| UniProt: | P77211 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG14233 | ||
| Length: | 457 (448) | ||
| Sequences: | 7957 | ||
| Seq/Len: | 17.76 |
| CUSC
Paralog alert: 0.84 [within 20: 0.16] - ratio of genomes with paralogs Cluster includes: CUSC MDTP MDTQ TOLC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 70_A | 169_V | 3.624 | 1.00 | |
| 194_Q | 225_R | 3.225 | 1.00 | |
| 187_E | 232_Q | 3.084 | 1.00 | |
| 201_E | 218_R | 3.001 | 1.00 | |
| 69_E | 248_S | 2.822 | 1.00 | |
| 402_Q | 433_R | 2.789 | 1.00 | |
| 201_E | 205_L | 2.765 | 1.00 | |
| 403_I | 406_Q | 2.594 | 1.00 | |
| 183_L | 228_I | 2.58 | 1.00 | |
| 190_L | 221_I | 2.525 | 1.00 | |
| 297_I | 359_Q | 2.422 | 1.00 | |
| 418_S | 421_E | 2.376 | 1.00 | |
| 187_E | 228_I | 2.372 | 1.00 | |
| 304_F | 352_L | 2.342 | 1.00 | |
| 176_Q | 235_L | 2.334 | 1.00 | |
| 195_Q | 198_A | 2.327 | 1.00 | |
| 86_E | 358_R | 2.303 | 1.00 | |
| 83_K | 361_Q | 2.272 | 1.00 | |
| 82_L | 357_I | 2.245 | 1.00 | |
| 208_S | 416_A | 2.234 | 1.00 | |
| 76_D | 368_Q | 2.213 | 1.00 | |
| 89_A | 350_A | 2.167 | 1.00 | |
| 409_R | 413_Q | 2.164 | 1.00 | |
| 211_V | 403_I | 2.159 | 1.00 | |
| 204_L | 214_L | 2.153 | 1.00 | |
| 190_L | 228_I | 2.142 | 1.00 | |
| 180_Y | 235_L | 2.122 | 1.00 | |
| 79_M | 365_N | 2.116 | 1.00 | |
| 157_A | 285_E | 2.102 | 1.00 | |
| 181_A | 184_Q | 2.096 | 1.00 | |
| 308_I | 338_I | 2.094 | 1.00 | |
| 90_Q | 354_I | 2.037 | 1.00 | |
| 68_S | 72_V | 1.975 | 1.00 | |
| 182_Q | 434_Q | 1.963 | 1.00 | |
| 402_Q | 406_Q | 1.957 | 1.00 | |
| 91_Y | 151_Y | 1.946 | 1.00 | |
| 146_A | 296_N | 1.939 | 1.00 | |
| 202_K | 410_A | 1.917 | 1.00 | |
| 194_Q | 221_I | 1.91 | 1.00 | |
| 156_E | 284_M | 1.885 | 1.00 | |
| 222_E | 225_R | 1.869 | 1.00 | |
| 194_Q | 198_A | 1.863 | 1.00 | |
| 150_N | 296_N | 1.836 | 1.00 | |
| 183_L | 232_Q | 1.835 | 1.00 | |
| 222_E | 396_R | 1.828 | 1.00 | |
| 179_A | 238_A | 1.804 | 1.00 | |
| 179_A | 231_R | 1.795 | 1.00 | |
| 149_Q | 288_H | 1.777 | 1.00 | |
| 191_R | 195_Q | 1.766 | 1.00 | |
| 153_A | 289_A | 1.761 | 1.00 | |
| 344_N | 348_N | 1.753 | 1.00 | |
| 387_L | 439_L | 1.71 | 1.00 | |
| 178_L | 441_Y | 1.701 | 1.00 | |
| 436_L | 440_N | 1.692 | 1.00 | |
| 156_E | 159_R | 1.68 | 1.00 | |
| 190_L | 225_R | 1.676 | 1.00 | |
| 285_E | 289_A | 1.669 | 1.00 | |
| 183_L | 235_L | 1.661 | 1.00 | |
| 82_L | 364_V | 1.658 | 1.00 | |
| 150_N | 292_A | 1.653 | 1.00 | |
| 388_N | 443_R | 1.647 | 1.00 | |
| 82_L | 360_Q | 1.635 | 1.00 | |
| 424_D | 427_R | 1.629 | 1.00 | |
| 375_K | 379_D | 1.628 | 1.00 | |
| 178_L | 437_L | 1.625 | 1.00 | |
| 358_R | 361_Q | 1.619 | 1.00 | |
| 294_N | 359_Q | 1.615 | 1.00 | |
| 395_Q | 436_L | 1.604 | 1.00 | |
| 62_Q | 65_T | 1.592 | 1.00 | |
| 188_E | 433_R | 1.589 | 1.00 | |
| 66_L | 169_V | 1.574 | 1.00 | |
| 409_R | 426_E | 1.564 | 1.00 | |
| 78_R | 364_V | 1.542 | 1.00 | |
| 143_M | 299_A | 1.538 | 1.00 | |
| 215_E | 403_I | 1.534 | 1.00 | |
| 84_V | 158_Q | 1.526 | 1.00 | |
| 64_K | 68_S | 1.522 | 1.00 | |
| 146_A | 299_A | 1.516 | 1.00 | |
| 152_L | 155_E | 1.513 | 1.00 | |
| 85_Q | 88_R | 1.507 | 1.00 | |
| 391_I | 436_L | 1.506 | 1.00 | |
| 67_I | 71_L | 1.49 | 1.00 | |
| 287_E | 366_Y | 1.486 | 1.00 | |
| 169_V | 242_L | 1.486 | 1.00 | |
| 93_L | 354_I | 1.486 | 1.00 | |
| 65_T | 68_S | 1.481 | 1.00 | |
| 67_I | 170_A | 1.478 | 1.00 | |
| 180_Y | 239_N | 1.474 | 1.00 | |
| 139_R | 307_S | 1.465 | 1.00 | |
| 359_Q | 363_V | 1.46 | 1.00 | |
| 288_H | 291_M | 1.46 | 1.00 | |
| 153_A | 292_A | 1.459 | 1.00 | |
| 197_Y | 221_I | 1.451 | 1.00 | |
| 218_R | 396_R | 1.446 | 1.00 | |
| 184_Q | 187_E | 1.445 | 1.00 | |
| 206_T | 414_H | 1.442 | 1.00 | |
| 311_T | 335_I | 1.44 | 1.00 | |
| 204_L | 211_V | 1.434 | 1.00 | |
| 69_E | 246_L | 1.42 | 1.00 | |
| 429_L | 433_R | 1.42 | 1.00 | |
| 186_A | 224_T | 1.418 | 1.00 | |
| 171_Q | 445_V | 1.417 | 1.00 | |
| 77_L | 165_L | 1.412 | 1.00 | |
| 71_L | 166_V | 1.409 | 1.00 | |
| 197_Y | 218_R | 1.407 | 0.99 | |
| 360_Q | 363_V | 1.404 | 0.99 | |
| 235_L | 239_N | 1.403 | 0.99 | |
| 89_A | 353_D | 1.392 | 0.99 | |
| 142_N | 145_E | 1.388 | 0.99 | |
| 197_Y | 201_E | 1.374 | 0.99 | |
| 185_I | 437_L | 1.364 | 0.99 | |
| 193_Y | 224_T | 1.358 | 0.99 | |
| 353_D | 356_E | 1.343 | 0.99 | |
| 86_E | 361_Q | 1.34 | 0.99 | |
| 219_G | 401_L | 1.338 | 0.99 | |
| 85_Q | 360_Q | 1.337 | 0.99 | |
| 240_N | 379_D | 1.335 | 0.99 | |
| 170_A | 448_I | 1.333 | 0.99 | |
| 212_L | 408_A | 1.331 | 0.99 | |
| 297_I | 352_L | 1.328 | 0.99 | |
| 291_M | 294_N | 1.327 | 0.99 | |
| 368_Q | 372_N | 1.326 | 0.99 | |
| 351_N | 354_I | 1.326 | 0.99 | |
| 56_T | 64_K | 1.321 | 0.99 | |
| 98_R | 144_S | 1.321 | 0.99 | |
| 198_A | 201_E | 1.319 | 0.99 | |
| 135_D | 138_G | 1.319 | 0.99 | |
| 405_L | 429_L | 1.315 | 0.99 | |
| 92_R | 350_A | 1.314 | 0.99 | |
| 191_R | 194_Q | 1.308 | 0.99 | |
| 140_L | 144_S | 1.308 | 0.99 | |
| 228_I | 232_Q | 1.304 | 0.99 | |
| 184_Q | 188_E | 1.302 | 0.99 | |
| 183_L | 187_E | 1.288 | 0.99 | |
| 218_R | 222_E | 1.277 | 0.99 | |
| 159_R | 162_H | 1.273 | 0.99 | |
| 398_L | 429_L | 1.272 | 0.99 | |
| 67_I | 166_V | 1.271 | 0.99 | |
| 96_A | 347_R | 1.271 | 0.99 | |
| 91_Y | 148_R | 1.269 | 0.99 | |
| 176_Q | 239_N | 1.267 | 0.99 | |
| 171_Q | 449_S | 1.262 | 0.99 | |
| 395_Q | 399_A | 1.261 | 0.99 | |
| 83_K | 86_E | 1.26 | 0.99 | |
| 286_A | 362_S | 1.257 | 0.99 | |
| 396_R | 399_A | 1.251 | 0.99 | |
| 402_Q | 429_L | 1.248 | 0.99 | |
| 69_E | 73_N | 1.246 | 0.98 | |
| 412_Y | 419_Y | 1.245 | 0.98 | |
| 149_Q | 291_M | 1.244 | 0.98 | |
| 233_G | 383_L | 1.243 | 0.98 | |
| 197_Y | 214_L | 1.241 | 0.98 | |
| 438_D | 442_A | 1.24 | 0.98 | |
| 229_A | 389_D | 1.236 | 0.98 | |
| 164_L | 168_N | 1.231 | 0.98 | |
| 398_L | 433_R | 1.227 | 0.98 | |
| 190_L | 194_Q | 1.224 | 0.98 | |
| 361_Q | 365_N | 1.224 | 0.98 | |
| 408_A | 417_V | 1.223 | 0.98 | |
| 395_Q | 440_N | 1.214 | 0.98 | |
| 290_L | 366_Y | 1.214 | 0.98 | |
| 84_V | 151_Y | 1.214 | 0.98 | |
| 84_V | 155_E | 1.211 | 0.98 | |
| 348_N | 352_L | 1.21 | 0.98 | |
| 188_E | 191_R | 1.209 | 0.98 | |
| 398_L | 436_L | 1.206 | 0.98 | |
| 198_A | 202_K | 1.205 | 0.98 | |
| 290_L | 363_V | 1.205 | 0.98 | |
| 89_A | 357_I | 1.204 | 0.98 | |
| 244_L | 375_K | 1.203 | 0.98 | |
| 82_L | 85_Q | 1.202 | 0.98 | |
| 53_G | 56_T | 1.196 | 0.98 | |
| 202_K | 205_L | 1.196 | 0.98 | |
| 79_M | 364_V | 1.196 | 0.98 | |
| 221_I | 225_R | 1.196 | 0.98 | |
| 280_R | 376_E | 1.194 | 0.98 | |
| 297_I | 356_E | 1.191 | 0.98 | |
| 367_E | 370_I | 1.19 | 0.98 | |
| 81_T | 158_Q | 1.177 | 0.98 | |
| 21_A | 142_N | 1.176 | 0.98 | |
| 290_L | 359_Q | 1.175 | 0.98 | |
| 343_F | 346_G | 1.174 | 0.98 | |
| 410_A | 413_Q | 1.171 | 0.98 | |
| 384_R | 443_R | 1.168 | 0.97 | |
| 387_L | 446_N | 1.164 | 0.97 | |
| 156_E | 288_H | 1.163 | 0.97 | |
| 182_Q | 438_D | 1.161 | 0.97 | |
| 90_Q | 93_L | 1.159 | 0.97 | |
| 215_E | 218_R | 1.156 | 0.97 | |
| 405_L | 409_R | 1.147 | 0.97 | |
| 366_Y | 370_I | 1.147 | 0.97 | |
| 392_S | 396_R | 1.146 | 0.97 | |
| 301_R | 352_L | 1.139 | 0.97 | |
| 152_L | 288_H | 1.138 | 0.97 | |
| 158_Q | 162_H | 1.136 | 0.97 | |
| 91_Y | 95_D | 1.123 | 0.97 | |
| 65_T | 69_E | 1.123 | 0.97 | |
| 187_E | 191_R | 1.121 | 0.97 | |
| 411_L | 417_V | 1.12 | 0.96 | |
| 377_V | 450_L | 1.116 | 0.96 | |
| 237_Q | 383_L | 1.115 | 0.96 | |
| 300_A | 303_A | 1.113 | 0.96 | |
| 283_I | 373_A | 1.111 | 0.96 | |
| 341_P | 344_N | 1.108 | 0.96 | |
| 70_A | 165_L | 1.107 | 0.96 | |
| 394_Q | 439_L | 1.105 | 0.96 | |
| 211_V | 215_E | 1.103 | 0.96 | |
| 181_A | 440_N | 1.1 | 0.96 | |
| 280_R | 373_A | 1.1 | 0.96 | |
| 390_Q | 442_A | 1.098 | 0.96 | |
| 443_R | 447_E | 1.091 | 0.96 | |
| 354_I | 358_R | 1.09 | 0.96 | |
| 175_N | 445_V | 1.087 | 0.96 | |
| 287_E | 291_M | 1.086 | 0.96 | |
| 220_V | 223_S | 1.083 | 0.96 | |
| 183_L | 231_R | 1.081 | 0.95 | |
| 66_L | 246_L | 1.08 | 0.95 | |
| 157_A | 289_A | 1.079 | 0.95 | |
| 174_F | 448_I | 1.075 | 0.95 | |
| 145_E | 295_A | 1.075 | 0.95 | |
| 110_W | 122_R | 1.073 | 0.95 | |
| 154_T | 157_A | 1.069 | 0.95 | |
| 282_D | 373_A | 1.062 | 0.95 | |
| 355_A | 358_R | 1.061 | 0.95 | |
| 237_Q | 382_A | 1.061 | 0.95 | |
| 160_A | 164_L | 1.06 | 0.95 | |
| 93_L | 351_N | 1.054 | 0.95 | |
| 149_Q | 295_A | 1.051 | 0.94 | |
| 406_Q | 410_A | 1.05 | 0.94 | |
| 447_E | 451_Y | 1.048 | 0.94 | |
| 280_R | 453_A | 1.044 | 0.94 | |
| 233_G | 386_S | 1.043 | 0.94 | |
| 24_Y | 27_P | 1.041 | 0.94 | |
| 63_V | 170_A | 1.036 | 0.94 | |
| 222_E | 400_S | 1.032 | 0.94 | |
| 200_V | 217_A | 1.029 | 0.94 | |
| 80_A | 161_V | 1.019 | 0.93 | |
| 55_R | 64_K | 1.016 | 0.93 | |
| 168_N | 171_Q | 1.014 | 0.93 | |
| 313_G | 333_N | 1.01 | 0.93 | |
| 391_I | 439_L | 1.01 | 0.93 | |
| 347_R | 351_N | 1.009 | 0.93 | |
| 372_N | 376_E | 1.009 | 0.93 | |
| 179_A | 182_Q | 1.006 | 0.93 | |
| 295_A | 298_G | 1.005 | 0.93 | |
| 250_G | 253_P | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4k7rA | 1 | 0.9628 | 100 | 0.214 | Contact Map | 0.652 |
| 3pikA | 1 | 0.9628 | 100 | 0.214 | Contact Map | 0.67 |
| 3d5kA | 3 | 0.9562 | 100 | 0.239 | Contact Map | 0.805 |
| 1yc9A | 1 | 0.9344 | 100 | 0.261 | Contact Map | 0.628 |
| 1ek9A | 3 | 0.8621 | 100 | 0.357 | Contact Map | 0.743 |
| 4dk0A | 1 | 0.3304 | 56.9 | 0.955 | Contact Map | 0.607 |
| 3zbiC | 14 | 0.105 | 40.2 | 0.959 | Contact Map | 0 |
| 3fppA | 2 | 0.3282 | 40 | 0.959 | Contact Map | 0.655 |
| 2f1mA | 4 | 0.2932 | 17.3 | 0.966 | Contact Map | 0.757 |
| 3lnnA | 2 | 0.3632 | 16.5 | 0.966 | Contact Map | 0.552 |
Sequence Conservation (Image Generated using WebLogo v3)