_Q | 72_D | 1.025 | 0.93 | |
| 562_Y | 599_T | 1.024 | 0.93 | |
| 552_H | 558_A | 1.019 | 0.93 | |
| 168_P | 204_D | 1.017 | 0.93 | |
| 354_L | 380_L | 1.016 | 0.93 | |
| 125_L | 251_E | 1.011 | 0.93 | |
| 121_A | 154_R | 1.011 | 0.93 | |
| 347_D | 378_S | 1.01 | 0.93 | |
| 464_L | 510_Y | 1.007 | 0.93 | |
| 558_A | 594_D | 1.007 | 0.93 | |
| 116_D | 241_V | 1.006 | 0.93 | |
| 94_A | 110_Y | 1.002 | 0.92 | |
| 330_F | 345_V | 1.002 | 0.92 | |
| 535_A | 586_E | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1pg4A | 2 | 1 | 100 | 0.098 | Contact Map | 0.785 |
| 1ry2A | 1 | 0.9893 | 100 | 0.141 | Contact Map | 0.729 |
| 2vsqA | 1 | 0.8957 | 100 | 0.237 | Contact Map | 0.725 |
| 1amuA | 2 | 0.8451 | 100 | 0.269 | Contact Map | 0.821 |
| 3etcA | 2 | 0.8742 | 100 | 0.271 | Contact Map | 0.834 |
| 3tsyA | 1 | 0.9187 | 100 | 0.282 | Contact Map | 0.772 |
| 3g7sA | 2 | 0.8267 | 100 | 0.283 | Contact Map | 0.798 |
| 4dg8A | 1 | 0.8144 | 100 | 0.284 | Contact Map | 0.699 |
| 4iz6A | 2 | 0.8773 | 100 | 0.284 | Contact Map | 0.739 |
| 1mdbA | 1 | 0.8221 | 100 | 0.287 | Contact Map | 0.765 |
Sequence Conservation (Image Generated using WebLogo v3)