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OPENSEQ.org
YADD - Uncharacterized protein YadD
UniProt: P31665 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11748
Length: 300 (295)
Sequences: 589
Seq/Len: 2.00
YADD
Paralog alert: 0.89 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: YADD YFAD YFCI YHGA YJIP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
255_K 259_Q 3.287 1.00
253_I 257_I 3.09 1.00
259_Q 263_E 2.787 1.00
83_Q 93_R 2.658 1.00
278_S 281_D 2.626 1.00
257_I 261_R 2.596 1.00
254_E 258_Q 2.564 1.00
288_L 296_V 2.556 1.00
269_A 288_L 2.479 1.00
258_Q 262_Q 2.356 1.00
261_R 264_V 2.331 1.00
45_H 66_S 2.304 1.00
253_I 259_Q 2.276 1.00
289_P 292_E 2.263 1.00
269_A 272_L 2.095 0.99
254_E 262_Q 2.024 0.99
269_A 286_A 2.019 0.99
245_A 248_F 1.963 0.99
282_V 286_A 1.958 0.99
275_K 284_E 1.953 0.99
264_V 268_F 1.95 0.99
255_K 258_Q 1.935 0.99
83_Q 90_M 1.919 0.99
282_V 288_L 1.916 0.98
269_A 276_G 1.863 0.98
265_S 268_F 1.798 0.97
249_E 255_K 1.784 0.97
102_M 116_V 1.767 0.97
271_R 287_N 1.709 0.96
90_M 93_R 1.679 0.96
276_G 286_A 1.673 0.96
283_A 293_I 1.607 0.94
276_G 282_V 1.585 0.94
280_E 290_L 1.567 0.93
269_A 282_V 1.563 0.93
253_I 261_R 1.557 0.93
255_K 263_E 1.549 0.93
272_L 285_M 1.548 0.93
132_S 137_D 1.512 0.92
283_A 290_L 1.487 0.91
268_F 272_L 1.475 0.90
282_V 293_I 1.462 0.90
283_A 295_K 1.457 0.89
292_E 295_K 1.443 0.89
251_K 255_K 1.438 0.89
277_M 281_D 1.413 0.87
20_A 65_Y 1.398 0.87
51_F 64_L 1.394 0.86
95_M 99_I 1.379 0.86
256_G 260_G 1.372 0.85
272_L 286_A 1.366 0.85
264_V 267_E 1.363 0.85
271_R 275_K 1.357 0.84
281_D 284_E 1.354 0.84
269_A 296_V 1.35 0.84
9_H 13_F 1.342 0.83
276_G 288_L 1.341 0.83
279_R 282_V 1.326 0.82
89_K 138_M 1.325 0.82
50_S 79_V 1.316 0.82
286_A 293_I 1.314 0.82
279_R 293_I 1.312 0.82
66_S 73_P 1.3 0.81
10_D 14_K 1.276 0.79
162_P 165_E 1.271 0.79
272_L 277_M 1.271 0.79
286_A 292_E 1.252 0.77
257_I 263_E 1.251 0.77
271_R 284_E 1.25 0.77
275_K 285_M 1.25 0.77
13_F 82_H 1.241 0.76
286_A 296_V 1.241 0.76
270_Q 286_A 1.24 0.76
268_F 286_A 1.217 0.74
270_Q 282_V 1.215 0.74
64_L 121_F 1.197 0.73
282_V 292_E 1.195 0.72
83_Q 105_H 1.175 0.71
265_S 281_D 1.161 0.69
254_E 259_Q 1.161 0.69
23_A 61_T 1.157 0.69
243_T 246_Q 1.157 0.69
285_M 297_I 1.157 0.69
100_A 103_H 1.155 0.69
102_M 135_W 1.155 0.69
293_I 296_V 1.154 0.69
277_M 285_M 1.15 0.68
177_L 180_K 1.147 0.68
92_F 106_L 1.135 0.67
266_Q 269_A 1.131 0.66
286_A 289_P 1.125 0.66
293_I 297_I 1.125 0.66
117_V 154_P 1.113 0.64
271_R 294_D 1.1 0.63
112_K 140_Y 1.098 0.63
122_Y 157_D 1.093 0.62
290_L 293_I 1.089 0.62
82_H 123_Q 1.085 0.62
290_L 294_D 1.085 0.62
269_A 292_E 1.083 0.61
284_E 290_L 1.081 0.61
111_D 141_S 1.078 0.61
85_K 93_R 1.077 0.61
269_A 278_S 1.077 0.61
9_H 118_P 1.073 0.60
275_K 281_D 1.07 0.60
282_V 287_N 1.068 0.60
69_M 72_N 1.068 0.60
284_E 296_V 1.058 0.59
52_I 58_G 1.045 0.57
286_A 297_I 1.045 0.57
92_F 99_I 1.044 0.57
103_H 107_E 1.043 0.57
283_A 291_A 1.041 0.57
12_V 83_Q 1.039 0.57
220_H 247_W 1.039 0.57
43_T 68_Q 1.039 0.57
172_I 208_L 1.039 0.57
74_G 104_R 1.039 0.57
268_F 297_I 1.037 0.56
98_S 118_P 1.029 0.56
59_H 93_R 1.027 0.55
273_L 282_V 1.023 0.55
230_V 233_D 1.02 0.55
211_M 227_F 1.017 0.54
55_S 103_H 1.015 0.54
64_L 101_A 1.014 0.54
271_R 283_A 1.008 0.53
284_E 293_I 1.006 0.53
208_L 216_L 1.005 0.53
281_D 293_I 1.002 0.53
294_D 297_I 1.001 0.52
270_Q 287_N 1.001 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dyqA20.173363.40.947Contact Map0.437
1jkoC10.1539.20.955Contact Map0.386
2lvsA10.31360.956Contact Map0.333
3e3vA10.463327.20.958Contact Map0.405
2cobA10.173326.40.958Contact Map0.418
2jpcA10.123326.40.958Contact Map0.379
2x48A30.183323.80.959Contact Map0.539
3c1dA20.3622.70.96Contact Map0.328
3frwA80.273320.50.961Contact Map0.46
1tc3C10.1520.20.961Contact Map0.42
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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