| UniProt: | P77495 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13604 | ||
| Length: | 628 (550) | ||
| Sequences: | 24616 | ||
| Seq/Len: | 44.76 |
| PRPE
Paralog alert: 0.81 [within 20: 0.41] - ratio of genomes with paralogs Cluster includes: ACSA CAIC ENTE FADK LCFA MENE PRPE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 234_T | 251_Q | 4.113 | 1.00 | |
| 440_L | 480_G | 3.773 | 1.00 | |
| 105_V | 133_A | 3.568 | 1.00 | |
| 153_D | 239_Y | 3.428 | 1.00 | |
| 420_N | 443_E | 3.279 | 1.00 | |
| 94_N | 130_R | 3.022 | 1.00 | |
| 109_D | 157_V | 2.957 | 1.00 | |
| 112_L | 156_P | 2.904 | 1.00 | |
| 425_N | 429_G | 2.854 | 1.00 | |
| 155_K | 456_G | 2.785 | 1.00 | |
| 253_D | 452_Q | 2.735 | 1.00 | |
| 457_D | 460_R | 2.731 | 1.00 | |
| 481_I | 489_F | 2.718 | 1.00 | |
| 522_E | 587_K | 2.706 | 1.00 | |
| 517_H | 565_L | 2.668 | 1.00 | |
| 69_L | 83_T | 2.666 | 1.00 | |
| 422_Q | 430_E | 2.631 | 1.00 | |
| 499_N | 504_R | 2.566 | 1.00 | |
| 124_T | 160_V | 2.546 | 1.00 | |
| 90_H | 130_R | 2.493 | 1.00 | |
| 320_T | 324_K | 2.491 | 1.00 | |
| 110_R | 136_S | 2.465 | 1.00 | |
| 437_K | 479_W | 2.376 | 1.00 | |
| 65_Q | 68_A | 2.345 | 1.00 | |
| 424_L | 441_V | 2.313 | 1.00 | |
| 514_I | 539_A | 2.298 | 1.00 | |
| 157_V | 190_R | 2.298 | 1.00 | |
| 153_D | 457_D | 2.297 | 1.00 | |
| 458_D | 462_V | 2.233 | 1.00 | |
| 72_I | 302_A | 2.215 | 1.00 | |
| 275_S | 357_E | 2.198 | 1.00 | |
| 515_S | 523_V | 2.194 | 1.00 | |
| 411_S | 489_F | 2.191 | 1.00 | |
| 59_D | 90_H | 2.187 | 1.00 | |
| 92_E | 123_I | 2.184 | 1.00 | |
| 107_R | 233_E | 2.162 | 1.00 | |
| 460_R | 463_K | 2.16 | 1.00 | |
| 500_V | 505_L | 2.132 | 1.00 | |
| 439_M | 475_A | 2.126 | 1.00 | |
| 96_V | 123_I | 2.119 | 1.00 | |
| 538_V | 580_W | 2.091 | 1.00 | |
| 276_V | 302_A | 2.085 | 1.00 | |
| 461_F | 465_Y | 2.072 | 1.00 | |
| 67_E | 87_R | 2.06 | 1.00 | |
| 87_R | 91_D | 2.052 | 1.00 | |
| 459_G | 463_K | 2.049 | 1.00 | |
| 482_R | 488_H | 2.026 | 1.00 | |
| 519_G | 561_A | 2.024 | 1.00 | |
| 128_C | 133_A | 2.023 | 1.00 | |
| 99_M | 103_L | 2.017 | 1.00 | |
| 90_H | 94_N | 2.017 | 1.00 | |
| 441_V | 475_A | 2.004 | 1.00 | |
| 423_L | 480_G | 1.985 | 1.00 | |
| 594_L | 597_T | 1.977 | 1.00 | |
| 101_R | 131_I | 1.973 | 1.00 | |
| 96_V | 127_A | 1.928 | 1.00 | |
| 516_S | 569_Q | 1.91 | 1.00 | |
| 148_A | 152_D | 1.907 | 1.00 | |
| 61_W | 65_Q | 1.882 | 1.00 | |
| 149_A | 246_K | 1.866 | 1.00 | |
| 422_Q | 441_V | 1.865 | 1.00 | |
| 129_A | 235_S | 1.85 | 1.00 | |
| 525_V | 539_A | 1.81 | 1.00 | |
| 111_V | 128_C | 1.808 | 1.00 | |
| 322_V | 355_S | 1.805 | 1.00 | |
| 304_I | 327_V | 1.804 | 1.00 | |
| 326_Q | 355_S | 1.799 | 1.00 | |
| 69_L | 85_T | 1.79 | 1.00 | |
| 275_S | 328_S | 1.786 | 1.00 | |
| 106_Q | 109_D | 1.786 | 1.00 | |
| 116_P | 162_A | 1.784 | 1.00 | |
| 230_E | 233_E | 1.777 | 1.00 | |
| 597_T | 600_A | 1.773 | 1.00 | |
| 84_F | 123_I | 1.765 | 1.00 | |
| 483_D | 489_F | 1.761 | 1.00 | |
| 105_V | 111_V | 1.758 | 1.00 | |
| 111_V | 133_A | 1.756 | 1.00 | |
| 368_E | 372_S | 1.752 | 1.00 | |
| 99_M | 215_L | 1.726 | 1.00 | |
| 372_S | 376_N | 1.723 | 1.00 | |
| 73_A | 119_A | 1.721 | 1.00 | |
| 127_A | 131_I | 1.713 | 1.00 | |
| 509_E | 574_G | 1.708 | 1.00 | |
| 408_R | 485_D | 1.696 | 1.00 | |
| 540_F | 598_I | 1.689 | 1.00 | |
| 70_A | 89_L | 1.682 | 1.00 | |
| 256_G | 450_C | 1.676 | 1.00 | |
| 480_G | 490_I | 1.668 | 1.00 | |
| 110_R | 455_W | 1.668 | 1.00 | |
| 94_N | 98_S | 1.667 | 1.00 | |
| 68_A | 274_G | 1.665 | 1.00 | |
| 112_L | 138_V | 1.653 | 1.00 | |
| 105_V | 158_L | 1.64 | 1.00 | |
| 332_S | 337_I | 1.631 | 1.00 | |
| 72_I | 325_Y | 1.631 | 1.00 | |
| 93_V | 130_R | 1.63 | 1.00 | |
| 91_D | 95_A | 1.626 | 1.00 | |
| 542_I | 585_L | 1.625 | 1.00 | |
| 85_T | 88_Q | 1.62 | 1.00 | |
| 72_I | 83_T | 1.62 | 1.00 | |
| 251_Q | 453_T | 1.62 | 1.00 | |
| 154_A | 239_Y | 1.619 | 1.00 | |
| 563_M | 579_V | 1.613 | 1.00 | |
| 483_D | 487_Y | 1.607 | 1.00 | |
| 93_V | 127_A | 1.605 | 1.00 | |
| 253_D | 256_G | 1.583 | 1.00 | |
| 560_K | 564_A | 1.582 | 1.00 | |
| 112_L | 151_I | 1.58 | 1.00 | |
| 519_G | 547_D | 1.579 | 1.00 | |
| 66_P | 87_R | 1.578 | 1.00 | |
| 83_T | 325_Y | 1.577 | 1.00 | |
| 88_Q | 91_D | 1.576 | 1.00 | |
| 60_R | 64_K | 1.562 | 1.00 | |
| 421_V | 442_V | 1.556 | 1.00 | |
| 434_V | 482_R | 1.554 | 1.00 | |
| 437_K | 491_L | 1.551 | 1.00 | |
| 433_G | 436_E | 1.545 | 1.00 | |
| 234_T | 452_Q | 1.544 | 1.00 | |
| 122_H | 293_V | 1.541 | 1.00 | |
| 464_T | 474_Y | 1.538 | 1.00 | |
| 96_V | 160_V | 1.537 | 1.00 | |
| 108_G | 233_E | 1.525 | 1.00 | |
| 69_L | 72_I | 1.514 | 1.00 | |
| 567_D | 575_R | 1.513 | 1.00 | |
| 138_V | 147_V | 1.505 | 1.00 | |
| 62_L | 90_H | 1.501 | 1.00 | |
| 276_V | 327_V | 1.496 | 1.00 | |
| 237_I | 455_W | 1.484 | 1.00 | |
| 388_Q | 474_Y | 1.482 | 1.00 | |
| 278_F | 327_V | 1.481 | 1.00 | |
| 153_D | 456_G | 1.477 | 1.00 | |
| 425_N | 432_C | 1.473 | 1.00 | |
| 256_G | 392_G | 1.47 | 1.00 | |
| 461_F | 464_T | 1.464 | 1.00 | |
| 317_V | 320_T | 1.455 | 1.00 | |
| 296_P | 301_M | 1.452 | 1.00 | |
| 588_T | 594_L | 1.45 | 1.00 | |
| 481_I | 491_L | 1.449 | 1.00 | |
| 272_K | 275_S | 1.448 | 1.00 | |
| 526_V | 540_F | 1.446 | 1.00 | |
| 496_D | 595_R | 1.445 | 1.00 | |
| 275_S | 329_R | 1.443 | 1.00 | |
| 511_E | 525_V | 1.431 | 1.00 | |
| 437_K | 481_I | 1.426 | 1.00 | |
| 337_I | 359_L | 1.41 | 1.00 | |
| 543_P | 581_F | 1.405 | 0.99 | |
| 134_I | 234_T | 1.405 | 0.99 | |
| 232_N | 255_G | 1.401 | 0.99 | |
| 282_D | 285_W | 1.394 | 0.99 | |
| 92_E | 95_A | 1.393 | 0.99 | |
| 211_D | 214_S | 1.383 | 0.99 | |
| 69_L | 302_A | 1.372 | 0.99 | |
| 462_V | 465_Y | 1.37 | 0.99 | |
| 564_A | 568_S | 1.369 | 0.99 | |
| 466_W | 475_A | 1.366 | 0.99 | |
| 528_V | 538_V | 1.365 | 0.99 | |
| 498_I | 507_T | 1.361 | 0.99 | |
| 443_E | 473_V | 1.36 | 0.99 | |
| 103_L | 191_H | 1.356 | 0.99 | |
| 565_L | 569_Q | 1.343 | 0.99 | |
| 361_L | 366_L | 1.342 | 0.99 | |
| 567_D | 572_N | 1.336 | 0.99 | |
| 84_F | 119_A | 1.334 | 0.99 | |
| 240_T | 250_V | 1.334 | 0.99 | |
| 515_S | 522_E | 1.321 | 0.99 | |
| 323_E | 351_H | 1.321 | 0.99 | |
| 61_W | 64_K | 1.321 | 0.99 | |
| 440_L | 490_I | 1.315 | 0.99 | |
| 521_A | 544_K | 1.315 | 0.99 | |
| 89_L | 126_L | 1.309 | 0.99 | |
| 395_I | 442_V | 1.304 | 0.99 | |
| 513_S | 566_V | 1.294 | 0.99 | |
| 252_R | 256_G | 1.288 | 0.99 | |
| 108_G | 452_Q | 1.288 | 0.99 | |
| 152_D | 246_K | 1.283 | 0.99 | |
| 530_D | 536_V | 1.274 | 0.99 | |
| 562_I | 579_V | 1.274 | 0.99 | |
| 498_I | 537_A | 1.271 | 0.99 | |
| 508_R | 512_E | 1.269 | 0.99 | |
| 58_I | 62_L | 1.262 | 0.99 | |
| 528_V | 578_H | 1.259 | 0.99 | |
| 408_R | 487_Y | 1.258 | 0.99 | |
| 151_I | 156_P | 1.254 | 0.99 | |
| 367_D | 370_T | 1.249 | 0.99 | |
| 541_V | 579_V | 1.246 | 0.98 | |
| 460_R | 464_T | 1.239 | 0.98 | |
| 442_V | 476_T | 1.237 | 0.98 | |
| 513_S | 569_Q | 1.236 | 0.98 | |
| 514_I | 523_V | 1.23 | 0.98 | |
| 239_Y | 249_G | 1.224 | 0.98 | |
| 566_V | 575_R | 1.223 | 0.98 | |
| 59_D | 130_R | 1.222 | 0.98 | |
| 426_E | 494_T | 1.217 | 0.98 | |
| 314_D | 317_V | 1.216 | 0.98 | |
| 540_F | 582_V | 1.215 | 0.98 | |
| 306_Y | 321_I | 1.215 | 0.98 | |
| 538_V | 578_H | 1.212 | 0.98 | |
| 559_E | 581_F | 1.211 | 0.98 | |
| 466_W | 470_S | 1.21 | 0.98 | |
| 89_L | 123_I | 1.21 | 0.98 | |
| 421_V | 488_H | 1.208 | 0.98 | |
| 149_A | 153_D | 1.206 | 0.98 | |
| 330_M | 356_L | 1.205 | 0.98 | |
| 321_I | 325_Y | 1.205 | 0.98 | |
| 423_L | 432_C | 1.201 | 0.98 | |
| 558_Q | 561_A | 1.201 | 0.98 | |
| 432_C | 436_E | 1.201 | 0.98 | |
| 425_N | 436_E | 1.2 | 0.98 | |
| 136_S | 154_A | 1.193 | 0.98 | |
| 113_V | 124_T | 1.193 | 0.98 | |
| 366_L | 371_A | 1.188 | 0.98 | |
| 96_V | 124_T | 1.188 | 0.98 | |
| 391_S | 474_Y | 1.188 | 0.98 | |
| 479_W | 494_T | 1.183 | 0.98 | |
| 335_T | 364_E | 1.179 | 0.98 | |
| 105_V | 109_D | 1.179 | 0.98 | |
| 517_H | 562_I | 1.178 | 0.98 | |
| 479_W | 492_G | 1.178 | 0.98 | |
| 241_S | 590_S | 1.178 | 0.98 | |
| 565_L | 568_S | 1.175 | 0.98 | |
| 451_I | 465_Y | 1.174 | 0.98 | |
| 517_H | 561_A | 1.17 | 0.97 | |
| 296_P | 303_T | 1.167 | 0.97 | |
| 231_S | 255_G | 1.159 | 0.97 | |
| 415_P | 421_V | 1.159 | 0.97 | |
| 126_L | 297_L | 1.156 | 0.97 | |
| 373_W | 377_T | 1.151 | 0.97 | |
| 149_A | 239_Y | 1.146 | 0.97 | |
| 146_S | 574_G | 1.142 | 0.97 | |
| 89_L | 93_V | 1.142 | 0.97 | |
| 421_V | 440_L | 1.136 | 0.97 | |
| 251_Q | 455_W | 1.133 | 0.97 | |
| 84_F | 92_E | 1.132 | 0.97 | |
| 100_L | 158_L | 1.131 | 0.97 | |
| 501_A | 533_K | 1.128 | 0.97 | |
| 342_K | 373_W | 1.127 | 0.97 | |
| 68_A | 302_A | 1.126 | 0.97 | |
| 276_V | 304_I | 1.123 | 0.97 | |
| 559_E | 563_M | 1.115 | 0.96 | |
| 100_L | 160_V | 1.115 | 0.96 | |
| 234_T | 253_D | 1.111 | 0.96 | |
| 516_S | 565_L | 1.109 | 0.96 | |
| 440_L | 488_H | 1.108 | 0.96 | |
| 158_L | 191_H | 1.106 | 0.96 | |
| 497_V | 506_G | 1.104 | 0.96 | |
| 536_V | 577_A | 1.104 | 0.96 | |
| 90_H | 93_V | 1.103 | 0.96 | |
| 419_Y | 449_G | 1.101 | 0.96 | |
| 539_A | 579_V | 1.1 | 0.96 | |
| 84_F | 89_L | 1.099 | 0.96 | |
| 266_D | 299_A | 1.098 | 0.96 | |
| 287_V | 331_F | 1.094 | 0.96 | |
| 541_V | 581_F | 1.092 | 0.96 | |
| 396_M | 488_H | 1.09 | 0.96 | |
| 237_I | 249_G | 1.087 | 0.96 | |
| 444_G | 450_C | 1.086 | 0.96 | |
| 459_G | 462_V | 1.085 | 0.96 | |
| 412_P | 490_I | 1.079 | 0.95 | |
| 70_A | 86_F | 1.077 | 0.95 | |
| 529_K | 535_Q | 1.076 | 0.95 | |
| 119_A | 123_I | 1.076 | 0.95 | |
| 585_L | 593_M | 1.074 | 0.95 | |
| 109_D | 133_A | 1.073 | 0.95 | |
| 98_S | 221_G | 1.073 | 0.95 | |
| 571_G | 574_G | 1.071 | 0.95 | |
| 414_V | 487_Y | 1.07 | 0.95 | |
| 238_L | 389_T | 1.069 | 0.95 | |
| 105_V | 131_I | 1.065 | 0.95 | |
| 423_L | 488_H | 1.061 | 0.95 | |
| 229_L | 233_E | 1.06 | 0.95 | |
| 91_D | 222_A | 1.058 | 0.95 | |
| 424_L | 430_E | 1.056 | 0.95 | |
| 92_E | 120_E | 1.054 | 0.95 | |
| 114_Y | 147_V | 1.052 | 0.95 | |
| 250_V | 451_I | 1.052 | 0.95 | |
| 110_R | 155_K | 1.046 | 0.94 | |
| 110_R | 237_I | 1.045 | 0.94 | |
| 82_R | 92_E | 1.041 | 0.94 | |
| 439_M | 494_T | 1.039 | 0.94 | |
| 559_E | 579_V | 1.037 | 0.94 | |
| 110_R | 134_I | 1.036 | 0.94 | |
| 99_M | 102_S | 1.035 | 0.94 | |
| 275_S | 301_M | 1.03 | 0.94 | |
| 153_D | 246_K | 1.029 | 0.94 | |
| 563_M | 567_D | 1.028 | 0.94 | |
| 582_V | 585_L | 1.025 | 0.93 | |
| 596_R | 600_A | 1.02 | 0.93 | |
| 561_A | 564_A | 1.02 | 0.93 | |
| 435_N | 484_A | 1.019 | 0.93 | |
| 128_C | 135_H | 1.018 | 0.93 | |
| 467_S | 470_S | 1.017 | 0.93 | |
| 100_L | 128_C | 1.015 | 0.93 | |
| 115_M | 195_V | 1.011 | 0.93 | |
| 374_V | 378_L | 1.009 | 0.93 | |
| 333_A | 336_A | 1.009 | 0.93 | |
| 277_F | 296_P | 1.005 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1pg4A | 2 | 0.9825 | 100 | 0.061 | Contact Map | 0.788 |
| 1ry2A | 1 | 0.9873 | 100 | 0.07 | Contact Map | 0.724 |
| 3etcA | 2 | 0.8981 | 100 | 0.235 | Contact Map | 0.849 |
| 2vsqA | 1 | 0.8869 | 100 | 0.27 | Contact Map | 0.739 |
| 3c5eA | 1 | 0.8901 | 100 | 0.271 | Contact Map | 0.787 |
| 3tsyA | 1 | 0.9252 | 100 | 0.272 | Contact Map | 0.775 |
| 3g7sA | 2 | 0.8551 | 100 | 0.273 | Contact Map | 0.795 |
| 3ni2A | 1 | 0.8424 | 100 | 0.274 | Contact Map | 0.799 |
| 2v7bA | 2 | 0.8408 | 100 | 0.275 | Contact Map | 0.799 |
| 1mdbA | 1 | 0.8535 | 100 | 0.276 | Contact Map | 0.776 |
Sequence Conservation (Image Generated using WebLogo v3)