May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
MDTP - Multidrug resistance outer membrane protein MdtP
UniProt: P32714 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11952
Length: 488 (456)
Sequences: 7622
Seq/Len: 16.71
MDTP
Paralog alert: 0.84 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: CUSC MDTP MDTQ TOLC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_T 190_V 3.716 1.00
215_D 246_D 3.377 1.00
208_E 253_K 3.233 1.00
222_Q 239_R 3.049 1.00
75_R 269_A 2.931 1.00
423_R 454_E 2.869 1.00
222_Q 226_A 2.805 1.00
424_F 427_R 2.708 1.00
204_L 249_I 2.704 1.00
211_H 242_I 2.677 1.00
208_E 249_I 2.445 1.00
197_M 256_I 2.426 1.00
92_K 379_A 2.372 1.00
318_V 380_S 2.357 1.00
325_F 373_L 2.352 1.00
439_S 442_Q 2.349 1.00
216_Y 219_K 2.346 1.00
89_R 382_M 2.314 1.00
88_L 378_A 2.297 1.00
229_L 437_L 2.286 1.00
430_E 434_Q 2.228 1.00
329_F 359_L 2.217 1.00
82_T 389_Q 2.213 1.00
202_Q 205_D 2.181 1.00
232_Q 424_F 2.178 1.00
201_Y 256_I 2.169 1.00
225_V 235_F 2.151 1.00
211_H 249_I 2.148 1.00
178_E 306_A 2.128 1.00
95_S 371_A 2.126 1.00
85_E 386_R 2.122 1.00
96_Q 375_G 2.075 1.00
74_Q 78_S 2.009 1.00
423_R 427_R 2.002 1.00
203_M 455_M 1.998 1.00
215_D 242_I 1.932 1.00
97_A 172_H 1.92 1.00
243_L 246_D 1.905 1.00
223_S 431_A 1.901 1.00
167_A 317_Q 1.899 1.00
171_A 317_Q 1.898 1.00
243_L 417_E 1.869 1.00
177_A 305_Q 1.866 1.00
215_D 219_K 1.851 1.00
200_S 252_V 1.832 1.00
204_L 253_K 1.818 1.00
365_D 369_L 1.816 1.00
170_G 309_W 1.779 1.00
200_S 259_T 1.779 1.00
174_A 310_Y 1.774 1.00
212_D 216_Y 1.772 1.00
199_A 462_S 1.749 1.00
204_L 256_I 1.719 1.00
445_E 448_L 1.715 1.00
306_A 310_Y 1.71 1.00
408_L 460_L 1.703 1.00
88_L 385_E 1.69 1.00
211_H 246_D 1.683 1.00
177_A 180_A 1.677 1.00
457_L 461_D 1.66 1.00
171_A 313_A 1.651 1.00
416_A 457_L 1.647 1.00
379_A 382_M 1.635 1.00
315_L 380_S 1.635 1.00
409_N 464_R 1.633 1.00
430_E 447_R 1.629 1.00
88_L 381_N 1.625 1.00
209_Q 454_E 1.619 1.00
396_R 400_V 1.617 1.00
199_A 458_L 1.575 1.00
190_V 263_L 1.559 1.00
84_A 385_E 1.541 1.00
173_N 176_L 1.536 1.00
167_A 320_S 1.533 1.00
239_R 417_E 1.528 1.00
225_V 232_Q 1.525 1.00
205_D 208_E 1.518 1.00
412_R 457_L 1.512 1.00
90_E 179_T 1.511 1.00
73_I 77_L 1.509 1.00
236_H 424_F 1.508 1.00
72_L 190_V 1.508 1.00
163_S 166_A 1.5 1.00
201_Y 260_R 1.499 1.00
73_I 191_A 1.497 1.00
164_A 320_S 1.491 1.00
207_L 245_V 1.489 1.00
227_H 435_R 1.484 1.00
380_S 384_I 1.481 1.00
70_D 74_Q 1.471 1.00
68_Q 71_A 1.471 1.00
71_A 74_Q 1.465 1.00
91_E 94_Q 1.462 1.00
206_L 458_L 1.461 1.00
160_V 328_S 1.444 1.00
218_V 242_I 1.442 1.00
83_L 186_L 1.437 1.00
240_A 422_T 1.436 1.00
99_L 375_G 1.431 1.00
91_E 381_N 1.429 1.00
214_I 245_V 1.428 1.00
450_V 454_E 1.428 1.00
308_R 387_Y 1.426 1.00
309_W 312_Q 1.409 1.00
192_Q 466_I 1.408 1.00
77_L 187_A 1.405 0.99
95_S 374_E 1.403 0.99
174_A 313_A 1.402 0.99
261_E 400_V 1.399 0.99
256_I 260_R 1.396 0.99
62_K 70_D 1.396 0.99
218_V 239_R 1.383 0.99
98_D 371_A 1.383 0.99
332_K 356_I 1.382 0.99
161_H 165_V 1.38 0.99
219_K 222_Q 1.377 0.99
218_V 222_Q 1.375 0.99
312_Q 315_L 1.371 0.99
75_R 267_I 1.368 0.99
381_N 384_I 1.364 0.99
374_E 377_R 1.353 0.99
104_S 165_V 1.352 0.99
212_D 215_D 1.35 0.99
191_A 469_I 1.347 0.99
92_K 382_M 1.344 0.99
233_V 429_A 1.331 0.99
318_V 373_L 1.328 0.99
389_Q 393_N 1.313 0.99
419_V 450_V 1.312 0.99
239_R 243_L 1.304 0.99
73_I 187_A 1.304 0.99
205_D 209_Q 1.297 0.99
254_G 404_R 1.294 0.99
249_I 253_K 1.292 0.99
204_L 208_E 1.29 0.99
59_Q 62_K 1.285 0.99
180_A 183_E 1.281 0.99
426_Q 450_V 1.268 0.99
102_A 368_R 1.265 0.99
95_S 378_A 1.263 0.99
209_Q 212_D 1.263 0.99
419_V 454_E 1.262 0.99
218_V 235_F 1.254 0.99
369_L 373_L 1.251 0.99
423_R 450_V 1.247 0.99
372_N 375_G 1.245 0.98
398_V 471_L 1.245 0.98
419_V 457_L 1.241 0.98
156_D 159_G 1.239 0.98
416_A 461_D 1.237 0.98
429_A 438_T 1.237 0.98
417_E 420_E 1.237 0.98
307_M 383_M 1.237 0.98
97_A 169_I 1.236 0.98
30_D 33_P 1.231 0.98
27_V 163_S 1.23 0.98
265_A 396_R 1.225 0.98
89_R 92_K 1.225 0.98
459_M 463_R 1.224 0.98
301_R 397_D 1.223 0.98
416_A 420_E 1.221 0.98
242_I 246_D 1.22 0.98
170_G 312_Q 1.217 0.98
197_M 260_R 1.215 0.98
75_R 79_G 1.212 0.98
250_V 410_D 1.212 0.98
433_Y 440_R 1.211 0.98
311_V 384_I 1.211 0.98
192_Q 470_Q 1.201 0.98
71_A 75_R 1.2 0.98
223_S 226_A 1.199 0.98
90_E 176_L 1.198 0.98
219_K 223_S 1.194 0.98
185_S 189_G 1.191 0.98
382_M 386_R 1.19 0.98
301_R 474_S 1.19 0.98
85_E 385_E 1.19 0.98
87_K 179_T 1.179 0.98
311_V 387_Y 1.177 0.98
408_L 467_Q 1.169 0.97
364_F 367_G 1.168 0.97
308_R 312_Q 1.168 0.97
211_H 215_D 1.165 0.97
90_E 172_H 1.163 0.97
304_L 394_A 1.155 0.97
236_H 239_R 1.153 0.97
177_A 309_W 1.153 0.97
413_E 417_E 1.146 0.97
318_V 377_R 1.144 0.97
375_G 379_A 1.14 0.97
387_Y 391_V 1.136 0.97
432_A 438_T 1.135 0.97
203_M 459_M 1.135 0.97
431_A 434_Q 1.135 0.97
179_T 183_E 1.133 0.97
96_Q 99_L 1.127 0.97
388_N 391_V 1.119 0.96
258_E 404_R 1.119 0.96
76_T 186_L 1.112 0.96
415_Q 460_L 1.111 0.96
322_R 373_L 1.111 0.96
405_L 464_R 1.103 0.96
88_L 91_E 1.1 0.96
464_R 468_S 1.1 0.96
154_D 160_V 1.097 0.96
116_R 143_T 1.096 0.96
97_A 101_D 1.094 0.96
204_L 252_V 1.093 0.96
166_A 316_D 1.087 0.96
311_V 380_S 1.085 0.96
232_Q 236_H 1.084 0.96
411_E 463_R 1.084 0.96
243_L 421_A 1.084 0.96
178_E 310_Y 1.082 0.96
303_D 394_A 1.081 0.95
195_Y 469_I 1.076 0.95
175_A 178_E 1.073 0.95
304_L 387_Y 1.072 0.95
72_L 267_I 1.071 0.95
321_A 324_L 1.071 0.95
362_P 365_D 1.071 0.95
208_E 212_D 1.07 0.95
61_W 70_D 1.062 0.95
173_N 309_W 1.061 0.95
86_A 182_V 1.058 0.95
376_T 379_A 1.057 0.95
189_G 192_Q 1.055 0.95
412_R 460_L 1.055 0.95
426_Q 430_E 1.055 0.95
99_L 372_N 1.053 0.95
254_G 407_T 1.048 0.94
393_N 397_D 1.046 0.94
202_Q 461_D 1.046 0.94
188_T 473_K 1.042 0.94
196_S 466_I 1.042 0.94
325_F 369_L 1.035 0.94
301_R 394_A 1.034 0.94
258_E 403_T 1.03 0.94
84_A 87_K 1.028 0.94
427_R 431_A 1.025 0.93
241_Q 244_A 1.022 0.93
468_S 472_M 1.019 0.93
181_A 185_S 1.019 0.93
167_A 171_A 1.019 0.93
316_D 319_D 1.018 0.93
413_E 416_A 1.016 0.93
108_V 151_A 1.016 0.93
154_D 157_L 1.006 0.93
332_K 358_G 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3d5kA30.92831000.277Contact Map0.806
1yc9A10.90161000.285Contact Map0.624
4k7rA10.90781000.286Contact Map0.655
3pikA10.90781000.286Contact Map0.668
1ek9A30.8341000.388Contact Map0.741
4dk0A10.33255.80.958Contact Map0.587
2f1mA40.297150.30.959Contact Map0.746
3fppA20.327946.20.96Contact Map0.668
3zbiC140.098427.70.965Contact Map0
3ioxA10.229517.80.968Contact Map0.482
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0502 seconds.