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OPENSEQ.org
GALM - Aldose 1-epimerase
UniProt: P0A9C3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11698
Length: 346 (343)
Sequences: 2472
Seq/Len: 7.21
GALM
Paralog alert: 0.45 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: GALM YEAD YIHR YPHB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_S 96_P 3.814 1.00
263_V 306_L 3.611 1.00
102_Q 138_F 3.597 1.00
28_V 40_A 3.412 1.00
84_R 91_T 2.862 1.00
226_K 231_E 2.845 1.00
129_L 135_D 2.708 1.00
141_N 165_D 2.69 1.00
197_D 251_Q 2.681 1.00
200_L 247_A 2.64 1.00
51_E 295_R 2.584 1.00
315_D 319_H 2.57 1.00
167_P 330_R 2.507 1.00
21_R 27_V 2.453 1.00
28_V 156_I 2.413 1.00
283_F 306_L 2.364 1.00
273_K 342_Q 2.281 1.00
30_L 127_F 2.237 1.00
18_L 125_V 2.199 1.00
58_S 61_C 2.178 1.00
130_S 143_G 2.162 1.00
216_A 223_R 2.094 1.00
159_T 338_L 2.06 1.00
28_V 37_L 2.056 1.00
130_S 141_N 2.052 1.00
118_V 128_A 2.023 1.00
35_A 72_S 1.998 1.00
201_P 211_G 1.984 1.00
126_L 147_Q 1.976 1.00
161_R 334_E 1.957 1.00
142_L 170_V 1.952 1.00
167_P 331_P 1.923 1.00
265_S 270_L 1.916 1.00
95_S 107_P 1.911 1.00
50_R 270_L 1.897 1.00
39_S 51_E 1.888 1.00
19_T 29_T 1.88 1.00
27_V 41_R 1.86 1.00
159_T 336_S 1.858 1.00
145_T 161_R 1.842 1.00
124_Q 149_R 1.826 1.00
31_M 38_L 1.784 1.00
113_R 129_L 1.778 1.00
35_A 127_F 1.759 1.00
76_Y 317_P 1.751 1.00
87_F 328_F 1.72 1.00
83_S 93_T 1.698 1.00
128_A 145_T 1.68 1.00
17_L 31_M 1.674 1.00
95_S 136_Q 1.669 1.00
262_H 273_K 1.656 1.00
32_D 114_R 1.636 1.00
155_R 340_E 1.621 1.00
310_S 339_T 1.619 1.00
78_N 282_Q 1.608 1.00
18_L 117_I 1.607 1.00
169_P 328_F 1.602 1.00
40_A 343_F 1.601 1.00
330_R 333_E 1.593 1.00
228_I 306_L 1.584 1.00
151_T 155_R 1.582 1.00
88_D 167_P 1.576 1.00
155_R 342_Q 1.56 1.00
271_Q 344_I 1.557 1.00
84_R 93_T 1.548 1.00
278_A 312_F 1.546 1.00
81_A 315_D 1.542 1.00
157_S 338_L 1.529 0.99
20_L 150_L 1.529 0.99
278_A 337_S 1.525 0.99
249_L 313_L 1.52 0.99
294_S 300_Y 1.518 0.99
72_S 146_V 1.516 0.99
262_H 271_Q 1.506 0.99
131_S 135_D 1.506 0.99
192_L 263_V 1.503 0.99
192_L 222_F 1.503 0.99
149_R 159_T 1.491 0.99
73_I 173_T 1.488 0.99
199_Y 213_K 1.484 0.99
110_F 144_A 1.48 0.99
128_A 143_G 1.47 0.99
53_L 176_V 1.47 0.99
86_T 91_T 1.467 0.99
222_F 226_K 1.464 0.99
286_G 289_L 1.46 0.99
181_D 265_S 1.46 0.99
30_L 125_V 1.453 0.99
29_T 39_S 1.447 0.99
272_L 343_F 1.442 0.99
126_L 145_T 1.441 0.99
247_A 282_Q 1.439 0.99
147_Q 161_R 1.41 0.99
76_Y 327_C 1.406 0.99
133_D 166_K 1.4 0.99
265_S 268_E 1.397 0.99
191_K 225_A 1.392 0.99
26_M 40_A 1.379 0.99
226_K 230_S 1.365 0.99
161_R 336_S 1.352 0.98
72_S 174_N 1.347 0.98
100_V 205_G 1.344 0.98
275_Y 342_Q 1.335 0.98
191_K 264_W 1.328 0.98
201_P 213_K 1.328 0.98
286_G 305_G 1.327 0.98
143_G 163_T 1.323 0.98
17_L 38_L 1.314 0.98
23_N 152_D 1.31 0.98
157_S 340_E 1.309 0.98
88_D 166_K 1.305 0.98
191_K 266_A 1.304 0.98
163_T 334_E 1.303 0.98
315_D 318_N 1.302 0.98
227_I 230_S 1.301 0.98
215_V 223_R 1.3 0.98
151_T 157_S 1.297 0.98
42_I 52_A 1.297 0.98
118_V 126_L 1.296 0.98
193_Q 262_H 1.295 0.98
250_L 260_A 1.277 0.97
312_F 327_C 1.275 0.97
88_D 330_R 1.274 0.97
194_I 283_F 1.249 0.97
31_M 36_T 1.247 0.97
202_V 206_G 1.239 0.97
93_T 96_P 1.232 0.97
37_L 53_L 1.224 0.97
10_P 63_Q 1.222 0.96
82_N 101_N 1.214 0.96
22_N 150_L 1.209 0.96
215_V 218_T 1.209 0.96
110_F 142_L 1.208 0.96
220_F 235_D 1.203 0.96
198_E 214_S 1.201 0.96
121_N 124_Q 1.196 0.96
144_A 172_M 1.164 0.95
280_A 325_P 1.16 0.95
37_L 156_I 1.159 0.95
170_V 335_Y 1.143 0.94
17_L 29_T 1.135 0.94
277_T 337_S 1.132 0.94
81_A 203_D 1.119 0.94
281_L 308_L 1.113 0.93
233_L 238_Q 1.107 0.93
141_N 164_V 1.105 0.93
22_N 154_N 1.102 0.93
54_L 305_G 1.099 0.93
116_Q 128_A 1.09 0.92
146_V 158_I 1.089 0.92
175_H 309_E 1.086 0.92
131_S 141_N 1.083 0.92
90_E 166_K 1.082 0.92
312_F 316_S 1.069 0.91
19_T 27_V 1.066 0.91
101_N 205_G 1.06 0.91
263_V 283_F 1.055 0.91
108_E 113_R 1.054 0.91
316_S 327_C 1.05 0.90
98_Q 101_N 1.05 0.90
220_F 246_H 1.039 0.90
68_F 111_D 1.038 0.90
113_R 132_D 1.038 0.90
190_H 265_S 1.037 0.90
40_A 178_F 1.036 0.90
26_M 42_I 1.033 0.89
236_D 240_K 1.032 0.89
33_W 114_R 1.032 0.89
79_R 103_L 1.03 0.89
301_A 304_Q 1.026 0.89
189_N 267_D 1.024 0.89
162_A 170_V 1.023 0.89
110_F 131_S 1.021 0.89
81_A 207_I 1.019 0.88
78_N 247_A 1.018 0.88
287_N 303_W 1.012 0.88
110_F 129_L 1.001 0.87
115_W 144_A 1.001 0.87
186_D 189_N 1.001 0.87
264_W 271_Q 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1nsxA20.95661000.131Contact Map0.806
1snzA20.97111000.135Contact Map0.865
1z45A10.93061000.136Contact Map0.725
1lurA20.96241000.141Contact Map0.835
3imhA20.93641000.16Contact Map0.813
1ygaA20.91621000.187Contact Map0.741
3os7A40.90751000.301Contact Map0.659
3mwxA20.88151000.309Contact Map0.737
3nreA40.81791000.335Contact Map0.683
3q1nA10.79771000.352Contact Map0.653
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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