May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YIHR - Uncharacterized protein YihR
UniProt: P32139 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11844
Length: 308 (286)
Sequences: 3135
Seq/Len: 10.96
YIHR
Paralog alert: 0.61 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: GALM YEAD YIHR YPHB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_G 90_I 3.717 1.00
98_A 130_Y 3.329 1.00
30_A 42_L 3.161 1.00
239_I 270_L 3.157 1.00
78_C 85_E 2.737 1.00
41_E 48_H 2.528 1.00
161_A 292_E 2.501 1.00
192_Y 227_T 2.465 1.00
111_S 121_T 2.432 1.00
280_N 284_S 2.425 1.00
189_N 231_A 2.352 1.00
122_A 127_S 2.331 1.00
241_H 246_L 2.316 1.00
133_M 159_T 2.303 1.00
37_A 120_L 2.197 1.00
29_H 43_T 2.19 1.00
30_A 39_L 2.179 1.00
24_A 29_H 2.172 1.00
123_F 135_A 2.159 1.00
259_V 270_L 2.155 1.00
119_T 139_V 2.152 1.00
33_V 40_A 2.143 1.00
30_A 148_L 2.136 1.00
153_A 296_P 2.028 1.00
22_S 31_T 2.001 1.00
151_E 300_F 1.991 1.00
175_N 241_H 1.966 1.00
217_K 222_T 1.963 1.00
123_F 133_M 1.954 1.00
21_V 118_V 1.949 1.00
151_E 298_R 1.94 1.00
124_L 127_S 1.924 1.00
155_Q 296_P 1.88 1.00
117_S 141_S 1.841 1.00
106_R 122_A 1.841 1.00
32_I 120_L 1.838 1.00
23_L 142_L 1.835 1.00
89_P 103_L 1.833 1.00
193_A 203_L 1.769 1.00
207_D 214_T 1.767 1.00
134_L 164_Y 1.766 1.00
141_S 151_E 1.759 1.00
238_T 249_S 1.758 1.00
137_Q 153_A 1.75 1.00
149_S 300_F 1.699 1.00
292_E 295_K 1.697 1.00
153_A 298_R 1.677 1.00
34_T 107_D 1.675 1.00
121_T 137_Q 1.672 1.00
72_N 258_Q 1.67 1.00
135_A 155_Q 1.651 1.00
184_F 213_F 1.621 1.00
78_C 87_Q 1.614 1.00
20_T 33_V 1.611 1.00
66_V 138_V 1.608 1.00
139_V 153_A 1.607 1.00
70_W 282_F 1.6 1.00
28_Y 42_L 1.585 1.00
21_V 110_I 1.567 1.00
89_P 128_Y 1.542 1.00
219_I 270_L 1.533 1.00
119_T 137_Q 1.53 1.00
80_R 85_E 1.527 1.00
161_A 293_S 1.514 1.00
67_L 167_G 1.511 1.00
37_A 66_V 1.494 1.00
238_T 247_S 1.494 1.00
163_P 290_L 1.493 1.00
82_Q 161_A 1.49 1.00
218_K 221_A 1.488 1.00
143_N 147_G 1.461 1.00
81_Y 290_L 1.461 1.00
121_T 135_A 1.461 1.00
254_Q 299_L 1.46 1.00
217_K 221_A 1.457 1.00
31_T 41_E 1.445 1.00
77_G 87_Q 1.437 1.00
183_L 240_T 1.418 1.00
169_H 273_E 1.413 1.00
111_S 119_T 1.412 1.00
124_L 133_M 1.406 0.99
22_S 29_H 1.401 0.99
227_T 258_Q 1.397 0.99
213_F 217_K 1.382 0.99
75_A 280_N 1.366 0.99
184_F 239_I 1.364 0.99
185_Q 238_T 1.358 0.99
66_V 168_I 1.35 0.99
96_K 197_H 1.339 0.99
87_Q 90_I 1.334 0.99
280_N 283_N 1.328 0.99
50_V 170_P 1.316 0.99
183_L 216_A 1.311 0.99
239_I 272_V 1.298 0.99
186_L 259_V 1.296 0.99
262_G 265_L 1.289 0.99
82_Q 160_V 1.281 0.99
274_P 301_F 1.27 0.99
147_G 302_N 1.269 0.99
33_V 38_G 1.254 0.99
143_N 149_S 1.237 0.98
114_T 117_S 1.223 0.98
191_V 204_H 1.22 0.98
249_S 304_Y 1.213 0.98
183_L 242_P 1.198 0.98
20_T 40_A 1.191 0.98
109_Q 121_T 1.191 0.98
164_Y 291_L 1.187 0.98
20_T 31_T 1.172 0.98
240_T 247_S 1.171 0.98
76_N 97_A 1.167 0.97
251_C 302_N 1.161 0.97
229_K 278_P 1.161 0.97
138_V 150_V 1.157 0.97
82_Q 292_E 1.145 0.97
35_V 107_D 1.125 0.97
193_A 204_H 1.12 0.96
141_S 149_S 1.119 0.96
100_H 273_E 1.118 0.96
126_P 160_V 1.116 0.96
262_G 269_G 1.112 0.96
149_S 302_N 1.11 0.96
241_H 244_Q 1.109 0.96
84_Q 160_V 1.103 0.96
39_L 50_V 1.103 0.96
111_S 137_Q 1.097 0.96
206_V 214_T 1.096 0.96
257_V 272_V 1.094 0.96
154_S 164_Y 1.09 0.96
194_V 198_A 1.089 0.96
100_H 169_H 1.082 0.96
44_F 49_L 1.077 0.95
78_C 90_I 1.072 0.95
90_I 96_K 1.07 0.95
164_Y 297_H 1.067 0.95
185_Q 216_A 1.057 0.95
70_W 289_L 1.046 0.94
76_N 90_I 1.04 0.94
256_W 287_D 1.038 0.94
106_R 125_P 1.033 0.94
230_T 236_E 1.027 0.94
134_L 162_A 1.024 0.93
190_Q 205_H 1.017 0.93
291_L 295_K 1.016 0.93
157_I 162_A 1.013 0.93
62_H 99_I 1.012 0.93
108_W 136_S 1.007 0.93
48_H 52_P 1.005 0.93
165_G 277_C 1.004 0.93
28_Y 44_F 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ygaA20.9611000.192Contact Map0.764
1lurA20.95781000.203Contact Map0.829
1z45A10.98381000.208Contact Map0.721
1nsxA20.95131000.209Contact Map0.831
1snzA20.95781000.219Contact Map0.87
3imhA20.94811000.221Contact Map0.812
3mwxA20.95781000.242Contact Map0.804
3nreA40.90911000.248Contact Map0.711
3os7A40.97731000.252Contact Map0.722
3q1nA10.87661000.267Contact Map0.666
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 1.2016 seconds.