| UniProt: | P37353 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12437 | ||
| Length: | 451 (441) | ||
| Sequences: | 30625 | ||
| Seq/Len: | 69.44 |
| MENE
Paralog alert: 0.84 [within 20: 0.45] - ratio of genomes with paralogs Cluster includes: ACSA CAIC ENTE FADK LCFA MENE PRPE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 136_L | 153_V | 3.789 | 1.00 | |
| 305_V | 338_G | 3.438 | 1.00 | |
| 97_N | 141_L | 3.267 | 1.00 | |
| 297_E | 308_R | 3.095 | 1.00 | |
| 49_V | 77_A | 3.009 | 1.00 | |
| 38_D | 74_Q | 2.983 | 1.00 | |
| 339_E | 346_T | 2.874 | 1.00 | |
| 319_N | 322_L | 2.861 | 1.00 | |
| 56_M | 100_L | 2.818 | 1.00 | |
| 53_S | 101_Q | 2.785 | 1.00 | |
| 356_F | 361_G | 2.748 | 1.00 | |
| 374_H | 410_W | 2.688 | 1.00 | |
| 155_T | 314_E | 2.611 | 1.00 | |
| 34_C | 74_Q | 2.548 | 1.00 | |
| 379_Q | 432_K | 2.532 | 1.00 | |
| 19_I | 27_Q | 2.475 | 1.00 | |
| 99_T | 318_R | 2.449 | 1.00 | |
| 54_G | 80_L | 2.356 | 1.00 | |
| 304_E | 333_A | 2.319 | 1.00 | |
| 301_V | 306_W | 2.316 | 1.00 | |
| 371_I | 396_A | 2.273 | 1.00 | |
| 15_R | 18_T | 2.264 | 1.00 | |
| 22_R | 202_R | 2.219 | 1.00 | |
| 372_A | 380_V | 2.209 | 1.00 | |
| 36_R | 67_L | 2.159 | 1.00 | |
| 97_N | 319_N | 2.159 | 1.00 | |
| 306_W | 333_A | 2.144 | 1.00 | |
| 68_A | 104_L | 2.128 | 1.00 | |
| 177_D | 202_R | 2.12 | 1.00 | |
| 72_L | 77_A | 2.119 | 1.00 | |
| 43_G | 47_Q | 2.118 | 1.00 | |
| 34_C | 38_D | 2.028 | 1.00 | |
| 395_V | 425_L | 2.028 | 1.00 | |
| 288_D | 346_T | 2.017 | 1.00 | |
| 176_D | 241_K | 2.007 | 1.00 | |
| 93_E | 148_L | 1.974 | 1.00 | |
| 439_S | 442_A | 1.973 | 1.00 | |
| 40_L | 67_L | 1.969 | 1.00 | |
| 366_E | 419_Q | 1.941 | 1.00 | |
| 51_E | 135_R | 1.912 | 1.00 | |
| 357_S | 362_I | 1.907 | 1.00 | |
| 341_H | 346_T | 1.9 | 1.00 | |
| 340_M | 345_L | 1.877 | 1.00 | |
| 299_K | 306_W | 1.876 | 1.00 | |
| 373_A | 414_K | 1.874 | 1.00 | |
| 320_G | 324_S | 1.87 | 1.00 | |
| 252_V | 256_E | 1.863 | 1.00 | |
| 45_A | 75_C | 1.856 | 1.00 | |
| 31_R | 35_A | 1.855 | 1.00 | |
| 322_L | 325_L | 1.829 | 1.00 | |
| 176_D | 219_T | 1.828 | 1.00 | |
| 11_W | 15_R | 1.819 | 1.00 | |
| 17_E | 31_R | 1.816 | 1.00 | |
| 50_V | 53_S | 1.809 | 1.00 | |
| 92_E | 96_P | 1.799 | 1.00 | |
| 341_H | 344_K | 1.767 | 1.00 | |
| 353_N | 440_R | 1.749 | 1.00 | |
| 300_I | 338_G | 1.72 | 1.00 | |
| 23_L | 63_P | 1.719 | 1.00 | |
| 397_V | 443_L | 1.708 | 1.00 | |
| 9_R | 34_C | 1.705 | 1.00 | |
| 56_M | 82_V | 1.69 | 1.00 | |
| 37_V | 74_Q | 1.68 | 1.00 | |
| 339_E | 348_V | 1.678 | 1.00 | |
| 442_A | 445_E | 1.675 | 1.00 | |
| 132_Q | 135_R | 1.659 | 1.00 | |
| 73_L | 137_C | 1.657 | 1.00 | |
| 28_L | 67_L | 1.656 | 1.00 | |
| 38_D | 42_S | 1.654 | 1.00 | |
| 376_A | 406_D | 1.653 | 1.00 | |
| 29_N | 32_E | 1.652 | 1.00 | |
| 55_V | 72_L | 1.641 | 1.00 | |
| 338_G | 347_I | 1.605 | 1.00 | |
| 372_A | 379_Q | 1.604 | 1.00 | |
| 321_Q | 325_L | 1.601 | 1.00 | |
| 22_R | 27_Q | 1.597 | 1.00 | |
| 49_V | 55_V | 1.58 | 1.00 | |
| 368_E | 382_I | 1.57 | 1.00 | |
| 223_L | 228_L | 1.567 | 1.00 | |
| 52_G | 135_R | 1.561 | 1.00 | |
| 256_E | 260_E | 1.557 | 1.00 | |
| 382_I | 396_A | 1.554 | 1.00 | |
| 155_T | 158_A | 1.553 | 1.00 | |
| 71_A | 75_C | 1.548 | 1.00 | |
| 20_A | 33_L | 1.537 | 1.00 | |
| 204_T | 218_C | 1.528 | 1.00 | |
| 18_T | 175_H | 1.52 | 1.00 | |
| 40_L | 71_A | 1.508 | 1.00 | |
| 98_L | 141_L | 1.507 | 1.00 | |
| 173_G | 176_D | 1.503 | 1.00 | |
| 66_L | 193_M | 1.497 | 1.00 | |
| 383_V | 397_V | 1.496 | 1.00 | |
| 19_I | 22_R | 1.496 | 1.00 | |
| 55_V | 77_A | 1.492 | 1.00 | |
| 399_E | 430_E | 1.482 | 1.00 | |
| 136_L | 314_E | 1.481 | 1.00 | |
| 285_G | 342_N | 1.469 | 1.00 | |
| 56_M | 95_L | 1.465 | 1.00 | |
| 141_L | 151_A | 1.462 | 1.00 | |
| 271_L | 332_Y | 1.461 | 1.00 | |
| 60_W | 106_P | 1.46 | 1.00 | |
| 153_V | 315_G | 1.456 | 1.00 | |
| 54_G | 317_W | 1.447 | 1.00 | |
| 139_M | 317_W | 1.446 | 1.00 | |
| 158_A | 275_A | 1.425 | 1.00 | |
| 298_V | 307_L | 1.422 | 1.00 | |
| 134_T | 157_Q | 1.421 | 1.00 | |
| 408_S | 424_W | 1.42 | 1.00 | |
| 412_K | 420_Q | 1.41 | 1.00 | |
| 16_G | 31_R | 1.402 | 0.99 | |
| 10_H | 14_V | 1.395 | 0.99 | |
| 12_R | 34_C | 1.394 | 0.99 | |
| 433_N | 439_S | 1.389 | 0.99 | |
| 196_W | 201_A | 1.389 | 0.99 | |
| 410_W | 414_K | 1.388 | 0.99 | |
| 97_N | 318_R | 1.386 | 0.99 | |
| 19_I | 29_N | 1.381 | 0.99 | |
| 35_A | 39_E | 1.378 | 0.99 | |
| 405_V | 409_E | 1.371 | 0.99 | |
| 305_V | 347_I | 1.366 | 0.99 | |
| 324_S | 327_N | 1.365 | 0.99 | |
| 308_R | 331_W | 1.362 | 0.99 | |
| 355_F | 364_P | 1.35 | 0.99 | |
| 28_L | 63_P | 1.346 | 0.99 | |
| 400_Y | 426_T | 1.345 | 0.99 | |
| 32_E | 35_A | 1.342 | 0.99 | |
| 176_D | 220_H | 1.341 | 0.99 | |
| 245_L | 250_I | 1.318 | 0.99 | |
| 158_A | 312_M | 1.316 | 0.99 | |
| 337_R | 351_L | 1.306 | 0.99 | |
| 37_V | 71_A | 1.306 | 0.99 | |
| 33_L | 70_L | 1.305 | 0.99 | |
| 19_I | 202_R | 1.304 | 0.99 | |
| 154_H | 158_A | 1.301 | 0.99 | |
| 95_L | 100_L | 1.298 | 0.99 | |
| 36_R | 39_E | 1.293 | 0.99 | |
| 167_L | 199_A | 1.291 | 0.99 | |
| 409_E | 413_D | 1.289 | 0.99 | |
| 142_T | 152_A | 1.287 | 0.99 | |
| 378_L | 401_D | 1.286 | 0.99 | |
| 228_L | 243_V | 1.276 | 0.99 | |
| 179_L | 218_C | 1.269 | 0.99 | |
| 52_G | 314_E | 1.267 | 0.99 | |
| 49_V | 102_F | 1.261 | 0.99 | |
| 78_R | 136_L | 1.26 | 0.99 | |
| 278_V | 307_L | 1.257 | 0.99 | |
| 57_L | 68_A | 1.252 | 0.99 | |
| 96_P | 148_L | 1.252 | 0.99 | |
| 153_V | 317_W | 1.246 | 0.98 | |
| 11_W | 14_V | 1.245 | 0.98 | |
| 398_M | 426_T | 1.244 | 0.98 | |
| 365_E | 369_R | 1.242 | 0.98 | |
| 385_V | 395_V | 1.241 | 0.98 | |
| 251_P | 254_L | 1.239 | 0.98 | |
| 398_M | 424_W | 1.235 | 0.98 | |
| 370_V | 414_K | 1.232 | 0.98 | |
| 353_N | 365_E | 1.229 | 0.98 | |
| 412_K | 417_R | 1.22 | 0.98 | |
| 40_L | 104_L | 1.217 | 0.98 | |
| 49_V | 53_S | 1.212 | 0.98 | |
| 54_G | 78_R | 1.207 | 0.98 | |
| 385_V | 423_R | 1.207 | 0.98 | |
| 177_D | 218_C | 1.206 | 0.98 | |
| 177_D | 204_T | 1.205 | 0.98 | |
| 80_L | 98_L | 1.204 | 0.98 | |
| 387_D | 393_R | 1.203 | 0.98 | |
| 292_P | 298_V | 1.202 | 0.98 | |
| 82_V | 91_L | 1.193 | 0.98 | |
| 291_S | 344_K | 1.191 | 0.98 | |
| 215_L | 239_S | 1.187 | 0.98 | |
| 304_E | 351_L | 1.186 | 0.98 | |
| 139_M | 151_A | 1.185 | 0.98 | |
| 299_K | 331_W | 1.184 | 0.98 | |
| 70_L | 197_L | 1.183 | 0.98 | |
| 93_E | 97_N | 1.179 | 0.98 | |
| 307_L | 334_T | 1.177 | 0.98 | |
| 226_T | 248_A | 1.177 | 0.98 | |
| 90_L | 419_Q | 1.175 | 0.98 | |
| 354_L | 363_Q | 1.163 | 0.97 | |
| 97_N | 148_L | 1.162 | 0.97 | |
| 410_W | 413_D | 1.154 | 0.97 | |
| 309_A | 312_M | 1.153 | 0.97 | |
| 233_V | 257_Q | 1.152 | 0.97 | |
| 386_A | 392_H | 1.143 | 0.97 | |
| 250_I | 255_T | 1.143 | 0.97 | |
| 411_V | 420_Q | 1.141 | 0.97 | |
| 416_A | 419_Q | 1.139 | 0.97 | |
| 28_L | 36_R | 1.138 | 0.97 | |
| 183_P | 186_H | 1.136 | 0.97 | |
| 395_V | 423_R | 1.126 | 0.97 | |
| 168_S | 294_P | 1.12 | 0.96 | |
| 54_G | 139_M | 1.113 | 0.96 | |
| 33_L | 67_L | 1.112 | 0.96 | |
| 397_V | 444_K | 1.109 | 0.96 | |
| 296_R | 311_S | 1.108 | 0.96 | |
| 370_V | 411_V | 1.103 | 0.96 | |
| 41_A | 74_Q | 1.102 | 0.96 | |
| 337_R | 349_G | 1.096 | 0.96 | |
| 143_S | 435_G | 1.096 | 0.96 | |
| 58_R | 91_L | 1.096 | 0.96 | |
| 20_A | 30_W | 1.095 | 0.96 | |
| 285_G | 344_K | 1.094 | 0.96 | |
| 157_Q | 310_A | 1.092 | 0.96 | |
| 221_A | 240_L | 1.092 | 0.96 | |
| 397_V | 427_L | 1.092 | 0.96 | |
| 355_F | 394_P | 1.086 | 0.96 | |
| 188_S | 222_S | 1.082 | 0.96 | |
| 23_L | 26_E | 1.081 | 0.95 | |
| 140_T | 272_T | 1.081 | 0.95 | |
| 358_G | 390_F | 1.08 | 0.95 | |
| 298_V | 345_L | 1.08 | 0.95 | |
| 83_N | 185_F | 1.073 | 0.95 | |
| 305_V | 345_L | 1.064 | 0.95 | |
| 43_G | 46_V | 1.062 | 0.95 | |
| 289_V | 347_I | 1.061 | 0.95 | |
| 374_H | 406_D | 1.06 | 0.95 | |
| 217_G | 239_S | 1.059 | 0.95 | |
| 326_V | 332_Y | 1.058 | 0.95 | |
| 133_P | 157_Q | 1.054 | 0.95 | |
| 300_I | 345_L | 1.054 | 0.95 | |
| 40_L | 68_A | 1.05 | 0.94 | |
| 153_V | 314_E | 1.05 | 0.94 | |
| 379_Q | 399_E | 1.05 | 0.94 | |
| 36_R | 64_Q | 1.047 | 0.94 | |
| 33_L | 37_V | 1.046 | 0.94 | |
| 34_C | 37_V | 1.045 | 0.94 | |
| 28_L | 33_L | 1.04 | 0.94 | |
| 63_P | 67_L | 1.033 | 0.94 | |
| 396_A | 424_W | 1.032 | 0.94 | |
| 93_E | 141_L | 1.03 | 0.94 | |
| 393_R | 422_V | 1.03 | 0.94 | |
| 137_C | 156_Y | 1.026 | 0.94 | |
| 206_R | 214_M | 1.024 | 0.93 | |
| 374_H | 407_L | 1.023 | 0.93 | |
| 274_F | 332_Y | 1.02 | 0.93 | |
| 18_T | 202_R | 1.019 | 0.93 | |
| 441_Q | 445_E | 1.019 | 0.93 | |
| 360_E | 418_F | 1.014 | 0.93 | |
| 373_A | 410_W | 1.011 | 0.93 | |
| 407_L | 424_W | 1.005 | 0.93 | |
| 152_A | 313_A | 1.003 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3tsyA | 1 | 0.9978 | 100 | 0.085 | Contact Map | 0.798 |
| 3r44A | 1 | 0.9956 | 100 | 0.091 | Contact Map | 0.831 |
| 1mdbA | 1 | 0.9978 | 100 | 0.095 | Contact Map | 0.767 |
| 3etcA | 2 | 0.9956 | 100 | 0.098 | Contact Map | 0.849 |
| 4fuqA | 4 | 0.9956 | 100 | 0.1 | Contact Map | 0.78 |
| 4gr5A | 4 | 0.9889 | 100 | 0.102 | Contact Map | 0.796 |
| 3ni2A | 1 | 0.9956 | 100 | 0.102 | Contact Map | 0.816 |
| 3o83A | 2 | 0.9978 | 100 | 0.103 | Contact Map | 0.748 |
| 3vnrA | 1 | 0.9978 | 100 | 0.104 | Contact Map | 0.823 |
| 1v25A | 2 | 0.9978 | 100 | 0.104 | Contact Map | 0.746 |
Sequence Conservation (Image Generated using WebLogo v3)