| UniProt: | P33369 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12020 | ||
| Length: | 478 (422) | ||
| Sequences: | 7742 | ||
| Seq/Len: | 18.35 |
| MDTQ
Paralog alert: 0.81 [within 20: 0.15] - ratio of genomes with paralogs Cluster includes: CUSC MDTP MDTQ TOLC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 74_A | 188_V | 3.599 | 1.00 | |
| 206_Q | 251_A | 3.058 | 1.00 | |
| 213_N | 244_R | 3.054 | 1.00 | |
| 220_R | 237_D | 2.836 | 1.00 | |
| 73_N | 267_N | 2.833 | 1.00 | |
| 220_R | 224_Q | 2.714 | 1.00 | |
| 420_L | 451_R | 2.713 | 1.00 | |
| 421_R | 424_G | 2.583 | 1.00 | |
| 202_N | 247_L | 2.468 | 1.00 | |
| 209_E | 240_A | 2.407 | 1.00 | |
| 436_A | 439_R | 2.391 | 1.00 | |
| 315_I | 377_S | 2.351 | 1.00 | |
| 206_Q | 247_L | 2.35 | 1.00 | |
| 90_L | 376_E | 2.331 | 1.00 | |
| 322_F | 370_L | 2.315 | 1.00 | |
| 214_T | 217_A | 2.242 | 1.00 | |
| 227_I | 434_I | 2.242 | 1.00 | |
| 87_R | 379_L | 2.239 | 1.00 | |
| 195_W | 254_M | 2.235 | 1.00 | |
| 86_Q | 375_A | 2.217 | 1.00 | |
| 80_D | 386_K | 2.178 | 1.00 | |
| 200_A | 203_T | 2.156 | 1.00 | |
| 427_Q | 431_N | 2.148 | 1.00 | |
| 199_A | 254_M | 2.093 | 1.00 | |
| 326_I | 356_L | 2.092 | 1.00 | |
| 93_A | 368_A | 2.089 | 1.00 | |
| 230_S | 421_R | 2.085 | 1.00 | |
| 176_E | 303_A | 2.074 | 1.00 | |
| 83_V | 383_S | 2.057 | 1.00 | |
| 94_Q | 372_I | 2.033 | 1.00 | |
| 223_Y | 233_G | 2.029 | 1.00 | |
| 209_E | 247_L | 2.002 | 1.00 | |
| 420_L | 424_G | 1.939 | 1.00 | |
| 72_N | 76_Q | 1.924 | 1.00 | |
| 201_L | 452_A | 1.886 | 1.00 | |
| 213_N | 217_A | 1.88 | 1.00 | |
| 169_T | 314_T | 1.879 | 1.00 | |
| 165_A | 314_T | 1.87 | 1.00 | |
| 175_A | 302_Q | 1.861 | 1.00 | |
| 241_S | 244_R | 1.851 | 1.00 | |
| 95_A | 170_V | 1.842 | 1.00 | |
| 221_Q | 428_A | 1.841 | 1.00 | |
| 202_N | 251_A | 1.807 | 1.00 | |
| 213_N | 240_A | 1.795 | 1.00 | |
| 362_D | 366_L | 1.793 | 1.00 | |
| 241_S | 414_Q | 1.778 | 1.00 | |
| 198_Q | 257_I | 1.767 | 1.00 | |
| 161_A | 164_T | 1.718 | 1.00 | |
| 210_K | 214_T | 1.709 | 1.00 | |
| 168_G | 306_W | 1.707 | 1.00 | |
| 405_L | 457_L | 1.705 | 1.00 | |
| 197_T | 459_G | 1.698 | 1.00 | |
| 172_A | 307_Y | 1.683 | 1.00 | |
| 209_E | 244_R | 1.682 | 1.00 | |
| 175_A | 178_E | 1.656 | 1.00 | |
| 454_G | 458_Q | 1.645 | 1.00 | |
| 198_Q | 250_V | 1.638 | 1.00 | |
| 202_N | 254_M | 1.634 | 1.00 | |
| 413_A | 454_G | 1.633 | 1.00 | |
| 86_Q | 382_A | 1.633 | 1.00 | |
| 406_A | 461_W | 1.627 | 1.00 | |
| 303_A | 307_Y | 1.609 | 1.00 | |
| 169_T | 310_S | 1.601 | 1.00 | |
| 442_E | 445_I | 1.595 | 1.00 | |
| 376_E | 379_L | 1.587 | 1.00 | |
| 312_L | 377_S | 1.58 | 1.00 | |
| 393_N | 397_R | 1.575 | 1.00 | |
| 86_Q | 378_N | 1.568 | 1.00 | |
| 197_T | 455_L | 1.562 | 1.00 | |
| 82_Q | 382_A | 1.521 | 1.00 | |
| 427_Q | 444_R | 1.516 | 1.00 | |
| 70_L | 188_V | 1.512 | 1.00 | |
| 66_Q | 69_S | 1.496 | 1.00 | |
| 207_Q | 451_R | 1.496 | 1.00 | |
| 377_S | 381_I | 1.495 | 1.00 | |
| 188_V | 261_L | 1.488 | 1.00 | |
| 234_V | 421_R | 1.485 | 1.00 | |
| 68_T | 72_N | 1.469 | 1.00 | |
| 158_K | 325_D | 1.46 | 1.00 | |
| 447_A | 451_R | 1.456 | 1.00 | |
| 71_I | 189_A | 1.452 | 1.00 | |
| 71_I | 75_L | 1.451 | 1.00 | |
| 223_Y | 230_S | 1.451 | 1.00 | |
| 88_I | 177_R | 1.45 | 1.00 | |
| 306_W | 309_E | 1.45 | 1.00 | |
| 89_Q | 92_E | 1.449 | 1.00 | |
| 165_A | 317_A | 1.445 | 1.00 | |
| 409_N | 454_G | 1.441 | 1.00 | |
| 190_R | 463_D | 1.441 | 1.00 | |
| 199_A | 258_E | 1.44 | 1.00 | |
| 75_L | 185_A | 1.435 | 1.00 | |
| 203_T | 206_Q | 1.434 | 1.00 | |
| 162_E | 317_A | 1.431 | 1.00 | |
| 225_N | 432_A | 1.42 | 1.00 | |
| 171_K | 174_A | 1.418 | 1.00 | |
| 237_D | 414_Q | 1.415 | 1.00 | |
| 205_L | 243_T | 1.407 | 0.99 | |
| 97_A | 372_I | 1.402 | 0.99 | |
| 73_N | 265_T | 1.393 | 0.99 | |
| 216_I | 240_A | 1.386 | 0.99 | |
| 254_M | 258_E | 1.386 | 0.99 | |
| 69_S | 72_N | 1.377 | 0.99 | |
| 305_H | 384_Y | 1.376 | 0.99 | |
| 378_N | 381_I | 1.368 | 0.99 | |
| 172_A | 310_S | 1.368 | 0.99 | |
| 93_A | 371_D | 1.357 | 0.99 | |
| 216_I | 237_D | 1.356 | 0.99 | |
| 204_V | 455_L | 1.352 | 0.99 | |
| 81_M | 184_L | 1.348 | 0.99 | |
| 371_D | 374_K | 1.346 | 0.99 | |
| 159_N | 163_V | 1.343 | 0.99 | |
| 60_L | 68_T | 1.342 | 0.99 | |
| 210_K | 213_N | 1.341 | 0.99 | |
| 102_D | 163_V | 1.34 | 0.99 | |
| 329_M | 353_T | 1.336 | 0.99 | |
| 217_A | 220_R | 1.334 | 0.99 | |
| 216_I | 220_R | 1.334 | 0.99 | |
| 386_K | 390_E | 1.332 | 0.99 | |
| 202_N | 206_Q | 1.329 | 0.99 | |
| 231_V | 426_A | 1.323 | 0.99 | |
| 90_L | 379_L | 1.321 | 0.99 | |
| 212_Q | 243_T | 1.319 | 0.99 | |
| 189_A | 466_I | 1.312 | 0.99 | |
| 259_A | 397_R | 1.311 | 0.99 | |
| 423_V | 447_A | 1.308 | 0.99 | |
| 315_I | 370_L | 1.301 | 0.99 | |
| 96_K | 368_A | 1.301 | 0.99 | |
| 203_T | 207_Q | 1.3 | 0.99 | |
| 238_I | 419_A | 1.297 | 0.99 | |
| 89_Q | 378_N | 1.293 | 0.99 | |
| 247_L | 251_A | 1.27 | 0.99 | |
| 190_R | 467_Q | 1.269 | 0.99 | |
| 304_A | 380_S | 1.261 | 0.99 | |
| 71_I | 185_A | 1.261 | 0.99 | |
| 309_E | 312_L | 1.26 | 0.99 | |
| 178_E | 181_R | 1.253 | 0.99 | |
| 240_A | 244_R | 1.253 | 0.99 | |
| 100_T | 365_R | 1.251 | 0.99 | |
| 416_E | 447_A | 1.249 | 0.99 | |
| 95_A | 167_L | 1.244 | 0.98 | |
| 420_L | 447_A | 1.241 | 0.98 | |
| 168_G | 309_E | 1.24 | 0.98 | |
| 195_W | 258_E | 1.239 | 0.98 | |
| 416_E | 451_R | 1.238 | 0.98 | |
| 207_Q | 210_K | 1.237 | 0.98 | |
| 237_D | 241_S | 1.23 | 0.98 | |
| 414_Q | 417_R | 1.226 | 0.98 | |
| 366_L | 370_L | 1.225 | 0.98 | |
| 216_I | 233_G | 1.224 | 0.98 | |
| 456_L | 460_Q | 1.22 | 0.98 | |
| 369_N | 372_I | 1.219 | 0.98 | |
| 413_A | 458_Q | 1.217 | 0.98 | |
| 221_Q | 224_Q | 1.212 | 0.98 | |
| 426_A | 435_I | 1.211 | 0.98 | |
| 416_E | 454_G | 1.209 | 0.98 | |
| 87_R | 90_L | 1.209 | 0.98 | |
| 209_E | 213_N | 1.206 | 0.98 | |
| 413_A | 417_R | 1.204 | 0.98 | |
| 73_N | 77_N | 1.204 | 0.98 | |
| 88_I | 174_A | 1.2 | 0.98 | |
| 263_A | 393_N | 1.199 | 0.98 | |
| 252_G | 401_Q | 1.194 | 0.98 | |
| 430_F | 437_G | 1.192 | 0.98 | |
| 183_L | 187_S | 1.19 | 0.98 | |
| 405_L | 464_A | 1.189 | 0.98 | |
| 83_V | 382_A | 1.189 | 0.98 | |
| 217_A | 221_Q | 1.184 | 0.98 | |
| 57_Q | 60_L | 1.181 | 0.98 | |
| 154_D | 157_G | 1.177 | 0.98 | |
| 410_Q | 414_Q | 1.169 | 0.97 | |
| 93_A | 375_A | 1.165 | 0.97 | |
| 69_S | 73_N | 1.161 | 0.97 | |
| 315_I | 374_K | 1.16 | 0.97 | |
| 308_V | 381_I | 1.154 | 0.97 | |
| 86_Q | 89_Q | 1.15 | 0.97 | |
| 74_A | 184_L | 1.148 | 0.97 | |
| 385_N | 388_V | 1.145 | 0.97 | |
| 248_N | 407_E | 1.143 | 0.97 | |
| 234_V | 237_D | 1.143 | 0.97 | |
| 379_L | 383_S | 1.143 | 0.97 | |
| 384_Y | 388_V | 1.139 | 0.97 | |
| 305_H | 309_E | 1.133 | 0.97 | |
| 461_W | 465_S | 1.129 | 0.97 | |
| 423_V | 427_Q | 1.127 | 0.97 | |
| 175_A | 306_W | 1.123 | 0.97 | |
| 88_I | 170_V | 1.122 | 0.97 | |
| 402_V | 461_W | 1.122 | 0.97 | |
| 85_E | 177_R | 1.12 | 0.96 | |
| 171_K | 306_W | 1.115 | 0.96 | |
| 308_V | 384_Y | 1.114 | 0.96 | |
| 372_I | 376_E | 1.111 | 0.96 | |
| 395_V | 468_L | 1.107 | 0.96 | |
| 94_Q | 97_A | 1.101 | 0.96 | |
| 428_A | 431_N | 1.099 | 0.96 | |
| 256_I | 401_Q | 1.093 | 0.96 | |
| 70_L | 265_T | 1.09 | 0.96 | |
| 301_L | 391_A | 1.088 | 0.96 | |
| 361_F | 364_G | 1.087 | 0.96 | |
| 298_R | 471_A | 1.086 | 0.96 | |
| 298_R | 394_D | 1.083 | 0.96 | |
| 201_L | 456_L | 1.082 | 0.96 | |
| 318_A | 321_A | 1.082 | 0.96 | |
| 194_E | 463_D | 1.08 | 0.95 | |
| 200_A | 458_Q | 1.077 | 0.95 | |
| 59_W | 68_T | 1.072 | 0.95 | |
| 429_R | 435_I | 1.071 | 0.95 | |
| 319_K | 370_L | 1.069 | 0.95 | |
| 408_K | 460_Q | 1.069 | 0.95 | |
| 308_V | 377_S | 1.068 | 0.95 | |
| 177_R | 181_R | 1.067 | 0.95 | |
| 202_N | 250_V | 1.065 | 0.95 | |
| 412_Q | 457_L | 1.06 | 0.95 | |
| 97_A | 369_N | 1.056 | 0.95 | |
| 359_P | 362_D | 1.055 | 0.95 | |
| 187_S | 190_R | 1.054 | 0.95 | |
| 173_R | 176_E | 1.054 | 0.95 | |
| 409_N | 457_L | 1.05 | 0.94 | |
| 164_T | 313_S | 1.044 | 0.94 | |
| 193_W | 466_I | 1.042 | 0.94 | |
| 206_Q | 210_K | 1.041 | 0.94 | |
| 424_G | 428_A | 1.039 | 0.94 | |
| 252_G | 404_T | 1.028 | 0.94 | |
| 251_A | 407_E | 1.022 | 0.93 | |
| 241_S | 418_D | 1.021 | 0.93 | |
| 298_R | 391_A | 1.02 | 0.93 | |
| 84_A | 180_T | 1.018 | 0.93 | |
| 331_F | 351_G | 1.007 | 0.93 | |
| 239_N | 242_K | 1.005 | 0.93 | |
| 95_A | 99_A | 1.005 | 0.93 | |
| 390_E | 394_D | 1.002 | 0.92 | |
| 230_S | 234_V | 1.001 | 0.92 | |
| 168_G | 313_S | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1yc9A | 1 | 0.91 | 100 | 0.272 | Contact Map | 0.627 |
| 3d5kA | 3 | 0.9205 | 100 | 0.274 | Contact Map | 0.812 |
| 3pikA | 1 | 0.9184 | 100 | 0.282 | Contact Map | 0.676 |
| 4k7rA | 1 | 0.9184 | 100 | 0.282 | Contact Map | 0.659 |
| 1ek9A | 3 | 0.8347 | 100 | 0.37 | Contact Map | 0.743 |
| 3zbiC | 14 | 0.1004 | 57.5 | 0.956 | Contact Map | 0 |
| 4dk0A | 1 | 0.3096 | 37.6 | 0.961 | Contact Map | 0.612 |
| 3fppA | 2 | 0.3201 | 31.7 | 0.962 | Contact Map | 0.667 |
| 2f1mA | 4 | 0.2887 | 16.9 | 0.967 | Contact Map | 0.764 |
| 3lnnA | 2 | 0.3515 | 12 | 0.969 | Contact Map | 0.573 |
Sequence Conservation (Image Generated using WebLogo v3)