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OPENSEQ.org
YFAD - Uncharacterized protein YfaD
UniProt: P37014 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12323
Length: 299 (298)
Sequences: 568
Seq/Len: 1.91
YFAD
Paralog alert: 0.89 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: YADD YFAD YFCI YHGA YJIP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
84_Q 94_R 2.881 1.00
255_H 259_W 2.863 1.00
259_W 263_M 2.837 1.00
280_E 283_I 2.752 1.00
257_I 261_E 2.705 1.00
271_A 290_L 2.642 1.00
290_L 298_C 2.476 1.00
260_Q 264_H 2.471 1.00
46_R 67_S 2.458 1.00
256_Q 260_Q 2.352 1.00
261_E 265_E 2.29 1.00
271_A 288_T 2.236 1.00
271_A 274_M 2.165 0.99
291_T 294_D 2.113 0.99
247_A 250_L 2.081 0.99
263_M 266_Q 2.072 0.99
284_V 288_T 2.028 0.99
277_Q 286_A 1.986 0.99
84_Q 91_M 1.98 0.99
266_Q 270_I 1.96 0.99
271_A 278_G 1.954 0.99
251_R 257_I 1.949 0.99
256_Q 264_H 1.908 0.98
267_A 270_I 1.839 0.98
255_H 261_E 1.836 0.98
257_I 260_Q 1.833 0.98
273_R 289_Q 1.831 0.98
284_V 290_L 1.8 0.97
103_M 117_V 1.784 0.97
278_G 288_T 1.767 0.97
91_M 94_R 1.738 0.96
278_G 284_V 1.623 0.94
285_L 295_I 1.608 0.94
274_M 287_T 1.597 0.94
258_G 262_G 1.579 0.93
271_A 284_V 1.578 0.93
133_S 138_D 1.571 0.93
282_E 292_D 1.57 0.93
52_F 65_L 1.555 0.92
279_F 283_I 1.531 0.92
255_H 263_M 1.507 0.91
67_S 74_D 1.471 0.89
285_L 292_D 1.454 0.89
294_D 297_N 1.453 0.88
284_V 295_I 1.428 0.87
288_T 295_I 1.424 0.87
270_I 274_M 1.422 0.87
96_M 100_T 1.416 0.87
21_P 66_W 1.412 0.86
51_S 80_V 1.395 0.86
253_E 257_I 1.379 0.85
274_M 288_T 1.368 0.84
281_R 284_V 1.366 0.84
278_G 290_L 1.364 0.84
259_W 265_E 1.347 0.83
266_Q 269_K 1.343 0.83
288_T 294_D 1.343 0.83
273_R 286_A 1.342 0.82
256_Q 259_W 1.334 0.82
285_L 297_N 1.329 0.82
274_M 279_F 1.321 0.81
273_R 277_Q 1.306 0.80
90_N 139_E 1.302 0.80
163_P 166_E 1.274 0.78
267_A 283_I 1.273 0.78
14_F 83_H 1.271 0.77
277_Q 287_T 1.268 0.77
11_D 15_K 1.246 0.75
271_A 298_C 1.244 0.75
270_I 288_T 1.243 0.75
245_T 248_E 1.242 0.75
101_A 104_Q 1.242 0.75
272_L 288_T 1.229 0.74
284_V 294_D 1.223 0.74
272_L 284_V 1.221 0.73
178_L 181_K 1.218 0.73
65_L 122_F 1.217 0.73
281_R 295_I 1.209 0.72
288_T 291_T 1.202 0.72
283_I 286_A 1.191 0.71
283_I 295_I 1.167 0.68
288_T 298_C 1.166 0.68
292_D 295_I 1.166 0.68
280_E 295_I 1.161 0.68
123_Y 158_D 1.157 0.67
257_I 265_E 1.151 0.67
70_T 73_G 1.142 0.66
93_F 100_T 1.135 0.65
256_Q 261_E 1.13 0.65
113_R 141_D 1.129 0.65
10_H 14_F 1.129 0.65
235_R 238_L 1.125 0.64
279_F 287_T 1.123 0.64
271_A 294_D 1.113 0.63
65_L 102_A 1.103 0.62
13_V 84_Q 1.102 0.62
83_H 124_H 1.096 0.61
75_G 105_R 1.095 0.61
284_V 289_Q 1.089 0.61
272_L 289_Q 1.088 0.60
261_E 264_H 1.082 0.60
276_E 280_E 1.079 0.60
268_I 271_A 1.076 0.59
99_A 119_P 1.075 0.59
268_I 290_L 1.073 0.59
86_S 94_R 1.072 0.59
213_F 232_I 1.07 0.59
84_Q 106_H 1.07 0.59
241_E 244_M 1.07 0.59
24_A 32_L 1.068 0.58
56_S 104_Q 1.068 0.58
44_T 69_E 1.067 0.58
87_A 131_P 1.062 0.58
281_R 285_L 1.056 0.57
286_A 292_D 1.052 0.57
118_V 155_L 1.051 0.57
93_F 107_Q 1.05 0.56
273_R 296_P 1.045 0.56
286_A 295_I 1.04 0.55
289_Q 298_C 1.038 0.55
286_A 289_Q 1.038 0.55
285_L 293_A 1.037 0.55
277_Q 283_I 1.036 0.55
53_I 59_A 1.033 0.55
279_F 292_D 1.03 0.54
264_H 270_I 1.03 0.54
269_K 293_A 1.025 0.54
24_A 62_S 1.025 0.54
273_R 285_L 1.024 0.54
292_D 296_P 1.022 0.53
271_A 289_Q 1.018 0.53
84_Q 124_H 1.018 0.53
271_A 280_E 1.017 0.53
281_R 292_D 1.008 0.52
104_Q 108_D 1.004 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dyqA20.1639530.951Contact Map0.399
1jkoC10.140522.50.96Contact Map0.348
1g8eA20.19421.90.961Contact Map0.34
2lvsA10.30115.30.963Contact Map0.317
2jpcA10.113714.70.964Contact Map0.339
3e3vA10.441514.60.964Contact Map0.389
1tc3C10.140513.50.964Contact Map0.388
1hx8A20.20413.40.964Contact Map0.289
2cobA10.163912.80.965Contact Map0.404
1j9iA20.076912.50.965Contact Map0.596
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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